Xinzhong Dong

Research output

Research output per year 1997 2019 2022 2023 2024

• 150 Article
• 18 Review article
• 6 Short survey
• 4 Chapter
• 6 More
  • 4 Comment/debate
  • 1 Editorial
  • 1 Letter

Research output per year

Research output per year

Search results

• 2024

  IL-33 potentiates histaminergic itch

  Trier, A. M., Ver Heul, A. M., Fredman, A., Le, V., Wang, Z., Auyeung, K., Meixiong, J., Lovato, P., Holtzman, M. J., Wang, F., Dong, X., Ji, A. L. & Kim, B. S., Mar 2024, In: Journal of Allergy and Clinical Immunology. 153, 3, p. 852-859.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-33 100%
  • Chronic Urticaria 35%
  • Mast Cells 25%
  • Histamine 19%
  • Histamine Antagonists 15%

• The MRGPR family of receptors in immunity

  Gour, N. & Dong, X., Jan 9 2024, In: Immunity. 57, 1, p. 28-39 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • G-Protein-Coupled Receptors 100%
  • Immunity 81%
  • Irritants 58%
  • Environmental Exposure 54%
  • Allergens 47%
• 2023

  Allantoin induces pruritus by activating MrgprD in chronic kidney disease

  Yang, Y., Sun, Y., Zhu, C., Shen, X., Sun, J., Jing, T., Jun, S., Wang, C., Yu, G., Dong, X., Sheng, M. & Tang, Z., Apr 2023, In: Journal of Cellular Physiology. 238, 4, p. 813-828 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Allantoin 100%
  • Pruritus 65%
  • Chronic Renal Insufficiency 57%
  • Diagnosis-Related Groups 31%
  • Calcium(0) 24%

• A tactile twist: decoding the phenomena of mechanical itch and alloknesis

  Follansbee, T. & Dong, X., 2023, In: Frontiers in Molecular Neuroscience. 16, 1278151.

  Research output: Contribution to journal › Short survey › peer-review

  Open Access

  • Mechanical Phenomena 100%
  • Touch 67%
  • Sensory Receptor Cells 47%
  • Neural Pathways 28%
  • Skin 24%

• Cholestatic Pruritus in Children: Conventional Therapies and Beyond

  Rodrigo, M., Dong, X., Chien, D. & Karnsakul, W., May 2023, In: Biology. 12, 5, 756.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Narcotic Antagonist 100%
  • pruritus 92%
  • Bile Acid 78%
  • Serotonin 74%
  • Pruritus 69%

• Crisaborole efficacy in murine models of skin inflammation and Staphylococcus aureus infection

  Youn, C., Dikeman, D. A., Chang, E., Liu, H., Nolan, S. J., Alphonse, M. P., Joyce, D. P., Liu, Q., Meixiong, J., Dong, X., Miller, L. S. & Archer, N. K., Apr 2023, In: Experimental Dermatology. 32, 4, p. 425-435 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Crisaborole 100%
  • crisaborole 90%
  • Staphylococcal Infections 52%
  • Inflammation 26%
  • Skin 25%

• Effects of Early Exposure to Isoflurane on Susceptibility to Chronic Pain Are Mediated by Increased Neural Activity Due to Actions of the Mammalian Target of the Rapamycin Pathway

  Li, Q., Mathena, R. P., Li, F., Dong, X., Guan, Y. & Mintz, C. D., Sep 2023, In: International journal of molecular sciences. 24, 18, 13760.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Isoflurane 100%
  • pain 91%
  • Neuroglia 72%
  • TOR Serine-Threonine Kinases 71%
  • Anesthetics 60%

• Identification of Persister Drug Combination Clinafloxacin + Cefuroxime + Gentamicin That Eradicates Persistent Pseudomonas aeruginosa Infection in a Murine Cystic Fibrosis Model

  Yuan, Y., Yee, R., Gour, N., Dong, X., Feng, J., Shi, W. & Zhang, Y., Mar 1 2023, In: Infectious Microbes and Diseases. 5, 1, p. 21-28 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • clinafloxacin 100%
  • Cefuroxime 75%
  • Pseudomonas Infections 70%
  • Gentamicins 58%
  • Drug Combinations 58%

• Landscape of mast cell populations across organs in mice and humans

  Tauber, M., Basso, L., Martin, J., Bostan, L., Pinto, M. M., Thierry, G. R., Houmadi, R., Serhan, N., Loste, A., Blériot, C., Kamphuis, J. B. J., Grujic, M., Kjellén, L., Pejler, G., Paul, C., Dong, X., Galli, S. J., Reber, L. L., Ginhoux, F., Bajenoff, M., & 2 othersGentek, R. & Gaudenzio, N., Oct 2 2023, In: Journal of Experimental Medicine. 220, 10, e20230570.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mast Cells 100%
  • Population 40%
  • Bone Marrow 16%
  • RNA Sequence Analysis 12%
  • Skin 12%

• Ligand recognition and G protein coupling of the human itch receptor MRGPRX1

  Guo, L., Zhang, Y., Fang, G., Tie, L., Zhuang, Y., Xue, C., Liu, Q., Zhang, M., Zhu, K., You, C., Xu, P., Yuan, Q., Zhang, C., Liu, L., Rong, N., Peng, S., Liu, Y., Wang, C., Luo, X., Lv, Z., & 10 othersKang, D., Yu, X., Zhang, C., Jiang, Y., Dong, X., Zhou, J., Liu, Z., Yang, F., Eric Xu, H. & Sun, J. P., Dec 2023, In: Nature communications. 14, 1, 5004.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ligands 80%
  • GTP-Binding Proteins 80%
  • Psychology Recognition 70%
  • proteins 63%
  • peptides 59%

• MrgprA3-expressing pruriceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel

  Lu, P., Zhao, Y., Xie, Z., Zhou, H., Dong, X., Wu, G. F., Kim, B. S., Feng, J. & Hu, H., Apr 25 2023, In: Cell Reports. 42, 4, 112283.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ablation 89%
  • Chloroquine 87%
  • Histamine 86%
  • Sensitization 82%
  • Drive 79%

• Neuronal Histone Methyltransferase EZH2 Regulates Neuronal Morphogenesis, Synaptic Plasticity, and Cognitive Behavior in Mice

  Zhang, M., Zhang, Y., Xu, Q., Crawford, J., Qian, C., Wang, G. H., Qian, J., Dong, X. Z., Pletnikov, M. V., Liu, C. M. & Zhou, F. Q., Oct 2023, In: Neuroscience Bulletin. 39, 10, p. 1512-1532 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Histone Methyltransferases 100%
  • Morphogenesis 73%
  • p21-Activated Kinases 69%
  • Neuronal Plasticity 69%
  • Dendritic Spines 59%

• Neuropathic pruritus

  Kwatra, S. G., Kambala, A. & Dong, X., Jul 2023, In: Journal of Allergy and Clinical Immunology. 152, 1, p. 36-38 3 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• Opioids and itch

  Lay, M., Follansbee, T. & Dong, X., Jul 11 2023, Histaminergic and Non-Histaminergic Itch: From Channels to Behavior. Nova Science Publisher Inc., p. 109-121 13 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Opioid Analgesics 100%
  • Papaver 37%
  • Opium 33%
  • Stupor 30%
  • Opioid-Related Disorders 27%

• Roles of mast cells and their interactions with the trigeminal nerve in migraine headache

  Guan, L. C., Dong, X. & Green, D. P., Jan 1 2023, In: Molecular Pain. 19

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Trigeminal Nerve 100%
  • Migraine Disorders 82%
  • Mast Cells 79%
  • Cell Communication 76%
  • Neurogenic Inflammation 16%

• Sensory neuron-expressed TRPC3 mediates acute and chronic itch

  Liu, Y., Liu, Y., Limjunyawong, N., Narang, C., Jamaldeen, H., Yu, S., Patiram, S., Nie, H., Caterina, M. J., Dong, X. & Qu, L., Jan 1 2023, In: Pain. 164, 1, p. 98-110 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Sensory Receptor Cells 83%
  • Contact Dermatitis 68%
  • Allergic Contact Dermatitis 49%
  • Neurons 36%
  • seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide 35%

• Targeting sensory neuron GPCRs for peripheral neuropathic pain

  Uniyal, A., Tiwari, V., Tsukamoto, T., Dong, X., Guan, Y. & Raja, S. N., Dec 2023, In: Trends in Pharmacological Sciences. 44, 12, p. 1009-1027 19 p.

  Research output: Contribution to journal › Review article › peer-review

  • Sensory Receptor Cells 100%
  • G-Protein-Coupled Receptors 93%
  • Central Nervous System 69%
  • Pain 26%
  • Drug Therapy 13%

• TMEM100, a regulator of TRPV1-TRPA1 interaction, contributes to temporomandibular disorder pain

  Wang, P., Zhang, Q., Dias, F. C., Suttle, A., Dong, X. & Chen, Y., 2023, In: Frontiers in Molecular Neuroscience. 16, 1160206.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Temporomandibular Joint Disorders 100%
  • Temporomandibular Joint 50%
  • Masseter Muscle 46%
  • Pain 46%
  • Neurons 32%

• Updates in SJS/TEN: collaboration, innovation, and community

  Marks, M. E., Botta, R. K., Abe, R., Beachkofsky, T. M., Boothman, I., Carleton, B. C., Chung, W. H., Cibotti, R. R., Dodiuk-Gad, R. P., Grimstein, C., Hasegawa, A., Hoofnagle, J. H., Hung, S. I., Kaffenberger, B., Kroshinsky, D., Lehloenya, R. J., Martin-Pozo, M., Micheletti, R. G., Mockenhaupt, M., Nagao, K., & 42 othersPakala, S., Palubinsky, A., Pasieka, H. B., Peter, J., Pirmohamed, M., Reyes, M., Saeed, H. N., Shupp, J., Sukasem, C., Syu, J. Y., Ueta, M., Zhou, L., Chang, W. C., Becker, P., Bellon, T., Bonnet, K., Cavalleri, G., Chodosh, J., Dewan, A. K., Dominguez, A., Dong, X., Ezhkova, E., Fuchs, E., Goldman, J., Himed, S., Mallal, S., Markova, A., McCawley, K., Norton, A. E., Ostrov, D., Phan, M., Sanford, A., Schlundt, D., Schneider, D., Shear, N., Shinkai, K., Tkaczyk, E., Trubiano, J. A., Volpi, S., Bouchard, C. S., Divito, S. J. & Phillips, E. J., 2023, In: Frontiers in Medicine. 10, 1213889.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Stevens-Johnson Syndrome 100%
  • Skin Pigmentation 11%
  • Clinical Pharmacology 11%
  • Allergy and Immunology 10%
  • Ophthalmology 9%
• 2022

  Anoctamin 1/TMEM16A in pruritoceptors is essential for Mas-related G protein receptor-dependent itch

  Kim, H., Kim, H., Cho, H., Lee, B., Lu, H. J., Kim, K., Chung, S., Shim, W. S., Shin, Y. K., Dong, X., Wood, J. N. & Oh, U., Nov 1 2022, In: Pain. 163, 11, p. 2172-2184 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Anoctamin-1 100%
  • Spinal Ganglia 61%
  • GTP-Binding Proteins 56%
  • Neurons 34%
  • Pruritus 29%

• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Vasavda, C., Semenza, E. R., Liew, J., Kothari, R., Dhindsa, R. S., Shanmukha, S., Lin, A., Tokhunts, R., Ricco, C., Snowman, A. M., Albacarys, L., Pastore, F., Ripoli, C., Grassi, C., Barone, E., Kornberg, M. D., Dong, X., Paul, B. D. & Snyder, S. H., May 10 2022, In: Science signaling. 15, 733, eabh3066.

  Research output: Contribution to journal › Article › peer-review

  • biliverdin reductase 100%
  • Biliverdin 82%
  • Focal Adhesion Protein-Tyrosine Kinases 72%
  • Focal Adhesions 19%
  • Plastic Property 19%

• Biological screening of a unique drug library targeting MRGPRX2

  Yang, F., Limjunyawong, N., Peng, Q., Schroeder, J. T., Saini, S., MacGlashan, D., Dong, X. & Gao, L., Oct 21 2022, In: Frontiers in immunology. 13, 997389.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drug Delivery Systems 100%
  • Libraries 90%
  • Drug Hypersensitivity 54%
  • Fluoroquinolones 45%
  • bacitracin A 43%

• BzATP Activates Satellite Glial Cells and Increases the Excitability of Dorsal Root Ganglia Neurons In Vivo

  Chen, Z., Zhang, C., Song, X., Cui, X., Liu, J., Ford, N. C., He, S., Zhu, G., Dong, X., Hanani, M. & Guan, Y., Aug 2022, In: Cells. 11, 15, 2280.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Spinal Ganglia 100%
  • Neuroglia 81%
  • Adenosine Triphosphate 71%
  • Calcium(0) 70%
  • Probenecid 70%

• Cluster Analysis of Circulating Plasma Biomarkers in Prurigo Nodularis Reveals a Distinct Systemic Inflammatory Signature in African Americans

  Sutaria, N., Alphonse, M. P., Marani, M., Parthasarathy, V., Deng, J., Wongvibulsin, S., Williams, K., Roh, Y. S., Choi, J., Bordeaux, Z., Pritchard, T., Dillen, C., Semenov, Y. R., Kwatra, M. M., Archer, N. K., Garza, L. A., Dong, X., Kang, S. & Kwatra, S. G., May 2022, In: Journal of Investigative Dermatology. 142, 5, p. 1300-1308.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prurigo 100%
  • African Americans 61%
  • Biological Marker 58%
  • Cluster Analysis 58%
  • Biomarkers 42%

• Ginger Constituent 6-Shogaol Attenuates Vincristine-Induced Activation of Mouse Gastroesophageal Vagal Afferent C-Fibers

  Patil, M. J., Huang, Y., Yu, M., Dong, X., Undem, B. J. & Yu, S., Nov 2022, In: Molecules. 27, 21, 7465.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • [6]-Shogaol 100%
  • shogaol 98%
  • Ginger 78%
  • Unmyelinated Nerve Fibers 72%
  • Vincristine 63%

• Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain

  Vasavda, C., Xu, R., Liew, J., Kothari, R., Dhindsa, R. S., Semenza, E. R., Paul, B. D., Green, D. P., Sabbagh, M. F., Shin, J. Y., Yang, W., Snowman, A. M., Albacarys, L. K., Moghekar, A., Pardo-Villamizar, C. A., Luciano, M., Huang, J., Bettegowda, C., Kwatra, S. G., Dong, X., & 2 othersLim, M. & Snyder, S. H., Aug 2022, In: Science Advances. 8, 31, eabo5633.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Trigeminal Neuralgia 100%
  • Gene Regulatory Networks 84%
  • United States Food and Drug Administration 51%
  • TRPA1 Cation Channel 43%
  • exemestane 39%

• In Vivo Calcium Imaging of Peripheral Ganglia

  Lay, M. & Dong, X., 2022, Neuromethods. Humana Press Inc., p. 313-319 7 p. (Neuromethods; vol. 178).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Ganglia 100%
  • Calcium(0) 78%
  • Calcium 70%
  • Electrophysiology 57%
  • Proxy 53%

• Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection

  Dong, X., Limjunyawong, N., Sypek, E. I., Wang, G., Ortines, R. V., Youn, C., Alphonse, M. P., Dikeman, D., Wang, Y., Lay, M., Kothari, R., Vasavda, C., Pundir, P., Goff, L., Miller, L. S., Lu, W., Garza, L. A., Kim, B. S., Archer, N. K. & Dong, X., Sep 13 2022, In: Immunity. 55, 9, p. 1645-1662.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Defensins 100%
  • Dysbiosis 90%
  • Keratinocytes 69%
  • Bacterial Infections 67%
  • Neutrophils 56%

• Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle

  Feng, J., Zhao, Y., Xie, Z., Zang, K., Sviben, S., Hu, X., Fitzpatrick, J. A. J., Wen, L., Liu, Y., Wang, T., Lawson, K., Liu, Q., Yan, Y., Dong, X., Han, L., Wu, G. F., Kim, B. S. & Hu, H., Jul 13 2022, In: Science translational medicine. 14, 653, eabn4819.

  Research output: Contribution to journal › Article › peer-review

  • Merkel Cells 100%
  • Unmyelinated Nerve Fibers 81%
  • Drive 66%
  • Skin 35%
  • Mechanoreceptors 16%

• Peripheral mechanisms of chronic pain

  Zheng, Q., Dong, X., Green, D. P. & Dong, X., Jun 1 2022, In: Medical Review. 2, 3, p. 251-270 20 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Chronic Pain 100%
  • Autonomic Nervous System 20%
  • Acute Pain 19%
  • Nervous System 14%
  • Neurons 11%

• Purinergic signaling between neurons and satellite glial cells of mouse dorsal root ganglia modulates neuronal excitability in vivo

  Chen, Z., Huang, Q., Song, X., Ford, N. C., Zhang, C., Xu, Q., Lay, M., He, S. Q., Dong, X., Hanani, M. & Guan, Y., Aug 1 2022, In: Pain. 163, 8, p. 1636-1647 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinal Ganglia 100%
  • Neuroglia 81%
  • Neurons 56%
  • Purinergic P2 Receptors 31%
  • Nociceptors 28%

• Role of primary sensory neurone cannabinoid type-1 receptors in pain and the analgesic effects of the peripherally acting agonist CB-13 in mice

  Ford, N. C., Barpujari, A., He, S. Q., Huang, Q., Zhang, C., Dong, X., Guan, Y. & Raja, S. N., Jan 2022, In: British journal of anaesthesia. 128, 1, p. 159-173 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone 100%
  • Cannabinoid Receptors 56%
  • Sensory Receptor Cells 47%
  • Analgesics 38%
  • Pain 25%

• Scratching the surface of itch receptors

  Kothari, R. & Dong, X., Mar 2022, In: Trends in Pharmacological Sciences. 43, 3, p. 168-170 3 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Solar System 100%
  • G-Protein-Coupled Receptors 91%
  • Surface 57%
  • Therapeutics 29%

• Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain

  Zheng, Q., Xie, W., Lückemeyer, D. D., Lay, M., Wang, X. W., Dong, X., Limjunyawong, N., Ye, Y., Zhou, F. Q., Strong, J. A., Zhang, J. M. & Dong, X., Jan 19 2022, In: Neuron. 110, 2, p. 209-220.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sensory Receptor Cells 100%
  • Drive 96%
  • Pain 53%
  • Spinal Ganglia 50%
  • Peripheral Nerve Injuries 19%

• Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1

  Sharma, S., Peng, Q., Vadukoot, A. K., Aretz, C. D., Jensen, A. A., Wallick, A. I., Dong, X. & Hopkins, C. R., 2022, (Accepted/In press) In: ACS Medicinal Chemistry Letters.

  Research output: Contribution to journal › Article › peer-review

  • Halogens 100%
  • Pharmaceutical Chemistry 95%
  • Chronic Pain 63%
  • Halogen 61%
  • Pharmacological Metabolism 53%

• Thieno[2,3-d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1)

  Berhane, I., Hin, N., Thomas, A. G., Huang, Q., Zhang, C., Veeravalli, V., Wu, Y., Ng, J., Alt, J., Rojas, C., Hihara, H., Aoki, M., Yoshizawa, K., Nishioka, T., Suzuki, S., He, S. Q., Peng, Q., Guan, Y., Dong, X., Raja, S. N., & 3 othersSlusher, B. S., Rais, R. & Tsukamoto, T., Feb 24 2022, In: Journal of medicinal chemistry. 65, 4, p. 3218-3228 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • thieno(2,3-d)pyrimidine 100%
  • G-Protein-Coupled Receptors 47%
  • Sensory Receptor Cells 25%
  • Cord 19%
  • High Throughput Screening 17%

• Touch-evoked itch pinned on Piezo1 ion-channel protein

  Follansbee, T. & Dong, X., Jul 7 2022, In: Nature. 607, 7917, p. 36-37 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Touch 100%
  • Ion Channels 98%
  • Proteins 36%

• Transcription Factor MAFA Regulates Mechanical Sensation by Modulating Piezo2 Expression

  Wang, C. M., Green, D. P. & Dong, X., Aug 2022, In: Neuroscience Bulletin. 38, 8, p. 933-937 5 p.

  Research output: Contribution to journal › Letter › peer-review
• 2021

  A basophil-neuronal axis promotes itch

  Wang, F., Trier, A. M., Li, F., Kim, S., Chen, Z., Chai, J. N., Mack, M. R., Morrison, S. A., Hamilton, J. D., Baek, J., Yang, T. L. B., Ver Heul, A. M., Xu, A. Z., Xie, Z., Dong, X., Kubo, M., Hu, H., Hsieh, C. S., Dong, X., Liu, Q., & 4 othersMargolis, D. J., Ardeleanu, M., Miller, M. J. & Kim, B. S., Jan 21 2021, In: Cell. 184, 2, p. 422-440.e17

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Basophils 100%
  • Disorder 71%
  • Allergens 52%
  • Leukotrienes 34%
  • Mast Cells 27%
  8 Scopus citations

• Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension

  Grundy, L., Caldwell, A., Garcia-Caraballo, S., Grundy, D., Spencer, N. J., Dong, X., Castro, J., Harrington, A. M. & Brierley, S. M., Apr 28 2021, In: Journal of Neuroscience. 41, 17, p. 3900-3916 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hypersensitivity 100%
  • Urinary Bladder 97%
  • Mouse Ccr10 protein 62%
  • bovine adrenal medulla 8-22 49%
  • Diagnosis-Related Groups 42%

• A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice

  Wolf, K., Kühn, H., Boehm, F., Gebhardt, L., Glaudo, M., Agelopoulos, K., Ständer, S., Ectors, P., Zahn, D., Riedel, Y. K., Thimm, D., Müller, C. E., Kretschmann, S., Kremer, A. N., Chien, D., Limjunyawong, N., Peng, Q., Dong, X., Kolkhir, P., Scheffel, J., & 7 othersSøgaard, M. L., Weigmann, B., Neurath, M. F., Hawro, T., Metz, M., Fischer, M. J. M. & Kremer, A. E., Aug 2021, In: Journal of Allergy and Clinical Immunology. 148, 2, p. 506-522.e8

  Research output: Contribution to journal › Article › peer-review

  • Mast Cells 100%
  • Clomipramine 69%
  • Drug Hypersensitivity 68%
  • Intradermal Injections 66%
  • Paroxetine 65%

• Astrocytes contribute to pain gating in the spinal cord

  Xu, Q., Ford, N. C., He, S., Huang, Q., Anderson, M., Chen, Z., Yang, F., Crawford, L. T. K., Caterina, M. J., Guan, Y. & Dong, X., Nov 2021, In: Science Advances. 7, 45, eabi6287.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Astrocytes 100%
  • Spinal Cord 88%
  • Pain 62%
  • Neurons 40%
  • Optogenetics 28%

• Calcium imaging in population of dorsal root ganglion neurons unravels novel mechanisms of visceral pain sensitization and referred somatic hypersensitivity

  Gao, X., Han, S., Huang, Q., He, S. Q., Ford, N. C., Zheng, Q., Chen, Z., Yu, S., Dong, X. & Guan, Y., Apr 1 2021, In: Pain. 162, 4, p. 1068-1081 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Visceral Pain 100%
  • Spinal Ganglia 76%
  • Hypersensitivity 58%
  • Calcium 48%
  • sym-trinitrobenzene 45%
  1 Scopus citations

• MRGPRX2 Activation Causes Increased Skin Reactivity in Patients with Chronic Spontaneous Urticaria

  Shtessel, M., Limjunyawong, N., Oliver, E. T., Chichester, K., Gao, L., Dong, X. & Saini, S. S., Mar 2021, In: Journal of Investigative Dermatology. 141, 3, p. 678-681.e2

  Research output: Contribution to journal › Article › peer-review

  Open Access
  5 Scopus citations

• Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice

  Sun, Q., Zhen, G., Li, T. P., Guo, Q., Li, Y., Su, W., Xue, P., Wang, X., Wan, M., Guan, Y., Dong, X., Li, S., Cai, M. & Cao, X., Mar 2021, In: eLife. 10, e66532.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Parathyroid Hormone 100%
  • Meniscus 94%
  • Tibial Meniscus 92%
  • Bone Remodeling 71%
  • Osteoarthritis 61%

• Population coding of capsaicin concentration by sensory neurons revealed using Ca²⁺ imaging of dorsal root ganglia explants from adult pirt-GCaMP3 mouse

  Lawrence, G. W., Zurawski, T. H., Dong, X. & Oliver Dolly, J., 2021, In: Cellular Physiology and Biochemistry. 55, 4, p. 428-448 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Capsaicin 100%
  • Spinal Ganglia 94%
  • Sensory Receptor Cells 93%
  • Population 34%
  • Fluorescence 23%

• Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates

  Klein, A., Solinski, H. J., Malewicz, N. M., Ieong, H. F. H., Sypek, E. I., Shimada, S. G., Hartke, T. V., Wooten, M., Wu, G., Dong, X., Hoon, M. A., Lamotte, R. H. & Ringkamp, M., 2021, In: eLife. 10, e64506.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nociceptors 100%
  • Adrenal Medulla 76%
  • Primates 75%
  • Alanine 61%
  • Unmyelinated Nerve Fibers 51%

• Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization

  Belzberg, M., Alphonse, M. P., Brown, I., Williams, K. A., Khanna, R., Ho, B., Wongvibulsin, S., Pritchard, T., Roh, Y. S., Sutaria, N., Choi, J., Jedrych, J., Johnston, A. D., Sarkar, K., Vasavda, C., Meixiong, J., Dillen, C., Bondesgaard, K., Paolini, J. F., Chen, W., & 9 othersCorcoran, D., Devos, N., Kwatra, M. M., Chien, A. L., Archer, N. K., Garza, L. A., Dong, X., Kang, S. & Kwatra, S. G., Sep 2021, In: Journal of Investigative Dermatology. 141, 9, p. 2208-2218.e14

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequencing 100%
  • Prurigo 92%
  • Polarization 44%
  • Flow 38%
  • Skin 33%
  2 Scopus citations

• Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions

  Zaufel, A., van de Wiel, S. M. W., Yin, L., Fauler, G., Chien, D., Dong, X., Gilmer, J. F., Truong, J. K., Dawson, P. A., van de Graaf, S. F. J., Fickert, P. & Moustafa, T., Aug 1 2021, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867, 8, 166153.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GW 4064 100%
  • Enterohepatic Circulation 40%
  • Ligands 39%
  • RNA Precursors 31%
  • Liver 28%

• Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation

  Wongvibulsin, S., Sutaria, N., Kannan, S., Alphonse, M. P., Belzberg, M., Williams, K. A., Brown, I. D., Choi, J., Roh, Y. S., Pritchard, T., Khanna, R., Eseonu, A. C., Jedrych, J., Dillen, C., Kwatra, M. M., Chien, A. L., Archer, N., Garza, L. A., Dong, X., Kang, S., & 1 othersKwatra, S. G., Dec 2021, In: Scientific reports. 11, 1, 11175.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • African Americans 89%
  • Skin 52%
  • Dermatitis 34%
  • Up-Regulation 22%
  • Ferritins 16%