Zachary A Kaminsky

Associate Professor

19982019
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Research Output 1998 2019

2019

Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2

Luo, A., Jung, J., Longley, M., Rosoff, D. B., Charlet, K., Muench, C., Lee, J., Hodgkinson, C. A., Goldman, D., Horvath, S., Kaminsky, Z. A. & Lohoff, F. W., Jan 1 2019, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Apolipoproteins
Epigenomics
Alcohols
Genome
Quantitative Trait Loci
2018

DNA methylation age is accelerated in alcohol dependence

Rosen, A. D., Robertson, K. D., Hlady, R. A., Muench, C., Lee, J., Philibert, R., Horvath, S., Kaminsky, Z. A. & Lohoff, F. W., Dec 1 2018, In : Translational Psychiatry. 8, 1, 182.

Research output: Contribution to journalArticle

DNA Methylation
Alcoholism
Epigenomics
Alcohol Drinking
Prefrontal Cortex

Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use

Lee, J. S., Sorcher, J. L., Rosen, A. D., Damadzic, R., Sun, H., Schwandt, M., Heilig, M., Kelly, J., Mauro, K. L., Luo, A., Rosoff, D., Muench, C., Jung, J., Kaminsky, Z. A. & Lohoff, F. W., Jan 1 2018, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Somatoform Disorders
Genes
Alcohols
Polymorphism
Thalamus

Methylomic profiling and replication implicates deregulation of PCSK9 in alcohol use disorder

Lohoff, F. W., Sorcher, J. L., Rosen, A. D., Mauro, K. L., Fanelli, R. R., Momenan, R., Hodgkinson, C. A., Vendruscolo, L. F., Koob, G. F., Schwandt, M., George, D. T., Jones, I. S., Holmes, A., Zhou, Z., Xu, M. J., Gao, B., Sun, H., Phillips, M. J., Muench, C. & Kaminsky, Z. A., Sep 1 2018, In : Molecular Psychiatry. 23, 9

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
Alcohols
Epigenomics
Lipid Metabolism

SLC9B1 methylation predicts fetal intolerance of labor

Knight, A. K., Conneely, K. N., Kilaru, V., Cobb, D., Payne, J., Meilman, S., Corwin, E. J., Kaminsky, Z. A., Dunlop, A. L. & Smith, A. K., Jan 1 2018, (Accepted/In press) In : Epigenetics. p. 1-7 7 p.

Research output: Contribution to journalArticle

DNA Methylation
Methylation
Pregnancy
Mothers
Fetal Hypoxia
2017

Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide

Murphy, T. M., Crawford, B., Dempster, E. L., Hannon, E., Burrage, J., Turecki, G., Kaminsky, Z. A. & Mill, J., Jan 3 2017, In : Translational Psychiatry. 7, 1, e989.

Research output: Contribution to journalArticle

Suicide
Depression
Major Depressive Disorder
Molecular Pathology
DNA Methylation
2016

Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model

Clive, M. L., Boks, M. P., Vinkers, C. H., Osborne, L., Payne, J., Ressler, K. J., Smith, A. K., Wilcox, H. & Kaminsky, Z. A., Nov 3 2016, In : Clinical Epigenetics. 8, 1, 113.

Research output: Contribution to journalArticle

DNA Methylation
Suicide
Methylation
Biomarkers
Postpartum Depression

Epigenetic assimilation in the aging human brain

Oh, G., Ebrahimi, S., Wang, S. C., Cortese, R., Kaminsky, Z. A., Gottesman, I. I., Burke, J. R., Plassman, B. L. & Petronis, A., Apr 28 2016, In : Genome Biology. 17, 1, 76.

Research output: Contribution to journalArticle

Epigenomics
epigenetics
brain
DNA
Brain

High Precision DNA Modification Analysis of HCG9 in Major Psychosis

Pal, M., Ebrahimi, S., Oh, G., Khare, T., Zhang, A., Kaminsky, Z. A., Wang, S. C. & Petronis, A., Jan 1 2016, In : Schizophrenia Bulletin. 42, 1, p. 170-177 8 p.

Research output: Contribution to journalArticle

Epigenomics
Psychotic Disorders
DNA
High-Throughput Nucleotide Sequencing
Cytosine

Oxytocin receptor DNA methylation in postpartum depression

Kimmel, M., Clive, M., Gispen, F., Guintivano, J., Brown, T., Cox, O., Beckmann, M. W., Kornhuber, J., Fasching, P. A., Osborne, L., Binder, E., Payne, J. & Kaminsky, Z. A., Jul 1 2016, In : Psychoneuroendocrinology. 69, p. 150-160 11 p.

Research output: Contribution to journalArticle

Oxytocin Receptors
Postpartum Depression
DNA Methylation
Epigenomics
Hormones

Role of epigenetic factors in the development of mental illness throughout life

Guintivano, J. & Kaminsky, Z. A., Jan 1 2016, In : Neuroscience Research. 102, p. 56-66 11 p.

Research output: Contribution to journalArticle

Epigenomics
Psychiatry
Genome-Wide Association Study
Animal Models
Biomarkers

SKA2 Methylation is Involved in Cortisol Stress Reactivity and Predicts the Development of Post-Traumatic Stress Disorder (PTSD) after Military Deployment

Boks, M. P., Rutten, B. P. F., Geuze, E., Houtepen, L. C., Vermetten, E., Kaminsky, Z. A. & Vinkers, C. H., Apr 1 2016, In : Neuropsychopharmacology. 41, 5, p. 1350-1356 7 p.

Research output: Contribution to journalArticle

Post-Traumatic Stress Disorders
Methylation
Hydrocortisone
Suicide
Biomarkers
2015

DNA methylation and expression of KCNQ3 in bipolar disorder

Kaminsky, Z. A., Jones, I., Verma, R., Saleh, L., Trivedi, H., Guintivano, J., Akman, R., Zandi, P. P., Lee, R. & Potash, J. B., Mar 1 2015, In : Bipolar Disorders. 17, 2, p. 150-159 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Bipolar Disorder
Exons
Gene Expression
Epigenomics

DNA modification study of major depressive disorder: Beyond locus-by-locus comparisons

Oh, G., Wang, S. C., Pal, M., Chen, Z. F., Khare, T., Tochigi, M., Ng, C., Yang, Y. A., Kwan, A., Kaminsky, Z. A., Mill, J., Gunasinghe, C., Tackett, J. L., Gottesman, I. I., Willemsen, G., De Geus, E. J. C., Vink, J. M., Slagboom, P. E., Wray, N. R., Heath, A. C. & 7 others, Montgomery, G. W., Turecki, G., Martin, N. G., Boomsma, D. I., McGuffin, P., Kustra, R. & Petronis, A., Feb 1 2015, In : Biological Psychiatry. 77, 3, p. 246-255 10 p.

Research output: Contribution to journalArticle

Major Depressive Disorder
Epigenomics
DNA
Psychiatry
Spermatozoa

Epigenetic and genetic variation at SKA2 predict suicidal behavior and post-traumatic stress disorder

Kaminsky, Z. A., Wilcox, H., Eaton, W. W., Van Eck, K., Kilaru, V., Jovanovic, T., Klengel, T., Bradley, B., Binder, E. B., Ressler, K. J. & Smith, A. K., Aug 25 2015, In : Translational Psychiatry. 5, 8, e627.

Research output: Contribution to journalArticle

Post-Traumatic Stress Disorders
Epigenomics
Wounds and Injuries
DNA Methylation
Saliva

Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels

Osborne, L., Clive, M., Kimmel, M., Gispen, F., Guintivano, J., Brown, T., Cox, O., Judy, J., Meilman, S., Braier, A., Beckmann, M. W., Kornhuber, J., Fasching, P. A., Goes, F. S., Payne, J., Binder, E. B. & Kaminsky, Z. A., Oct 27 2015, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Postpartum Depression
Epigenomics
Biomarkers
Hormones
DNA Methylation

Traumatic stress and human DNA methylation: A critical review

Vinkers, C. H., Kalafateli, A. L., Rutten, B. P., Kas, M. J., Kaminsky, Z. A., Turner, J. D. & Boks, M. P., Jun 1 2015, In : Epigenomics. 7, 4, p. 593-608 16 p.

Research output: Contribution to journalArticle

DNA Methylation
Wounds and Injuries
Epigenomics
Methylation
Psychiatry
2014

Antenatal prediction of postpartum depression with blood DNA methylation biomarkers

Guintivano, J., Arad, M., Gould, T. D., Payne, J. & Kaminsky, Z. A., 2014, In : Molecular Psychiatry. 19, 5, p. 560-567 8 p.

Research output: Contribution to journalArticle

Postpartum Depression
DNA Methylation
Biomarkers
Estrogens
Epigenomics

Epigenetics in Major Depressive Disorder

Kaminsky, Z. A., Jun 20 2014, Epigenetics in Psychiatry. Elsevier Inc., p. 279-302 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Major Depressive Disorder
Epigenomics
Histone Code
Genome
Depression
Postpartum Depression
DNA Methylation
Psychiatry
Biomarkers

Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors

Guintivano, J., Brown, T., Newcomer, A., Jones, M., Cox, O., Maher, B., Eaton, W. W., Payne, J., Wilcox, H. & Kaminsky, Z. A., Dec 1 2014, In : American Journal of Psychiatry. 171, 12, p. 1287-1296 10 p.

Research output: Contribution to journalArticle

Epigenomics
Suicide
Biomarkers
Hydrocortisone
Suicidal Ideation

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

Lunnon, K., Smith, R., Hannon, E., De Jager, P. L., Srivastava, G., Volta, M., Troakes, C., Al-Sarraj, S., Burrage, J., Macdonald, R., Condliffe, D., Harries, L. W., Katsel, P., Haroutunian, V., Kaminsky, Z. A., Joachim, C., Powell, J., Lovestone, S., Bennett, D. A., Schalkwyk, L. C. & 1 others, Mill, J., Sep 1 2014, In : Nature Neuroscience. 17, 9, p. 1164-1170 7 p.

Research output: Contribution to journalArticle

Ankyrins
Alzheimer Disease
Temporal Lobe
Entorhinal Cortex
Brain

Seeing the future: Epigenetic biomarkers of postpartum depression

Kaminsky, Z. A. & Payne, J., Jan 2014, In : Neuropsychopharmacology. 39, 1, p. 233-234 2 p.

Research output: Contribution to journalArticle

Nerve Tissue Proteins
Non Histone Chromosomal Proteins
Genetic Epigenesis
Postpartum Depression
DNA Methylation
2013

A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression

Guintivano, J., Aryee, M. J. & Kaminsky, Z. A., Mar 2013, In : Epigenetics. 8, 3, p. 290-302 13 p.

Research output: Contribution to journalArticle

Depression
DNA Methylation
Brain
Epigenomics
Frontal Lobe

Biomarker or pathophysiology? the role of DNA methylation in postpartum depression

Kimmel, M., Kaminsky, Z. A. & Payne, J., Oct 2013, In : Epigenomics. 5, 5, p. 473-475 3 p.

Research output: Contribution to journalArticle

Genetic Epigenesis
Postpartum Depression
DNA Methylation
Postpartum Period
Estrogens

BioTile, A Perl based tool for the identification of differentially enriched regions in tiling microarray data

Guintivano, J., Arad, M., Tamashiro, K., Gould, T. D. & Kaminsky, Z. A., Mar 3 2013, In : BMC Bioinformatics. 14, 76.

Research output: Contribution to journalArticle

DNA Methylation
Microarrays
Tiling
Microarray Data
Genes
2012

A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder

Kaminsky, Z. A., Tochigi, M., Jia, P., Pal, M., Mill, J., Kwan, A., Ioshikhes, I., Vincent, J. B., Kennedy, J. L., Strauss, J., Pai, S., Wang, S. C. & Petronis, A., Jul 2012, In : Molecular Psychiatry. 17, 7, p. 728-740 13 p.

Research output: Contribution to journalArticle

DNA Methylation
HLA Antigens
Bipolar Disorder
Methylation
Epigenomics

Epigenetic markers of prostate cancer in plasma circulating DNA

Cortese, R., Kwan, A., Lalonde, E., Bryzgunova, O., Bondar, A., Wu, Y., Gordevicius, J., Park, M., Oh, G., Kaminsky, Z. A., Tverkuviene, J., Laurinavicius, A., Jankevicius, F., Sendorek, D. H. S., Haider, S., Wang, S. C., Jarmalaite, S., Laktionov, P., Boutros, P. C. & Petronis, A., Aug 2012, In : Human Molecular Genetics. 21, 16, p. 3619-3631 13 p., dds192.

Research output: Contribution to journalArticle

Epigenomics
Prostatic Neoplasms
DNA
Prostate
Biomarkers
2009

DNA methylation profiles in monozygotic and dizygotic twins

Kaminsky, Z. A., Tang, T., Wang, S. C., Ptak, C., Oh, G. H. T., Wong, A. H. C., Feldcamp, L. A., Virtanen, C., Halfvarson, J., Tysk, C., McRae, A. F., Visscher, P. M., Montgomery, G. W., Gottesman, I. I., Martin, N. G. & Petronis, A., Feb 2009, In : Nature Genetics. 41, 2, p. 240-245 6 p.

Research output: Contribution to journalArticle

Dizygotic Twins
Monozygotic Twins
DNA Methylation
Epigenomics
Cheek
DNA Methylation
Methylation
Cytosine
Nucleotides
Genome
2008

Epigenetics of personality traits: An illustrative study of identical twins discordant for risk-taking behavior

Kaminsky, Z. A., Petronis, A., Wang, S. C., Levine, B., Ghaffar, O., Floden, D. & Feinstein, A., Feb 2008, In : Twin Research and Human Genetics. 11, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Monozygotic Twins
Risk-Taking
Epigenomics
Personality
DNA Methylation

Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis

Mill, J., Tang, T., Kaminsky, Z. A., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., Wang, S. C. & Petronis, A., Mar 3 2008, In : American Journal of Human Genetics. 82, 3, p. 696-711 16 p.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
Psychotic Disorders
Schizophrenia
Frontal Lobe
2006

Complex disease, gender and epigenetics

Kaminsky, Z. A., Wang, S. C. & Petronis, A., Dec 2006, In : Annals of Medicine. 38, 8, p. 530-544 15 p.

Research output: Contribution to journalArticle

Epigenomics
Histone Code
Sex Characteristics
Genetic Linkage
Nucleic Acid Regulatory Sequences

Microarray-based DNA methylation profiling: Technology and applications

Schumacher, A., Kapranov, P., Kaminsky, Z. A., Flanagan, J., Assadzadeh, A., Yau, P., Virtanen, C., Winegarden, N., Cheng, J., Gingeras, T. & Petronis, A., Feb 2006, In : Nucleic Acids Research. 34, 2, p. 528-542 15 p.

Research output: Contribution to journalArticle

DNA Fingerprinting
DNA Methylation
Methylation
Technology
Chromosomes, Human, Pair 22

Whole genome amplification of sodium bisulfite-treated DNA allows the accurate estimate of methylated cytosine density in limited DNA resources

Mill, J., Yazdanpanah, S., Gückel, E., Ziegler, S., Kaminsky, Z. A. & Petronis, A., Nov 2006, In : BioTechniques. 41, 5, p. 603-607 5 p.

Research output: Contribution to journalArticle

Cytosine
Amplification
Genes
Genome
DNA Methylation
2005

Search for somatic DNA variation in the brain: Investigation of the serotonin 2A receptor gene

Kaminsky, Z. A., Popendikyte, V., Assadzadeh, A. & Petronis, A., Aug 2005, In : Mammalian Genome. 16, 8, p. 587-593 7 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2A
DNA
Brain
Genes
Leukocytes

Single nucleotide extension technology for quantitative site-specific evaluation of metC/C in GC-rich regions

Kaminsky, Z. A., Assadzadeh, A., Flanagan, J. & Petronis, A., 2005, In : Nucleic Acids Research. 33, 10, p. 1-12 12 p.

Research output: Contribution to journalArticle

GC Rich Sequence
Cytosine
Nucleotides
Technology
Methylation
2004

Epigenetic studies of genomic retroelements in major psychosis

Kan, P. X., Popendikyte, V., Kaminsky, Z. A., Yolken, R. H. & Petronis, A., Mar 1 2004, In : Schizophrenia Research. 67, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle

Retroelements
Epigenomics
Psychotic Disorders
Genetic Transcription
Endogenous Retroviruses
1999

Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions

Engelender, S., Kaminsky, Z. A., Xin, G., Sharp, A. H., Amaravi, R. K., Kleiderlein, J. J., Margolis, R. L., Troncoso, J. C., Lanahan, A. A., Worley, P. F., Dawson, V., Dawson, T. M. & Ross, C. A., May 1999, In : Nature Genetics. 22, 1, p. 110-114 5 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Lewy Bodies
Inclusion Bodies
Proteins
1998

Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins

Wood, J. D., Yuan, J., Margolis, R. L., Colomer, V., Duan, K., Kushi, J., Kaminsky, Z. A., Kleiderlein, J. J., Sharp, A. H. & Ross, C. A., Jun 1998, In : Molecular and Cellular Neuroscience. 11, 3, p. 149-160 12 p.

Research output: Contribution to journalArticle

Progressive Myoclonic Epilepsy
Genes
Proteins
Guanylate Kinases
PDZ Domains

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture

Cooper, J. K., Schilling, G., Peters, M. F., Herring, W. J., Sharp, A. H., Kaminsky, Z. A., Masone, J., Khan, F. A., Delanoy, M., Borchelt, D. R., Dawson, V., Dawson, T. M. & Ross, C. A., May 1998, In : Human Molecular Genetics. 7, 5, p. 783-790 8 p.

Research output: Contribution to journalArticle

Glutamine
Huntington Disease
Cell Culture Techniques
Intranuclear Inclusion Bodies
Cytoplasm