Research output per year
Research output per year
- 29 results
Search results
-
2024
SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity
Araki, Y., Rajkovich, K. E., Gerber, E. E., Gamache, T. R., Johnson, R. C., Tran, T. H. N., Liu, B., Zhu, Q., Hong, I., Kirkwood, A. & Huganir, R., Mar 1 2024, In: Science. 383, 6686, eadk1291.Research output: Contribution to journal › Article › peer-review
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2023
Mouse models of SYNGAP1-related intellectual disability
Araki, Y., Gerber, E. E., Rajkovich, K. E., Hong, I., Johnson, R. C., Lee, H. K., Kirkwood, A. & Huganir, R. L., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 37, e2308891120.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Arc weakens synapses by dispersing AMPA receptors from postsynaptic density via modulating PSD phase separation
Chen, X., Jia, B., Araki, Y., Liu, B., Ye, F., Huganir, R. & Zhang, M., Oct 2022, In: Cell Research. 32, 10, p. 914-930 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Endogenous Syngap1 Alpha Splice Forms Promote Cognitive Function and Seizure Protection
Kilinc, M., Arora, V., Creson, T. K., Rojas, C., Le, A. A., Lauterborn, J., Wilkinson, B., Hartel, N., Graham, N., Reich, A., Gou, G., Araki, Y., Bayés, À., Coba, M. P., Lynch, G., Miller, C. A. & Rumbaugh, G., Apr 2022, In: eLife. 11, e75707.Research output: Contribution to journal › Review article › peer-review
Open Access -
2020
Low-Dose Perampanel Rescues Cortical Gamma Dysregulation Associated With Parvalbumin Interneuron GluA2 Upregulation in Epileptic Syngap1+/− Mice
Sullivan, B. J., Ammanuel, S., Kipnis, P. A., Araki, Y., Huganir, R. L. & Kadam, S. D., May 1 2020, In: Biological psychiatry. 87, 9, p. 829-842 14 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Syngap isoforms differentially regulate synaptic plasticity and dendritic development
Araki, Y., Hong, I., Gamache, T. R., Ju, S., Collado-Torres, L., Shin, J. H. & Huganir, R. L., Jun 2020, In: eLife. 9, p. 1-28 28 p., e56273.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
SynGAP splice variants display heterogeneous spatio-temporal expression and subcellular distribution in the developing mammalian brain
Gou, G., Roca-Fernandez, A., Kilinc, M., Serrano, E., Reig-Viader, R., Araki, Y., Huganir, R. L., de Quintana-Schmidt, C., Rumbaugh, G. & Bayés, À., Sep 1 2020, In: Journal of Neurochemistry. 154, 6, p. 618-634 17 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Twenty years of syngap research: From synapses to cognition
Gamache, T. R., Araki, Y. & Huganir, R. L., Feb 19 2020, In: Journal of Neuroscience. 40, 8, p. 1596-1605 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access17 Scopus citations -
2019
Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division
Itoh, K., Murata, D., Kato, T., Yamada, T., Araki, Y., Saito, A., Adachi, Y., Igarashi, A., Li, S., Pletnikov, M., Huganir, R. L., Watanabe, S., Kamiya, A., Iijima, M. & Sesaki, H., Oct 2019, In: eLife. 8, e44739.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2018
Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease
Yamada, T., Murata, D., Adachi, Y., Itoh, K., Kameoka, S., Igarashi, A., Kato, T., Araki, Y., Huganir, R. L., Dawson, T. M., Yanagawa, T., Okamoto, K., Iijima, M. & Sesaki, H., Oct 2 2018, In: Cell Metabolism. 28, 4, p. 588-604.e5Research output: Contribution to journal › Article › peer-review
Open Access64 Scopus citations -
2017
BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method
Lim, C. S., Kang, X., Mirabella, V., Zhang, H., Bu, Q., Araki, Y., Hoang, E. T., Wang, S., Shen, Y., Choi, S., Kaang, B. K., Chang, Q., Pang, Z. P., Huganir, R. L. & Zhu, J. J., Mar 15 2017, In: Genes & development. 31, 6, p. 537-552 16 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2016
Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity
Zeng, M., Shang, Y., Araki, Y., Guo, T., Huganir, R. L. & Zhang, M., Aug 25 2016, In: Cell. 166, 5, p. 1163-1175.e12Research output: Contribution to journal › Article › peer-review
Open Access176 Scopus citations -
2015
Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage
Takei, N., Sobu, Y., Kimura, A., Urano, S., Piao, Y., Araki, Y., Taru, H., Yamamoto, T., Hata, S., Nakaya, T. & Suzuki, T., Jan 9 2015, In: Journal of Biological Chemistry. 290, 2, p. 987-995 9 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Rapid Dispersion of SynGAP from Synaptic Spines Triggers AMPA Receptor Insertion and Spine Enlargement during LTP
Araki, Y., Zeng, M., Zhang, M. & Huganir, R. L., Jan 7 2015, In: Neuron. 85, 1, p. 173-189 17 p.Research output: Contribution to journal › Article › peer-review
Open Access119 Scopus citations -
2014
PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence
Hayashi-Takagi, A., Araki, Y., Nakamura, M., Vollrath, B., Duron, S. G., Yan, Z., Kasai, H., Huganir, R. L., Campbell, D. A. & Sawa, A., Apr 29 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 17, p. 6461-6466 6 p.Research output: Contribution to journal › Article › peer-review
Open Access59 Scopus citations -
Quantitative analysis of APP axonal transport in neurons: Role of JIP1 in enhanced APP anterograde transport
Chiba, K., Araseki, M., Nozawa, K., Furukori, K., Araki, Y., Matsushima, T., Nakaya, T., Hata, S., Saito, Y., Uchida, S., Okada, Y., Nairn, A. C., Davis, R. J., Yamamoto, T., Kinjo, M., Taru, H. & Suzuki, T., Nov 5 2014, In: Molecular biology of the cell. 25, 22, p. 3569-3580 12 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
2013
Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation
Mihalas, A. B., Araki, Y., Huganir, R. L. & Meffert, M. K., 2013, In: Journal of Neuroscience. 33, 42, p. 16490-16501 12 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
2012
A Small Peptide Sequence is Sufficient for Initiating Kinesin-1 Activation Through Part of TPR Region of KLC1
Kawano, T., Araseki, M., Araki, Y., Kinjo, M., Yamamoto, T. & Suzuki, T., Jun 2012, In: Traffic. 13, 6, p. 834-848 15 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2011
Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and alzheimer's disease: Evidence for γ-secretase dysfunction
Hata, S., Fujishige, S., Araki, Y., Taniguchi, M., Urakami, K., Peskind, E., Akatsu, H., Araseki, M., Yamamoto, K., Martins, R. N., Maeda, M., Nishimura, M., Levey, A., Chung, K. A., Montine, T., Leverenz, J., Fagan, A., Goate, A., Bateman, R., Holtzman, D. M., & 4 others, Jun 2011, In: Annals of neurology. 69, 6, p. 1026-1031 6 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
Erratum: Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability (American Journal of Human Genetics (2011) 88 (306-316))
Hamdan, F. F., Gauthier, J., Araki, Y., Lin, D-T. T., Yoshizawa, Y., Higashi, K., Park, A. R., Spiegelman, D., Dobrzeniecka, S., Piton, A., Tomitori, H., Daoud, H., Massicotte, C., Henrion, E., Diallo, O., Shekarabi, M., Marineau, C., Shevell, M., Maranda, B., Mitchell, G., & 13 others, Apr 8 2011, In: American journal of human genetics. 88, 4, p. 516 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability
Hamdan, F. F., Gauthier, J., Araki, Y., Lin, D-T. T., Yoshizawa, Y., Higashi, K., Park, A. R., Spiegelman, D., Dobrzeniecka, S., Piton, A., Tomitori, H., Daoud, H., Massicotte, C., Henrion, E., Diallo, O., Shekarabi, M., Marineau, C., Shevell, M., Maranda, B., Mitchell, G., & 13 others, Mar 11 2011, In: American journal of human genetics. 88, 3, p. 306-316 11 p.Research output: Contribution to journal › Article › peer-review
Open Access241 Scopus citations -
Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like
Saito, Y., Akiyama, M., Araki, Y., Sumioka, A., Shiono, M., Taru, H., Nakaya, T., Yamamoto, T. & Suzuki, T., 2011, In: PloS one. 6, 7, e22108.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
2010
Plasma membrane insertion of the AMPA receptor GluA2 subunit is regulated by NSF binding and Q/R editing of the ion pore
Araki, Y., Lin, D. T. & Huganir, R. L., Jun 15 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 24, p. 11080-11085 6 p.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
2009
Alcadein cleavages by amyloid β-precursor protein (APP) α- and γ-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related γ-secretase dysfunction
Hata, S., Fujishige, S., Araki, Y., Kato, N., Araseki, M., Nishimura, M., Hartmann, D., Saftig, P., Fahrenholz, F., Taniguchi, M., Urakami, K., Akatsu, H., Martins, R. N., Yamamoto, K., Maeda, M., Yamamoto, T., Nakaya, T., Gandy, S. & Suzuki, T., Dec 25 2009, In: Journal of Biological Chemistry. 284, 52, p. 36024-36033 10 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
2008
The X11L/X11β/MINT2 and X11L2/X11γ/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm
Sumioka, A., Saito, Y., Sakuma, M., Araki, Y., Yamamoto, T. & Suzuki, T., Mar 10 2008, In: Experimental cell research. 314, 5, p. 1155-1162 8 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
2007
The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport
Araki, Y., Kawano, T., Taru, H., Saito, Y., Wada, S., Miyamoto, K., Kobayashi, H., Ishikawa, H. O., Ohsugi, Y., Yamamoto, T., Matsuno, K., Kinjo, M. & Suzuki, T., Mar 21 2007, In: EMBO Journal. 26, 6, p. 1475-1486 12 p.Research output: Contribution to journal › Article › peer-review
Open Access116 Scopus citations -
2006
Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis
Suzuki, T., Araki, Y., Yamamoto, T. & Nakaya, T., Jun 1 2006, In: Journal of biochemistry. 139, 6, p. 949-955 7 p.Research output: Contribution to journal › Short survey › peer-review
40 Scopus citations -
2004
Coordinated metabolism of Alcadein and amyloid β-protein precursor regulates FE65-dependent gene transactivation
Araki, Y., Miyagi, N., Kato, N., Yoshida, T., Wada, S., Nishimura, M., Komano, H., Yamamoto, T., De Strooper, B., Yamamoto, K. & Suzuki, T., Jun 4 2004, In: Journal of Biological Chemistry. 279, 23, p. 24343-24354 12 p.Research output: Contribution to journal › Article › peer-review
Open Access72 Scopus citations -
2003
Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism.
Araki, Y., Tomita, S., Yamaguchi, H., Miyagi, N., Sumioka, A., Kirino, Y. & Suzuki, T., Dec 5 2003, In: The Journal of biological chemistry. 278, 49, p. 49448-49458 11 p.Research output: Contribution to journal › Article › peer-review
Open Access109 Scopus citations