Wenbing Xie

Research Associate

20122020

Research output per year

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Research Output

2020

Epigenetic therapy inhibits metastases by disrupting premetastatic niches

Lu, Z., Zou, J., Li, S., Topper, M. J., Tao, Y., Zhang, H., Jiao, X., Xie, W., Kong, X., Vaz, M., Li, H., Cai, Y., Xia, L., Huang, P., Rodgers, K., Lee, B., Riemer, J. B., Day, C. P., Yen, R. W. C., Cui, Y. & 28 others, Wang, Y., Wang, Y., Zhang, W., Easwaran, H., Hulbert, A., Kim, K. B., Juergens, R. A., Yang, S. C., Battafarano, R. J., Bush, E. L., Broderick, S. R., Cattaneo, S. M., Brahmer, J. R., Rudin, C. M., Wrangle, J., Mei, Y., Kim, Y. J., Zhang, B., Wang, K. K. H., Forde, P. M., Margolick, J. B., Nelkin, B. D., Zahnow, C. A., Pardoll, D. M., Housseau, F., Baylin, S. B., Shen, L. & Brock, M. V., Mar 12 2020, In : Nature. 579, 7798, p. 284-290 7 p.

Research output: Contribution to journalArticle

2019

Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf V600E -Induced Tumorigenesis

Tao, Y., Kang, B., Petkovich, D. A., Bhandari, Y. R., In, J., Stein-O'Brien, G., Kong, X., Xie, W., Zachos, N., Maegawa, S., Vaidya, H., Brown, S., Chiu Yen, R. W., Shao, X., Thakor, J., Lu, Z., Cai, Y., Zhang, Y., Mallona, I., Peinado, M. A. & 6 others, Zahnow, C. A., Ahuja, N., Fertig, E., Issa, J. P., Baylin, S. B. & Easwaran, H., Feb 11 2019, In : Cancer cell. 35, 2, p. 315-328.e6

Research output: Contribution to journalArticle

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

Kong, X., Chen, J., Xie, W., Brown, S. M., Cai, Y., Wu, K., Fan, D., Nie, Y., Yegnasubramanian, S., Tiedemann, R. L., Tao, Y., Chiu Yen, R. W., Topper, M. J., Zahnow, C. A., Easwaran, H., Rothbart, S. B., Xia, L. & Baylin, S. B., Apr 15 2019, In : Cancer cell. 35, 4, p. 633-648.e7

Research output: Contribution to journalArticle

2018

Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1

Ye, F., Kong, X., Zhang, H., Liu, Y., Shao, Z., Jin, J., Cai, Y., Zhang, R., Li, L., Zhang, Y., Liu, Y. C., Zhang, C., Xie, W., Yu, K., Ding, H., Zhao, K., Chen, S., Jiang, H., Baylin, S. B. & Luo, C., Mar 16 2018, In : ACS Chemical Biology. 13, 3, p. 772-781 10 p.

Research output: Contribution to journalArticle

DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk

Xie, W., Kagiampakis, I., Pan, L., Zhang, Y., Murphy, L., Tao, Y., Kong, X., Kang, B., Xia, L., Carvalho, F. L. F., Sen, S., Yen, R-W., Zahnow, C., Ahuja, N., Baylin, S. B. & Easwaran, H., Feb 12 2018, In : Cancer Cell. 33, 2, p. 309-321.e5

Research output: Contribution to journalArticle

Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase i transcriptional elongation

Lyu, G., Zong, L., Zhang, C., Huang, X., Xie, W., Fang, J., Guan, Y., Zhang, L., Ni, T., Gu, J. & Tao, W., Mar 21 2018, In : Journal of molecular cell biology. 11, 1, p. 78-90 13 p.

Research output: Contribution to journalArticle

2017

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

Zhang, Y., Wang, Z., Xie, W., Cai, Y., Xia, L., Easwaran, H., Luo, J., Yen, R-W., Li, Y. & Baylin, S. B., Jan 19 2017, In : Molecular Cell. 65, 2, p. 323-335 13 p.

Research output: Contribution to journalArticle

CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes

Xia, L., Huang, W., Bellani, M., Seidman, M. M., Wu, K., Fan, D., Nie, Y., Cai, Y., Zhang, Y. W., Yu, L. R., Li, H., Zahnow, C. A., Xie, W., Chiu Yen, R. W., Rassool, F. V. & Baylin, S. B., May 8 2017, In : Cancer cell. 31, 5, p. 653-668.e7

Research output: Contribution to journalArticle

2016

DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation

Huang, S., Xu, X., Wang, G., Lu, G., Xie, W., Tao, W., Zhang, H., Jiang, Q. & Zhang, C., Apr 1 2016, In : Journal of Cell Science. 129, 7, p. 1429-1440 12 p.

Research output: Contribution to journalArticle

2015

Heterochromatin remodeling by CDK12 contributes to learning in Drosophila

Pan, L., Xie, W., Li, K. L., Yang, Z., Xu, J., Zhang, W., Liu, L. P., Ren, X., He, Z., Wu, J., Sun, J., Wei, H. M., Wang, D., Xie, W., Li, W., Ni, J. Q. & Sun, F. L., Nov 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 45, p. 13988-13993 6 p.

Research output: Contribution to journalArticle

Open Access
2013

CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5

Ling, T., Xie, W., Luo, M., Shen, M., Zhu, Q., Zong, L., Zhou, T., Gu, J., Lu, Z., Zhang, F. & Tao, W., Jul 19 2013, In : Biochemical and Biophysical Research Communications. 437, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

NuRD blocks reprogramming of mouse somatic cells into Pluripotent stem cells

Luo, M., Ling, T., Xie, W., Sun, H., Zhou, Y., Zhu, Q., Shen, M., Zong, L., Lyu, G., Zhao, Y., Ye, T., Gu, J., Tao, W., Lu, Z. & Grummt, I., Jul 1 2013, In : Stem Cells. 31, 7, p. 1278-1286 9 p.

Research output: Contribution to journalArticle

The Chromatin Remodeling Factor CSB Recruits Histone Acetyltransferase PCAF to rRNA Gene Promoters in Active State for Transcription Initiation

Shen, M., Zhou, T., Xie, W., Ling, T., Zhu, Q., Zong, L., Lyu, G., Gao, Q., Zhang, F. & Tao, W., May 7 2013, In : PloS one. 8, 5, e62668.

Research output: Contribution to journalArticle

2012

The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions

Xie, W., Ling, T., Zhou, Y., Feng, W., Zhu, Q., Stunnenberg, H. G., Grummt, I. & Tao, W., May 22 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 21, p. 8161-8166 6 p.

Research output: Contribution to journalArticle