Xiaobo Mao

Assistant Professor

20082018
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Scanning tunneling microscopy Chemical Compounds
Peptides Engineering & Materials Science
peptides Physics & Astronomy
Molecules Chemical Compounds
scanning tunneling microscopy Physics & Astronomy
liquid-solid interfaces Physics & Astronomy
Cytotoxicity Chemical Compounds
Amyloid Chemical Compounds

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Research Output 2008 2018

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

Kim, S., Yun, S. P., Lee, S., Umanah, G. E., Bandaru, V. V. R., Yin, X., Rhee, P., Karuppagounder, S. S., Kwon, S. H., Lee, H., Mao, X., Kim, D., Pandey, A., Lee, G., Dawson, V. L., Dawson, T. M. & Ko, H. S. Jan 23 2018 In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. 798-803 6 p.

Research output: Contribution to journalArticle

Gaucher Disease
alpha-Synuclein
Glucosylceramidase
Glycosphingolipids
Dopaminergic Neurons

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., Ono, Y., Mao, X., Quach, T. H., Iwai, K., Dawson, V. L., Dawson, T. M. & Takahashi, R. Jan 1 2018 (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

Multiple System Atrophy
alpha-Synuclein
Oligodendroglia
Neuroglia
Inclusion Bodies

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Xiong, Y., Neifert, S., Karuppagounder, S. S., Liu, Q., Stankowski, J. N., Lee, B. D., Ko, H. S., Lee, Y., Grima, J. C., Mao, X., Jiang, H., Kang, S. U., Swing, D. A., Iacovitti, L., Tessarollo, L., Dawson, T. M. & Dawson, V. L. Feb 13 2018 In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1635-1640 6 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Transgenic Mice
Norepinephrine
Phosphotransferases
Parkinson Disease

T cells from patients with Parkinson's disease recognize α-synuclein peptides

Sulzer, D. , Alcalay, R. N. , Garretti, F. , Cote, L. , Kanter, E. , Agin-Liebes, J. , Liong, C. , McMurtrey, C. , Hildebrand, W. H. , Mao, X. , Dawson, V. L. , Dawson, T. M. , Oseroff, C. , Pham, J. , Sidney, J. , Dillon, M. B. , Carpenter, C. , Weiskopf, D. , Phillips, E. , Mallal, S. & 4 others Peters, B., Frazier, A., Lindestam Arlehamn, C. S. & Sette, A. Jun 29 2017 In : Nature. 546, 7660, p. 656-661 6 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Parkinson Disease
T-Lymphocytes
Peptides
Alleles

Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel

Umanah, G. K. E. , Pignatelli, M. , Yin, X. , Chen, R. , Crawford, J. , Neifert, S. , Scarffe, L. , Behensky, A. A. , Guiberson, N. , Chang, M. , Ma, E. , Kim, J. W. , Castro, C. C. , Mao, X. , Chen, L. , Andrabi, S. A. , Pletnikov, M. V. , Pulver, A. E. , Avramopoulos, D. , Bonci, A. & 3 others Valle, D., Dawson, T. M. & Dawson, V. L. Dec 13 2017 In : Science Translational Medicine. 9, 420, aah4985

Research output: Contribution to journalArticle

Synaptic Transmission
Acids
Neuronal Plasticity
United States Food and Drug Administration
Adenosine Triphosphatases