Xiaobo Mao

Assistant Professor

20082019
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Research Output 2008 2019

Article

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration

Brahmachari, S., Ge, P., Lee, S. H., Kim, D., Karuppagounder, S., Kumar, M., Mao, X., Shin, J. H., Lee, Y., Pletnikova, O., Troncoso, J. C., Dawson, V., Dawson, T. M. & Ko, H. S., Aug 1 2016, In : Journal of Clinical Investigation. 126, 8, p. 2970-2988 19 p.

Research output: Contribution to journalArticle

Synucleins
Protein-Tyrosine Kinases
Phosphotyrosine
Parkinson Disease
abl Genes

Amyloid β (1-42) Folding Multiplicity and Single-Molecule Binding Behavior Studied with STM

Ma, X., Liu, L., Mao, X., Niu, L., Deng, K., Wu, W., Li, Y., Yang, Y. & Wang, C., May 15 2009, In : Journal of Molecular Biology. 388, 4, p. 894-901 8 p.

Research output: Contribution to journalArticle

Amyloid
Peptides
Scanning Tunnelling Microscopy
Congo Red
Neurodegenerative Diseases

Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies

Mao, X., Wang, C. X., Wu, X. K., Ma, X. J., Liu, L., Zhang, L., Niu, L., Guo, Y. Y., Li, D. H., Yang, Y. L. & Wang, C., Dec 6 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 49, p. 19605-19610 6 p.

Research output: Contribution to journalArticle

Islet Amyloid Polypeptide
Scanning Tunnelling Microscopy
Amyloid
Amino Acids
Peptides

Binding modes of thioflavin T molecules to prion peptide assemblies identified by using scanning tunneling microscopy

Mao, X., Guo, Y., Wang, C., Zhang, M., Ma, X., Liu, L., Niu, L., Zeng, Q., Yang, Y. & Wang, C., Jun 15 2011, In : ACS Chemical Neuroscience. 2, 6, p. 281-287 7 p.

Research output: Contribution to journalArticle

Scanning Tunnelling Microscopy
Prions
Scanning tunneling microscopy
Peptides
Molecules

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Yun, S. P., Kam, T-I., Panicker, N., Kim, S., Oh, Y., Park, J. S., Kwon, S. H., Park, Y. J., Karuppagounder, S., Park, H., Kim, S., Oh, N., Kim, N. A., Lee, S., Brahmachari, S., Mao, X., Lee, J. H., Kumar, M., An, D., Kang, S. & 13 others, Lee, Y., Lee, K. C., Na, D. H., Kim, D., Lee, S. H., Roschke, V. V., Liddelow, S. A., Mari, Z., Barres, B. A., Dawson, V., Lee, S., Dawson, T. M. & Ko, H. S., Jul 1 2018, In : Nature Medicine. 24, 7, p. 931-938 8 p.

Research output: Contribution to journalArticle

Microglia
Astrocytes
Parkinson Disease
Synucleins
Nervous System Diseases

Carbon nanotubes induce secondary structure changes of bovine albumin in aqueous phase

Yang, M., Meng, J., Mao, X., Yang, Y., Cheng, X., Yuan, H., Wang, C. & Xu, H., Nov 2010, In : Journal of Nanoscience and Nanotechnology. 10, 11, p. 7550-7553 4 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Bovine Serum Albumin
albumins
Albumins
Carbon nanotubes

Chaperon-Mediated single molecular approach toward modulating aβ peptide aggregation

Liu, L., Zhang, L., Mao, X., Niu, L., Yang, Y. & Wang, C., Dec 9 2009, In : Nano Letters. 9, 12, p. 4066-4072 7 p.

Research output: Contribution to journalArticle

Peptides
peptides
Agglomeration
Modulators
modulators

Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy

Wang, C., Wang, C., Mao, X., Yang, A., Niu, L., Wang, S., Li, D., Guo, Y., Wang, Y. & Yang, Y., Oct 14 2011, In : Chemical Communications. 47, 38, p. 10638-10640 3 p.

Research output: Contribution to journalArticle

Scanning tunneling microscopy
Labeling
Amino acids
Amino Acids
Molecules

Extracellular RNAs-TLR3 signaling contributes to cognitive decline in a mouse model of postoperative cognitive dysfunction

Chen, C., Gao, R., Li, M., Wang, Q., Chen, H., Zhang, S., Mao, X., Behensky, A., Zhang, Z., Gan, L., Li, T., Liao, R., Li, Q., Yu, H., Yang, J., Zhu, T. & Liu, J., Jan 1 2019, In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Toll-Like Receptor 3
RNA
Hippocampus
Double-Stranded RNA
Cytokines

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

Kim, S., Yun, S. P., Lee, S., Umanah, G., Bandaru, V. V. R., Yin, X., Rhee, P., Karuppagounder, S., Kwon, S. H., Lee, H., Mao, X., Kim, D., Pandey, A., Lee, G., Dawson, V., Dawson, T. M. & Ko, H. S., Jan 23 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. 798-803 6 p.

Research output: Contribution to journalArticle

Synucleins
Glucosylceramidase
Gaucher Disease
Glycosphingolipids
Dopaminergic Neurons

Growth mechanism for controlled synthesis of metal nanotube and nanowire arrays using anodic aluminum oxide templates

Guo, Y. Y., Wang, M., Mao, X., Jiang, Y. X., Wang, C. & Yang, Y. L., 2010, In : Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica. 26, 7, p. 2037-2043 7 p.

Research output: Contribution to journalArticle

Aluminum Oxide
Nanotubes
Nanowires
nanotubes
nanowires

High-content genome-wide rnai screen reveals ccr3 as a key mediator of neuronal cell death

Zhang, J., Wang, H., Sherbini, O., Pai, E. L. L., Kang, S., Kwon, J. S., Yang, J., He, W., Wang, H., Eacker, S., Chi, Z., Mao, X., Xu, J., Jiang, H., Andrabi, S. A., Dawson, T. M. & Dawson, V., Sep 1 2016, In : eNeuro. 3, 5, e0185-16.2016.

Research output: Contribution to journalArticle

Cell Death
Genome
Small Interfering RNA
Wounds and Injuries
Neural Stem Cells

Identification of the Potential Key Long Non-coding RNAs in Aged Mice with Postoperative Cognitive Dysfunction

Li, M., Chen, C., Zhang, W., Gao, R., Wang, Q., Chen, H., Zhang, S., Mao, X., Leblanc, M., Behensky, A., Zhang, Z., Gan, L., Yu, H., Zhu, T. & Liu, J., Jan 1 2019, In : Frontiers in Aging Neuroscience. 10, JUL, 189.

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Messenger RNA
Gene Ontology
Apoptosis
Inflammation

Molecular-level evidence of the surface-induced transformation of peptide structures revealed by scanning tunneling microscopy

Mao, X., Wang, Y., Liu, L., Niu, L., Yang, Y. & Wang, C., Aug 18 2009, In : Langmuir. 25, 16, p. 8849-8853 5 p.

Research output: Contribution to journalArticle

Polypeptides
polypeptides
Scanning tunneling microscopy
Peptides
peptides

Molecular level studies on binding modes of labeling molecules with polyalanine peptides

Mao, X., Wang, C., Ma, X., Zhang, M., Liu, L., Zhang, L., Niu, L., Zeng, Q., Yang, Y. & Wang, C., Apr 2011, In : Nanoscale. 3, 4, p. 1592-1599 8 p.

Research output: Contribution to journalArticle

Labeling
Peptides
Molecules
Congo Red
Scanning tunneling microscopy

Molecularly tuned peptide assemblies at the liquid-solid interface studied by scanning tunneling microscopy

Niu, L., Ma, X., Liu, L., Mao, X., Wu, D., Yang, Y., Zeng, Q. & Wang, C., Oct 7 2010, In : Physical Chemistry Chemical Physics. 12, 37, p. 11683-11687 5 p.

Research output: Contribution to journalArticle

Scanning tunneling microscopy
liquid-solid interfaces
assemblies
peptides
scanning tunneling microscopy

Observation of reduced cytotoxicity of aggregated amyloidogenic peptides with chaperone-like molecules

Liu, L., Zhang, L., Niu, L., Xu, M., Mao, X., Yang, Y. & Wang, C., Jul 26 2011, In : ACS Nano. 5, 7, p. 6001-6007 7 p.

Research output: Contribution to journalArticle

Cytotoxicity
Peptides
peptides
Molecules
molecules

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease

Brahmachari, S., Lee, S., Kim, S., Yuan, C., Karuppagounder, S., Ge, P., Shi, R., Kim, E. J., Liu, A., Kim, D., Quintin, S., Jiang, H., Kumar, M., Yun, S. P., Kam, T-I., Mao, X., Lee, Y., Swing, D. A., Tessarollo, L., Ko, H. S. & 2 others, Dawson, V. & Dawson, T. M., Aug 1 2019, In : Brain : a journal of neurology. 142, 8, p. 2380-2401 22 p.

Research output: Contribution to journalArticle

Zinc Fingers
Synucleins
Parkinson Disease
Proteins
Amino Acyl-tRNA Synthetases

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., Ono, Y., Mao, X., Quach, T. H., Iwai, K., Dawson, V., Dawson, T. M. & Takahashi, R., Jan 1 2018, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

Synucleins
Multiple System Atrophy
Oligodendroglia
Inclusion Bodies
Neuroglia

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3

Mao, X., Ou, M. T., Karuppagounder, S., Kam, T-I., Yin, X., Xiong, Y., Ge, P., Umanah, G., Brahmachari, S., Shin, J. H., Kang, H. C., Zhang, J., Xu, J., Chen, R., Park, H., Andrabi, S. A., Kang, S., Gonçalves, R. A., Liang, Y., Zhang, S. & 12 others, Qi, C., Lam, S., Keiler, J. A., Tyson, J., Kim, D., Panicker, N., Yun, S. P., Workman, C. J., Vignali, D. A. A., Dawson, V., Ko, H. S. & Dawson, T. M., Sep 30 2016, In : Science. 353, 6307, aah3374.

Research output: Contribution to journalArticle

Synucleins
Lymphocyte Activation
Genes
Parkinson Disease
Neurons

Peptide-tailored assembling of Au nanorods

He, W., Hou, S., Mao, X., Wu, X., Ji, Y., Liu, J., Hu, X., Zhang, K., Wang, C., Yang, Y. & Wang, Q., May 21 2011, In : Chemical Communications. 47, 19, p. 5482-5484 3 p.

Research output: Contribution to journalArticle

Nanorods
Peptides

Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease

Kam, T-I., Mao, X., Park, H., Chou, S. C., Karuppagounder, S., Umanah, G., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A., Ko, H. S., Rosenthal, L. I. S. & 2 others, Dawson, T. M. & Dawson, V., Nov 2 2018, In : Science. 362, 6414, eaat8407.

Research output: Contribution to journalArticle

Synucleins
Poly Adenosine Diphosphate Ribose
Parkinson Disease
Adenosine
Poisons

Porous α-Fe2O3 nanostructures with branched topology: Growth, formation mechanism, and properties

Yang, H., Mao, X., Guo, Y., Wang, D., Ge, G., Yang, R., Qiu, X., Yang, Y., Wang, C., Wang, Y. & Liu, G., Jun 2010, In : CrystEngComm. 12, 6, p. 1842-1849 8 p.

Research output: Contribution to journalArticle

Nanostructures
rods
topology
Topology
attachment

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Xiong, Y., Neifert, S., Karuppagounder, S., Liu, Q., Stankowski, J. N., Lee, B. D., Ko, H. S., Lee, Y., Grima, J. C., Mao, X., Jiang, H., Kang, S., Swing, D. A., Iacovitti, L., Tessarollo, L., Dawson, T. M. & Dawson, V., Feb 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1635-1640 6 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Transgenic Mice
Norepinephrine
Phosphotransferases
Parkinson Disease

Self-assembly of truxene derivatives investigated by STM

Mao, X., Ma, Z., Yang, Y. L., Lei, S. B., Wang, C. & Huang, W., Mar 2008, In : Frontiers of Materials Science in China. 2, 1, p. 26-30 5 p.

Research output: Contribution to journalArticle

Scanning tunneling microscopy
Self assembly
Hydrogen bonds
Derivatives
Molecular orientation

Sequence effects on peptide assembly characteristics observed by using scanning tunneling microscopy

Mao, X., Guo, Y., Luo, Y., Niu, L., Liu, L., Ma, X., Wang, H., Yang, Y., Wei, G. & Wang, C., Feb 13 2013, In : Journal of the American Chemical Society. 135, 6, p. 2181-2187 7 p.

Research output: Contribution to journalArticle

Scanning Tunnelling Microscopy
Scanning tunneling microscopy
Peptides
Graphite
Luminance

Single molecule studies of cyclic peptides using molecular matrix at liquid/solid interface by scanning tunneling microscopy

Wang, Y., Niu, L., Li, Y., Mao, X., Yang, Y. & Wang, C., Nov 2 2010, In : Langmuir. 26, 21, p. 16305-16311 7 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Scanning tunneling microscopy
liquid-solid interfaces
Cyclosporine
peptides

State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice

Willard, A. M., Isett, B. R., Whalen, T. C., Mastro, K. J., Ki, C. S., Mao, X. & Gittis, A. H., Mar 1 2019, In : eLife. 8, e42746.

Research output: Contribution to journalArticle

Open Access
Basal Ganglia
Dopamine
Prodromal Symptoms
Trajectories
Neurodegenerative Diseases

Straight and branched goethite topology by oriented attachment at high pH

Mao, X., Yang, H., Zhou, X., Wang, C., Wang, Y., Yang, Y., Waang, C. & Liu, G., Feb 3 2010, In : Crystal Growth and Design. 10, 2, p. 504-509 6 p.

Research output: Contribution to journalArticle

Nanocrystallites
attachment
Nanostructures
topology
Oxide minerals

Structural characteristics of the beta-sheet-like human and rat islet amyloid polypeptides as determined by scanning tunneling microscopy

Mao, X., Ma, X., Liu, L., Niu, L., Yang, Y. & Wang, C., Sep 2009, In : Journal of Structural Biology. 167, 3, p. 209-215 7 p.

Research output: Contribution to journalArticle

Scanning Tunnelling Microscopy
Islet Amyloid Polypeptide
Graphite
Molecular Structure
beta-Strand Protein Conformation

T cells from patients with Parkinson's disease recognize α-synuclein peptides

Sulzer, D., Alcalay, R. N., Garretti, F., Cote, L., Kanter, E., Agin-Liebes, J., Liong, C., McMurtrey, C., Hildebrand, W. H., Mao, X., Dawson, V., Dawson, T. M., Oseroff, C., Pham, J., Sidney, J., Dillon, M. B., Carpenter, C., Weiskopf, D., Phillips, E., Mallal, S. & 4 others, Peters, B., Frazier, A., Lindestam Arlehamn, C. S. & Sette, A., Jun 29 2017, In : Nature. 546, 7660, p. 656-661 6 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
T-Lymphocytes
Peptides
Alleles

The effect of graphene oxide on conformation change, aggregation and cytotoxicity of HIV-1 regulatory protein (Vpr)

Zhang, M., Mao, X., Wang, C., Zeng, W., Zhang, C., Li, Z., Fang, Y., Yang, Y., Liang, W. & Wang, C., Jan 2013, In : Biomaterials. 34, 4, p. 1383-1390 8 p.

Research output: Contribution to journalArticle

vpr Gene Products
Graphite
Cytotoxicity
Oxides
Graphene

Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel

Umanah, G., Pignatelli, M., Yin, X., Chen, R., Crawford, J., Neifert, S., Scarffe, L., Behensky, A. A., Guiberson, N., Chang, M., Ma, E., Kim, J. W., Castro, C. C., Mao, X., Chen, L., Andrabi, S. A., Pletnikov, M., Pulver, A. E., Avramopoulos, D., Bonci, A. & 3 others, Valle, D., Dawson, T. M. & Dawson, V., Dec 13 2017, In : Science Translational Medicine. 9, 420, aah4985.

Research output: Contribution to journalArticle

Synaptic Transmission
Acids
Neuronal Plasticity
United States Food and Drug Administration
Adenosine Triphosphatases

Visible light induced photocatalytic degradation of rhodamine B on one-Dimensional iron oxide particles

Zhou, X., Yang, H., Wang, C., Mao, X., Wang, Y., Yang, Y. & Liu, G., Oct 14 2010, In : Journal of Physical Chemistry C. 114, 40, p. 17051-17061 11 p.

Research output: Contribution to journalArticle

rhodamine B
rhodamine
Nanorods
Iron oxides
iron oxides
Review article

Nanomaterials for reducing amyloid cytotoxicity

Wang, C., Zhang, M., Mao, X., Yu, Y., Wang, C. X. & Yang, Y. L., Jul 26 2013, In : Advanced Materials. 25, 28, p. 3780-3801 22 p.

Research output: Contribution to journalReview article

Cytotoxicity
Amyloid
Nanostructured materials
Nanoparticles
Peptides

Observation of molecular inhibition and binding structures of amyloid peptides

Yang, A., Li, X., Li, D., Zhang, M., Du, H., Li, C., Guo, Y., Mao, X., Dong, M., Besenbacher, F., Yang, Y., Wang, C. & Wang, C., Mar 21 2012, In : Nanoscale. 4, 6, p. 1895-1909 15 p.

Research output: Contribution to journalReview article

Amyloid
Peptides
Scanning probe microscopy
Molecular interactions
Pharmaceutical Preparations

Study on the fine structure of polypeptides at solid-liquid interfaces by scanning tunneling microscopy

Mao, X., Wang, C. X., Liu, L., Ma, X. J., Niu, L., Yang, Y. L. & Wang, C., Apr 2010, In : Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica. 26, 4, p. 850-861 12 p.

Research output: Contribution to journalReview article

polypeptides
Scanning tunneling microscopy
liquid-solid interfaces
peptides
scanning tunneling microscopy