William Agnew

Professor

1975 …2007

Research output per year

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Research Output

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Article
2007

Multivariate analysis and visualization of splicing correlations in single-gene transcriptomes

Emerick, M. C., Parmigiani, G. & Agnew, W. S., Feb 19 2007, In : BMC Bioinformatics. 8, 16.

Research output: Contribution to journalArticle

2006

A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies

Zhong, X., Liu, J. R., Kyle, J. W., Hanck, D. A. & Agnew, W. S., May 1 2006, In : Human molecular genetics. 15, 9, p. 1497-1512 16 p.

Research output: Contribution to journalArticle

Profiling the array of Cav3.1 variants from the human T-type calcium channel gene CACNA1G: Alternative structures, developmental expression, and biophysical variations

Emerick, M. C., Stein, R., Kunze, R., McNulty, M. M., Regan, M. R., Hanck, D. A. & Agnew, W. S., Aug 1 2006, In : Proteins: Structure, Function and Genetics. 64, 2, p. 320-342 23 p.

Research output: Contribution to journalArticle

2005
2002

Systematic identification of splice variants in human P/Q-type channel α,2.1 subunits: Implications for current density and Ca2+-dependent inactivation

Soong, T. W., DeMaria, C. D., Alvania, R. S., Zweifel, L. S., Cheng Liang, M., Mittman, S., Agnew, W. S. & Yue, D. T., Dec 1 2002, In : Journal of Neuroscience. 22, 23, p. 10142-10152 11 p.

Research output: Contribution to journalArticle

2000

Full-length single-gene cDNA libraries: Applications in splice variant analysis

Regan, M. R., Emerick, M. C. & Agnew, W. S., Nov 15 2000, In : Analytical biochemistry. 286, 2, p. 265-276 12 p.

Research output: Contribution to journalArticle

1999

Structure and alternative splicing of the gene encoding α(1G), a human brain T calcium channel α1 subunit

Mittman, S., Guo, J. & Agnew, W. S., Oct 29 1999, In : Neuroscience Letters. 274, 3, p. 143-146 4 p.

Research output: Contribution to journalArticle

Structure and alternative splicing of the gene encoding α(1I), a human brain T calcium channel α1 subunit

Mittman, S., Guo, J., Emerick, M. C. & Agnew, W. S., Jul 16 1999, In : Neuroscience Letters. 269, 3, p. 121-124 4 p.

Research output: Contribution to journalArticle

1997

Mechanism of modulation of the voltage-gated skeletal and cardiac muscle sodium channels by fatty acids

Bendahhou, S., Cummins, T. R. & Agnew, W. S., Feb 1 1997, In : American Journal of Physiology - Cell Physiology. 272, 2 41-2, p. C592-C600

Research output: Contribution to journalArticle

The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse

Street, V. A., Bosma, M. M., Demas, V. P., Regan, M. R., Lin, D. D., Robinson, L. C., Agnew, W. S. & Tempel, B. L., Jan 20 1997, In : Journal of Neuroscience. 17, 2, p. 635-645 11 p.

Research output: Contribution to journalArticle

1996
1995

Serine-1321-independent regulation of the μ1 adult skeletal muscle Na+ channel by protein kinase C

Bendahhou, S., Cummins, T. R., Potts, J. F., Tong, J. & Agnew, W. S., Dec 19 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 26, p. 12003-12007 5 p.

Research output: Contribution to journalArticle

1994

A simplified method for single-cell RT-PCR that can detect and distinguish genomic DNA and mRNA transcripts

Tong, J., Bendahhou, S., Chen, H. & Agnew, W. S., Aug 11 1994, In : Nucleic acids research. 22, 15, p. 3253-3254 2 p.

Research output: Contribution to journalArticle

The μI skeletal muscle sodium channel: Mutation E403Q eliminates sensitivity to tetrodotoxin but not to μ-conotoxins GIIIA and GIIIB

Stephan, M. M., Potts, J. F. & Agnew, W. S., Jan 1 1994, In : The Journal of Membrane Biology. 137, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

1993

A glial-specific voltage-sensitive na channel gene maps close to clustered genes for neuronal isoforms on mouse chromosome 2

Potts, J. F., Regan, M. R., Rochelle, J. M., Seldin, M. F. & Agnew, W. S., Nov 30 1993, In : Biochemical and Biophysical Research Communications. 197, 1, p. 100-104 5 p.

Research output: Contribution to journalArticle

A Single B1 Subunit Mapped to Mouse Chromosome 7 May Be a Common Component of Na Channel Isoforms from Brain, Skeletal Muscle and Heart

Tong, J. F., Potts, J. F., Rochelle, J. M., Seldin, M. F. & Agnew, W. S., Sep 15 1993, In : Biochemical and Biophysical Research Communications. 195, 2, p. 679-685 7 p.

Research output: Contribution to journalArticle

Functional consequences of a Na+ channel mutation causing hyperkalemic periodic paralysis

Cummins, T. R., Zhou, J., Sigworth, F. J., Ukomadu, C., Stephan, M., Ptáčk, L. J. & Agnew, W. S., Apr 1993, In : Neuron. 10, 4, p. 667-678 12 p.

Research output: Contribution to journalArticle

Regulation of the Eel Electroplax Na Channel and Phosphorylation of Residues on Amino- and Carboxyl-Terminal Domains by cAMP-Dependent Protein Kinase

Emerick, M. C., Shenkel, S. & Agnew, W. S., Jan 1 1993, In : Biochemistry. 32, 36, p. 9435-9444 10 p.

Research output: Contribution to journalArticle

1992

Assay and purification of neuronal receptors for inositol 1,4,5-trisphosphate

Hingorani, S. R. & Agnew, W. S., Jan 1 1992, In : Methods in enzymology. 207, C, p. 573-591 19 p.

Research output: Contribution to journalArticle

μl Na+ channels expressed transiently in human embryonic kidney cells: Biochemical and biophysical properties

Ukomadu, C., Zhou, J., Sigworth, F. J. & Agnew, W. S., Apr 1992, In : Neuron. 8, 4, p. 663-676 14 p.

Research output: Contribution to journalArticle

1991

Analysis in a large hyperkalemic periodic paralysis pedigree supports tight linkage to a sodium channel locus

Ptacek, L. J., Tyler, F., Trimmer, J. S., Agnew, W. S. & Leppert, M., Dec 1 1991, In : American journal of human genetics. 49, 2, p. 378-382 5 p.

Research output: Contribution to journalArticle

A rapid ion-exchange assay for detergent-solubilized inositol 1,4,5-trisphosphate receptors

Hingorani, S. R. & Agnew, W. S., Apr 1991, In : Analytical biochemistry. 194, 1, p. 204-213 10 p.

Research output: Contribution to journalArticle

Multiple gating modes and the effect of modulating factors on the μI sodium channel

Zhou, J., Potts, J. F., Trimmer, J. S., Agnew, W. S. & Sigworth, F. J., Nov 1991, In : Neuron. 7, 5, p. 775-785 11 p.

Research output: Contribution to journalArticle

Paramyotonia congenita and hyperkalemic periodic paralysis map to the same sodium-channel gene locus

Ptacek, L. J., Trimmer, J. S., Agnew, W. S., Roberts, J. W., Petajan, J. H. & Leppert, M., Oct 16 1991, In : American journal of human genetics. 49, 4, p. 851-854 4 p.

Research output: Contribution to journalArticle

Voltage-sensitive Na+ channels: motifs, modes and modulation

Stephan, M. & Agnew, W. S., Aug 1991, In : Current Opinion in Cell Biology. 3, 4, p. 676-684 9 p.

Research output: Contribution to journalArticle

Voltage‐Sensitive Sodium Channelsg: Agents That Perturb Inactivation Gating

AGNEW, W. S., COOPER, E. C., SHENKEL, S., CORREA, A. M., JAMES, W. M., UKOMADU, C. & TOMIKO, S. A., Jun 1991, In : Annals of the New York Academy of Sciences. 625, 1, p. 200-223 24 p.

Research output: Contribution to journalArticle

1990

Regulation of muscle sodium channel transcripts during development and in response to denervation

Trimmer, J. S., Cooperman, S. S., Agnew, W. S. & Mandel, G., Dec 1990, In : Developmental biology. 142, 2, p. 360-367 8 p.

Research output: Contribution to journalArticle

Voltage Activation of Purified Eel Sodium Channels Reconstituted into Artificial Liposomes

Correa, A. M., Bezanilla, F. & Agnew, W. S., Jul 1 1990, In : Biochemistry. 29, 26, p. 6230-6240 11 p.

Research output: Contribution to journalArticle

1989

Affinity Purification of the Voltage-Sensitive Sodium Channel from Electroplax with Resins Selective for Sialic Acid

James, W. M., Emerick, M. C. & Agnew, W. S., Jul 1 1989, In : Biochemistry. 28, 14, p. 6001-6009 9 p.

Research output: Contribution to journalArticle

Primary structure and functional expression of a mammalian skeletal muscle sodium channel

Trimmer, J. S., Cooperman, S. S., Tomiko, S. A., Zhou, J., Crean, S. M., Boyle, M. B., Kalen, R. G., Sheng, Z., Barchi, R. L., Sigworth, F. J., Goodman, R. H., Agnew, W. S. & Mandel, G., Jul 1989, In : Neuron. 3, 1, p. 33-49 17 p.

Research output: Contribution to journalArticle

Purified, modified eel sodium channels are active in planar bilayers in the absence of activating neurotoxins

Shenkel, S., Cooper, E. C., James, W., Agnew, W. S. & Sigworth, F. J., Dec 22 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 23, p. 9592-9596 5 p.

Research output: Contribution to journalArticle

1988

A Rosetta stone for K channels

Agnew, W. S., Jan 1 1988, In : Nature. 331, 6152, p. 114-115 2 p.

Research output: Contribution to journalArticle

Dual roles for DHP receptors in excitation-contraction coupling?

Agnew, W. S., Dec 1 1988, In : Nature. 328, 6128, 1 p.

Research output: Contribution to journalArticle

Fusion of native or reconstituted membranes to liposomes, optimized for single channel recording

Correa, A. M. & Agnew, W. S., Jan 1 1988, In : Biophysical journal. 54, 3, p. 569-575 7 p.

Research output: Contribution to journalArticle

Open Access

Voltage-Sensitive Sodium Channels: Molecular Structure and Function

Agnew, W. S., Cooper, E. C., James, W. M., Tomiko, S. A., Rosenberg, R. L., Emerick, M. C., Correa, A. M. & Zhou, J. Y., Jan 1988, In : Current Topics in Membranes and Transport. 33, C, p. 329-365 37 p.

Research output: Contribution to journalArticle

1987

Hydrodynamic Properties of the Chromaffin Granule Hydrogen Ion Pumping Adenosinetriphosphatase

Dean, G. E., Rudnic, G., Agnew, W. & Nelson, P. J., Jan 1 1987, In : Biochemistry. 26, 8, p. 2301-2305 5 p.

Research output: Contribution to journalArticle

Molecular Weight and Hydrodynamic Properties of the Chromaffin Granule ATPase

DEAN, GARY. E., NELSON, PAMLEA. J., Agnew, W. & RUDNICK, GARY., 1987, In : Annals of the New York Academy of Sciences. 493, 1, p. 268-269 2 p.

Research output: Contribution to journalArticle

Open Access
1986

Fluorescence Assay for Neurotoxin-Modulated Ion Transport by the Reconstituted Voltage-Activated Sodium Channel Isolated from Eel Electric Organ

Tomiko, S. A., Rosenberg, R. L., Emerick, M. C. & Agnew, W. S., Apr 1986, In : Biochemistry. 25, 8, p. 2162-2174 13 p.

Research output: Contribution to journalArticle

Neurochemistry: Lessons from large molecules

Agnew, W. S., Dec 1 1986, In : Nature. 322, 6082, p. 770-771 2 p.

Research output: Contribution to journalArticle

The Structure and Function of the Voltage‐Sensitive Na Channel

AGNEW, W. S., TOMIKO, S. A., ROSENBERG, R. L., EMERICK, M. C. & COOPER, E. C., Dec 1986, In : Annals of the New York Academy of Sciences. 479, 1, p. 238-256 19 p.

Research output: Contribution to journalArticle

1985

[41] Squalene synthetase

Agnew, W. S., Jan 1 1985, In : Methods in Enzymology. 110, C, p. 359-373 15 p.

Research output: Contribution to journalArticle

1984
Open Access
Open Access

Voltage-regulated sodium channel molecules

Agnew, W. S., Jan 1 1984, In : Annual review of physiology. VOL. 46, p. 517-530 14 p.

Research output: Contribution to journalArticle