Yi Cai

Research Associate

20092019
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Fingerprint Dive into the research topics where Yi Cai is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 15 Similar Profiles
DNA Methylation Medicine & Life Sciences
DNA Medicine & Life Sciences
Methyltransferases Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Colorectal Neoplasms Medicine & Life Sciences
Tumor Suppressor Genes Medicine & Life Sciences
CpG Islands Medicine & Life Sciences

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Research Output 2009 2019

Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf V600E -Induced Tumorigenesis

Tao, Y., Kang, B., Petkovich, D. A., Bhandari, Y. R., In, J., Stein-O'Brien, G., Kong, X., Xie, W., Zachos, N., Maegawa, S., Vaidya, H., Brown, S., Chiu Yen, R. W., Shao, X., Thakor, J., Lu, Z., Cai, Y., Zhang, Y., Mallona, I., Peinado, M. A. & 6 others, Zahnow, C. A., Ahuja, N., Fertig, E., Issa, J. P., Baylin, S. B. & Easwaran, H., Feb 11 2019, In : Cancer cell. 35, 2, p. 315-328.e6

Research output: Contribution to journalArticle

Epigenomics
Organoids
Colon
Carcinogenesis
Clustered Regularly Interspaced Short Palindromic Repeats

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

Kong, X., Chen, J., Xie, W., Brown, S. M., Cai, Y., Wu, K., Fan, D., Nie, Y., Yegnasubramanian, S., Tiedemann, R. L., Tao, Y., Yen, R-W., Topper, M. J., Zahnow, C., Easwaran, H., Rothbart, S. B., Xia, L. & Baylin, S. B., Apr 15 2019, In : Cancer cell. 35, 4, p. 633-648.e7

Research output: Contribution to journalArticle

DNA Methylation
Colonic Neoplasms
Colorectal Neoplasms
Ubiquitin-Protein Ligases
Tumor Suppressor Genes

A novel epigenetic modulating agent sensitizes pancreatic cells to a chemotherapy agent

Thakar, M., Hu, Y., Morreale, M., Lerner, L., Lin, W. Y., Sen, R., Cai, Y., Karunasena, E., Thakar, M., Saggi, S., Keer, H. & Ahuja, N., Jun 1 2018, In : PLoS One. 13, 6, e0199130.

Research output: Contribution to journalArticle

Chemotherapy
adenocarcinoma
Epigenomics
epigenetics
drug therapy

Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1

Ye, F., Kong, X., Zhang, H., Liu, Y., Shao, Z., Jin, J., Cai, Y., Zhang, R., Li, L., Zhang, Y., Liu, Y. C., Zhang, C., Xie, W., Yu, K., Ding, H., Zhao, K., Chen, S., Jiang, H., Baylin, S. B. & Luo, C., Mar 16 2018, In : ACS Chemical Biology. 13, 3, p. 772-781 10 p.

Research output: Contribution to journalArticle

Methyltransferases
Molecular Dynamics Simulation
Molecular dynamics
DNA
Computer simulation

Treatment with epigenetic agents profoundly inhibits tumor growth in leiomyosarcoma

Fischer, C. D. C., Hu, Y., Morreale, M., Lin, W. Y., Wali, A., Thakar, M., Karunasena, E., Sen, R., Cai, Y., Murphy, L., Zahnow, C., Keer, H., Thakar, M. & Ahuja, N., Apr 10 2018, In : Oncotarget. 9, 27, p. 19379-19395 17 p.

Research output: Contribution to journalArticle

Leiomyosarcoma
Epigenomics
Azacitidine
Growth
Neoplasms