Weiran Chen

Research Associate

19982019
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Research Output 1998 2019

2019

Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging

Jha, M. K., Lee, Y., Russell, K. A., Yang, F., Dastgheyb, R. M., Deme, P., Ament, X. H., Chen, W., Liu, Y., Guan, Y., Polydefkis, M. J., Hoke, A., Haughey, N. J., Rothstein, J. D. & Morrison, B. M., Jan 1 2019, (Accepted/In press) In : Glia.

Research output: Contribution to journalArticle

Schwann Cells
Maintenance
Peripheral Nerves
Myelin-Associated Glycoprotein
Nerve Growth Factor Receptor
2018

Different ketogenesis strategies lead to disparate seizure outcomes

Dolce, A., Santos, P., Chen, W., Hoke, A. & Hartman, A. L., Jul 1 2018, In : Epilepsy Research. 143, p. 90-97 8 p.

Research output: Contribution to journalArticle

Ketogenic Diet
Seizures
Respiration
Kainic Acid
Diet
2014

Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

Kageyama, Y., Hoshijima, M., Seo, K., Bedja, D., Sysa-Shah, P., Andrabi, S. A., Chen, W., Hoke, A., Dawson, V., Dawson, T. M., Gabrielson, K. L., Kass, D. A., Iijima, M. & Sesaki, H., Dec 1 2014, In : The EMBO journal. 33, 23, p. 2798-2813 16 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondria
Brain
Ubiquitination
Mitochondrial Dynamics
2013

Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation

Zhu, J., Chen, W., Mi, R., Zhou, C., Reed, N. & Hoke, A., Dec 2013, In : Annals of Neurology. 74, 6, p. 893-904 12 p.

Research output: Contribution to journalArticle

Ethoxyquin
HSP90 Heat-Shock Proteins
Drug Therapy
Paclitaxel
Peripheral Nervous System Diseases
2012

Human schwann cells retain essential phenotype characteristics after immortalization

Lehmann, H. C., Chen, W., Mi, R., Wang, S., Liu, Y., Rao, M. & Hoke, A., Feb 10 2012, In : Stem Cells and Development. 21, 3, p. 423-431 9 p.

Research output: Contribution to journalArticle

Schwann Cells
Phenotype
Extracellular Matrix
Oxidative Stress
Cell Culture Techniques
2011

Mitochondrial dysfunction in distal axons contributes to human immunodeficiency virus sensory neuropathy

Lehmann, H. C., Chen, W., Borzan, J., Mankowski, J. L. & Hoke, A., Jan 2011, In : Annals of Neurology. 69, 1, p. 100-110 11 p.

Research output: Contribution to journalArticle

Axons
Mitochondrial DNA
HIV
Sural Nerve
Sequence Deletion
2007
Spinal Ganglia
TRPV Cation Channels
Preclinical Drug Evaluations
Adenosine Triphosphate
High-Throughput Screening Assays
Nerve Growth Factors
Motor Neurons
Regeneration
Denervation
Sciatic Nerve
2006

Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-associated sensory neuropathy

Melli, G., Keswani, S. C., Fischer, A., Chen, W. & Hoke, A., May 2006, In : Brain. 129, 5, p. 1330-1338 9 p.

Research output: Contribution to journalArticle

HIV
Chemokine Receptors
Axons
Polyneuropathies
Virus Diseases
2003

Unexpected T-cell diversity in syngeneic graft-versus-host disease revealed by interaction with peptide-loaded soluble mhc class II molecules

Hess, A. D., Thoburn, C. J., Chen, W. & Bright, E. C., Apr 27 2003, In : Transplantation. 75, 8, p. 1361-1367 7 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
T-Lymphocytes
Peptides
Immunoglobulin Isotypes
T-Cell Antigen Receptor
2002

Cytokine and chemokine profiles in autologous graft-versus-host disease (GVHD): Interleukin 10 and interferon γ may be critical mediators for the development of autologous GVHD

Miura, Y., Thoburn, C. J., Bright, E. C., Chen, W., Nakao, S. & Hess, A. D., Oct 1 2002, In : Blood. 100, 7, p. 2650-2658 9 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Chemokines
Grafts
Interleukin-10
Interferons

Oligoclonal expansion of T cell receptor V beta 2 and 3 cells in the livers of mice with graft-versus-host disease

Chen, W. & Howell, C. D., 2002, In : Hepatology. 35, 1, p. 23-29 7 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
T-Cell Antigen Receptor
Liver
T-Lymphocytes
Minor Histocompatibility Antigens
2001

Autoimmune-mediated vasculopathy

Chen, W., Thoburn, C. J., Miura, Y., Sommer, M., Hruban, R. H., Qian, Z., Baldwin, W. & Hess, A. D., 2001, In : Clinical Immunology. 100, 1, p. 57-70 14 p.

Research output: Contribution to journalArticle

Cyclosporine
T-Lymphocytes
Transplants
Endothelial Cells
Cytokines

Autoreactive T-Cell subsets in acute and chronic syngeneic graft-versus-host disease

Hess, A., Thoburn, C., Chen, W. & Horwitz, L., 2001, In : Transplantation Proceedings. 33, 1-2, p. 1754-1756 3 p.

Research output: Contribution to journalArticle

Immunologic Cytotoxicity
Inbred Lew Rats
Isogeneic Transplantation
Histocompatibility Antigens Class II
T-Lymphocyte Subsets
Neoplasm Antigens
Allergy and Immunology
Epitopes
Peptides
invariant chain

The N-terminal flanking region of the invariant chain peptide augments the immunogenicity of a cryptic "self" epitope from a tumor-associated antigen

Hess, A. D., Thoburn, C., Chen, W., Miura, Y. & Van Der Wall, E., 2001, In : Clinical Immunology. 101, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

Neoplasm Antigens
Epitopes
Peptides
Immunization
Immunity
2000
Graft vs Host Disease
Cyclosporine
Cytokines
T-Lymphocytes
Clone Cells
1999

Pathogenic specificity of effector T lymphocytes in syngeneic graft- versus-host disease

Thoburn, C., Chen, W., Horwitz, L. & Hess, A., Feb 1999, In : Transplantation Proceedings. 31, 1-2, p. 684-686 3 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Inbred Lew Rats
Isogeneic Transplantation
Antigen Receptors, T-Cell, alpha-beta
Peptide Fragments
Lymphocyte Function-Associated Antigen-1
Cholangitis
Graft vs Host Disease
Intercellular Adhesion Molecule-1
Bile Ducts
1998

Characterization of the pathogenic autoreactive T cells in cyclosporine- induced syngeneic graft-versus-host disease

Chen, W., Thoburn, C. & Hess, A. D., Dec 15 1998, In : Journal of Immunology. 161, 12, p. 7040-7046 7 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Cyclosporine
Clone Cells
T-Lymphocytes
Isogeneic Transplantation