Research Output 1979 2018

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2018

Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis

Zhang, W., Lun, S., Wang, S. H., Jiang, X. W., Yang, F., Tang, J., Manson, A. L., Earl, A. M., Gunosewoyo, H., Bishai, W. R. & Yu, L. F. Feb 8 2018 In : Journal of Medicinal Chemistry. 61, 3, p. 791-803 13 p.

Research output: Contribution to journalArticle

Mycolic Acids
Antitubercular Agents
Polyketide Synthases
Mycobacterium tuberculosis
Benzofurans

Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data

Rifat, D., Prideaux, B., Savic, R. M., Urbanowski, M. E., Parsons, T. L., Luna, B., Marzinke, M. A., Ordonez, A. A., DeMarco, V. P., Jain, S. K., Dartois, V., Bishai, W. R. & Dooley, K. E. Apr 4 2018 In : Science translational medicine. 10, 435, eaai7786

Research output: Contribution to journalArticle

rifapentine
Rifampin
Tuberculosis
Pharmacokinetics
Clinical Trials
2017

Bacterial subversion of cAMP signalling inhibits cathelicidin expression, which is required for innate resistance to Mycobacterium tuberculosis

Gupta, S., Winglee, K., Gallo, R. & Bishai, W. R. May 1 2017 In : Journal of Pathology. 242, 1, p. 52-61 10 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Genes
Macrophages
Cathelicidins
Calcium

Ex vivo culture of tumor cells from N-methyl-N-nitrosourea-induced bladder cancer in rats: Development of organoids and an immortalized cell line

Yoshida, T., Kates, M., Sopko, N. A., Liu, X., Singh, A. K., Bishai, W. R., Joice, G., McConkey, D. J. & Bivalacqua, T. J. Jan 1 2017 (Accepted/In press) In : Urologic Oncology: Seminars and Original Investigations.

Research output: Contribution to journalArticle

Organoids
Methylnitrosourea
Urinary Bladder Neoplasms
Cell Culture Techniques
Cell Line

Genetics of human susceptibility to active and latent tuberculosis: Present knowledge and future perspectives

Abel, L., Fellay, J., Haas, D. W., Schurr, E., Srikrishna, G., Urbanowski, M., Chaturvedi, N., Srinivasan, S., Johnson, D. H. & Bishai, W. R. 2017 (Accepted/In press) In : The Lancet Infectious Diseases.

Research output: Contribution to journalArticle

Latent Tuberculosis
Genetic Predisposition to Disease
Tuberculosis
Annual Reports
Inborn Genetic Diseases

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

TBResist Global Genome Consortium, Ellner, J. & Farnia, P. Jan 16 2017 (Accepted/In press) In : Nature Genetics.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Multiple Drug Resistance
Mycobacterium tuberculosis
Molecular Pathology
Rifampin

Inhibition of innate immune cytosolic surveillance by an M.Tuberculosis phosphodiesterase

Dey, R. J., Dey, B., Zheng, Y., Cheung, L. S., Zhou, J., Sayre, D., Kumar, P., Guo, H., Lamichhane, G., Sintim, H. O. & Bishai, W. R. Feb 1 2017 In : Nature Chemical Biology. 13, 2, p. 210-217 8 p.

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Interferon Type I
Tuberculosis
Mycobacterium Infections
Phosphodiesterase Inhibitors

Mycobacterium tuberculosis induction of heme oxygenase-1 expression is dependent on oxidative stress and reflects treatment outcomes

Rockwood, N., Costa, D. L., Amaral, E. P., Du Bruyn, E., Kubler, A., Gil-Santana, L., Fukutani, K. F., Scanga, C. A., Flynn, J. A. L., Jackson, S. H., Wilkinson, K. A., Bishai, W. R., Sher, A., Wilkinson, R. J. & Andrade, B. B. May 12 2017 In : Frontiers in Immunology. 8, MAY, 542

Research output: Contribution to journalArticle

Heme Oxygenase-1
Mycobacterium tuberculosis
Oxidative Stress
HIV-1
Tuberculosis

Partners in Crime: Phenolic Glycolipids and Macrophages

Singh, A. K. & Bishai, W. R. 2017 (Accepted/In press) In : Trends in Molecular Medicine.

Research output: Contribution to journalArticle

Glycolipids
Crime
Macrophages
Mycobacterium marinum
Immune Evasion

Suppressor Cell-Depleting Immunotherapy with Denileukin Diftitox is an Effective Host-Directed Therapy for Tuberculosis

Gupta, S., Cheung, L., Pokkali, S., Winglee, K., Guo, H., Murphy, J. R. & Bishai, W. R. Jun 15 2017 In : Journal of Infectious Diseases. 215, 12, p. 1883-1887 5 p.

Research output: Contribution to journalArticle

Immunotherapy
Tuberculosis
Therapeutics
Cell- and Tissue-Based Therapy
Infection

Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections

Kozikowski, A. P., Onajole, O. K., Stec, J., Dupont, C., Viljoen, A., Richard, M., Chaira, T., Lun, S., Bishai, W., Raj, V. S., Ordway, D. & Kremer, L. Jul 13 2017 In : Journal of Medicinal Chemistry. 60, 13, p. 5876-5888 13 p.

Research output: Contribution to journalArticle

Mycolic Acids
Mycobacterium Infections
Cystic Fibrosis
Cord Factors
Mycobacterium
2016

Blockade of the Kv1.3 K+ Channel Enhances BCG Vaccine Efficacy by Expanding Central Memory T Lymphocytes

Singh, D. K., Dwivedi, V. P., Ranganathan, A., Bishai, W. R., Van Kaer, L. & Das, G. Nov 1 2016 In : Journal of Infectious Diseases. 214, 9, p. 1456-1464 9 p.

Research output: Contribution to journalArticle

BCG Vaccine
Clofazimine
Tuberculosis
T-Lymphocytes
Vaccines

Canonical pathways, networks and transcriptional factor regulation by clinical strains of Mycobacterium tuberculosis in pulmonary alveolar epithelial cells

Mvubu, N. E., Pillay, B., Gamieldien, J., Bishai, W. & Pillay, M. Mar 1 2016 In : Tuberculosis. 97, p. 73-85 13 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Gene Regulatory Networks
Mycobacterium tuberculosis
Epithelial Cells
Lung

Cathepsin K contributes to cavitation and collagen turnover in pulmonary tuberculosis

Kubler, A., Larsson, C., Luna, B., Andrade, B. B., Amaral, E. P., Urbanowski, M., Orandle, M., Bock, K., Ammerman, N. C., Cheung, L. S., Winglee, K., Halushka, M., Park, J. K., Sher, A., Friedland, J. S., Elkington, P. T. & Bishai, W. R. Feb 15 2016 In : Journal of Infectious Diseases. 213, 4, p. 618-627 10 p.

Research output: Contribution to journalArticle

Cathepsin K
Pulmonary Tuberculosis
Matrix Metalloproteinases
Collagen
Tuberculosis

Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries

Charles, M. K. , Lindegren, M. L. , Wester, C. W. , Blevins, M. , Sterling, T. R. , Dung, N. T. , Dusingize, J. C. , Avit-Edi, D. , Durier, N. , Castelnuovo, B. , Nakigozi, G. , Cortes, C. P. , Ballif, M. , Fenner, L. , Ajayi, S. , Anastos, K. , Bashi, J. , Bishai, W. , Boulle, A. , Braitstein, P. & 31 others Carriquiry, G., Carter, J. E., Cegielski, P., Chimbetete, C., Davies, M. A., Diero, L., Duda, S., Egger, M., Eboua, T. F., Gasser, A., Geng, E., Gnokori, J. C., Hardwicke, L., Hoffmann, C., Huebner, R., Kancheya, N., Kiertiburanakul, S., Kim, P., Lameck, D., Leroy, V., Lewden, C., Mandalakas, A., Maskew, M., McKaig, R., Mofenson, L., Mpoudi-Etame, M., Okwara, B., Phiri, S., Prasitsuebsai, W., Petit, A. & International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration Apr 1 2016 In : PLoS ONE. 11, 4, e0153243

Research output: Contribution to journalArticle

isoniazid
Isoniazid
Infection Control
tuberculosis
disease control

Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection

Stec, J., Onajole, O. K., Lun, S., Guo, H., Merenbloom, B., Vistoli, G., Bishai, W. R. & Kozikowski, A. P. Jul 14 2016 In : Journal of Medicinal Chemistry. 59, 13, p. 6232-6247 16 p.

Research output: Contribution to journalArticle

Tuberculosis
Animal Models
Rifampin
Infection
Aerosols

Mycobacterium tuberculosis strains exhibit differential and strain-specific molecular signatures in pulmonary epithelial cells

Mvubu, N. E., Pillay, B., Gamieldien, J., Bishai, W. & Pillay, M. Dec 1 2016 In : Developmental and Comparative Immunology. 65, p. 321-329 9 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Epithelial Cells
Lung
Genes
Gene Expression

Paradoxical Hypersusceptibility of Drug-resistant Mycobacterium tuberculosis to β-lactam Antibiotics

Cohen, K. A., El-Hay, T., Wyres, K. L., Weissbrod, O., Munsamy, V., Yanover, C., Aharonov, R., Shaham, O., Conway, T. C., Goldschmidt, Y., Bishai, W. R. & Pym, A. S. 2016 In : EBioMedicine. 9, p. 170-179 10 p.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Clavulanic Acid
Amoxicillin
beta-Lactams
Mycobacterium tuberculosis

REMap: Operon map of M. tuberculosis based on RNA sequence data

Pelly, S., Winglee, K., Xia, F., Stevens, R. L., Bishai, W. R. & Lamichhane, G. Jul 1 2016 In : Tuberculosis. 99, p. 70-80 11 p.

Research output: Contribution to journalArticle

Operon
Tuberculosis
RNA
RNA Sequence Analysis
Intergenic DNA

Stool microbiome reveals diverse bacterial ureases as confounders of oral urea breath testing for Helicobacter pylori and Mycobacterium tuberculosis in Bamako, Mali

Maiga, M. , Cohen, K. , Baya, B. , Srikrishna, G. , Siddiqui, S. , Sanogo, M. , Somboro, A. M. , Diarra, B. , Diallo, M. H. , Mazumdar, V. , Yoder, C. , Orsega, S. , Belson, M. , Kassambara, H. , Goita, D. , Murphy, R. L. , Dao, S. , Polis, M. , Diallo, S. , Timmins, G. S. & 3 others Dodd, L., Earl, A. M. & Bishai, W. R. Aug 17 2016 In : Journal of Breath Research. 10, 3, 036012

Research output: Contribution to journalArticle

Mali
Urease
Microbiota
Mycobacterium tuberculosis
Helicobacter pylori

Targeting the cell wall of Mycobacterium tuberculosis: A molecular modeling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2

Silva, J. R. A., Bishai, W. R., Govender, T., Lamichhane, G., Maguire, G. E. M., Kruger, H. G., Lameira, J. & Alves, C. N. 2016 In : Journal of Biomolecular Structure and Dynamics. 34, 2, p. 304-317 14 p.

Research output: Contribution to journalArticle

meropenem
Peptidyl Transferases
Imipenem
Mycobacterium tuberculosis
Cell Wall

The Non-Linear Child: Ontogeny, Isoniazid Concentration, and NAT2 Genotype Modulate Enzyme Reaction Kinetics and Metabolism

Rogers, Z., Hiruy, H., Pasipanodya, J. G., Mbowane, C., Adamson, J., Ngotho, L., Karim, F., Jeena, P., Bishai, W. & Gumbo, T. Sep 1 2016 In : EBioMedicine. 11, p. 118-126 9 p.

Research output: Contribution to journalArticle

Acetyltransferases
Isoniazid
Metabolism
Reaction kinetics
Genotype

Whole Genome Sequencing of Mycobacterium africanum Strains from Mali Provides Insights into the Mechanisms of Geographic Restriction

Winglee, K., Manson McGuire, A., Maiga, M., Abeel, T., Shea, T., Desjardins, C. A., Diarra, B., Baya, B., Sanogo, M., Diallo, S., Earl, A. M. & Bishai, W. R. Jan 11 2016 In : PLoS Neglected Tropical Diseases. 10, 1, e0004332

Research output: Contribution to journalArticle

Mali
Mycobacterium
Mycobacterium tuberculosis
Genome
Mutation
2015

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

Dey, B., Dey, R. J., Cheung, L. S., Pokkali, S., Guo, H., Lee, J. H. & Bishai, W. R. Apr 1 2015 In : Nature Medicine. 21, 4, p. 401-408 8 p.

Research output: Contribution to journalArticle

Adenosine Monophosphate
Cyclic AMP
Tuberculosis
Mycobacterium tuberculosis
Interferon-beta

Biomarkers for Tuberculosis Based on Secreted, Species-Specific, Bacterial Small Molecules

Pan, S. J., Tapley, A., Adamson, J., Little, T., Urbanowski, M., Cohen, K., Pym, A., Almeida, D., Dorasamy, A., Layre, E., Young, D. C., Singh, R., Patel, V. B., Wallengren, K., Ndung'U, T., Wilson, D., Moody, D. B. & Bishai, W. 2015 In : Journal of Infectious Diseases. 212, 10, p. 1827-1834 8 p.

Research output: Contribution to journalArticle

Tuberculosis
Biomarkers
Sputum
Cerebrospinal Fluid
Lymph Nodes

Computer-aided pulmonary image analysis in small animal models

Xu, Z., Bagci, U., Mansoor, A., Kramer-Marek, G., Luna, B., Kubler, A., Dey, B., Foster, B., Papadakis, G. Z., Camp, J. V., Jonsson, C. B., Bishai, W. R., Jain, S., Udupa, J. K. & Mollura, D. J. Jul 1 2015 In : Medical Physics. 42, 7, p. 3896-3910 15 p.

Research output: Contribution to journalArticle

Animal Models
Lung
Lung Diseases
Communicable Diseases
Total Lung Capacity

Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis

Maiga, M., Ahidjo, B. A., Maiga, M. C., Cheung, L., Pelly, S., Lun, S., Bougoudogo, F. & Bishai, W. R. Aug 1 2015 In : EBioMedicine. 2, 8, p. 868-873 6 p.

Research output: Contribution to journalArticle

Tuberculosis
Mycobacterium tuberculosis
Janus Kinases
Therapeutics
Mycobacterium Infections

Erratum to "Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis" [EBioMedicine 2 (8), August 2015, 868-873] DOI: 10.1016/j.ebiom.2015.07.014

Maiga, M., Ahidjo, B. A., Maiga, M. C., Cheung, L., Pelly, S., Lun, S., Bougoudogo, F. & Bishai, W. R. Nov 1 2015 In : EBioMedicine. 2, 11, p. 1834 1 p.

Research output: Contribution to journalArticle

Tuberculosis
Therapeutics
tofacitinib

Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal

Cohen, K. A. , Abeel, T. , Manson McGuire, A. , Desjardins, C. A. , Munsamy, V. , Shea, T. P. , Walker, B. J. , Bantubani, N. , Almeida, D. V. , Alvarado, L. , Chapman, S. B. , Mvelase, N. R. , Duffy, E. Y. , Fitzgerald, M. G. , Govender, P. , Gujja, S. , Hamilton, S. , Howarth, C. , Larimer, J. D. , Maharaj, K. & 13 others Pearson, M. D., Priest, M. E., Zeng, Q., Padayatchi, N., Grosset, J., Young, S. K., Wortman, J., Mlisana, K. P., O'Donnell, M. R., Birren, B. W., Bishai, W. R., Pym, A. S. & Earl, A. M. Sep 1 2015 In : PLoS Medicine. 12, 9, e1001880

Research output: Contribution to journalArticle

Extensively Drug-Resistant Tuberculosis
Mycobacterium tuberculosis
Rifampin
Disease Outbreaks
Genome

Evolution of extensively drug-resistant tuberculosis over four decades revealed by whole genome sequencing of Mycobacterium tuberculosis from KwaZulu-Natal, South Africa

Cohen, K. A. , Abeel, T. , McGuire, A. M. , Desjardins, C. A. , Munsamy, V. , Shea, T. P. , Walker, B. J. , Bantubani, N. , Almeida, D. V. , Alvarado, L. , Chapman, S. , Mvelase, N. R. , Duffy, E. Y. , Fitzgerald, M. G. , Govender, P. , Gujja, S. , Hamilton, S. , Howarth, C. , Larimer, J. D. , Maharaj, K. & 13 others Pearson, M. D., Priest, M. E., Zeng, Q., Padayatchi, N., Grosset, J., Young, S. K., Wortman, J., Mlisana, K. P., O'Donnell, M. R., Birren, B. W., Bishai, W. R., Pym, A. S. & Earl, A. M. 2015 (Accepted/In press) In : International Journal of Mycobacteriology.

Research output: Contribution to journalArticle

Extensively Drug-Resistant Tuberculosis
South Africa
Mycobacterium tuberculosis
Drug Resistance
Disease Outbreaks

High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells

Sharma, P. K., Wong, E. B., Napier, R. J., Bishai, W. R., Ndung'u, T., Kasprowicz, V. O., Lewinsohn, D. A., Lewinsohn, D. M. & Gold, M. C. Jul 1 2015 In : Immunology. 145, 3, p. 443-453 11 p.

Research output: Contribution to journalArticle

Mucous Membrane
Bacteria
T-Lymphocytes
Tuberculosis
T-Cell Antigen Receptor

Immunogenicity without efficacy of an adenoviral tuberculosis vaccine in a stringent mouse model for immunotherapy during treatment

Alyahya, S. A., Nolan, S. T., Smith, C. M. R., Bishai, W. R., Sadoff, J. & Lamichhane, G. May 21 2015 In : PLoS One. 10, 5, e0127907

Research output: Contribution to journalArticle

Tuberculosis Vaccines
immunotherapy
tuberculosis
Immunotherapy
Immunity

In vivo biosynthesis of terpene nucleosides provides unique chemical markers of mycobacterium tuberculosis infection

Young, D. C., Layre, E., Pan, S. J., Tapley, A., Adamson, J., Seshadri, C., Wu, Z., Buter, J., Minnaard, A. J., Coscolla, M., Gagneux, S., Copin, R., Ernst, J. D., Bishai, W. R., Snider, B. B. & Moody, D. B. Apr 23 2015 In : Chemistry and Biology. 22, 4, p. 516-526 11 p.

Research output: Contribution to journalArticle

Mycobacterium Infections
Biosynthesis
Terpenes
Mycobacterium tuberculosis
Nucleosides

In vivo prediction of tuberculosis-associated cavity formation in rabbits

Luna, B., Kubler, A., Larsson, C., Foster, B., Bagci, U., Mollura, D. J., Jain, S. K. & Bishai, W. R. Feb 1 2015 In : Journal of Infectious Diseases. 211, 3, p. 481-485 5 p.

Research output: Contribution to journalArticle

Tuberculosis
Rabbits
Sensitivity and Specificity
Fluorodeoxyglucose F18
Treatment Failure

Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV

Sullivan, Z. A., Wong, E. B., Ndung'u, T., Kasprowicz, V. O. & Bishai, W. R. Apr 1 2015 In : EBioMedicine. 2, 4, p. 334-340 7 p.

Research output: Contribution to journalArticle

Latent Tuberculosis
Chemical activation
HIV
T-cells
Coinfection

Mutation of Rv2887, a marR-Like gene, confers mycobacterium tuberculosis resistance to an imidazopyridine-based agent

Winglee, K., Lun, S., Pieroni, M., Kozikowski, A. & Bishai, W. Nov 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6873-6881 9 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Mutation
Microbial Drug Resistance
Genes
Pharmaceutical Preparations

Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation

Kübler, A. , Luna, B. , Larsson, C. , Ammerman, N. C. , Andrade, B. B. , Orandle, M. , Bock, K. W. , Xu, Z. , Bagci, U. , Molura, D. J. , Marshall, J. , Burns, J. , Winglee, K. , Ahidjo, B. A. , Cheung, L. S. , Klunk, M. , Jain, S. K. , Kumar, N. P. , Babu, S. , Sher, A. & 3 others Friedland, J. S., Elkington, P. T. G. & Bishai, W. R. Feb 1 2015 In : Journal of Pathology. 235, 3, p. 431-444 14 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Matrix Metalloproteinase 1
Mycobacterium tuberculosis
Tuberculosis
Lung

Mycobacterium tuberculosis TlyA protein negatively regulates T helper (Th) 1 and Th17 differentiation and promotes tuberculosis pathogenesis

Rahman, M. A., Sobia, P., Dwivedi, V. P., Bhawsar, A., Singh, D. K., Sharma, P., Moodley, P., Kaer, L. V., Bishai, W. R. & Das, G. Jun 5 2015 In : Journal of Biological Chemistry. 290, 23, p. 14407-14417 11 p.

Research output: Contribution to journalArticle

Virulence Factors
Mycobacterium tuberculosis
Bacteria
Animals
Tuberculosis

Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis

Maiga, M. C., Ahidjo, B. A., Maiga, M. & Bishai, W. R. Dec 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7888-7890 3 p.

Research output: Contribution to journalArticle

Phosphodiesterase 4 Inhibitors
Tuberculosis
Lung
Phosphodiesterase Inhibitors
Isoniazid

Tuberculosis in pediatric antiretroviral therapy programs in low- and middle-income countries: Diagnosis and screening practices

Ballif, M. , Renner, L. , Dusingize, J. C. , Leroy, V. , Ayaya, S. , Wools-Kaloustian, K. , Cortes, C. P. , McGowan, C. C. , Graber, C. , Mandalakas, A. M. , Mofenson, L. M. , Egger, M. , Wati, K. D. K. , Nallusamy, R. , Reubenson, G. , Davies, M. A. , Fenner, L. , Ajayi, S. , Anastos, K. , Bashi, J. & 31 others Bishai, W., Boulle, A., Braitstein, P., Carriquiry, G., Carter, J. E., Cegielski, P., Chimbetete, C., Cortes, C., Davies, M. A., Diero, L., Duda, S., Durier, N., Eboua, T. F., Gasser, A., Geng, E., Gnokori, J. C., Hoffmann, C., Kancheya, N., Kiertiburanakul, S., Kim, P., Lameck, D., Lewden, C., Lou Lindegren, M., Mandalakas, A., Maskew, M., Mofenson, L., Mpoudi-Etame, M., Okwara, B., Phiri, S., Prasitsuebsai, W. & for the International Epidemiologic Databases to Evaluate AIDS (IeDEA) 2015 In : Journal of the Pediatric Infectious Diseases Society. 4, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

Tuberculosis
Pediatrics
Sputum
Microscopy
Thorax
2014

Aerosol mycobacterium tuberculosis infection causes rapid loss of diversity in gut microbiota

Winglee, K., Eloe-Fadrosh, E., Gupta, S., Guo, H., Fraser, C. & Bishai, W. May 12 2014 In : PLoS One. 9, 5, e97048

Research output: Contribution to journalArticle

Mycobacterium Infections
Mycobacterium tuberculosis
Pathogens
aerosols
Aerosols

Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of mycobacterium tuberculosis

Stec, J., Vilchèze, C., Lun, S., Perryman, A. L., Wang, X., Freundlich, J. S., Bishai, W., Jacobs, W. R. & Kozikowski, A. P. Nov 1 2014 In : ChemMedChem. 9, 11, p. 2528-2537 10 p.

Research output: Contribution to journalArticle

Triclosan
Acyl Carrier Protein
Mycobacterium tuberculosis
Oxidoreductases
Pharmaceutical Preparations

Crosstalk between mycobacterium tuberculosis and the host cell

Dey, B. & Bishai, W. R. Dec 1 2014 In : Seminars in Immunology. 26, 6, p. 486-496 11 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Survival
Cyclic Nucleotides
Virulence Factors
Bacterial Infections

Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries

Ballif, M. , Nhandu, V. , Wood, R. , Dusingize, J. C. , Carter, E. J. , Cortes, C. P. , McGowan, C. C. , Diero, L. , Graber, C. , Renner, L. , Hawerlander, D. , Kiertiburanakul, S. , Du, Q. T. , Sterling, T. R. , Egger, M. , Fenner, L. , Ajayi, S. , Anastos, K. , Ballif, M. , Bashi, J. & 381 others Bishai, W., Boulle, A., Braitstein, P., Carriquiry, G., Carter, J. E., Cegielski, P., Chimbetete, C., Conrad, J., Cortes, C. P., Davies, M. A., Diero, L., Duda, S., Durier, N., Dusingize, J. C., Egger, M., Eboua, T. F., Fenner, L., Gasser, A., Geng, E., Hardwicke, L., Hoffmann, C., Huebner, R., Kancheya, N., Kiertiburanakul, S., Kim, P., Lameck, D., Leroy, V., Lewden, C., Lindegren, M. L., Mandalakas, A., Maskew, M., McKaig, R., Mofenson, L., Mpoudi-Etame, M., Okwara, B., Phiri, S., Prasitsuebsai, W., Petit, A., Prozesky, H., Reid, S. E., Renner, L., Reubenson, G., Sohn, A., Sterling, T. 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Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
HIV
Tuberculosis
Directly Observed Therapy
Therapeutics

Diagnostic point-of-care tests in resource-limited settings

Drain, P. K., Hyle, E. P., Noubary, F., Freedberg, K. A., Wilson, D., Bishai, W. R., Rodriguez, W. & Bassett, I. V. Mar 2014 In : Lancet Infectious Diseases. 14, 3, p. 239-249 11 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Routine Diagnostic Tests
Clinical Decision Support Systems
Costs and Cost Analysis
Needs Assessment

Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis

Gupta, S., Cohen, K. A., Winglee, K., Maiga, M., Diarra, B. & Bishai, W. R. Jan 2014 In : Antimicrobial Agents and Chemotherapy. 58, 1, p. 574-576 3 p.

Research output: Contribution to journalArticle

bedaquiline
Verapamil
Mycobacterium tuberculosis
Clofazimine
Pharmaceutical Preparations

Expression of a subset of heat stress induced genes of mycobacterium tuberculosis is regulated by 3′,5′-cyclic AMP

Choudhary, E., Bishai, W. & Agarwal, N. Feb 28 2014 In : PLoS One. 9, 2, e89759

Research output: Contribution to journalArticle

cyclic AMP
Mycobacterium tuberculosis
Cyclic AMP
heat stress
Hot Temperature

In vitro and in vivo studies of a rapid and selective breath test for tuberculosis based upon mycobacterial CO dehydrogenase

Maiga, M., Choi, S. W., Atudorei, V., Maiga, M. C., Sharp, Z. D., Bishai, W. R. & Timmins, G. S. Apr 15 2014 In : mBio. 5, 2, e00990-14

Research output: Contribution to journalArticle

carbon monoxide dehydrogenase
Breath Tests
Tuberculosis
Point-of-Care Systems
Phenotype

Molecular basis of drug resistance in Mycobacterium tuberculosis

Cohen, K. A., Bishai, W. R. & Pym, A. S. 2014 In : Microbiology spectrum. 2, 3

Research output: Contribution to journalArticle

drug resistance
tuberculosis
Mycobacterium tuberculosis
Drug Resistance
antibiotics