Yash Chhabra

Research output

Research output per year 2011 2017 2018 2019 2021 2022 2023 2024

• 16 Article
• 4 Review article
• 1 Comment/debate

Research output per year

Research output per year

Search results

• 2024

  Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma

  Marino-Bravante, G. E., Carey, A. E., Hüser, L., Dixit, A., Wang, V., Kaur, A., Liu, Y., Ding, S., Schnellmann, R., Gerecht, S., Gu, L., Eisinger-Mathason, T. S. K., Chhabra, Y. & Weeraratna, A. T., Mar 2024, In: Nature Aging. 4, 3, p. 350-363 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Melanoma 100%
  • Up-Regulation 86%
  • cadherin 5 82%
  • Blood Vessels 70%
  • Extracellular Matrix 50%
• 2023

  Erratum: sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients (Clinical Cancer Research (2020) 26 (5709-5719) DOI: 10.1158/1078-0432.CCR-20-0446)

  Fane, M., Ecker, B. L., Kaur, A., Marino, G. E., Alicea, G. M., Douglass, S., Chhabra, Y., Webster, M. R., Marshall, A., Colling, R., Espinosa, O., Coupe, N., Maroo, N., Campo, L., Middleton, M. R., Corrie, P., Xu, X., Karakousis, G. C. & Weeraratna, A. T., May 15 2023, In: Clinical Cancer Research. 29, 10, p. 2012 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Vascular Endothelial Growth Factor A 100%
  • Melanoma 96%
  • Coloring Agents 71%
  • Neoplasms 37%
  • Emotions 22%

• Fibroblasts in cancer: Unity in heterogeneity

  Chhabra, Y. & Weeraratna, A. T., Apr 13 2023, In: Cell. 186, 8, p. 1580-1609 30 p.

  Research output: Contribution to journal › Review article › peer-review

  • Plastic Property 100%
  • Cancer-Associated Fibroblasts 90%
  • Heterogeneity 79%
  • Soil 72%
  • Fibroblasts 64%

• Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

  Chhabra, Y., Seiffert, P., Gormal, R. S., Vullings, M., Lee, C. M. M., Wallis, T. P., Dehkhoda, F., Indrakumar, S., Jacobsen, N. L., Lindorff-Larsen, K., Durisic, N., Waters, M. J., Meunier, F. A., Kragelund, B. B. & Brooks, A. J., May 30 2023, In: Cell Reports. 42, 5, 112490.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Somatotropin Receptors 100%
  • Growth Hormone 92%
  • Cytokine Receptors 86%
  • Tyrosine 65%
  • Protein-Tyrosine Kinases 65%
• 2022

  Reciprocal Regulation of BRN2 and NOTCH1/2 Signaling Synergistically Drives Melanoma Cell Migration and Invasion

  Fane, M. E., Chhabra, Y., Spoerri, L., Simmons, J. L., Ludwig, R., Bonvin, E., Goding, C. R., Sturm, R. A., Boyle, G. M., Haass, N. K., Piper, M. & Smith, A. G., Jul 2022, In: Journal of Investigative Dermatology. 142, 7, p. 1845-1857 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Heterogeneity 100%
  • Melanoma 89%
  • Cell Movement 88%
  • Proliferative 72%
  • Phenotype 65%

• Stromal changes in the aged lung induce an emergence from melanoma dormancy

  Fane, M., Chhabra, Y., Alicea, G. M., Maranto, D. A., Douglass, S., Webster, M. R., Rebecca, V. W., Marino, G. E., Almeida, F., Ecker, B. L., Zabransky, D. J., Hüser, L., Beer, T., Tang, H. Y., Kossenkov, A., Herlyn, M., Speicher, D. W., Xu, W., Xu, X., Jaffee, E. M., & 2 othersAguirre-Ghiso, J. A. & Weeraratna, A. T., Jun 9 2022, In: Nature. 606, 7913, p. 396-405 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Melanoma 100%
  • Lung 64%
  • Neoplasms 21%
  • Fibroblasts 19%
  • Neoplasm Metastasis 16%
• 2021

  GHR signalling: Receptor activation and degradation mechanisms

  Chhabra, Y., Lee, C. M. M., Müller, A. F. & Brooks, A. J., Jan 15 2021, In: Molecular and Cellular Endocrinology. 520, 111075.

  Research output: Contribution to journal › Review article › peer-review

  • Growth Hormone 100%
  • Phosphotransferases 30%
  • Somatotropin Receptors 27%
  • Physiological Phenomena 20%
  • Signal Transduction 15%

• Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2-Bl/HLA-G

  Ishikawa, M., Brooks, A. J., Fernández-Rojo, M. A., Medina, J., Chhabra, Y., Minami, S., Tunny, K. A., Parton, R. G., Vivian, J. P., Rossjohn, J., Chikani, V., Ramm, G. A., Ho, K. K. Y. & Waters, M. J., Feb 2021, In: Hepatology. 73, 2, p. 759-775 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Liver Regeneration 100%
  • Hepatectomy 87%
  • HLA Antigens 83%
  • Growth Hormone 77%
  • Inflammation 47%
  6 Scopus citations

• Myeloid-Derived Suppressor Cells Are a Major Source of Wnt5A in the Melanoma Microenvironment and Depend on Wnt5A for Full Suppressive Activity

  Douglass, S. M., Fane, M. E., Sanseviero, E., Ecker, B. L., Kugel, C. H., Behera, R., Kumar, V., Tcyganov, E. N., Yin, X., Liu, Q., Chhabra, Y., Alicea, G. M., Kuruvilla, R., Gabrilovich, D. I. & Weeraratna, A. T., Feb 1 2021, In: Cancer Research. 81, 3, p. 658-670 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myeloid-Derived Suppressor Cells 100%
  • Melanoma 62%
  • Tumor Microenvironment 44%
  • Immunosuppressive Agents 26%
  • Myeloid Cells 21%

• sFRP2 Supersedes VEGF as an age-related driver of angiogenesis in melanoma, affecting response to anti-VEGF therapy in older patients

  Fane, M. E., Ecker, B. L., Kaur, A., Marino, G. E., Alicea, G. M., Douglass, S. M., Chhabra, Y., Webster, M. R., Marshall, A., Colling, R., Espinosa, O., Coupe, N., Maroo, N., Campo, L., Middleton, M. R., Corrie, P., Xu, X., Karakousis, G. C. & Weeraratna, A. T., Nov 1 2021, In: Clinical Cancer Research. 26, 21, p. 5709-5719 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • WD repeat containing planar cell polarity effector 100%
  • Bevacizumab 69%
  • Vascular Endothelial Growth Factor A 53%
  • Melanoma 51%
  • Neoplasm Metastasis 11%
  3 Scopus citations
• 2020

  Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning

  Bridgford, J. L., Lee, S. M., Lee, C. M. M., Guglielmelli, P., Rumi, E., Pietra, D., Wilcox, S., Chhabra, Y., Rubin, A. F., Cazzola, M., Vannucchi, A. M., Brooks, A. J., Call, M. E. & Call, M. J., Jan 23 2020, In: Blood. 135, 4, p. 287-292 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oncogenic Transformation 100%
  • Mutation 45%
  • Leukemia 44%
  • Exons 22%
  • human MPL protein 13%
  8 Scopus citations
• 2019

  BRN2, a POUerful driver of melanoma phenotype switching and metastasis

  Fane, M. E., Chhabra, Y., Smith, A. G. & Sturm, R. A., Jan 2019, In: Pigment Cell and Melanoma Research. 32, 1, p. 9-24 16 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Developmental 100%
  • Melanoma 68%
  • Neoplasm Metastasis 51%
  • Phenotype 49%
  • POU Domain Factors 26%
  18 Scopus citations

• Loss of growth hormone–mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity

  Chhabra, Y., Nelson, C. N., Plescher, M., Barclay, J. L., Smith, A. G., Andrikopoulos, S., Mangiafico, S., Waxman, D. J., Brooks, A. J. & Waters, M. J., May 1 2019, In: FASEB Journal. 33, 5, p. 6412-6430 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • STAT5 Transcription Factor 100%
  • Insulin Derivative 70%
  • Insulin Resistance 56%
  • Obesity 47%
  • Growth 34%
  8 Scopus citations
• 2018

  A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

  Chhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, B. B., Brooks, A. J. & Waters, M. J., Jan 25 2018, In: Oncogene. 37, 4, p. 489-501 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Somatotropin Receptors 100%
  • Single Nucleotide Polymorphism 60%
  • Growth Hormone 59%
  • Lung Neoplasms 56%
  • Cytokines 44%
  22 Scopus citations

• Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells

  Chhabra, Y., Yong, H. X. L., Fane, M. E., Soogrim, A., Lim, W., Mahiuddin, D. N., Kim, R. S. Q., Ashcroft, M., Beatson, S. A., Ainger, S. A., Smit, D. J., Jagirdar, K., Walker, G. J., Sturm, R. A. & Smith, A. G., Jan 2018, In: Pigment Cell and Melanoma Research. 31, 1, p. 51-63 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Monophenol Monooxygenase 100%
  • Cell Viability 78%
  • Genetic Variation 76%
  • Interferons 72%
  • Interferon-gamma 70%
  11 Scopus citations

• Growth hormone activated STAT5 is required for induction of beige fat in vivo

  Nelson, C. N., List, E. O., Ieremia, M., Constantin, L., Chhabra, Y., Kopchick, J. J. & Waters, M. J., Oct 1 2018, In: Growth Hormone and IGF Research. 42-43, p. 40-51 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Beige Adipose Tissue 100%
  • White Adipose Tissue 70%
  • Growth Hormone 55%
  • disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate 28%
  • Groin 25%
  10 Scopus citations
• 2017

  CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis

  Iyer, S., Chhabra, Y., Harvey, T. J., Wang, R., Chiu, H. S., Smith, A. G., Thomas, W. G., Pennisi, D. J. & Piper, M., Feb 1 2017, In: Journal of Molecular Histology. 48, 1, p. 53-61 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial Cells 100%
  • Homeostasis 99%
  • Cardiovascular Diseases 13%
  • Genes 7%
  • Proteins 7%
  6 Scopus citations

• NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF

  Fane, M. E., Chhabra, Y., Hollingsworth, D. E. J., Simmons, J. L., Spoerri, L., Oh, T. G., Chauhan, J., Chin, T., Harris, L., Harvey, T. J., Muscat, G. E. O., Goding, C. R., Sturm, R. A., Haass, N. K., Boyle, G. M., Piper, M. & Smith, A. G., Feb 1 2017, In: EBioMedicine. 16, p. 63-75 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proliferative 100%
  • Melanoma 62%
  • Cell Movement 61%
  • Effector 40%
  • Heterogeneity 34%
  44 Scopus citations

• NR4A2 promotes DNA double-strand break repair upon exposure to UVR

  Yin, K., Chhabra, Y., Tropee, R., Lim, Y. C., Fane, M., Dray, E., Sturm, R. A. & Smith, A. G., Sep 1 2017, In: Molecular Cancer Research. 15, 9, p. 1184-1196 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Double-Stranded DNA Breaks 100%
  • Ultraviolet Rays 89%
  • DNA Repair 80%
  • Melanocytes 65%
  • Nuclear Receptor Subfamily 4, Group A, Member 2 51%
  4 Scopus citations
• 2014

  Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

  Brooks, A. J., Dai, W., O'Mara, M. L., Abankwa, D., Chhabra, Y., Pelekanos, R. A., Gardon, O., Tunny, K. A., Blucher, K. M., Morton, C. J., Parker, M. W., Sierecki, E., Gambin, Y., Gomez, G. A., Alexandrov, K., Wilson, I. A., Doxastakis, M., Mark, A. E. & Waters, M. J., 2014, In: Science. 344, 6185, 1249783.

  Research output: Contribution to journal › Article › peer-review

  • Somatotropin Receptors 100%
  • Protein Kinases 66%
  • Cytokine Receptors 65%
  • Phosphotransferases 55%
  • Fluorescence Resonance Energy Transfer 23%
  229 Scopus citations
• 2011

  Role of the growth hormone-IGF-1 axis in cancer

  Chhabra, Y., Waters, M. J. & Brooks, A. J., Jan 2011, In: Expert Review of Endocrinology and Metabolism. 6, 1, p. 71-84 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Insulin-Like Growth Factor I 100%
  • Growth Hormone 94%
  • Somatotropin Receptors 59%
  • Hormone Antagonists 38%
  • Neoplasms 31%
  53 Scopus citations