Research Output 1979 2017

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2017

Bacterial subversion of cAMP signalling inhibits cathelicidin expression, which is required for innate resistance to Mycobacterium tuberculosis

Gupta, S., Winglee, K., Gallo, R. & Bishai, W. R. May 1 2017 In : Journal of Pathology. 242, 1, p. 52-61 10 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Peptides
Genes
Macrophages
Calcium

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

Manson, A. L. , Cohen, K. A. , Abeel, T. , Desjardins, C. A. , Armstrong, D. T. , Barry, C. E. , Brand, J. , Chapman, S. B. , Cho, S. N. , Gabrielian, A. , Gomez, J. , Jodals, A. M. , Joloba, M. , Jureen, P. , Lee, J. S. , Malinga, L. , Maiga, M. , Nordenberg, D. , Noroc, E. , Romancenco, E. & 27 others Salazar, A., Ssengooba, W., Velayati, A. A., Winglee, K., Zalutskaya, A., Via, L. E., Cassell, G. H., Dorman, S. E., Ellner, J., Farnia, P., Galagan, J. E., Rosenthal, A., Crudu, V., Homorodean, D., Hsueh, P. R., Narayanan, S., Pym, A. S., Skrahina, A., Swaminathan, S., van der Walt, M., Alland, D., Bishai, W. R., Cohen, T., Hoffner, S., Birren, B. W., Earl, A. M. & TBResist Global Genome Consortium Jan 16 2017 In : Nature Genetics.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Multiple Drug Resistance
Mycobacterium tuberculosis
Mutation
Molecular Pathology

Inhibition of innate immune cytosolic surveillance by an M.Tuberculosis phosphodiesterase

Dey, R. J., Dey, B., Zheng, Y., Cheung, L. S., Zhou, J., Sayre, D., Kumar, P., Guo, H., Lamichhane, G., Sintim, H. O. & Bishai, W. R. Feb 1 2017 In : Nature Chemical Biology. 13, 2, p. 210-217 8 p.

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Tuberculosis
Interferon Type I
Adenosine Monophosphate
Mycobacterium Infections

Mycobacterium tuberculosis induction of heme oxygenase-1 expression is dependent on oxidative stress and reflects treatment outcomes

Rockwood, N., Costa, D. L., Amaral, E. P., Du Bruyn, E., Kubler, A., Gil-Santana, L., Fukutani, K. F., Scanga, C. A., Flynn, J. A. L., Jackson, S. H., Wilkinson, K. A., Bishai, W. R., Sher, A., Wilkinson, R. J. & Andrade, B. B. May 12 2017 In : Frontiers in Immunology. 8, MAY, 542

Research output: Contribution to journalArticle

Heme Oxygenase-1
Mycobacterium tuberculosis
Oxidative Stress
HIV-1
Tuberculosis

Suppressor Cell-Depleting Immunotherapy with Denileukin Diftitox is an Effective Host-Directed Therapy for Tuberculosis

Gupta, S., Cheung, L., Pokkali, S., Winglee, K., Guo, H., Murphy, J. R. & Bishai, W. R. Jun 15 2017 In : Journal of Infectious Diseases. 215, 12, p. 1883-1887 5 p.

Research output: Contribution to journalArticle

Immunotherapy
Tuberculosis
Infection
Cell- and Tissue-Based Therapy
Spleen

Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections

Kozikowski, A. P., Onajole, O. K., Stec, J., Dupont, C., Viljoen, A., Richard, M., Chaira, T., Lun, S., Bishai, W., Raj, V. S., Ordway, D. & Kremer, L. Jul 13 2017 In : Journal of Medicinal Chemistry. 60, 13, p. 5876-5888 13 p.

Research output: Contribution to journalArticle

Mycolic Acids
Mycobacterium Infections
Cystic Fibrosis
Cord Factors
Trehalose
2016

Blockade of the Kv1.3 K+ Channel Enhances BCG Vaccine Efficacy by Expanding Central Memory T Lymphocytes

Singh, D. K., Dwivedi, V. P., Ranganathan, A., Bishai, W. R., Van Kaer, L. & Das, G. Nov 1 2016 In : Journal of Infectious Diseases. 214, 9, p. 1456-1464 9 p.

Research output: Contribution to journalArticle

BCG Vaccine
Tuberculosis
T-Lymphocytes
Clofazimine
Vaccines

Canonical pathways, networks and transcriptional factor regulation by clinical strains of Mycobacterium tuberculosis in pulmonary alveolar epithelial cells

Mvubu, N. E., Pillay, B., Gamieldien, J., Bishai, W. & Pillay, M. Mar 1 2016 In : Tuberculosis. 97, p. 73-85 13 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Mycobacterium tuberculosis
Epithelial Cells
Lung
Infection

Cathepsin K contributes to cavitation and collagen turnover in pulmonary tuberculosis

Kubler, A., Larsson, C., Luna, B., Andrade, B. B., Amaral, E. P., Urbanowski, M., Orandle, M., Bock, K., Ammerman, N. C., Cheung, L. S., Winglee, K., Halushka, M., Park, J. K., Sher, A., Friedland, J. S., Elkington, P. T. & Bishai, W. R. Feb 15 2016 In : Journal of Infectious Diseases. 213, 4, p. 618-627 10 p.

Research output: Contribution to journalArticle

Cathepsin K
Pulmonary Tuberculoses
Collagen
Matrix Metalloproteinases
Tuberculosis

Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries

Charles, M. K. , Lindegren, M. L. , Wester, C. W. , Blevins, M. , Sterling, T. R. , Dung, N. T. , Dusingize, J. C. , Avit-Edi, D. , Durier, N. , Castelnuovo, B. , Nakigozi, G. , Cortes, C. P. , Ballif, M. , Fenner, L. , Ajayi, S. , Anastos, K. , Bashi, J. , Bishai, W. , Boulle, A. , Braitstein, P. & 341 others Carriquiry, G., Carter, J. E., Cegielski, P., Chimbetete, C., Davies, M. A., Diero, L., Duda, S., Egger, M., Eboua, T. F., Gasser, A., Geng, E., Gnokori, J. C., Hardwicke, L., Hoffmann, C., Huebner, R., Kancheya, N., Kiertiburanakul, S., Kim, P., Lameck, D., Leroy, V., Lewden, C., Mandalakas, A., Maskew, M., McKaig, R., Mofenson, L., Mpoudi-Etame, M., Okwara, B., Phiri, S., Prasitsuebsai, W., Petit, A., Prozesky, H., Reid, S. E., Renner, L., Reubenson, G., Sohn, A., Vo, Q., Walker, D., Wehbe, F., Wejse, C., Williams, C., Wood, R., Wools-Kaloustian, K., Yao, Z., Yunihastuti, E., Zhang, F. J., Zhao, H. X., Han, N., Merati, T. P., Wirawan, D. N., Yuliana, F., Ditangco, R., Uy, E., Bantique, R., Phanuphak, P., Ruxrungtham, K., Avihingsanon, A., Khongphattanayothin, M., Kiertiburanakul, S., Sungkanuparph, S., Sanmeema, N., Chaiwarith, R., Sirisanthana, T., Kotarathititum, W., Pham, T. T., Cuong, D. D., Ha, H. L., Nguyen, V. K., Bui, V. H., Nguyen, T. D., Sohn, A. H., Petersen, B., Cooper, D. A., Law, M. G., Jiamsakul, A., Boettiger, D. C., Wati, D. K., Atmikasari, L. P. P., Malino, I. Y., Nallusamy, R., Chan, K. C., Lumbiganon, P., Kosalaraksa, P., Tharnprisan, P., Udomphanit, T., Chokephaibulkit, K., Lapphra, K., Phongsamart, W., Wittawatmongkol, O., Dung, K. T. K., Lam, N. V., An, P. N., Loan, N. T., Truong, H. K., Du, T. Q., Chau, N. H., Do, C. V., Ha, M. T., Sohn, A. H., Nipathakosol, P., Cooper, D. A., Law, M. G., Kariminia, A., Mutimura, E., Gitembagara, A., Tatwangire, J., Izabelle, I., Niyongabo, T., Twizere, C., Baramperanye, E., Edmonds, A., Yotebieng, M., Azinyue, I., Ayangma, L., Dickinson, D., Eley, B., Fritz, C., Garone, D., Giddy, J., Hoffmann, C., MacPhail, P., Moultrie, H., Ndirangu, J., Pestilli, S., Rabie, H., Stringer, J., Technau, K., Graber, C., Kaeser, F., Keiser, O., Cornell, M., Maxwell, N., Zannou, D. M., Ahouada, C., Akakpo, J., Ahomadegbé, C., Gougounon-Houéto, A., Azon-Kouanou, A., Houngbé, F., Sehonou, J., Koumakpaï, S., Alihonou, F., D'Almeida, M., Hodonou, I., Hounhoui, G., Sagbo, G., Tossa-Bagnan, L., Adjide, H., Drabo, J., Bognounou, R., Dienderé, A., Traore, E., Zoungrana, L., Zerbo, B., Sawadogo, A. B., Zoungrana, J., Héma, A., Soré, I., Bado, G., Tapsoba, A., Yé, D., Kouéta, F., Ouedraogo, S., Ouédraogo, R., Hiembo, W., Gansonré, M., Messou, E., Gnokoro, J. C., Koné, M., Kouakou, G. M., Bosse, C. A., Brou, K., Assi, A. I., Chenal, H., Hawerlander, D., Soppi, F., Minga, A., Abo, Y., Yoboue, J. M., Eholié, S. P., Amego, M. D. N., Andavi, V., Diallo, Z., Ello, F., Tanon, A. K., Koule, S. O., Anzan, K. C., Guehi, C., Aka, E. A., Issouf, K. L., Kouakou, J. C., N'Gbeche, M. S., Pety, T., Kouakou, K., Moh, M., Yao, V. A., Folquet, M. A., Dainguy, M. E., Kouakou, C., Méa-Assande, V. T., Oka-Berete, G., Zobo, N., Acquah, P., Kokora, M. B., Eboua, T. F., Timité-Konan, M., Ahoussou, L. D., Assouan, J. K., Sami, M. F., Kouadio, C., Goka, B., Welbeck, J., Sackey, A., Owiafe, S. N., Da Silva, Z. J., Paulo, J., Rodrigues, A., Da Silva, D., Medina, C., Oliviera-Souto, I., Østergaard, L., Laursen, A., Sodemann, M., Aaby, P., Fomsgaard, A., Erikstrup, C., Eugen-Olsen, J., Maïga, M. Y., Diakité, F. F., Kalle, A., Katile, D., Traore, H. A., Minta, D., Cissé, T., Dembelé, M., Doumbia, M., Fomba, M., Kaya, A. S., Traoré, A. M., Traoré, H., Toure, A. A., Dicko, F., Sylla, M., Berthé, A., Traoré, H. C., Koïta, A., Koné, N., N'Diaye, C., Coulibaly, S. T., Traoré, M., Traoré, N., Charurat, M., Alim, G., Dapiap, S., Otu, Igbinoba, F., Benson, O., Adebamowo, C., James, J., Obaseki, Osakede, P., Olasode, J., Seydi, M., Sow, P. S., Diop, B., Manga, N. M., Tine, J. M., Bassabi, C. C., Sy, H. S., Ba, A., Diagne, A., Dior, H., Faye, M., Gueye, R. D., Mbaye, A. D., Patassi, A., Kotosso, A., Kariyare, B. G., Gbadamassi, G., Komi, A., Mensah-Zukong, K. E., Pakpame, P., Lawson-Evi, A. K., Atakouma, Y., Takassi, E., Djeha, A., Ephoévigah, A., Djibril, S. E. H., Dabis, F., Bissagnene, E., Arrivé, E., Coffie, P., Ekouevi, D., Jaquet, A., Sasco, A. J., Amani, D., Azani, J. C., Balestre, E., Bessekon, S., Bohossou, F., Gilbert, C., Karcher, S., Gonsan, J. M., Le Carrou, J., Lenaud, S., Nchot, C., Malateste, K., Yao, A. R., Siloué, B., Clouet, G., Dosso, M., Doring, A., Kouakou, A., Rabourdin, E., Rivenc, J., Anglaret, X., Ba, B., Essanin, J. B., Ciaranello, A., Datté, S., Desmonde, S., Diby, J. S. E., Gottlieb, G. S., Horo, A. G., Kangah, S. N. Z., Malvy, D., Meless, D., Mounkaila-Harouna, A., Ndondoki, C., Shiboski, C., Tchounga, B., Thiébaut, R., Wandeler, G., McGowan, C., Cahn, P., Gotuzzo, E., Reyes, M. W., Grinsztejn, B., Pape, J. W., Padgett, D., Madero, J. S. & International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration Apr 1 2016 In : PLoS ONE. 11, 4, e0153243

Research output: Contribution to journalArticle

tuberculosis
Isoniazid
Infection Control
Tuberculosis
HIV

Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection

Stec, J., Onajole, O. K., Lun, S., Guo, H., Merenbloom, B., Vistoli, G., Bishai, W. R. & Kozikowski, A. P. Jul 14 2016 In : Journal of Medicinal Chemistry. 59, 13, p. 6232-6247 16 p.

Research output: Contribution to journalArticle

Tuberculosis
Infection
Trehalose
Rifampin
Aerosols

Mycobacterium tuberculosis strains exhibit differential and strain-specific molecular signatures in pulmonary epithelial cells

Mvubu, N. E., Pillay, B., Gamieldien, J., Bishai, W. & Pillay, M. Dec 1 2016 In : Developmental and Comparative Immunology. 65, p. 321-329 9 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Epithelial Cells
Lung
Genes
Gene Expression

Paradoxical Hypersusceptibility of Drug-resistant Mycobacterium tuberculosis to β-lactam Antibiotics

Cohen, K. A., El-Hay, T., Wyres, K. L., Weissbrod, O., Munsamy, V., Yanover, C., Aharonov, R., Shaham, O., Conway, T. C., Goldschmidt, Y., Bishai, W. R. & Pym, A. S. 2016 In : EBioMedicine. 9, p. 170-179 10 p.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Clavulanic Acid
Amoxicillin
beta-Lactams
Mycobacterium tuberculosis

REMap: Operon map of M. tuberculosis based on RNA sequence data

Pelly, S., Winglee, K., Xia, F., Stevens, R. L., Bishai, W. R. & Lamichhane, G. Jul 1 2016 In : Tuberculosis. 99, p. 70-80 11 p.

Research output: Contribution to journalArticle

Operon
Tuberculosis
RNA
Genes
RNA Sequence Analysis

Stool microbiome reveals diverse bacterial ureases as confounders of oral urea breath testing for Helicobacter pylori and Mycobacterium tuberculosis in Bamako, Mali

Maiga, M. , Cohen, K. , Baya, B. , Srikrishna, G. , Siddiqui, S. , Sanogo, M. , Somboro, A. M. , Diarra, B. , Diallo, M. H. , Mazumdar, V. , Yoder, C. , Orsega, S. , Belson, M. , Kassambara, H. , Goita, D. , Murphy, R. L. , Dao, S. , Polis, M. , Diallo, S. , Timmins, G. S. & 3 others Dodd, L., Earl, A. M. & Bishai, W. R. Aug 17 2016 In : Journal of Breath Research. 10, 3, 036012

Research output: Contribution to journalArticle

Mali
Urease
Microbiota
Mycobacterium tuberculosis
Helicobacter pylori

Targeting the cell wall of Mycobacterium tuberculosis: A molecular modeling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2

Silva, J. R. A., Bishai, W. R., Govender, T., Lamichhane, G., Maguire, G. E. M., Kruger, H. G., Lameira, J. & Alves, C. N. 2016 In : Journal of Biomolecular Structure and Dynamics. 34, 2, p. 304-317 14 p.

Research output: Contribution to journalArticle

Peptidyl Transferases
Imipenem
Mycobacterium tuberculosis
Cell Wall
Enzymes

The Non-Linear Child: Ontogeny, Isoniazid Concentration, and NAT2 Genotype Modulate Enzyme Reaction Kinetics and Metabolism

Rogers, Z., Hiruy, H., Pasipanodya, J. G., Mbowane, C., Adamson, J., Ngotho, L., Karim, F., Jeena, P., Bishai, W. & Gumbo, T. Sep 1 2016 In : EBioMedicine. 11, p. 118-126 9 p.

Research output: Contribution to journalArticle

Acetyltransferases
Isoniazid
Genotype
Enzymes
Benin

Whole Genome Sequencing of Mycobacterium africanum Strains from Mali Provides Insights into the Mechanisms of Geographic Restriction

Winglee, K., Manson McGuire, A., Maiga, M., Abeel, T., Shea, T., Desjardins, C. A., Diarra, B., Baya, B., Sanogo, M., Diallo, S., Earl, A. M. & Bishai, W. R. Jan 11 2016 In : PLoS Neglected Tropical Diseases. 10, 1, e0004332

Research output: Contribution to journalArticle

Mali
Mycobacterium
Genome
Mutation
Mycobacterium tuberculosis
2015

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

Dey, B., Dey, R. J., Cheung, L. S., Pokkali, S., Guo, H., Lee, J. H. & Bishai, W. R. Apr 1 2015 In : Nature Medicine. 21, 4, p. 401-408 8 p.

Research output: Contribution to journalArticle

Cyclic AMP
Tuberculosis
Mycobacterium tuberculosis
Interferon-beta
Interferon Type I

Biomarkers for Tuberculosis Based on Secreted, Species-Specific, Bacterial Small Molecules

Pan, S. J., Tapley, A., Adamson, J., Little, T., Urbanowski, M., Cohen, K., Pym, A., Almeida, D., Dorasamy, A., Layre, E., Young, D. C., Singh, R., Patel, V. B., Wallengren, K., Ndung'U, T., Wilson, D., Moody, D. B. & Bishai, W. 2015 In : Journal of Infectious Diseases. 212, 10, p. 1827-1834 8 p.

Research output: Contribution to journalArticle

Tuberculosis
Biological Markers
Serum
Sputum
Cerebrospinal Fluid
Verapamil
Tuberculosis

Computer-aided pulmonary image analysis in small animal models

Xu, Z., Bagci, U., Mansoor, A., Kramer-Marek, G., Luna, B., Kubler, A., Dey, B., Foster, B., Papadakis, G. Z., Camp, J. V., Jonsson, C. B., Bishai, W. R., Jain, S., Udupa, J. K. & Mollura, D. J. Jul 1 2015 In : Medical Physics. 42, 7, p. 3896-3910 15 p.

Research output: Contribution to journalArticle

Lung
Lung Diseases
Communicable Diseases
Total Lung Capacity
Ferrets

Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis

Maiga, M., Ahidjo, B. A., Maiga, M. C., Cheung, L., Pelly, S., Lun, S., Bougoudogo, F. & Bishai, W. R. Aug 1 2015 In : EBioMedicine. 2, 8, p. 868-873 6 p.

Research output: Contribution to journalArticle

Tuberculosis
Mycobacterium tuberculosis
Janus Kinases
Cefatrizine
Mycobacterium Infections

Erratum to "Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis" [EBioMedicine 2 (8), August 2015, 868-873] DOI: 10.1016/j.ebiom.2015.07.014

Maiga, M., Ahidjo, B. A., Maiga, M. C., Cheung, L., Pelly, S., Lun, S., Bougoudogo, F. & Bishai, W. R. Nov 1 2015 In : EBioMedicine. 2, 11, p. 1834 1 p.

Research output: Contribution to journalArticle

Tuberculosis

Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal

Cohen, K. A. , Abeel, T. , Manson McGuire, A. , Desjardins, C. A. , Munsamy, V. , Shea, T. P. , Walker, B. J. , Bantubani, N. , Almeida, D. V. , Alvarado, L. , Chapman, S. B. , Mvelase, N. R. , Duffy, E. Y. , Fitzgerald, M. G. , Govender, P. , Gujja, S. , Hamilton, S. , Howarth, C. , Larimer, J. D. , Maharaj, K. & 13 others Pearson, M. D., Priest, M. E., Zeng, Q., Padayatchi, N., Grosset, J., Young, S. K., Wortman, J., Mlisana, K. P., O'Donnell, M. R., Birren, B. W., Bishai, W. R., Pym, A. S. & Earl, A. M. Sep 1 2015 In : PLoS Medicine. 12, 9, e1001880

Research output: Contribution to journalArticle

Extensively Drug-Resistant Tuberculosis
Mycobacterium tuberculosis
Genome
Mutation
Disease Outbreaks

Evolution of extensively drug-resistant tuberculosis over four decades revealed by whole genome sequencing of Mycobacterium tuberculosis from KwaZulu-Natal, South Africa

Cohen, K. A. , Abeel, T. , McGuire, A. M. , Desjardins, C. A. , Munsamy, V. , Shea, T. P. , Walker, B. J. , Bantubani, N. , Almeida, D. V. , Alvarado, L. , Chapman, S. , Mvelase, N. R. , Duffy, E. Y. , Fitzgerald, M. G. , Govender, P. , Gujja, S. , Hamilton, S. , Howarth, C. , Larimer, J. D. , Maharaj, K. & 13 others Pearson, M. D., Priest, M. E., Zeng, Q., Padayatchi, N., Grosset, J., Young, S. K., Wortman, J., Mlisana, K. P., O'Donnell, M. R., Birren, B. W., Bishai, W. R., Pym, A. S. & Earl, A. M. 2015 In : International Journal of Mycobacteriology.

Research output: Contribution to journalArticle

Extensively Drug-Resistant Tuberculosis
South Africa
Mycobacterium tuberculosis
Drug Resistance
Disease Outbreaks

High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells

Sharma, P. K., Wong, E. B., Napier, R. J., Bishai, W. R., Ndung'u, T., Kasprowicz, V. O., Lewinsohn, D. A., Lewinsohn, D. M. & Gold, M. C. Jul 1 2015 In : Immunology. 145, 3, p. 443-453 11 p.

Research output: Contribution to journalArticle

Mucous Membrane
Bacteria
T-Lymphocytes
Tuberculosis
T-Cell Antigen Receptor

Immunogenicity without efficacy of an adenoviral tuberculosis vaccine in a stringent mouse model for immunotherapy during treatment

Alyahya, S. A., Nolan, S. T., Smith, C. M. R., Bishai, W. R., Sadoff, J. & Lamichhane, G. May 21 2015 In : PLoS One. 10, 5, e0127907

Research output: Contribution to journalArticle

immunotherapy
immunity
lungs
Tuberculosis Vaccines
Immunotherapy

In vivo biosynthesis of terpene nucleosides provides unique chemical markers of mycobacterium tuberculosis infection

Young, D. C., Layre, E., Pan, S. J., Tapley, A., Adamson, J., Seshadri, C., Wu, Z., Buter, J., Minnaard, A. J., Coscolla, M., Gagneux, S., Copin, R., Ernst, J. D., Bishai, W. R., Snider, B. B. & Moody, D. B. Apr 23 2015 In : Chemistry and Biology. 22, 4, p. 516-526 11 p.

Research output: Contribution to journalArticle

Mycobacterium Infections
Terpenes
Mycobacterium tuberculosis
Nucleosides
Tuberculosis

In vivo prediction of tuberculosis-associated cavity formation in rabbits

Luna, B., Kubler, A., Larsson, C., Foster, B., Bagci, U., Mollura, D. J., Jain, S. K. & Bishai, W. R. Feb 1 2015 In : Journal of Infectious Diseases. 211, 3, p. 481-485 5 p.

Research output: Contribution to journalArticle

Tuberculosis
Rabbits
Positron-Emission Tomography
Tomography
Fluorodeoxyglucose F18

Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV

Sullivan, Z. A., Wong, E. B., Ndung'u, T., Kasprowicz, V. O. & Bishai, W. R. Apr 1 2015 In : EBioMedicine. 2, 4, p. 334-340 7 p.

Research output: Contribution to journalArticle

Latent Tuberculosis
HIV
Cape Verde
Supravalvular Aortic Stenosis
Mortality

Mutation of Rv2887, a marR-Like gene, confers mycobacterium tuberculosis resistance to an imidazopyridine-based agent

Winglee, K., Lun, S., Pieroni, M., Kozikowski, A. & Bishai, W. Nov 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6873-6881 9 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Mutation
Genes
Proteins
Microbial Drug Resistance

Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation

Kübler, A. , Luna, B. , Larsson, C. , Ammerman, N. C. , Andrade, B. B. , Orandle, M. , Bock, K. W. , Xu, Z. , Bagci, U. , Molura, D. J. , Marshall, J. , Burns, J. , Winglee, K. , Ahidjo, B. A. , Cheung, L. S. , Klunk, M. , Jain, S. K. , Kumar, N. P. , Babu, S. , Sher, A. & 3 others Friedland, J. S., Elkington, P. T. G. & Bishai, W. R. Feb 1 2015 In : Journal of Pathology. 235, 3, p. 431-444 14 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Mycobacterium tuberculosis
Tuberculosis
Matrix Metalloproteinase 1
Lung

Mycobacterium tuberculosis TlyA protein negatively regulates T helper (Th) 1 and Th17 differentiation and promotes tuberculosis pathogenesis

Rahman, M. A., Sobia, P., Dwivedi, V. P., Bhawsar, A., Singh, D. K., Sharma, P., Moodley, P., Kaer, L. V., Bishai, W. R. & Das, G. Jun 5 2015 In : Journal of Biological Chemistry. 290, 23, p. 14407-14417 11 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Tuberculosis
Proteins
Bufo arenarum
Porphobilinogen Synthase

Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis

Maiga, M. C., Ahidjo, B. A., Maiga, M. & Bishai, W. R. Dec 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7888-7890 3 p.

Research output: Contribution to journalArticle

Phosphodiesterase 4 Inhibitors
Tuberculosis
Lung
Phosphodiesterase Inhibitors
Isoniazid

Tuberculosis in pediatric antiretroviral therapy programs in low- and middle-income countries: Diagnosis and screening practices

Ballif, M. , Renner, L. , Dusingize, J. C. , Leroy, V. , Ayaya, S. , Wools-Kaloustian, K. , Cortes, C. P. , McGowan, C. C. , Graber, C. , Mandalakas, A. M. , Mofenson, L. M. , Egger, M. , Wati, K. D. K. , Nallusamy, R. , Reubenson, G. , Davies, M. A. , Fenner, L. , Ajayi, S. , Anastos, K. , Bashi, J. & 73 others Bishai, W., Boulle, A., Braitstein, P., Carriquiry, G., Carter, J. E., Cegielski, P., Chimbetete, C., Cortes, C., Davies, M. A., Diero, L., Duda, S., Durier, N., Eboua, T. F., Gasser, A., Geng, E., Gnokori, J. C., Hoffmann, C., Kancheya, N., Kiertiburanakul, S., Kim, P., Lameck, D., Lewden, C., Lou Lindegren, M., Mandalakas, A., Maskew, M., Mofenson, L., Mpoudi-Etame, M., Okwara, B., Phiri, S., Prasitsuebsai, W., Petit, A., Prozesky, H., Reid, S. E., Sohn, A., Sterling, T., Vo, Q., Walker, D., Wejse, C., Wood, R., Yao, Z., Yunihastuti, E., Abrams, E., Ananworanich, J., Azondekon, A., Bacon, M., Behets, F., Cahn, P., Cesar, C., Ciaranello, A., Conrad, J., Dabis, F., Edmonds, A., Feinstein, L., Hardwicke, L., Hazra, R., Hoover, D., Huebner, R., Keiser, O., Lindegren, M. L., Magneres, M. C., McGowan, C., McKaig, R., Messerschmidt, L., Biribonwoha, H. N., Sharp, G., Vreeman, R., Wehbe, F., Wester, W., Williams, C., Worrell, C., Yiannoutsos, C., Zwickl, B. & for the International Epidemiologic Databases to Evaluate AIDS (IeDEA) 2015 In : Journal of the Pediatric Infectious Diseases Society. 4, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

Tuberculosis
Pediatrics
Sputum
Microscopy
Thorax
2014

Aerosol mycobacterium tuberculosis infection causes rapid loss of diversity in gut microbiota

Winglee, K., Eloe-Fadrosh, E., Gupta, S., Guo, H., Fraser, C. & Bishai, W. May 12 2014 In : PLoS One. 9, 5, e97048

Research output: Contribution to journalArticle

Mycobacterium Infections
Microbiota
Aerosols
Mycobacterium tuberculosis
infection

Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of mycobacterium tuberculosis

Stec, J., Vilchèze, C., Lun, S., Perryman, A. L., Wang, X., Freundlich, J. S., Bishai, W., Jacobs, W. R. & Kozikowski, A. P. Nov 1 2014 In : ChemMedChem. 9, 11, p. 2528-2537 10 p.

Research output: Contribution to journalArticle

Triclosan
Acyl Carrier Protein
Mycobacterium tuberculosis
Oxidoreductases
Cross Circulation

Crosstalk between mycobacterium tuberculosis and the host cell

Dey, B. & Bishai, W. R. Dec 1 2014 In : Seminars in Immunology. 26, 6, p. 486-496 11 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Cyclic Nucleotides
Virulence Factors
Bacterial Infections
Bacillus

Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries

Ballif, M. , Nhandu, V. , Wood, R. , Dusingize, J. C. , Carter, E. J. , Cortes, C. P. , McGowan, C. C. , Diero, L. , Graber, C. , Renner, L. , Hawerlander, D. , Kiertiburanakul, S. , Du, Q. T. , Sterling, T. R. , Egger, M. , Fenner, L. , Ajayi, S. , Anastos, K. , Ballif, M. , Bashi, J. & 381 others Bishai, W., Boulle, A., Braitstein, P., Carriquiry, G., Carter, J. E., Cegielski, P., Chimbetete, C., Conrad, J., Cortes, C. P., Davies, M. A., Diero, L., Duda, S., Durier, N., Dusingize, J. C., Egger, M., Eboua, T. F., Fenner, L., Gasser, A., Geng, E., Hardwicke, L., Hoffmann, C., Huebner, R., Kancheya, N., Kiertiburanakul, S., Kim, P., Lameck, D., Leroy, V., Lewden, C., Lindegren, M. L., Mandalakas, A., Maskew, M., McKaig, R., Mofenson, L., Mpoudi-Etame, M., Okwara, B., Phiri, S., Prasitsuebsai, W., Petit, A., Prozesky, H., Reid, S. E., Renner, L., Reubenson, G., Sohn, A., Sterling, T. R., Vo, Q., Walker, D., Wehbe, F., Wejse, C., Wester, W., Williams, C., Wood, R., Wools-Kaloustian, K., Yao, Z., Yunihastuti, E., Zhang, F. J., Zhao, H. X., Han, N., Merati, T. P., Wirawan, D. N., Yuliana, F., Ditangco, R., Uy, E., Bantique, R., Phanuphak, P., Ruxrungtham, K., Avihingsanon, A., Mengthaisong, T., Kiertiburanakul, S., Sungkanuparph, S., Sanmeema, N., Chaiwarith, R., Sirisanthana, T., Kotarathititum, W., Pham, T. T., Cuong, D. D., Ha, H. L., Nguyen, V. K., Bui, V. H., Cao, T. T., Sohn, A. H., Durier, N., Petersen, B., Cooper, D. A., Law, M. G., Jiamsakul, A., Boettiger, D. C., Wati, D. K., Atmikasari, L. P. P., Malino, I. Y., Nallusamy, R., Chan, K. C., Lumbiganon, P., Kosalaraksa, P., Tharnprisan, P., Udomphanit, T., Chokephaibulkit, K., Lapphra, K., Phongsamart, W., Wittawatmongkol, O., Dung, K. T. K., Lam, N. V., An, P. N., Loan, N. T., Truong, H. K., Du, T. Q., Chau, N. H., Do, C. V., Ha, M. T., Sohn, A. H., Durier, N., Nipathakosol, P., Cooper, D. A., Law, M. G., Kariminia, A., Dusingize, J. C., Mutimura, E., Gitembagara, A., Anastos, K., Tatwangire, J., Izabelle, I., Niyongabo, T., Twizere, C., Baramperanye, E., Edmonds, A., Yotebieng, M., Azinyue, I., Ayangma, L., Yiannoutsos, C., Ayaya, S., Bukusi, E. A., Lewis-Kulzer, J., Somi, G., Lyamuya, R., Ngonyani, K., Ssali, J., Ssemuwemba, H., Mwebesa, B. B., Kambugu, A., Hermans, S., Nalugoda, F., Jjingo, K., Chimbetete, C., Dickinsonn, D., Eley, B., Fritz, C., Garone, D., Giddy, J., Hoffmann, C., MacPhail, P., Moultrie, H., Ndirangu, J., Pestilli, S., Phiri, S., Prozesky, H., Rabie, H., Stringer, J., Technau, K., Wood, R., Egger, M., Graber, C., Kaeser, F., Keiser, O., Boulle, A., Cornell, M., Davies, M. A., Maxwell, N., Zannou, D. M., Ahouada, C., Akakpo, J., Ahomadegbé, C., Bashi, J., Gougounon-Houéto, A., Azon-Kouanou, A., Houngbé, F., Sehonou, J., Koumakpaï, S., Alihonou, F., D'Almeida, M., Hodonou, I., Hounhoui, G., Sagbo, G., Tossa-Bagnan, L., Adjide, H., Drabo, J., Bognounou, R., Dienderé, A., Traore, E., Zoungrana, L., Zerbo, B., Sawadogo, A. B., Zoungrana, J., Héma, A., Soré, I., Bado, G., Tapsoba, A., Yé, D., Kouéta, F., Ouedraogo, S., Ouédraogo, R., Hiembo, W., Gansonré, M., Messou, E., Gnokoro, J. C., Koné, M., Kouakou, G. M., Bosse, C. A., Brou, K., Assi, A. I., Chenal, H., Hawerlander, D., Soppi, F., Minga, A., Abo, Y., Yoboue, J. M., Eholié, S. P., Amego, M. D. N., Andavi, V., Diallo, Z., Ello, F., Tanon, A. K., Koule, S. O., Anzan, K. C., Guehi, C., Aka, E. A., Issouf, K. L., Kouakou, J. C., N'Gbeche, M. S., Pety, T., Avit-Edi, D., Kouakou, K., Moh, M., Yao, V. A., Folquet, M. A., Dainguy, M. E., Kouakou, C., Méa-Assande, V. T., Oka-Berete, G., Zobo, N., Acquah, P., Kokora, M. B., Eboua, T. F., Timité-Konan, M., Diecket Ahoussou, L., Assouan, J. K., Sami, M. F., Kouadio, S., Renner, L., Goka, B., Welbeck, J., Sackey, A., Owiafe, S. N., Wejse, C., Da Silva, Z. J., Paulo, J., Rodrigues, A., Da Silva, D., Medina, C., Oliviera-Souto, I., Østergaard, L., Laursen, A., Sodemann, M., Aaby, P., Fomsgaard, A., Erikstrup, C., Eugen-Olsen, J., Maïga, M. Y., Diakité, F. F., Kalle, A., Katile, D., Traore, H. A., Minta, D., Cissé, T., Dembelé, M., Doumbia, M., Fomba, M., Kaya, A. S., Traoré, A. M., Traoré, H., Toure, A. A., Dicko, F., Sylla, M., Berthé, A., Traoré, H. C., Koïta, A., Koné, N., N'Diaye, C., Coulibaly, S. T., Traoré, M., Traoré, N., Charurat, M., Ajayi, S., Alim, G., Dapiap, S., Igbinoba, F., Benson, O., Adebamowo, C., James, J., Obaseki, . N. V., Osakede, P., Olasode, J., Seydi, M., Sow, P. S., Diop, B., Manga, N. M., Tine, J. M., Bassabi, C. C., Sy, H. S., Ba, A., Diagne, A., Dior, H., Faye, M., Gueye, R. D., Mbaye, A. D., Patassi, A., Kotosso, A., Kariyare, B. G., Gbadamassi, G., Komi, A., Mensah-Zukong, K. E., Pakpame, P., Koko Lawson-Evi, A., Atakouma, Y., Takassi, E., Djeha, A., Ephoévi-gah, A., El-Hadj Djibril, S., Dabis, F., Bissagnene, E., Arrivé, E., Coffie, P., Ekouevi, D., Jaquet, A., Leroy, V., Lewden, C., Sasco, A. J., Amani, D., Azani, J. C., Balestre, E., Bessekon, S., Bohossou, F., Gilbert, C., Karcher, S., Gonsan, J. M., Le Carrou, J., Lenaud, S., Nchot, C., Malateste, K., Yao, A. R., Siloué, B., Clouet, G., Dosso, M., Doring, A., Kouakou, A., Rabourdin, E., Rivenc, J., Anglaret, X., Ba, B., Essanin, J. B., Ciaranello, A., Datté, S., Desmonde, S., Elvis Diby, J. S., Gottlieb, G. S., Horo, A. G., Kangah, S. N., Malvy, D., Meless, D., Mounkaila-Harouna, A., Ndondoki, C., Shiboski, C., Tchounga, B., Thiébaut, R., Wandeler, G., McGowan, C., Cahn, P., Gotuzzo, E., Wolff, M., Grinsztejn, B., Pape, J., Padgett, D. & Madero, J. S. Nov 1 2014 In : International Journal of Tuberculosis and Lung Disease. 18, 11, p. 1327-1336 10 p.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
HIV
Tuberculosis
Directly Observed Therapy
Drug Resistance

Diagnostic point-of-care tests in resource-limited settings

Drain, P. K., Hyle, E. P., Noubary, F., Freedberg, K. A., Wilson, D., Bishai, W. R., Rodriguez, W. & Bassett, I. V. Mar 2014 In : Lancet Infectious Diseases. 14, 3, p. 239-249 11 p.

Research output: Contribution to journalArticle

Routine Diagnostic Tests
Point-of-Care Systems
Costs and Cost Analysis
Needs Assessment
Health

Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis

Gupta, S., Cohen, K. A., Winglee, K., Maiga, M., Diarra, B. & Bishai, W. R. Jan 2014 In : Antimicrobial Agents and Chemotherapy. 58, 1, p. 574-576 3 p.

Research output: Contribution to journalArticle

Verapamil
Mycobacterium tuberculosis
Clofazimine

Expression of a subset of heat stress induced genes of mycobacterium tuberculosis is regulated by 3′,5′-cyclic AMP

Choudhary, E., Bishai, W. & Agarwal, N. Feb 28 2014 In : PLoS One. 9, 2, e89759

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Cyclic AMP
Hot Temperature
Genes
cyclic AMP

In vitro and in vivo studies of a rapid and selective breath test for tuberculosis based upon mycobacterial CO dehydrogenase

Maiga, M., Choi, S. W., Atudorei, V., Maiga, M. C., Sharp, Z. D., Bishai, W. R. & Timmins, G. S. Apr 15 2014 In : mBio. 5, 2, e00990-14

Research output: Contribution to journalArticle

Breath Tests
Oxidoreductases
Tuberculosis
In Vitro Techniques
Phenotype

Molecular basis of drug resistance in Mycobacterium tuberculosis

Cohen, K. A., Bishai, W. R. & Pym, A. S. 2014 In : Microbiology spectrum. 2, 3

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Drug Resistance
Tuberculosis
Anti-Bacterial Agents
drug resistance
Peptidyl Transferases
beta-Lactam Resistance
Cell Size
Mycobacterium tuberculosis
Virulence

Novel adjunctive therapies for the treatment of tuberculosis

Ordonez, A. A., Maiga, M., Gupta, S., Weinstein, E. A., Bishai, W. R. & Jain, S. K. 2014 In : Current Molecular Medicine. 14, 3, p. 385-395 11 p.

Research output: Contribution to journalArticle

Supravalvular Aortic Stenosis
Tuberculosis
Database Management Systems
Blood Flow Velocity
Pathogens

Rapid in vivo detection of isoniazid-sensitive Mycobacterium tuberculosis by breath test

Choi, S. W., Maiga, M., Maiga, M. C., Atudorei, V., Sharp, Z. D., Bishai, W. R. & Timmins, G. S. 2014 In : Nature Communications. 5, 4989

Research output: Contribution to journalArticle

Breath Tests
Isoniazid
Mycobacterium tuberculosis
Tuberculosis
tuberculosis

Segmentation of PET images for computer-aided functional quantification of tuberculosis in small animal models

Foster, B., Bagci, U., Xu, Z., Dey, B., Luna, B., Bishai, W., Jain, S. & Mollura, D. J. Mar 2014 In : IEEE Transactions on Biomedical Engineering. 61, 3, p. 711-724 14 p., 6655914

Research output: Contribution to journalArticle

Positron emission tomography
Image segmentation
Pathology
Animals

Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis

Bhattacharya, D., Dwivedi, V. P., Maiga, M., Maiga, M., Van Kaer, L., Bishai, W. R. & Das, G. Jun 6 2014 In : Journal of Biological Chemistry. 289, 23, p. 16508-16515 8 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Immunotherapy
Infection
Tuberculosis
Inborn Errors Amino Acid Metabolism