Wei Dong Gao

Associate Professor

1989 …2020

Research output per year

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Research Output

2020

Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy

Huang, Y., Lu, H., Ren, X., Li, F., Bu, W., Liu, W., Dailey, W. P., Saeki, H., Gabrielson, K., Abraham, R., Eckenhoff, R. & Gao, W. D., May 1 2020, In : Cardiovascular research. 116, 6, p. 1175-1185 11 p.

Research output: Contribution to journalArticle

2019

Anesthetic Agents Isoflurane and Propofol Decrease Maximal Ca2+-Activated Force and Thus Contractility in the Failing Myocardium

Meng, T., Ren, X., Chen, X., Yu, J., Agrimi, J., Paolocci, N. & Gao, W. D., Dec 1 2019, In : The Journal of pharmacology and experimental therapeutics. 371, 3, p. 615-623 9 p.

Research output: Contribution to journalArticle

Right heart in pulmonary hypertension: from adaptation to failure

Ren, X., Johns, R. A. & Gao, W. D., Jul 1 2019, In : Pulmonary Circulation. 9, 3

Research output: Contribution to journalReview article

Open Access
2018

Fropofol decreases force development in cardiac muscle

Ren, X., Schmidt, W., Huang, Y., Lu, H., Liu, W., Bu, W., Eckenhoff, R., Cammarato, A. & Gao, W. D., Aug 2018, In : FASEB Journal. 32, 8, p. 4203-4213 11 p.

Research output: Contribution to journalArticle

2017

Involvement of glycogen synthase kinase-3β in liver ischemic conditioning induced cardioprotection against myocardial ischemia and reperfusion injury in rats

Yang, S., Abbott, G. W., Gao, W. D., Liu, J., Luo, C. & Hu, Z., May 1 2017, In : Journal of Applied Physiology. 122, 5, p. 1095-1105 11 p.

Research output: Contribution to journalArticle

2016

Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways

Sysa-Shah, P., Tocchetti, C. G., Gupta, M., Rainer, P. P., Shen, X., Kang, B. H., Belmonte, F., Li, J., Xu, Y., Guo, X., Bedja, D., Gao, W. D., Paolocci, N., Rath, R., Sawyer, D. B., Naga Prasad, S. V. & Gabrielson, K., Mar 1 2016, In : Cardiovascular research. 109, 3, p. 358-373 16 p.

Research output: Contribution to journalArticle

Force development and intracellular Ca2+ in intact cardiac muscles from gravin mutant mice

Li, Z., Singh, S., Suryavanshi, S. V., Ding, W., Shen, X., Wijaya, C. S., Gao, W. D. & McConnell, B. K., Jul 27 2016, (Accepted/In press) In : European Journal of Pharmacology.

Research output: Contribution to journalArticle

Molecular mechanism of anesthetic-induced depression of myocardial contraction

Meng, T., Bu, W., Ren, X., Chen, X., Yu, J., Eckenhoff, R. G. & Gao, W. D., Aug 1 2016, In : FASEB Journal. 30, 8, p. 2915-2925 11 p.

Research output: Contribution to journalArticle

2015

5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Promotes Phenotypic Switching from Dedifferentiated to Differentiated Phenotype via Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase in Vascular Smooth Muscle Cells

Dan, J., Sun, X., Li, W., Zhang, Y., Li, X., Xu, H., Li, Z., Tian, Z., Guo, S., Yao, J., Gao, W. & Tian, Y., Jun 1 2015, In : Ultrasound in Medicine and Biology. 41, 6, p. 1681-1689 9 p.

Research output: Contribution to journalArticle

Cardiac troponin i Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativity

Ramirez-Correa, G. A., Frazier, A. H., Zhu, G., Zhang, P., Rappold, T., Kooij, V., Bedja, D., Snyder, G. A., Lugo-Fagundo, N. S., Hariharan, R., Li, Y., Shen, X., Gao, W. D., Cingolani, O. H., Takimoto, E., Foster, D. B. & Murphy, A. M., Jan 15 2015, In : Journal of applied physiology. 118, 2, p. 212-223 12 p.

Research output: Contribution to journalArticle

Removal of abnormal myofilament O-GlcNAcylation restores Ca2+ sensitivity in diabetic cardiac muscle

Ramirez-Correa, G. A., Ma, J., Slawson, C., Zeidan, Q., Lugo-Fagundo, N. S., Xu, M., Shen, X., Gao, W. D., Caceres, V., Chakir, K., DeVine, L., Cole, R. N., Marchionni, L., Paolocci, N., Hart, G. W. & Murphy, A. M., Oct 2015, In : Diabetes. 64, 10, p. 3573-3587 15 p.

Research output: Contribution to journalArticle

Restoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose

Bhatt, N. M., Aon, M. A., Tocchetti, C. G., Shen, X., Dey, S., Ramirez-Correa, G., Rourke, B., Gao, W. D. & Cortassa, S., Jan 1 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 4, p. H291-H302

Research output: Contribution to journalArticle

Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition

Woll, K. A., Weiser, B. P., Liang, Q., Meng, T., McKinstry-Wu, A., Pinch, B., Dailey, W. P., Gao, W. D., Covarrubias, M. & Eckenhoff, R. G., Jun 17 2015, In : ACS Chemical Neuroscience. 6, 6, p. 927-935 9 p.

Research output: Contribution to journalArticle

2014

Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3?

Kirk, J. A., Holewinski, R. J., Kooij, V., Agnetti, G., Tunin, R. S., Witayavanitkul, N., De Tombe, P. P., Gao, W. D., Van Eyk, J. & Kass, D. A., Jan 2 2014, In : Journal of Clinical Investigation. 124, 1, p. 129-139 11 p.

Research output: Contribution to journalArticle

Effect of isoflurane on myocardial energetic and oxidative stress in cardiac muscle from Zucker diabetic fatty rat

Shen, X., Bhatt, N., Xu, J., Meng, T., Aon, M. A., O'Rourke, B., Berkowitz, D. E., Cortassa, S. & Gao, W. D., Apr 2014, In : Journal of Pharmacology and Experimental Therapeutics. 349, 4, p. 21-28 8 p.

Research output: Contribution to journalArticle

Low molecular weight fucoidan alleviates cardiac dysfunction in diabetic goto-kakizaki rats by reducing oxidative stress and cardiomyocyte apoptosis

Yu, X., Zhang, Q., Cui, W., Zeng, Z., Yang, W., Zhang, C., Zhao, H., Gao, W., Wang, X. & Luo, D., 2014, In : Journal of diabetes research. 2014, 420929.

Research output: Contribution to journalArticle

Low-molecular-weight fucoidan protects endothelial function and ameliorates basal hypertension in diabetic Goto-Kakizaki rats

Cui, W., Zheng, Y., Zhang, Q., Wang, J., Wang, L., Yang, W., Guo, C., Gao, W., Wang, X. & Luo, D., Apr 2014, In : Laboratory Investigation. 94, 4, p. 382-393 12 p.

Research output: Contribution to journalArticle

2013

Endocardial endothelium is a key determinant of force-frequency relationship in rat ventricular myocardium

Shen, X., Tan, Z., Zhong, X., Tian, Y., Wang, X., Yu, B., Ramirez-Correa, G., Murphy, A., Gabrielson, K., Paolocci, N. & Gao, W. D., Aug 1 2013, In : Journal of applied physiology. 115, 3, p. 383-393 11 p.

Research output: Contribution to journalArticle

2012

Case 1 - 2012 - A perfect storm: Fatality resulting from metoclopramide unmasking a pheochromocytoma and its management

Sheinberg, R., Gao, W. D., Wand, G., Abraham, S., Schulick, R., Roy, R. & Mitter, N., Feb 1 2012, In : Journal of cardiothoracic and vascular anesthesia. 26, 1, p. 161-165 5 p.

Research output: Contribution to journalArticle

Congestive heart failure

Coleman, J. F. & Gao, W. D., Oct 31 2012, 5-Minute Anesthesia Consult. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function

Gao, W. D., Murray, C. I., Tian, Y., Zhong, X., Dumond, J. F., Shen, X., Stanley, B. A., Brian Foster, D., Wink, D. A., Bruce King, S., Van Eyk, J. E. & Paolocci, N., Sep 1 2012, In : Circulation research. 111, 8, p. 1002-1011 10 p.

Research output: Contribution to journalArticle

2011

Playing with cardiac redox switches: The HNO way to modulate cardiac function

Tocchetti, C. G., Stanley, B. A., Murray, C. I., Sivakumaran, V., Donzelli, S., Mancardi, D., Pagliaro, P., Gao, W. D., Van Eyk, J., Kass, D. A., Wink, D. A. & Paolocci, N., May 1 2011, In : Antioxidants and Redox Signaling. 14, 9, p. 1687-1698 12 p.

Research output: Contribution to journalArticle

Reversal of isoflurane-induced depression of myocardial contraction by nitroxyl via myofilament sensitization to Ca 2+

Ding, W., Li, Z., Shen, X., Martin, J., King, S. B., Sivakumaran, V., Paolocci, N. & Gao, W. D., Dec 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 339, 3, p. 825-831 7 p.

Research output: Contribution to journalArticle

2010

Calcium sensitivity, force frequency relationship and cardiac troponin I: Critical role of PKA and PKC phosphorylation sites

Ramirez-Correa, G. A., Cortassa, S., Stanley, B., Gao, W. D. & Murphy, A. M., May 1 2010, In : Journal of Molecular and Cellular Cardiology. 48, 5, p. 943-953 11 p.

Research output: Contribution to journalArticle

Long-term effects of oxypurinol on oxidative modification of actin and myocardial contractility in mice with heart failure

Tan, Z., Zhang, Z., Dai, Q. Y., Zhang, J. J. & Gao, W. D., Feb 1 2010, In : Journal of Shanghai Jiaotong University (Medical Science). 30, 2, p. 174-179 6 p.

Research output: Contribution to journalArticle

Nitroxyl enhances myocyte Ca2+ transients by exclusively targeting SR Ca2+-cycling

Kohr, M. J., Kaludercic, N., Tocchetti, C. G., Gao, W. D., Kass, D. A., Janssen, P. M. L., Paolocci, N. & Ziolo, M. T., Jan 1 2010, In : Frontiers in Bioscience - Elite. 2 E, 2, p. 614-626 13 p.

Research output: Contribution to journalArticle

2009

Preservation of cardiac contractility after long-term therapy with oxypurinol in post-ischemic heart failure in mice

Tan, Z., Dai, T., Zhong, X., Tian, Y., Leppo, M. K. & Gao, W. D., Oct 25 2009, In : European Journal of Pharmacology. 621, 1-3, p. 71-77 7 p.

Research output: Contribution to journalArticle

2008

O-linked GlcNAc modification of cardiac myofilament proteins: A novel regulator of myocardial contractile function

Ramirez-Correa, G. A., Jin, W., Wang, Z., Zhong, X., Gao, W. D., Dias, W. B., Vecoli, C., Hart, G. W. & Murphy, A. M., Dec 5 2008, In : Circulation research. 103, 12, p. 1354-1358 5 p.

Research output: Contribution to journalArticle

2007

Heart failure-associated alterations in troponin I phosphorylation impair ventricular relaxation-afterload and force-frequency responses and systolic function

Bilchick, K. C., Duncan, J. G., Ravi, R., Takimoto, E., Champion, H. C., Wei, D. G., Stull, L. B., Kass, D. A. & Murphy, A. M., Jan 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 1, p. H318-H325

Research output: Contribution to journalArticle

Local control in thin filament activation of cardiac muscle

Gao, W. D. & Murphy, A. M., Apr 15 2007, In : Journal of Physiology. 580, 2, 1 p.

Research output: Contribution to journalArticle

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling

Tocchetti, C. G., Wang, W., Froehlich, J. P., Huke, S., Aon, M. A., Wilson, G. M., Di Benedetto, G., O'Rourke, B., Gao, W. D., Wink, D. A., Toscano, J. P., Zaccolo, M., Bers, D. M., Valdivia, H. H., Cheng, H., Kass, D. A. & Paolocci, N., Jan 1 2007, In : Circulation research. 100, 1, p. 96-104 9 p.

Research output: Contribution to journalArticle

Nitroxyl increases force development in rat cardiac muscle

Dai, T., Tian, Y., Tocchetti, C. G., Katori, T., Murphy, A. M., Kass, D. A., Paolocci, N. & Gao, W. D., May 1 2007, In : Journal of Physiology. 580, 3, p. 951-960 10 p.

Research output: Contribution to journalArticle

2006

Apelin increases contractility in failing cardiac muscle

Dai, T., Ramirez-Correa, G. & Gao, W. D., Dec 28 2006, In : European Journal of Pharmacology. 553, 1-3, p. 222-228 7 p.

Research output: Contribution to journalArticle

Increased cross-bridge cycling rate in stunned myocardium

Wei, D. G., Dai, T. & Nyhan, D., Feb 1 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 290, 2, p. H886-H893

Research output: Contribution to journalArticle

2004

Chronic treatment with allopurinol boosts survival and cardiac contractility in murine postischemic cardiomyopathy

Stull, L. B., Leppo, M. K., Szweda, L., Gao, W. D. & Marbán, E., Nov 12 2004, In : Circulation research. 95, 10, p. 1005-1011 7 p.

Research output: Contribution to journalArticle

2001

Myocardial stunning and preconditioning: Potential clinical implications

Gao, W. D. & Marbán, E., Jan 1 2001, In : Problems in Anesthesia. 13, 2, p. 172-180 9 p.

Research output: Contribution to journalReview article

1999

Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy

Gao, W. D., Pérez, N. G., Seidman, C. E., Seidman, J. G. & Marbán, E., Mar 1999, In : Journal of Clinical Investigation. 103, 5, p. 661-666 6 p.

Research output: Contribution to journalArticle

Open Access
1998

Calcium cycling and contractile activation in intact mouse cardiac muscle

Gao, W. D., Perez, N. G. & Marban, E., Feb 15 1998, In : Journal of Physiology. 507, 1, p. 175-184 10 p.

Research output: Contribution to journalArticle

Novel myofilament Ca2+-sensitizing property of xanthine oxidase inhibitors

Pérez, N. G., Gao, W. D. & Marbán, E., Aug 24 1998, In : Circulation research. 83, 4, p. 423-430 8 p.

Research output: Contribution to journalArticle

Open Access
1997

Ca2+ 'sparks' and waves in intact ventricular muscle resolved by confocal imaging

Wier, W. G., Ter Keurs, H. E. D. J., Marban, E., Gao, W. D. & Balke, C. W., Jan 1 1997, In : Circulation research. 81, 4, p. 462-469 8 p.

Research output: Contribution to journalArticle

Role of troponin I proteolysis in the pathogenesis of stunned myocardium

Gao, W. D., Atar, D., Liu, Y., Perez, N. G., Murphy, A. M. & Marban, E., Mar 8 1997, In : Circulation research. 80, 3, p. 393-399 7 p.

Research output: Contribution to journalArticle

1996

Cell-type specificity of preconditioning in an in vitro model

Liu, Y., Gao, W. D., O'Rourke, B. & Marban, E., Nov 1 1996, In : Basic Research in Cardiology. 91, 6, p. 450-457 8 p.

Research output: Contribution to journalArticle

Force-frequency response in isoproterenol-induced hypertrophied rat heart

Tang, L., Gao, W. & Taylor, P. B., Dec 30 1996, In : European Journal of Pharmacology. 318, 2-3, p. 349-356 8 p.

Research output: Contribution to journalArticle

Intrinsic Myofilament Alterations Underlying the Decreased Contractility of Stunned Myocardium: A Consequence of Ca2+-Dependent Proteolysis?

Gao, W. D., Liu, Y., Mellgren, R. & Marban, E., Mar 1 1996, In : Circulation research. 78, 3, p. 455-465 11 p.

Research output: Contribution to journalArticle

Selective effects of oxygen free radicals on excitation-contraction coupling in ventricular muscle: Implications for the mechanism of stunned myocardium

Gao, W. D., Liu, Y. & Marban, E., Jan 1 1996, In : Circulation. 94, 10, p. 2597-2604 8 p.

Research output: Contribution to journalArticle

Synergistic modulation of ATP-sensitive K+ currents by protein kinase C and adenosine: Implications for ischemic preconditioning

Liu, Y., Gao, W. D., O'Rourke, B. & Marban, E., Mar 1996, In : Circulation research. 78, 3, p. 443-454 12 p.

Research output: Contribution to journalArticle

1995

Alterations of excitation-contraction coupling in stunned myocardium and in failing myocardium

Atar, D., Gao, W. D. & Marban, E., Feb 1995, In : Journal of Molecular and Cellular Cardiology. 27, 2, p. 783-791 9 p.

Research output: Contribution to journalArticle

Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channels

Atar, D., Backx, P. H., Appel, M. M., Gao, W. D. & Marban, E., Feb 10 1995, In : Journal of Biological Chemistry. 270, 6, p. 2473-2477 5 p.

Research output: Contribution to journalArticle

Open Access