Yun Zhou

Assistant Professor

19962019
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Research Output 1996 2019

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Article
2019

A cholecystokinin B receptor antagonist and cocaine interaction, phase I study

Elkashef, A., Brasic, J. R., Cantelina, L. R., Kahn, R., Chiang, N., Ye, W., Zhou, Y., Mojsiak, J., Warren, K. R., Crabb, A., Hilton, J., Wong, D. F. & Vocci, F., Jan 1 2019, In : CNS Neuroscience and Therapeutics. 25, 1, p. 136-146 11 p.

Research output: Contribution to journalArticle

Cholecystokinin B Receptor
Cocaine
Raclopride
Dopamine
Pharmacokinetics
Open Access
Echocardiography
pulmonary artery
Hypertrophic Cardiomyopathy
cardiomyopathy
echocardiography

Diffusion-weighted imaging as a part of PET/MR for small lesion detection in patients with primary abdominal and pelvic cancer, with or without TOF reconstruction technique

Song, T., Cui, B., Yang, H., Ma, J., Shuai, D., Chen, Z., Liang, Z., Zhou, Y. & Lu, J., Jan 1 2019, In : Abdominal Radiology.

Research output: Contribution to journalArticle

Pelvic Neoplasms
Multimodal Imaging
Logistic Models
Vesicular Monoamine Transport Proteins
Corpus Striatum
Thalamic Nuclei
Deep Brain Stimulation
Parkinson Disease

Longitudinal evaluation of surrogates of regional cerebral blood flow computed from dynamic amyloid PET imaging

Bilgel, M., Beason-Held, L., An, Y., Zhou, Y., Wong, D. F. & Resnick, S. M., Jan 1 2019, In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Regional Blood Flow
Amyloid
Baltimore
Radioactivity

PET imaging of dopamine release in the frontal cortex of manganese-exposed non-human primates

Guilarte, T. R., Yeh, C. L., McGlothan, J. L., Perez, J., Finley, P., Zhou, Y., Wong, D. F., Dydak, U. & Schneider, J. S., Jan 1 2019, In : Journal of Neurochemistry.

Research output: Contribution to journalArticle

Frontal Lobe
Manganese
Primates
Dopamine
Imaging techniques
Open Access
Positron-Emission Tomography
Alzheimer Disease
Entorhinal Cortex
Brain
Amygdala

The Correlation Between [ 68 Ga]DOTATATE PET/CT and Cell Proliferation in Patients With GEP-NENs

Yu, J., Li, N., Li, J., Lu, M., Leal, J. P., Tan, H., Su, H., Fan, Y., Zhang, Y., Zhao, W., Zhu, H., Pomper, M. G., Zhou, Y. & Yang, Z., Jan 1 2019, In : Molecular Imaging and Biology.

Research output: Contribution to journalArticle

Cell Proliferation
Neuroendocrine Tumors
Neoplasms
ROC Curve
Neuroendocrine Cells

The effect of ApoE ε4 on longitudinal brain region-specific glucose metabolism in patients with mild cognitive impairment: a FDG-PET study

for the Alzheimer's Disease Neuroimaging Initiative, Jan 1 2019, In : NeuroImage: Clinical. 22, 101795.

Research output: Contribution to journalArticle

Open Access
Apolipoproteins E
Glucose
Brain
Alzheimer Disease
Prosencephalon
2018

Arterial stiffness and dementia pathology: Atherosclerosis Risk in Communities (ARIC)-PET Study

Hughes, T. M., Wagenknecht, L. E., Craft, S., Mintz, A., Heiss, G., Palta, P., Wong, D. F., Zhou, Y., Knopman, D., Mosley, T. H. & Gottesman, R. F., Apr 3 2018, In : Neurology. 90, 14, p. e1248-e1256

Research output: Contribution to journalArticle

Vascular Stiffness
Cerebral Small Vessel Diseases
Dementia
Atherosclerosis
Pathology

Clinical value of hybrid TOF-PET/MR imaging-based multiparametric imaging in localizing seizure focus in patients with MRI-negative temporal lobe epilepsy

Shang, K., Wang, J., Fan, X., Cui, B., Ma, J., Yang, H., Zhou, Y., Zhao, G. & Lu, J., Oct 1 2018, In : American Journal of Neuroradiology. 39, 10, p. 1791-1798 8 p.

Research output: Contribution to journalArticle

Temporal Lobe Epilepsy
Seizures
Cerebrovascular Circulation
Temporal Lobe
ROC Curve

Comparison of two software systems for quantification of myocardial blood flow in patients with hypertrophic cardiomyopathy

Yalcin, H., Valenta, I., Zhao, M., Tahari, A., Lu, D. Y., Higuchi, T., Yalcin, F., Kucukler, N., Soleimanifard, Y., Zhou, Y., Pomper, M. G., Abraham, T. P., Tsui, B., Lodge, M., Schindler, T. H. & Roselle Abraham, M., Jan 22 2018, (Accepted/In press) In : Journal of Nuclear Cardiology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Software
Coronary Artery Disease
Cardiomyopathies
Positron-Emission Tomography

Correction to: Comparison of two software systems for quantification of myocardial blood flow in patients with hypertrophic cardiomyopathy

Yalcin, H., Valenta, I., Zhao, M., Tahari, A., Lu, D. Y., Higuchi, T., Yalcin, F., Kucukler, N., Soleimanifard, Y., Zhou, Y., Pomper, M. G., Abraham, T. P., Tsui, B., Lodge, M., Schindler, T. H. & Abraham, M. R., Feb 8 2018, (Accepted/In press) In : Journal of Nuclear Cardiology. 1 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Names
Software

Dopamine D2 receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia

Vanover, K. E., Davis, R. E., Zhou, Y., Ye, W., Brasic, J. R., Gapasin, L., Saillard, J., Weingart, M., Litman, R. E., Mates, S. & Wong, D. F., Jan 1 2018, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Positron-Emission Tomography
Antipsychotic Agents
Schizophrenia
Hyperprolactinemia

Modeling Spatial and Temporal Patterns of APOE ε4 Mediated Glucose Uptake in Mild Cognitive Impairment and Normal Controls

Chen, X., Paranjpe, M., Wang, R., Feng, D. D., Zhou, Y. & for the Alzheimer's Disease Neuroimaging Initiative, T. A. D. N. I., Jan 1 2018, In : IFAC-PapersOnLine. 51, 27, p. 396-401 6 p.

Research output: Contribution to journalArticle

Glucose
Neuroimaging
Apolipoproteins
Biomarkers
Medicine

Quantitative in vivo mapping of myocardial mitochondrial membrane potential

Alpert, N. M., Guehl, N., Ptaszek, L., Pelletier-Galarneau, M., Ruskin, J., Mansour, M. C., Wooten, D., Ma, C., Takahashi, K., Zhou, Y., Shoup, T. M., Normandin, M. D. & Fakhri, G. E., Jan 1 2018, In : PLoS One. 13, 1, e0190968.

Research output: Contribution to journalArticle

Mitochondrial Membrane Potential
membrane potential
Swine
Membranes
swine

The Association of Mid-and Late-Life Systemic Inflammation with Brain Amyloid Deposition: The ARIC-PET Study

Walker, K. A., Windham, B. G., Brown, C., Knopman, D. S., Jack, C. R., Mosley, T. H., Selvin, E., Wong, D. F., Hughes, T. M., Zhou, Y., Gross, A. L. & Gottesman, R. F., Jan 1 2018, In : Journal of Alzheimer's Disease. 66, 3, p. 1041-1052 12 p.

Research output: Contribution to journalArticle

Encephalitis
Amyloid
Atherosclerosis
C-Reactive Protein
Brain
2017

A classifier integrating plasma biomarkers and radiological characteristics for distinguishing malignant from benign pulmonary nodules

Lin, Y., Leng, Q., Jiang, Z., Guarnera, M. A., Zhou, Y., Chen, X., Wang, H., Zhou, W., Cai, L., Fang, H. B., Li, J., Jin, H., Wang, L., Yi, S., Lu, W., Evers, D., Fowle, C. B., Su, Y. & Jiang, F., Sep 15 2017, In : International Journal of Cancer. 141, 6, p. 1240-1248 9 p.

Research output: Contribution to journalArticle

Biomarkers
Lung
Lung Neoplasms
MicroRNAs
Mortality

Association between midlife vascular risk factors and estimated brain amyloid deposition

Gottesman, R. F., Schneider, A. L. C., Zhou, Y., Coresh, J., Green, E., Gupta, N., Knopman, D. S., Mintz, A., Rahmim, A., Sharrett, A. R., Wagenknecht, L. E., Wong, D. F. & Mosley, T. H., Apr 11 2017, In : JAMA - Journal of the American Medical Association. 317, 14, p. 1443-1450 8 p.

Research output: Contribution to journalArticle

Amyloid
Brain
Positron-Emission Tomography
Dementia
vascular factor
Denervation
Serotonin
Alzheimer Disease
Parietal Lobe
Brain

Clinical evaluation of whole-body oncologic PET with time-of-flight and point-spread function for the hybrid PET/MR system

Shang, K., Cui, B., Ma, J., Shuai, D., Liang, Z., Jansen, F., Zhou, Y., Lu, J. & Zhao, G., Aug 1 2017, In : European Journal of Radiology. 93, p. 70-75 6 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Magnetic Resonance Spectroscopy
Fluorodeoxyglucose F18
Thorax
Magnetic Resonance Imaging

Molecular imaging of serotonin degeneration in mild cognitive impairment

Smith, G., Barrett, F., Joo, J. H., Nassery, N., Savonenko, A., Sodums, D. J., Marano, C. M., Munro, C., Brandt, J., Kraut, M. A., Zhou, Y., Wong, D. F. & Workman, C. I., Sep 1 2017, In : Neurobiology of Disease. 105, p. 33-41 9 p.

Research output: Contribution to journalArticle

Molecular Imaging
Serotonin Plasma Membrane Transport Proteins
Serotonin
Cerebrovascular Circulation
Regional Blood Flow
2016

CSF biomarkers and its associations with 18F-AV133 cerebral VMAT2 binding in Parkinson's Disease-A preliminary report

Gao, R., Zhang, G., Chen, X., Yang, A., Smith, G., Wong, D. F. & Zhou, Y., Oct 1 2016, In : PLoS One. 11, 10, e0164762.

Research output: Contribution to journalArticle

Vesicular Monoamine Transport Proteins
Cerebrospinal fluid
monoamines
Parkinson disease
Biomarkers

Effect of Diffuse Subendocardial Hypoperfusion on Left Ventricular Cavity Size by 13N-Ammonia Perfusion PET in Patients With Hypertrophic Cardiomyopathy

Yalçin, H., Valenta, I., Yalçin, F., Corona-Villalobos, C., Vasquez, N., Ra, J., Kucukler, N., Tahari, A., Pozios, I., Zhou, Y., Pomper, M. G., Abraham, T. P., Schindler, T. H. & Abraham, M. R., Dec 15 2016, In : American Journal of Cardiology. 118, 12, p. 1908-1915 8 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Ammonia
Positron-Emission Tomography
Dilatation
Perfusion

Individual estimates of age at detectable amyloid onset for risk factor assessment

Bilgel, M., An, Y., Zhou, Y., Wong, D. F., Prince, J. L., Ferrucci, L. & Resnick, S. M., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Age of Onset
Amyloid
Baltimore
Sex Education
Survival Analysis

Noninvasive bi-graphical analysis for the quantification of slowly reversible radioligand binding

Seo, S., Kim, S. J., Yoo, H. B., Lee, J. Y., Kim, Y. K., Lee, D. S., Zhou, Y. & Lee, J. S., Aug 31 2016, In : Physics in Medicine and Biology. 61, 18, p. 6770-6790 21 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Noise
Brain
Population
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

Potential clinical value of multiparametric pet in the prediction of Alzheimer's disease progression

Alzheimer's Disease NeuroimagingInitiative, May 1 2016, In : PLoS One. 11, 5, e0154406.

Research output: Contribution to journalArticle

Cerebrospinal fluid
Pets
Biomarkers
cerebrospinal fluid
amyloid

Quantitative multimodal multiparametric imaging in Alzheimer’s disease

Zhao, Q., Chen, X. & Zhou, Y., Mar 1 2016, In : Brain Informatics. 3, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Multimodal Imaging
Alzheimer Disease
Neuroimaging
Imaging techniques
Positron emission tomography

The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE

Gottesman, R. F., Schneider, A. L. C., Zhou, Y., Chen, X., Green, E., Gupta, N., Knopman, D. S., Mintz, A., Rahmim, A., Sharrett, A. R., Wagenknecht, L. E., Wong, D. F. & Mosley, T. H., Aug 2 2016, In : Neurology. 87, 5, p. 473-480 8 p.

Research output: Contribution to journalArticle

Amyloid
Neuroimaging
Dementia
Sex Education
Alleles
2015

Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts

Resnick, S. M., Bilgel, M., Moghekar, A. R., An, Y., Cai, Q., Wang, M. C., Thambisetty, M., Prince, J. L., Zhou, Y., Soldan, A., Wong, D. F., O'Brien, R. J., Ferrucci, L. & Albert, M., 2015, In : Neurobiology of Aging. 36, 8, p. 2333-2339 7 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Biomarkers
Genotype
Positron-Emission Tomography
Apolipoprotein E4

Generalized whole-body Patlak parametric imaging for enhanced quantification in clinical PET

Karakatsanis, N. A., Zhou, Y., Lodge, M., Casey, M. E., Wahl, R. L., Zaidi, H. & Rahmim, A., Oct 28 2015, In : Physics in Medicine and Biology. 60, 22, p. 8643-8673 31 p.

Research output: Contribution to journalArticle

Noise
Whole Body Imaging
Public Opinion

ITI-007 demonstrates brain occupancy at serotonin 5-HT2A and dopamine D2 receptors and serotonin transporters using positron emission tomography in healthy volunteers

Davis, R. E., Vanover, K. E., Zhou, Y., Brasic, J. R., Guevara, M., Bisuna, B., Ye, W., Raymont, V., Willis, W., Kumar, A., Gapasin, L., Goldwater, D. R., Mates, S. & Wong, D. F., Apr 7 2015, In : Psychopharmacology. 232, 15, p. 2863-2872 10 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Dopamine D2 Receptors
Corpus Striatum
Receptor, Serotonin, 5-HT2A
Positron-Emission Tomography

Large margin local estimate with applications to medical image classification

Song, Y., Cai, W., Huang, H., Zhou, Y., Feng, D. D., Wang, Y., Fulham, M. J. & Chen, M., Jun 1 2015, In : IEEE Transactions on Medical Imaging. 34, 6, p. 1362-1377 16 p., 7014242.

Research output: Contribution to journalArticle

Image classification
Imaging techniques
Pulmonary diseases
Binary images
Interstitial Lung Diseases

Locality-constrained Subcluster Representation Ensemble for lung image classification

Song, Y., Cai, W., Huang, H., Zhou, Y., Wang, Y. & Feng, D. D., May 1 2015, In : Medical Image Analysis. 22, 1, p. 102-113 12 p.

Research output: Contribution to journalArticle

Image classification
Tomography
Lung
Pulmonary diseases
Interstitial Lung Diseases

Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior

Freeman, Z. T., Rice, K. A., Soto, P. L., Pate, K., Weed, M. R., Ator, N. A., DeLeon, I. G., Wong, D. F., Zhou, Y., Mankowski, J. L., Zink, M. C., Adams, R. J. & Hutchinson, E., May 26 2015, In : Translational Psychiatry. 5, 5, e567.

Research output: Contribution to journalArticle

Guanfacine
Self-Injurious Behavior
Macaca mulatta
Pharmacology
Macaca

Voxelwise relationships between distribution volume ratio and cerebral blood flow: Implications for analysis of b-amyloid images

Sojkova, J., Goh, J., Bilgel, M., Landman, B., Yang, X., Zhou, Y., An, Y., Beason-Held, L. L., Kraut, M. A., Wong, D. F. & Resnick, S. M., Jul 1 2015, In : Journal of Nuclear Medicine. 56, 7, p. 1042-1047 6 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Amyloid
Occipital Lobe
Baltimore
Parietal Lobe
2014

Erratum: 11C-RO5013853: A New PET radioligand for the glycine transporter TYPE 1 (Neuropsychopharmacology 35 (S297-S408) DOI: 10.1038/npp.2010.218)

Wong, D. F., Ostrowitzki, S., Zhou, Y., Alberati, D., Pinard, E., Raymont, V., Martin-Facklam, M., Hofmann, C., Parkar, N., Brasic, J. R., Hilton, J., Dannals, R. F. & Borroni, E., 2014, In : Neuropsychopharmacology. 39, 9, p. 2272 1 p.

Research output: Contribution to journalArticle

Glycine Plasma Membrane Transport Proteins

Erratum to "Memory decline shows stronger associations with estimated spatial patterns of amyloid deposition progression than total amyloid burden" [Neurobiol. Aging 34 (2013) 2835-2842]

Yotter, R. A., Doshi, J., Clark, V., Sojkova, J., Zhou, Y., Wong, D. F., Ferrucci, L., Resnick, S. M. & Davatzikos, C., 2014, In : Neurobiology of Aging. 35, 10

Research output: Contribution to journalArticle

Amyloid

Lesion detection and characterization with context driven approximation in thoracic FDG PET-CT images of NSCLC studies

Song, Y., Cai, W., Huang, H., Wang, X., Zhou, Y., Fulham, M. J. & Feng, D. D., Feb 2014, In : IEEE Transactions on Medical Imaging. 33, 2, p. 408-421 14 p., 6634250.

Research output: Contribution to journalArticle

Positron emission tomography
Non-Small Cell Lung Carcinoma
Tomography
Thorax
Atlases

Lung nodule classification with multilevel patch-based context analysis

Zhang, F., Song, Y., Cai, W., Lee, M. Z., Zhou, Y., Huang, H., Shan, S., Fulham, M. J. & Feng, D. D., 2014, In : IEEE Transactions on Biomedical Engineering. 61, 4, p. 1155-1166 12 p., 6690248.

Research output: Contribution to journalArticle

Tomography
Classifiers
Textures
Semantics

Regional brain distribution of translocator protein using [ 11C]DPA-713 PET in individuals infected with HIV

Coughlin, J. M., Wang, Y., Ma, S., Yue, C., Kim, P. K., Adams, A. V., Roosa, H. V., Gage, K. L., Stathis, M., Rais, R., Rojas, C., McGlothan, J. L., Watkins, C., Sacktor, N., Guilarte, T. R., Zhou, Y., Sawa, A., Slusher, B., Caffo, B. S., Kassiou, M. & 2 othersEndres, C. J. & Pomper, M. G., 2014, In : Journal of NeuroVirology. 20, 3, p. 219-232 14 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
HIV
Gyrus Cinguli
Brain
Neuroglia
2013

Characterization of [11C]RO5013853, a novel PET tracer for the glycine transporter type 1 (GlyT1) in humans

Wong, D. F., Ostrowitzki, S., Zhou, Y., Raymont, V., Hofmann, C., Borroni, E., Kumar, A., Parkar, N., Brasic, J. R., Hilton, J., Dannals, R. F. & Martin-Facklam, M., Jul 15 2013, In : NeuroImage. 75, p. 282-290 9 p.

Research output: Contribution to journalArticle

Glycine Plasma Membrane Transport Proteins
Intravenous Injections
Healthy Volunteers
Pons
Papio

Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18 (AV-45) positron emission tomography

Rosenberg, P. B., Wong, D. F., Edell, S. L., Ross, J. S., Joshi, A. D., Brasic, J. R., Zhou, Y., Raymont, V., Kumar, A., Ravert, H. T., Dannals, R. F., Pontecorvo, M. J., Skovronsky, D. M. & Lyketsos, C. G., Mar 2013, In : American Journal of Geriatric Psychiatry. 21, 3, p. 272-278 7 p.

Research output: Contribution to journalArticle

Amyloid
Positron-Emission Tomography
Cognition
Alzheimer Disease
Healthy Volunteers

Dynamic whole-body PET parametric imaging: II. Task-oriented statistical estimation

Karakatsanis, N. A., Lodge, M., Zhou, Y., Wahl, R. L. & Rahmim, A., Oct 21 2013, In : Physics in Medicine and Biology. 58, 20, p. 7419-7445 27 p.

Research output: Contribution to journalArticle

Least-Squares Analysis
Noise
Whole Body Imaging
Task Performance and Analysis
Neoplasms

Dynamic whole-body PET parametric imaging: I. Concept, acquisition protocol optimization and clinical application

Karakatsanis, N. A., Lodge, M., Tahari, A. K., Zhou, Y., Wahl, R. L. & Rahmim, A., Oct 21 2013, In : Physics in Medicine and Biology. 58, 20, p. 7391-7418 28 p.

Research output: Contribution to journalArticle

Clinical Protocols
Noise
Positron-Emission Tomography
Whole Body Imaging
Neoplasms

Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype

Thambisetty, M., An, Y., Nalls, M., Sojkova, J., Swaminathan, S., Zhou, Y., Singleton, A. B., Wong, D. F., Ferrucci, L., Saykin, A. J. & Resnick, S. M., Mar 1 2013, In : Biological Psychiatry. 73, 5, p. 422-428 7 p.

Research output: Contribution to journalArticle

Amyloid
Genotype
Alzheimer Disease
Brain
Neuroimaging

Feature-based image patch approximation for lung tissue classification

Song, Y., Cai, W., Zhou, Y. & Feng, D. D., 2013, In : IEEE Transactions on Medical Imaging. 32, 4, p. 797-808 12 p., 6415277.

Research output: Contribution to journalArticle

Tissue
Lung
Labeling
Tomography
Textures

Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore longitudinal study of aging

Thambisetty, M., Metter, E. J., Yang, A., Dolan, H., Marano, C., Zonderman, A. B., Troncoso, J. C., Zhou, Y., Wong, D. F., Ferrucci, L., Egan, J., Resnick, S. M. & O'Brien, R. J., 2013, In : JAMA Neurology. 70, 9, p. 1167-1172 6 p.

Research output: Contribution to journalArticle

Baltimore
Glucose Intolerance
Longitudinal Studies
Insulin Resistance
Alzheimer Disease

Glycine transporter type 1 occupancy by bitopertin: A positron emission tomography study in healthy volunteers

Martin-Facklam, M., Pizzagalli, F., Zhou, Y., Ostrowitzki, S., Raymont, V., Brasic, J. R., Parkar, N., Umbricht, D., Dannals, R. F., Goldwater, R. & Wong, D. F., Feb 2013, In : Neuropsychopharmacology. 38, 3, p. 504-512 9 p.

Research output: Contribution to journalArticle

Glycine Plasma Membrane Transport Proteins
Positron-Emission Tomography
Healthy Volunteers
N-Methyl-D-Aspartate Receptors
Glycine