Yi Cai

Research Associate

20092018
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  • 14 Similar Profiles
Methyltransferases Medicine & Life Sciences
DNA Medicine & Life Sciences
DNA Methylation Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Tumor Suppressor Genes Medicine & Life Sciences
CpG Islands Medicine & Life Sciences
decitabine Medicine & Life Sciences

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Research Output 2009 2018

A novel epigenetic modulating agent sensitizes pancreatic cells to a chemotherapy agent

Thakar, M., Hu, Y., Morreale, M., Lerner, L., Lin, W. Y., Sen, R., Cai, Y., Karunasena, E., Thakar, M., Saggi, S., Keer, H. & Ahuja, N., Jun 1 2018, In : PLoS One. 13, 6, e0199130

Research output: Contribution to journalArticle

adenocarcinoma
Epigenomics
epigenetics
drug therapy
Adenocarcinoma

Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1

Ye, F., Kong, X., Zhang, H., Liu, Y., Shao, Z., Jin, J., Cai, Y., Zhang, R., Li, L., Zhang, Y. W., Liu, Y. C., Zhang, C., Xie, W., Yu, K., Ding, H., Zhao, K., Chen, S., Jiang, H., Baylin, S. B. & Luo, C., Mar 16 2018, In : ACS Chemical Biology. 13, 3, p. 772-781 10 p.

Research output: Contribution to journalArticle

Methyltransferases
Molecular Dynamics Simulation
DNA
S-Adenosylmethionine
DNA Methylation

Treatment with epigenetic agents profoundly inhibits tumor growth in leiomyosarcoma

Fischer, C. D. C., Hu, Y., Morreale, M., Lin, W. Y., Wali, A., Thakar, M., Karunasena, E., Sen, R., Cai, Y., Murphy, L., Zahnow, C. A., Keer, H., Thakar, M. & Ahuja, N., Apr 10 2018, In : Oncotarget. 9, 27, p. 19379-19395 17 p.

Research output: Contribution to journalArticle

Leiomyosarcoma
Epigenomics
Azacitidine
Growth
Neoplasms

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

Zhang, Y. W., Wang, Z., Xie, W., Cai, Y., Xia, L., Easwaran, H., Luo, J., Yen, R. W. C., Li, Y. & Baylin, S. B., Jan 19 2017, In : Molecular Cell. 65, 2, p. 323-335 13 p.

Research output: Contribution to journalArticle

DNA Methylation
Acetylation
Oxidative Stress
5-Methylcytosine
CpG Islands

CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes

Xia, L., Huang, W., Bellani, M., Seidman, M. M., Wu, K., Fan, D., Nie, Y., Cai, Y., Zhang, Y. W., Yu, L. R., Li, H., Zahnow, C. A., Xie, W., Chiu Yen, R. W., Rassool, F. V. & Baylin, S. B., May 8 2017, In : Cancer Cell. 31, 5, p. 653-668.e7

Research output: Contribution to journalArticle

Tumor Suppressor Genes
Epigenomics
DNA Repair
Colorectal Neoplasms
DNA