William Brennen

Assistant Professor

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Prostatic Neoplasms Medicine & Life Sciences
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Prostate Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Tumor Microenvironment Medicine & Life Sciences
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Research Output 2003 2018

Prostatic Neoplasms
Tumor Microenvironment

PSA-alpha-2-macroglobulin complex is enzymatically active in the serum of patients with advanced prostate cancer and can degrade circulating peptide hormones

Kostova, M. B., Brennen, W. N., Lopez, D., Anthony, L., Wang, H., Platz, E. & Denmeade, S. R., Jan 1 2018, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Peptide Hormones
Prostate-Specific Antigen
Prostatic Neoplasms

PSA-selective activation of cytotoxic human serine proteases within the tumor microenvironment as a therapeutic strategy to target prostate cancer

Rogers, O. C., Anthony, L., Rosen, D. M., Brennen, W. N. & Denmeade, S. R., Apr 27 2018, In : Oncotarget. 9, 32, p. 22436-22450 15 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Serine Proteases
Prostate-Specific Antigen
Prostatic Neoplasms
Peptide Hydrolases

The what, when, and why of human prostate cancer xenografts

Brennen, W. N. & Isaacs, J. T. Jan 1 2018 (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Precision Medicine
Genetic Heterogeneity

Cellular Origin of Androgen Receptor Pathway-Independent Prostate Cancer and Implications for Therapy

Brennen, W. N. & Isaacs, J. T., Oct 9 2017, In : Cancer Cell. 32, 4, p. 399-401 3 p.

Research output: Contribution to journalShort survey

Androgen Receptors
Prostatic Neoplasms