Research Output 1979 2017

2017

Bacterial subversion of cAMP signalling inhibits cathelicidin expression, which is required for innate resistance to Mycobacterium tuberculosis

Gupta, S., Winglee, K., Gallo, R. & Bishai, W. R. May 1 2017 In : Journal of Pathology. 242, 1, p. 52-61 10 p.

Research output: Research - peer-reviewArticle

Mycobacterium tuberculosis
Genes
CAP18 lipopolysaccharide-binding protein
cathelicidin antimicrobial peptide
Macrophages

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

Manson, A. L. , Cohen, K. A. , Abeel, T. , Desjardins, C. A. , Armstrong, D. T. , Barry, C. E. , Brand, J. , Chapman, S. B. , Cho, S. N. , Gabrielian, A. , Gomez, J. , Jodals, A. M. , Joloba, M. , Jureen, P. , Lee, J. S. , Malinga, L. , Maiga, M. , Nordenberg, D. , Noroc, E. , Romancenco, E. & 27 others Salazar, A., Ssengooba, W., Velayati, A. A., Winglee, K., Zalutskaya, A., Via, L. E., Cassell, G. H., Dorman, S. E., Ellner, J., Farnia, P., Galagan, J. E., Rosenthal, A., Crudu, V., Homorodean, D., Hsueh, P. R., Narayanan, S., Pym, A. S., Skrahina, A., Swaminathan, S., van der Walt, M., Alland, D., Bishai, W. R., Cohen, T., Hoffner, S., Birren, B. W., Earl, A. M. & TBResist Global Genome Consortium Jan 16 2017 (Accepted/In press) In : Nature Genetics.

Research output: Research - peer-reviewArticle

Multidrug-Resistant Tuberculosis
Multiple Drug Resistance
Mycobacterium tuberculosis
Mutation
Molecular Pathology

Inhibition of innate immune cytosolic surveillance by an M.Tuberculosis phosphodiesterase

Dey, R. J., Dey, B., Zheng, Y., Cheung, L. S., Zhou, J., Sayre, D., Kumar, P., Guo, H., Lamichhane, G., Sintim, H. O. & Bishai, W. R. Feb 1 2017 In : Nature Chemical Biology. 13, 2, p. 210-217 8 p.

Research output: Research - peer-reviewArticle

Phosphoric Diester Hydrolases
Tuberculosis
Interferon Type I
cyclic guanosine monophosphate-adenosine monophosphate
cyclic diadenosine phosphate

Locking down metabolism

Bishai, W. R. Aug 18 2017 In : Nature Chemical Biology. 13, 9, p. 925-926 2 p.

Research output: Research - peer-reviewShort survey

Mycobacterium tuberculosis induction of heme oxygenase-1 expression is dependent on oxidative stress and reflects treatment outcomes

Rockwood, N., Costa, D. L., Amaral, E. P., Du Bruyn, E., Kubler, A., Gil-Santana, L., Fukutani, K. F., Scanga, C. A., Flynn, J. A. L., Jackson, S. H., Wilkinson, K. A., Bishai, W. R., Sher, A., Wilkinson, R. J. & Andrade, B. B. May 12 2017 In : Frontiers in Immunology. 8, MAY, 542

Research output: Research - peer-reviewArticle

Heme Oxygenase-1
Mycobacterium tuberculosis
Oxidative Stress
HIV-1
Tuberculosis

Partners in Crime: Phenolic Glycolipids and Macrophages

Singh, A. K. & Bishai, W. R. 2017 (Accepted/In press) In : Trends in Molecular Medicine.

Research output: Research - peer-reviewArticle

Glycolipids
Crime
Macrophages
Mycobacterium marinum
Immune Evasion

Reply to Levis and Rendini

Singh, D. K., Dwivedi, V. P., Ranganathan, A., Bishai, W. R., Kaer, L. V. & Das, G. 2017 In : Journal of Infectious Diseases. 215, 9, p. 1488-1489 2 p.

Research output: Research - peer-reviewLetter

Suppressor Cell-Depleting Immunotherapy with Denileukin Diftitox is an Effective Host-Directed Therapy for Tuberculosis

Gupta, S., Cheung, L., Pokkali, S., Winglee, K., Guo, H., Murphy, J. R. & Bishai, W. R. Jun 15 2017 In : Journal of Infectious Diseases. 215, 12, p. 1883-1887 5 p.

Research output: Research - peer-reviewArticle

Immunotherapy
Tuberculosis
Therapeutics
denileukin diftitox
Infection

Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections

Kozikowski, A. P., Onajole, O. K., Stec, J., Dupont, C., Viljoen, A., Richard, M., Chaira, T., Lun, S., Bishai, W., Raj, V. S., Ordway, D. & Kremer, L. Jul 13 2017 In : Journal of Medicinal Chemistry. 60, 13, p. 5876-5888 13 p.

Research output: Research - peer-reviewArticle

Mycolic Acids
Mycobacterium Infections
Cystic Fibrosis
Therapeutics
indole
2016

Blockade of the Kv1.3 K+ Channel Enhances BCG Vaccine Efficacy by Expanding Central Memory T Lymphocytes

Singh, D. K., Dwivedi, V. P., Ranganathan, A., Bishai, W. R., Van Kaer, L. & Das, G. Nov 1 2016 In : Journal of Infectious Diseases. 214, 9, p. 1456-1464 9 p.

Research output: Research - peer-reviewArticle

BCG Vaccine
Tuberculosis
T-Lymphocytes
Clofazimine
Vaccines

Canonical pathways, networks and transcriptional factor regulation by clinical strains of Mycobacterium tuberculosis in pulmonary alveolar epithelial cells

Mvubu, N. E., Pillay, B., Gamieldien, J., Bishai, W. & Pillay, M. Mar 1 2016 In : Tuberculosis. 97, p. 73-85 13 p.

Research output: Research - peer-reviewArticle

Alveolar Epithelial Cells
Gene Regulatory Networks
Mycobacterium tuberculosis
Epithelial Cells
Lung

Cathepsin K contributes to cavitation and collagen turnover in pulmonary tuberculosis

Kubler, A., Larsson, C., Luna, B., Andrade, B. B., Amaral, E. P., Urbanowski, M., Orandle, M., Bock, K., Ammerman, N. C., Cheung, L. S., Winglee, K., Halushka, M., Park, J. K., Sher, A., Friedland, J. S., Elkington, P. T. & Bishai, W. R. Feb 15 2016 In : Journal of Infectious Diseases. 213, 4, p. 618-627 10 p.

Research output: Research - peer-reviewArticle

Cathepsin K
Pulmonary Tuberculosis
Collagen
Matrix Metalloproteinases
Tuberculosis

Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries

Charles, M. K. , Lindegren, M. L. , Wester, C. W. , Blevins, M. , Sterling, T. R. , Dung, N. T. , Dusingize, J. C. , Avit-Edi, D. , Durier, N. , Castelnuovo, B. , Nakigozi, G. , Cortes, C. P. , Ballif, M. , Fenner, L. , Ajayi, S. , Anastos, K. , Bashi, J. , Bishai, W. , Boulle, A. , Braitstein, P. & 341 others Carriquiry, G., Carter, J. E., Cegielski, P., Chimbetete, C., Davies, M. A., Diero, L., Duda, S., Egger, M., Eboua, T. F., Gasser, A., Geng, E., Gnokori, J. C., Hardwicke, L., Hoffmann, C., Huebner, R., Kancheya, N., Kiertiburanakul, S., Kim, P., Lameck, D., Leroy, V., Lewden, C., Mandalakas, A., Maskew, M., McKaig, R., Mofenson, L., Mpoudi-Etame, M., Okwara, B., Phiri, S., Prasitsuebsai, W., Petit, A., Prozesky, H., Reid, S. E., Renner, L., Reubenson, G., Sohn, A., Vo, Q., Walker, D., Wehbe, F., Wejse, C., Williams, C., Wood, R., Wools-Kaloustian, K., Yao, Z., Yunihastuti, E., Zhang, F. J., Zhao, H. X., Han, N., Merati, T. P., Wirawan, D. N., Yuliana, F., Ditangco, R., Uy, E., Bantique, R., Phanuphak, P., Ruxrungtham, K., Avihingsanon, A., Khongphattanayothin, M., Kiertiburanakul, S., Sungkanuparph, S., Sanmeema, N., Chaiwarith, R., Sirisanthana, T., Kotarathititum, W., Pham, T. T., Cuong, D. D., Ha, H. L., Nguyen, V. K., Bui, V. H., Nguyen, T. D., Sohn, A. H., Petersen, B., Cooper, D. A., Law, M. G., Jiamsakul, A., Boettiger, D. C., Wati, D. K., Atmikasari, L. P. P., Malino, I. Y., Nallusamy, R., Chan, K. C., Lumbiganon, P., Kosalaraksa, P., Tharnprisan, P., Udomphanit, T., Chokephaibulkit, K., Lapphra, K., Phongsamart, W., Wittawatmongkol, O., Dung, K. T. K., Lam, N. V., An, P. N., Loan, N. T., Truong, H. K., Du, T. Q., Chau, N. H., Do, C. V., Ha, M. T., Sohn, A. H., Nipathakosol, P., Cooper, D. A., Law, M. G., Kariminia, A., Mutimura, E., Gitembagara, A., Tatwangire, J., Izabelle, I., Niyongabo, T., Twizere, C., Baramperanye, E., Edmonds, A., Yotebieng, M., Azinyue, I., Ayangma, L., Dickinson, D., Eley, B., Fritz, C., Garone, D., Giddy, J., Hoffmann, C., MacPhail, P., Moultrie, H., Ndirangu, J., Pestilli, S., Rabie, H., Stringer, J., Technau, K., Graber, C., Kaeser, F., Keiser, O., Cornell, M., Maxwell, N., Zannou, D. M., Ahouada, C., Akakpo, J., Ahomadegbé, C., Gougounon-Houéto, A., Azon-Kouanou, A., Houngbé, F., Sehonou, J., Koumakpaï, S., Alihonou, F., D'Almeida, M., Hodonou, I., Hounhoui, G., Sagbo, G., Tossa-Bagnan, L., Adjide, H., Drabo, J., Bognounou, R., Dienderé, A., Traore, E., Zoungrana, L., Zerbo, B., Sawadogo, A. B., Zoungrana, J., Héma, A., Soré, I., Bado, G., Tapsoba, A., Yé, D., Kouéta, F., Ouedraogo, S., Ouédraogo, R., Hiembo, W., Gansonré, M., Messou, E., Gnokoro, J. C., Koné, M., Kouakou, G. M., Bosse, C. A., Brou, K., Assi, A. I., Chenal, H., Hawerlander, D., Soppi, F., Minga, A., Abo, Y., Yoboue, J. M., Eholié, S. P., Amego, M. D. N., Andavi, V., Diallo, Z., Ello, F., Tanon, A. K., Koule, S. O., Anzan, K. C., Guehi, C., Aka, E. A., Issouf, K. L., Kouakou, J. C., N'Gbeche, M. S., Pety, T., Kouakou, K., Moh, M., Yao, V. A., Folquet, M. A., Dainguy, M. E., Kouakou, C., Méa-Assande, V. T., Oka-Berete, G., Zobo, N., Acquah, P., Kokora, M. B., Eboua, T. F., Timité-Konan, M., Ahoussou, L. D., Assouan, J. K., Sami, M. F., Kouadio, C., Goka, B., Welbeck, J., Sackey, A., Owiafe, S. N., Da Silva, Z. J., Paulo, J., Rodrigues, A., Da Silva, D., Medina, C., Oliviera-Souto, I., Østergaard, L., Laursen, A., Sodemann, M., Aaby, P., Fomsgaard, A., Erikstrup, C., Eugen-Olsen, J., Maïga, M. Y., Diakité, F. F., Kalle, A., Katile, D., Traore, H. A., Minta, D., Cissé, T., Dembelé, M., Doumbia, M., Fomba, M., Kaya, A. S., Traoré, A. M., Traoré, H., Toure, A. A., Dicko, F., Sylla, M., Berthé, A., Traoré, H. C., Koïta, A., Koné, N., N'Diaye, C., Coulibaly, S. T., Traoré, M., Traoré, N., Charurat, M., Alim, G., Dapiap, S., Otu, Igbinoba, F., Benson, O., Adebamowo, C., James, J., Obaseki, Osakede, P., Olasode, J., Seydi, M., Sow, P. S., Diop, B., Manga, N. M., Tine, J. M., Bassabi, C. C., Sy, H. S., Ba, A., Diagne, A., Dior, H., Faye, M., Gueye, R. D., Mbaye, A. D., Patassi, A., Kotosso, A., Kariyare, B. G., Gbadamassi, G., Komi, A., Mensah-Zukong, K. E., Pakpame, P., Lawson-Evi, A. K., Atakouma, Y., Takassi, E., Djeha, A., Ephoévigah, A., Djibril, S. E. H., Dabis, F., Bissagnene, E., Arrivé, E., Coffie, P., Ekouevi, D., Jaquet, A., Sasco, A. J., Amani, D., Azani, J. C., Balestre, E., Bessekon, S., Bohossou, F., Gilbert, C., Karcher, S., Gonsan, J. M., Le Carrou, J., Lenaud, S., Nchot, C., Malateste, K., Yao, A. R., Siloué, B., Clouet, G., Dosso, M., Doring, A., Kouakou, A., Rabourdin, E., Rivenc, J., Anglaret, X., Ba, B., Essanin, J. B., Ciaranello, A., Datté, S., Desmonde, S., Diby, J. S. E., Gottlieb, G. S., Horo, A. G., Kangah, S. N. Z., Malvy, D., Meless, D., Mounkaila-Harouna, A., Ndondoki, C., Shiboski, C., Tchounga, B., Thiébaut, R., Wandeler, G., McGowan, C., Cahn, P., Gotuzzo, E., Reyes, M. W., Grinsztejn, B., Pape, J. W., Padgett, D., Madero, J. S. & International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration Apr 1 2016 In : PLoS ONE. 11, 4, e0153243

Research output: Research - peer-reviewArticle

isoniazid
tuberculosis
disease control
income
therapeutics

Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection

Stec, J., Onajole, O. K., Lun, S., Guo, H., Merenbloom, B., Vistoli, G., Bishai, W. R. & Kozikowski, A. P. Jul 14 2016 In : Journal of Medicinal Chemistry. 59, 13, p. 6232-6247 16 p.

Research output: Research - peer-reviewArticle

Tuberculosis
Animal Models
Infection
Pharmaceutical Preparations
indole

Mycobacterium tuberculosis strains exhibit differential and strain-specific molecular signatures in pulmonary epithelial cells

Mvubu, N. E., Pillay, B., Gamieldien, J., Bishai, W. & Pillay, M. Dec 1 2016 In : Developmental and Comparative Immunology. 65, p. 321-329 9 p.

Research output: Research - peer-reviewArticle

Mycobacterium tuberculosis
Epithelial Cells
Lung
Genes
Gene Expression

Paradoxical Hypersusceptibility of Drug-resistant Mycobacterium tuberculosis to β-lactam Antibiotics

Cohen, K. A., El-Hay, T., Wyres, K. L., Weissbrod, O., Munsamy, V., Yanover, C., Aharonov, R., Shaham, O., Conway, T. C., Goldschmidt, Y., Bishai, W. R. & Pym, A. S. 2016 In : EBioMedicine. 9, p. 170-179 10 p.

Research output: Research - peer-reviewArticle

Multidrug-Resistant Tuberculosis
Clavulanic Acid
Amoxicillin
beta-Lactams
Mycobacterium tuberculosis

Phosphodiesterase inhibitors as adjunctive therapies for tuberculosis

Ahidjo, B. A. & Bishai, W. R. Feb 1 2016 In : EBioMedicine. 4, p. 7-8 2 p.

Research output: Research - peer-reviewComment/debate

REMap: Operon map of M. tuberculosis based on RNA sequence data

Pelly, S., Winglee, K., Xia, F., Stevens, R. L., Bishai, W. R. & Lamichhane, G. Jul 1 2016 In : Tuberculosis. 99, p. 70-80 11 p.

Research output: Research - peer-reviewArticle

Operon
Tuberculosis
RNA
Genes
RNA Sequence Analysis

Stool microbiome reveals diverse bacterial ureases as confounders of oral urea breath testing for Helicobacter pylori and Mycobacterium tuberculosis in Bamako, Mali

Maiga, M. , Cohen, K. , Baya, B. , Srikrishna, G. , Siddiqui, S. , Sanogo, M. , Somboro, A. M. , Diarra, B. , Diallo, M. H. , Mazumdar, V. , Yoder, C. , Orsega, S. , Belson, M. , Kassambara, H. , Goita, D. , Murphy, R. L. , Dao, S. , Polis, M. , Diallo, S. , Timmins, G. S. & 3 others Dodd, L., Earl, A. M. & Bishai, W. R. Aug 17 2016 In : Journal of Breath Research. 10, 3, 036012

Research output: Research - peer-reviewArticle

Mali
Urease
Microbiota
Mycobacterium tuberculosis
Helicobacter pylori

Targeting the cell wall of Mycobacterium tuberculosis: A molecular modeling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2

Silva, J. R. A., Bishai, W. R., Govender, T., Lamichhane, G., Maguire, G. E. M., Kruger, H. G., Lameira, J. & Alves, C. N. 2016 In : Journal of Biomolecular Structure and Dynamics. 34, 2, p. 304-317 14 p.

Research output: Research - peer-reviewArticle

meropenem
Peptidyl Transferases
Imipenem
Mycobacterium tuberculosis
Cell Wall

The Non-Linear Child: Ontogeny, Isoniazid Concentration, and NAT2 Genotype Modulate Enzyme Reaction Kinetics and Metabolism

Rogers, Z., Hiruy, H., Pasipanodya, J. G., Mbowane, C., Adamson, J., Ngotho, L., Karim, F., Jeena, P., Bishai, W. & Gumbo, T. Sep 1 2016 In : EBioMedicine. 11, p. 118-126 9 p.

Research output: Research - peer-reviewArticle

Acetyltransferases
Isoniazid
Metabolism
Reaction kinetics
Enzymes

Whole Genome Sequencing of Mycobacterium africanum Strains from Mali Provides Insights into the Mechanisms of Geographic Restriction

Winglee, K., Manson McGuire, A., Maiga, M., Abeel, T., Shea, T., Desjardins, C. A., Diarra, B., Baya, B., Sanogo, M., Diallo, S., Earl, A. M. & Bishai, W. R. Jan 11 2016 In : PLoS Neglected Tropical Diseases. 10, 1, e0004332

Research output: Research - peer-reviewArticle

Mali
Mycobacterium
Genome
Mutation
Mycobacterium tuberculosis
2015

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

Dey, B., Dey, R. J., Cheung, L. S., Pokkali, S., Guo, H., Lee, J. H. & Bishai, W. R. Apr 1 2015 In : Nature Medicine. 21, 4, p. 401-408 8 p.

Research output: Research - peer-reviewArticle

Cyclic AMP
Tuberculosis
Adenosine Monophosphate
Mycobacterium tuberculosis
Interferon-beta

Biomarkers for Tuberculosis Based on Secreted, Species-Specific, Bacterial Small Molecules

Pan, S. J., Tapley, A., Adamson, J., Little, T., Urbanowski, M., Cohen, K., Pym, A., Almeida, D., Dorasamy, A., Layre, E., Young, D. C., Singh, R., Patel, V. B., Wallengren, K., Ndung'U, T., Wilson, D., Moody, D. B. & Bishai, W. 2015 In : Journal of Infectious Diseases. 212, 10, p. 1827-1834 8 p.

Research output: Research - peer-reviewArticle

Tuberculosis
Biomarkers
Serum
Sputum
Cerebrospinal Fluid

Computer-aided pulmonary image analysis in small animal models

Xu, Z., Bagci, U., Mansoor, A., Kramer-Marek, G., Luna, B., Kubler, A., Dey, B., Foster, B., Papadakis, G. Z., Camp, J. V., Jonsson, C. B., Bishai, W. R., Jain, S., Udupa, J. K. & Mollura, D. J. Jul 1 2015 In : Medical Physics. 42, 7, p. 3896-3910 15 p.

Research output: Research - peer-reviewArticle

Animal Models
Lung
Lung Diseases
Communicable Diseases
Sensitivity and Specificity

Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis

Maiga, M., Ahidjo, B. A., Maiga, M. C., Cheung, L., Pelly, S., Lun, S., Bougoudogo, F. & Bishai, W. R. Aug 1 2015 In : EBioMedicine. 2, 8, p. 868-873 6 p.

Research output: Research - peer-reviewArticle

Tuberculosis
Therapeutics
tofacitinib
Mycobacterium tuberculosis
Janus Kinases

Erratum to "Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis" [EBioMedicine 2 (8), August 2015, 868-873] DOI: 10.1016/j.ebiom.2015.07.014

Maiga, M., Ahidjo, B. A., Maiga, M. C., Cheung, L., Pelly, S., Lun, S., Bougoudogo, F. & Bishai, W. R. Nov 1 2015 In : EBioMedicine. 2, 11, p. 1834 1 p.

Research output: Research - peer-reviewArticle

Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal

Cohen, K. A. , Abeel, T. , Manson McGuire, A. , Desjardins, C. A. , Munsamy, V. , Shea, T. P. , Walker, B. J. , Bantubani, N. , Almeida, D. V. , Alvarado, L. , Chapman, S. B. , Mvelase, N. R. , Duffy, E. Y. , Fitzgerald, M. G. , Govender, P. , Gujja, S. , Hamilton, S. , Howarth, C. , Larimer, J. D. , Maharaj, K. & 13 others Pearson, M. D., Priest, M. E., Zeng, Q., Padayatchi, N., Grosset, J., Young, S. K., Wortman, J., Mlisana, K. P., O'Donnell, M. R., Birren, B. W., Bishai, W. R., Pym, A. S. & Earl, A. M. Sep 1 2015 In : PLoS Medicine. 12, 9, e1001880

Research output: Research - peer-reviewArticle

Extensively Drug-Resistant Tuberculosis
Mycobacterium tuberculosis
Genome
Mutation
Disease Outbreaks

Evolution of extensively drug-resistant tuberculosis over four decades revealed by whole genome sequencing of Mycobacterium tuberculosis from KwaZulu-Natal, South Africa

Cohen, K. A. , Abeel, T. , McGuire, A. M. , Desjardins, C. A. , Munsamy, V. , Shea, T. P. , Walker, B. J. , Bantubani, N. , Almeida, D. V. , Alvarado, L. , Chapman, S. , Mvelase, N. R. , Duffy, E. Y. , Fitzgerald, M. G. , Govender, P. , Gujja, S. , Hamilton, S. , Howarth, C. , Larimer, J. D. , Maharaj, K. & 13 others Pearson, M. D., Priest, M. E., Zeng, Q., Padayatchi, N., Grosset, J., Young, S. K., Wortman, J., Mlisana, K. P., O'Donnell, M. R., Birren, B. W., Bishai, W. R., Pym, A. S. & Earl, A. M. 2015 (Accepted/In press) In : International Journal of Mycobacteriology.

Research output: Research - peer-reviewArticle

Extensively Drug-Resistant Tuberculosis
South Africa
Mycobacterium tuberculosis
Drug Resistance
Disease Outbreaks

High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells

Sharma, P. K., Wong, E. B., Napier, R. J., Bishai, W. R., Ndung'u, T., Kasprowicz, V. O., Lewinsohn, D. A., Lewinsohn, D. M. & Gold, M. C. Jul 1 2015 In : Immunology. 145, 3, p. 443-453 11 p.

Research output: Research - peer-reviewArticle

Mucous Membrane
Bacteria
T-Lymphocytes
Tuberculosis
T-Cell Antigen Receptor

Immunogenicity without efficacy of an adenoviral tuberculosis vaccine in a stringent mouse model for immunotherapy during treatment

Alyahya, S. A., Nolan, S. T., Smith, C. M. R., Bishai, W. R., Sadoff, J. & Lamichhane, G. May 21 2015 In : PLoS One. 10, 5, e0127907

Research output: Research - peer-reviewArticle

immunotherapy
tuberculosis
immunity
animal models
lungs

In vivo biosynthesis of terpene nucleosides provides unique chemical markers of mycobacterium tuberculosis infection

Young, D. C., Layre, E., Pan, S. J., Tapley, A., Adamson, J., Seshadri, C., Wu, Z., Buter, J., Minnaard, A. J., Coscolla, M., Gagneux, S., Copin, R., Ernst, J. D., Bishai, W. R., Snider, B. B. & Moody, D. B. Apr 23 2015 In : Chemistry and Biology. 22, 4, p. 516-526 11 p.

Research output: Research - peer-reviewArticle

Mycobacterium Infections
Terpenes
Mycobacterium tuberculosis
Nucleosides
Tuberculosis

In vivo prediction of tuberculosis-associated cavity formation in rabbits

Luna, B., Kubler, A., Larsson, C., Foster, B., Bagci, U., Mollura, D. J., Jain, S. K. & Bishai, W. R. Feb 1 2015 In : Journal of Infectious Diseases. 211, 3, p. 481-485 5 p.

Research output: Research - peer-reviewArticle

Tuberculosis
Rabbits
Sensitivity and Specificity
Fluorodeoxyglucose F18
Treatment Failure

Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV

Sullivan, Z. A., Wong, E. B., Ndung'u, T., Kasprowicz, V. O. & Bishai, W. R. Apr 1 2015 In : EBioMedicine. 2, 4, p. 334-340 7 p.

Research output: Research - peer-reviewArticle

Latent Tuberculosis
HIV
Chemical activation
T-cells
Mortality

Mutation of Rv2887, a marR-Like gene, confers mycobacterium tuberculosis resistance to an imidazopyridine-based agent

Winglee, K., Lun, S., Pieroni, M., Kozikowski, A. & Bishai, W. Nov 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6873-6881 9 p.

Research output: Research - peer-reviewArticle

Mycobacterium tuberculosis
Mutation
Genes
Pharmaceutical Preparations
Proteins

Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation

Kübler, A. , Luna, B. , Larsson, C. , Ammerman, N. C. , Andrade, B. B. , Orandle, M. , Bock, K. W. , Xu, Z. , Bagci, U. , Molura, D. J. , Marshall, J. , Burns, J. , Winglee, K. , Ahidjo, B. A. , Cheung, L. S. , Klunk, M. , Jain, S. K. , Kumar, N. P. , Babu, S. , Sher, A. & 3 others Friedland, J. S., Elkington, P. T. G. & Bishai, W. R. Feb 1 2015 In : Journal of Pathology. 235, 3, p. 431-444 14 p.

Research output: Research - peer-reviewArticle

Matrix Metalloproteinases
Mycobacterium tuberculosis
Tuberculosis
Matrix Metalloproteinase 1
Lung

Mycobacterium tuberculosis TlyA protein negatively regulates T helper (Th) 1 and Th17 differentiation and promotes tuberculosis pathogenesis

Rahman, M. A., Sobia, P., Dwivedi, V. P., Bhawsar, A., Singh, D. K., Sharma, P., Moodley, P., Kaer, L. V., Bishai, W. R. & Das, G. Jun 5 2015 In : Journal of Biological Chemistry. 290, 23, p. 14407-14417 11 p.

Research output: Research - peer-reviewArticle

Virulence Factors
Bacteria
Animals
Mycobacterium tuberculosis TlyA protein
Mycobacterium tuberculosis

Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis

Maiga, M. C., Ahidjo, B. A., Maiga, M. & Bishai, W. R. Dec 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7888-7890 3 p.

Research output: Research - peer-reviewArticle

Phosphodiesterase 4 Inhibitors
Tuberculosis
Therapeutics
Roflumilast
Lung

Tuberculosis in pediatric antiretroviral therapy programs in low- and middle-income countries: Diagnosis and screening practices

Ballif, M. , Renner, L. , Dusingize, J. C. , Leroy, V. , Ayaya, S. , Wools-Kaloustian, K. , Cortes, C. P. , McGowan, C. C. , Graber, C. , Mandalakas, A. M. , Mofenson, L. M. , Egger, M. , Wati, K. D. K. , Nallusamy, R. , Reubenson, G. , Davies, M. A. , Fenner, L. , Ajayi, S. , Anastos, K. , Bashi, J. & 73 others Bishai, W., Boulle, A., Braitstein, P., Carriquiry, G., Carter, J. E., Cegielski, P., Chimbetete, C., Cortes, C., Davies, M. A., Diero, L., Duda, S., Durier, N., Eboua, T. F., Gasser, A., Geng, E., Gnokori, J. C., Hoffmann, C., Kancheya, N., Kiertiburanakul, S., Kim, P., Lameck, D., Lewden, C., Lou Lindegren, M., Mandalakas, A., Maskew, M., Mofenson, L., Mpoudi-Etame, M., Okwara, B., Phiri, S., Prasitsuebsai, W., Petit, A., Prozesky, H., Reid, S. E., Sohn, A., Sterling, T., Vo, Q., Walker, D., Wejse, C., Wood, R., Yao, Z., Yunihastuti, E., Abrams, E., Ananworanich, J., Azondekon, A., Bacon, M., Behets, F., Cahn, P., Cesar, C., Ciaranello, A., Conrad, J., Dabis, F., Edmonds, A., Feinstein, L., Hardwicke, L., Hazra, R., Hoover, D., Huebner, R., Keiser, O., Lindegren, M. L., Magneres, M. C., McGowan, C., McKaig, R., Messerschmidt, L., Biribonwoha, H. N., Sharp, G., Vreeman, R., Wehbe, F., Wester, W., Williams, C., Worrell, C., Yiannoutsos, C., Zwickl, B. & for the International Epidemiologic Databases to Evaluate AIDS (IeDEA) 2015 In : Journal of the Pediatric Infectious Diseases Society. 4, 1, p. 30-38 9 p.

Research output: Research - peer-reviewArticle

Tuberculosis
Pediatrics
Therapeutics
Sputum
Microscopy
2014

Aerosol mycobacterium tuberculosis infection causes rapid loss of diversity in gut microbiota

Winglee, K., Eloe-Fadrosh, E., Gupta, S., Guo, H., Fraser, C. & Bishai, W. May 12 2014 In : PLoS One. 9, 5, e97048

Research output: Research - peer-reviewArticle

Mycobacterium tuberculosis
aerosols
intestinal microorganisms
infection
Mycobacterium Infections

Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of mycobacterium tuberculosis

Stec, J., Vilchèze, C., Lun, S., Perryman, A. L., Wang, X., Freundlich, J. S., Bishai, W., Jacobs, W. R. & Kozikowski, A. P. Nov 1 2014 In : ChemMedChem. 9, 11, p. 2528-2537 10 p.

Research output: Research - peer-reviewArticle

Triclosan
Acyl Carrier Protein
Mycobacterium tuberculosis
Oxidoreductases
Pharmaceutical Preparations

Crosstalk between mycobacterium tuberculosis and the host cell

Dey, B. & Bishai, W. R. Dec 1 2014 In : Seminars in Immunology. 26, 6, p. 486-496 11 p.

Research output: Research - peer-reviewArticle

Mycobacterium tuberculosis
Survival
Cyclic Nucleotides
Virulence Factors
Bacterial Infections

Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries

Ballif, M. , Nhandu, V. , Wood, R. , Dusingize, J. C. , Carter, E. J. , Cortes, C. P. , McGowan, C. C. , Diero, L. , Graber, C. , Renner, L. , Hawerlander, D. , Kiertiburanakul, S. , Du, Q. T. , Sterling, T. R. , Egger, M. , Fenner, L. , Ajayi, S. , Anastos, K. , Ballif, M. , Bashi, J. & 381 others Bishai, W., Boulle, A., Braitstein, P., Carriquiry, G., Carter, J. E., Cegielski, P., Chimbetete, C., Conrad, J., Cortes, C. P., Davies, M. A., Diero, L., Duda, S., Durier, N., Dusingize, J. C., Egger, M., Eboua, T. F., Fenner, L., Gasser, A., Geng, E., Hardwicke, L., Hoffmann, C., Huebner, R., Kancheya, N., Kiertiburanakul, S., Kim, P., Lameck, D., Leroy, V., Lewden, C., Lindegren, M. L., Mandalakas, A., Maskew, M., McKaig, R., Mofenson, L., Mpoudi-Etame, M., Okwara, B., Phiri, S., Prasitsuebsai, W., Petit, A., Prozesky, H., Reid, S. E., Renner, L., Reubenson, G., Sohn, A., Sterling, T. R., Vo, Q., Walker, D., Wehbe, F., Wejse, C., Wester, W., Williams, C., Wood, R., Wools-Kaloustian, K., Yao, Z., Yunihastuti, E., Zhang, F. J., Zhao, H. X., Han, N., Merati, T. P., Wirawan, D. N., Yuliana, F., Ditangco, R., Uy, E., Bantique, R., Phanuphak, P., Ruxrungtham, K., Avihingsanon, A., Mengthaisong, T., Kiertiburanakul, S., Sungkanuparph, S., Sanmeema, N., Chaiwarith, R., Sirisanthana, T., Kotarathititum, W., Pham, T. T., Cuong, D. D., Ha, H. L., Nguyen, V. K., Bui, V. H., Cao, T. T., Sohn, A. H., Durier, N., Petersen, B., Cooper, D. A., Law, M. G., Jiamsakul, A., Boettiger, D. C., Wati, D. K., Atmikasari, L. P. P., Malino, I. Y., Nallusamy, R., Chan, K. C., Lumbiganon, P., Kosalaraksa, P., Tharnprisan, P., Udomphanit, T., Chokephaibulkit, K., Lapphra, K., Phongsamart, W., Wittawatmongkol, O., Dung, K. T. K., Lam, N. V., An, P. N., Loan, N. T., Truong, H. K., Du, T. Q., Chau, N. H., Do, C. V., Ha, M. T., Sohn, A. H., Durier, N., Nipathakosol, P., Cooper, D. A., Law, M. G., Kariminia, A., Dusingize, J. C., Mutimura, E., Gitembagara, A., Anastos, K., Tatwangire, J., Izabelle, I., Niyongabo, T., Twizere, C., Baramperanye, E., Edmonds, A., Yotebieng, M., Azinyue, I., Ayangma, L., Yiannoutsos, C., Ayaya, S., Bukusi, E. A., Lewis-Kulzer, J., Somi, G., Lyamuya, R., Ngonyani, K., Ssali, J., Ssemuwemba, H., Mwebesa, B. B., Kambugu, A., Hermans, S., Nalugoda, F., Jjingo, K., Chimbetete, C., Dickinsonn, D., Eley, B., Fritz, C., Garone, D., Giddy, J., Hoffmann, C., MacPhail, P., Moultrie, H., Ndirangu, J., Pestilli, S., Phiri, S., Prozesky, H., Rabie, H., Stringer, J., Technau, K., Wood, R., Egger, M., Graber, C., Kaeser, F., Keiser, O., Boulle, A., Cornell, M., Davies, M. A., Maxwell, N., Zannou, D. M., Ahouada, C., Akakpo, J., Ahomadegbé, C., Bashi, J., Gougounon-Houéto, A., Azon-Kouanou, A., Houngbé, F., Sehonou, J., Koumakpaï, S., Alihonou, F., D'Almeida, M., Hodonou, I., Hounhoui, G., Sagbo, G., Tossa-Bagnan, L., Adjide, H., Drabo, J., Bognounou, R., Dienderé, A., Traore, E., Zoungrana, L., Zerbo, B., Sawadogo, A. B., Zoungrana, J., Héma, A., Soré, I., Bado, G., Tapsoba, A., Yé, D., Kouéta, F., Ouedraogo, S., Ouédraogo, R., Hiembo, W., Gansonré, M., Messou, E., Gnokoro, J. C., Koné, M., Kouakou, G. M., Bosse, C. A., Brou, K., Assi, A. I., Chenal, H., Hawerlander, D., Soppi, F., Minga, A., Abo, Y., Yoboue, J. M., Eholié, S. P., Amego, M. D. N., Andavi, V., Diallo, Z., Ello, F., Tanon, A. K., Koule, S. O., Anzan, K. C., Guehi, C., Aka, E. A., Issouf, K. L., Kouakou, J. C., N'Gbeche, M. S., Pety, T., Avit-Edi, D., Kouakou, K., Moh, M., Yao, V. A., Folquet, M. A., Dainguy, M. E., Kouakou, C., Méa-Assande, V. T., Oka-Berete, G., Zobo, N., Acquah, P., Kokora, M. B., Eboua, T. F., Timité-Konan, M., Diecket Ahoussou, L., Assouan, J. K., Sami, M. F., Kouadio, S., Renner, L., Goka, B., Welbeck, J., Sackey, A., Owiafe, S. N., Wejse, C., Da Silva, Z. J., Paulo, J., Rodrigues, A., Da Silva, D., Medina, C., Oliviera-Souto, I., Østergaard, L., Laursen, A., Sodemann, M., Aaby, P., Fomsgaard, A., Erikstrup, C., Eugen-Olsen, J., Maïga, M. Y., Diakité, F. F., Kalle, A., Katile, D., Traore, H. A., Minta, D., Cissé, T., Dembelé, M., Doumbia, M., Fomba, M., Kaya, A. S., Traoré, A. M., Traoré, H., Toure, A. A., Dicko, F., Sylla, M., Berthé, A., Traoré, H. C., Koïta, A., Koné, N., N'Diaye, C., Coulibaly, S. T., Traoré, M., Traoré, N., Charurat, M., Ajayi, S., Alim, G., Dapiap, S., Igbinoba, F., Benson, O., Adebamowo, C., James, J., Obaseki, . N. V., Osakede, P., Olasode, J., Seydi, M., Sow, P. S., Diop, B., Manga, N. M., Tine, J. M., Bassabi, C. C., Sy, H. S., Ba, A., Diagne, A., Dior, H., Faye, M., Gueye, R. D., Mbaye, A. D., Patassi, A., Kotosso, A., Kariyare, B. G., Gbadamassi, G., Komi, A., Mensah-Zukong, K. E., Pakpame, P., Koko Lawson-Evi, A., Atakouma, Y., Takassi, E., Djeha, A., Ephoévi-gah, A., El-Hadj Djibril, S., Dabis, F., Bissagnene, E., Arrivé, E., Coffie, P., Ekouevi, D., Jaquet, A., Leroy, V., Lewden, C., Sasco, A. J., Amani, D., Azani, J. C., Balestre, E., Bessekon, S., Bohossou, F., Gilbert, C., Karcher, S., Gonsan, J. M., Le Carrou, J., Lenaud, S., Nchot, C., Malateste, K., Yao, A. R., Siloué, B., Clouet, G., Dosso, M., Doring, A., Kouakou, A., Rabourdin, E., Rivenc, J., Anglaret, X., Ba, B., Essanin, J. B., Ciaranello, A., Datté, S., Desmonde, S., Elvis Diby, J. S., Gottlieb, G. S., Horo, A. G., Kangah, S. N., Malvy, D., Meless, D., Mounkaila-Harouna, A., Ndondoki, C., Shiboski, C., Tchounga, B., Thiébaut, R., Wandeler, G., McGowan, C., Cahn, P., Gotuzzo, E., Wolff, M., Grinsztejn, B., Pape, J., Padgett, D. & Madero, J. S. Nov 1 2014 In : International Journal of Tuberculosis and Lung Disease. 18, 11, p. 1327-1336 10 p.

Research output: Research - peer-reviewArticle

Multidrug-Resistant Tuberculosis
HIV
Therapeutics
Tuberculosis
Pharmaceutical Preparations

Diagnostic point-of-care tests in resource-limited settings

Drain, P. K., Hyle, E. P., Noubary, F., Freedberg, K. A., Wilson, D., Bishai, W. R., Rodriguez, W. & Bassett, I. V. Mar 2014 In : Lancet Infectious Diseases. 14, 3, p. 239-249 11 p.

Research output: Research - peer-reviewArticle

Point-of-Care Systems
Point-of-Care Testing
Routine Diagnostic Tests
Costs and Cost Analysis
Clinical Decision Support Systems

Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis

Gupta, S., Cohen, K. A., Winglee, K., Maiga, M., Diarra, B. & Bishai, W. R. Jan 2014 In : Antimicrobial Agents and Chemotherapy. 58, 1, p. 574-576 3 p.

Research output: Research - peer-reviewArticle

bedaquiline
Verapamil
Mycobacterium tuberculosis
Pharmaceutical Preparations
Clofazimine

Expression of a subset of heat stress induced genes of mycobacterium tuberculosis is regulated by 3′,5′-cyclic AMP

Choudhary, E., Bishai, W. & Agarwal, N. Feb 28 2014 In : PLoS One. 9, 2, e89759

Research output: Research - peer-reviewArticle

Mycobacterium tuberculosis
Cyclic AMP
Hot Temperature
Genes
cyclic AMP

In vitro and in vivo studies of a rapid and selective breath test for tuberculosis based upon mycobacterial CO dehydrogenase

Maiga, M., Choi, S. W., Atudorei, V., Maiga, M. C., Sharp, Z. D., Bishai, W. R. & Timmins, G. S. Apr 15 2014 In : mBio. 5, 2, e00990-14

Research output: Research - peer-reviewArticle

carbon monoxide dehydrogenase
Breath Tests
Tuberculosis
In Vitro Techniques
Phenotype

Molecular basis of drug resistance in Mycobacterium tuberculosis

Cohen, K. A., Bishai, W. R. & Pym, A. S. 2014 In : Microbiology spectrum. 2, 3

Research output: Research - peer-reviewArticle

Mycobacterium tuberculosis
Drug Resistance
Tuberculosis
Anti-Bacterial Agents
drug resistance
Peptidyl Transferases
beta-Lactam Resistance
Cell Size
Mycobacterium tuberculosis
Virulence