Research output per year
Research output per year
- 1 - 50 out of 69 results
Search results
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2022
Mutant VPS35-D620N induces motor dysfunction and impairs DAT-mediated dopamine recycling pathway
Huang, Y., Huang, H., Zhou, L., Li, J., Chen, X., Thomas, J., He, X., Guo, W., Zeng, Y., Low, B. C., Liang, F., Zeng, J., Ross, C. A., Tan, E. K., Smith, W. & Pei, Z., Nov 15 2022, In: Human molecular genetics. 31, 22, p. 3886-3896 11 p.Research output: Contribution to journal › Article › peer-review
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VPS35 Protects Against TMEM230-mutation-induced Progressive Locomotor Deficits in Drosophila
Ma, C., Wang, X., Smith, W. W. & Liu, Z., Jun 2022, In: Neuroscience Bulletin. 38, 6, p. 652-656 5 p.Research output: Contribution to journal › Letter › peer-review
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2021
Activation of nrf2 in astrocytes suppressed pd‐like phenotypes via antioxidant and autophagy pathways in rat and drosophila models
Guo, Q., Wang, B., Wang, X., Smith, W. W., Zhu, Y. & Liu, Z., Aug 2021, In: Cells. 10, 8, 1850.Research output: Contribution to journal › Article › peer-review
Open Access -
A lrrk2 gtp binding inhibitor, 68, reduces lps‐induced signaling events and tnf‐α release in human lymphoblasts
Li, T., Ning, B., Kong, L., Dai, B., He, X., Thomas, J. M., Sawa, A., Ross, C. A. & Smith, W. W., Feb 2021, In: Cells. 10, 2, p. 1-12 12 p., 480.Research output: Contribution to journal › Article › peer-review
Open Access -
AMPK signaling mediates synphilin-1-induced hyperphagia and obesity in Drosophila
Liu, J., Wang, X., Ma, R., Li, T., Guo, G., Ning, B., Moran, T. H. & Smith, W. W., Feb 2021, In: Journal of cell science. 134, 3, jcs247742.Research output: Contribution to journal › Article › peer-review
Open Access -
Cell cytoskeleton and proliferation study for the RANKL-induced RAW264.7 differentiation
Kong, L., Ma, R., Cao, Y., Smith, W., Liu, Y., Yang, X. & Yan, L., May 2021, In: Journal of Cellular and Molecular Medicine. 25, 10, p. 4649-4657 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Controversy of TMEM230 Associated with Parkinson's Disease
Wang, X., Whelan, E., Liu, Z., Liu, C. F. & Smith, W. W., Jan 15 2021, In: Neuroscience. 453, p. 280-286 7 p.Research output: Contribution to journal › Review article › peer-review
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Curcumin Reduced H2O2- and G2385R-LRRK2-Induced Neurodegeneration
Zhang, J., Li, K., Wang, X., Smith, A. M., Ning, B., Liu, Z., Liu, C., Ross, C. A. & Smith, W. W., Oct 15 2021, In: Frontiers in Aging Neuroscience. 13, 754956.Research output: Contribution to journal › Article › peer-review
Open Access -
Mutant G2019S-LRRK2 Induces Abnormalities in Arteriolar Cerebral Blood Volume in Mouse Brains: An MRI Study
Ning, B., Guo, G., Gu, C., Xu, J., Bibic, A., He, X., Liu, H., Chen, L., Wei, Z., Duan, W., Liu, P., Lu, H., Van Zijl, P. C. M., Ross, C. A., Smith, W. & Hua, J., Feb 2021, In: Neurodegenerative Diseases. 20, 2-3, p. 65-72 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mutant-TMEM230-induced neurodegeneration and impaired axonal mitochondrial transport
Wang, X., Guo, G., Zhang, J., Aebez, N., Liu, Z., Liu, C. F., Ross, C. A. & Smith, W. W., Aug 15 2021, In: Human molecular genetics. 30, 16, p. 1535-1542 8 p.Research output: Contribution to journal › Article › peer-review
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2020
G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice
Arbez, N., He, X. F., Huang, Y., Ren, M., Liang, Y., Nucifora, F. C., Wang, X., Pei, Z., Tessarolo, L., Smith, W. W. & Ross, C. A., Mar 13 2020, In: Human molecular genetics. 29, 4, p. 580-590 11 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions
Thomas, J. M., Wang, X., Guo, G., Li, T., Dai, B., Nucifora, L. G., Nucifora, F. C., Liu, Z., Xue, F., Liu, C., Ross, C. A. & Smith, W. W., Oct 1 2020, In: Journal of Cellular Physiology. 235, 10, p. 7309-7320 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway
Wei, M., Gan, L., Liu, Z., Liu, L., Chang, J. R., Yin, D. C., Cao, H. L., Su, X. L. & Smith, W. W., Jan 1 2020, In: CardioRenal Medicine. 10, 1, p. 42-50 9 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Natural products for regulating macrophages M2 polarization
Chang, Z., Wang, Y., Liu, C., Smith, W. & Kong, L., 2020, In: Current Stem Cell Research and Therapy. 15, 7, p. 559-569 11 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Study of monocytes/macrophages stimuli as the targets of treating inflammatory bone diseases
Liu, Y., Cao, Y., Smith, W., He, B. & Yan, L., 2020, In: Current Drug Targets. 21, 4, p. 338-343 6 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Synphilin-1 interacts with AMPK and increases AMPK phosphorylation
Li, T., Liu, J., Guo, G., Ning, B., Li, X., Zhu, G., Yang, D., Moran, T. H. & Smith, W. W., Jun 2 2020, In: International journal of molecular sciences. 21, 12, p. 1-11 11 p., 4352.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The role of Rho GTPases' substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study
Liu, Y., Dou, Y., Yan, L., Yang, X., He, B., Kong, L. & Smith, W., Jul 2020, In: Bioscience Reports. 40, 7, BSR20200407.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Transmembrane Protein 230 Mediates a Poly(ADP-ribose) Polymerase-1-Linked Apoptosis
Wang, X., Wu, T., Zhang, J., Guo, G., He, X. F., Pei, Z., Liu, Z., Liu, C. F., Ross, C. A. & Smith, W. W., Aug 7 2020, In: Frontiers in Aging Neuroscience. 12, 235.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2019
Evaluation of efficacy on RANKL induced osteoclast from RAW264.7 cells
Song, C., Yang, X., Lei, Y., Zhang, Z., Smith, W., Yan, J. & Kong, L., Jul 2019, In: Journal of Cellular Physiology. 234, 7, p. 11969-11975 7 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds
Wang, Y., Smith, W., Hao, D., He, B. & Kong, L., May 2019, In: International immunopharmacology. 70, p. 459-466 8 p.Research output: Contribution to journal › Review article › peer-review
45 Scopus citations -
Macrophages in Bone Homeostasis
Kong, L., Wang, Y., Smith, W. & Hao, D., 2019, In: Current Stem Cell Research and Therapy. 14, 6, p. 474-481 8 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Overview of cellular mechanisms and signaling pathways of piceatannol
Cao, Y., Smith, W., Yan, L. & Kong, L., 2019, In: Current Stem Cell Research and Therapy. 15, 1, p. 4-10 7 p.Research output: Contribution to journal › Short survey › peer-review
2 Scopus citations -
Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli
Kong, L., Smith, W. & Hao, D., May 2019, In: Journal of Cellular and Molecular Medicine. 23, 5, p. 3077-3087 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access26 Scopus citations -
Regulation effects of melatonin on bone marrow mesenchymal stem cell differentiation
Wang, B., Wen, H., Smith, W., Hao, D., He, B. & Kong, L., Feb 1 2019, In: Journal of Cellular Physiology. 234, 2, p. 1008-1015 8 p.Research output: Contribution to journal › Review article › peer-review
15 Scopus citations -
2018
The Drosophila hep pathway mediates Lrrk2-induced neurodegeneration
Yang, D., Thomas, J. M., Li, T., Lee, Y., Liu, Z. & Smith, W. W., 2018, In: Biochemistry and Cell Biology. 96, 4, p. 441-449 9 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
2017
68 and FX2149 attenuate mutant LRRK2-R1441C-induced neural transport impairment
Thomas, J. M., Li, T., Yang, W., Xue, F., Fishman, P. S. & Smith, W. W., Jan 10 2017, In: Frontiers in Aging Neuroscience. 8, JAN, 337.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus
Yang, Y., Choi, P. P., Smith, W. W., Xu, W., Ma, D., Cordner, Z. A., Liang, N. C. & Moran, T. H., Dec 1 2017, In: Scientific reports. 7, 1, 6936.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2016
Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models
Liu, J., Li, T., Thomas, J. M., Pei, Z., Jiang, H., Engelender, S., Ross, C. A. & Smith, W. W., Feb 15 2016, In: Human molecular genetics. 25, 4, p. 672-680 9 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1
Nucifora, F. C., Nucifora, L. G., Ng, C. H., Arbez, N., Guo, Y., Roby, E., Shani, V., Engelender, S., Wei, D., Wang, X. F., Li, T., Moore, D. J., Pletnikova, O., Troncoso, J. C., Sawa, A., Dawson, T. M., Smith, W., Lim, K. L. & Ross, C. A., Jun 7 2016, In: Nature communications. 7, 11792.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
2015
A novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson's disease models
Li, T., He, X., Thomas, J. M., Yang, D., Zhong, S., Xue, F. & Smith, W. W., Mar 27 2015, In: PloS one. 10, 3, e0122461.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
CCK response deficiency in synphilin-1 transgenic mice
Smith, W. W., Smith, M., Yang, D., Choi, P. P., Moghadam, A., Li, T. & Moran, T. H., Nov 1 2015, In: PloS one. 10, 11, e0142314.Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of the full-length β-actin sequence and expression profiles in the tree shrew (Tupaia belangeri)
Zheng, Y., Yun, C., Wang, Q., Smith, W. W. & Leng, J., Feb 1 2015, In: International journal of molecular medicine. 35, 2, p. 519-524 6 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2014
Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice
Li, X., Treesukosol, Y., Moghadam, A., Smith, M., Ofeldt, E., Yang, D., Li, T., Tamashiro, K., Choi, P., Moran, T. H. & Smith, W. W., May 14 2014, In: PloS one. 9, 5, e91449.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
From fat fruit fly to human obesity
Smith, W. W., Thomas, J., Liu, J., Li, T. & Moran, T. H., Sep 1 2014, In: Physiology and Behavior. 136, p. 15-21 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access22 Scopus citations -
Identification of glyceraldehyde 3-phosphate dehydrogenase sequence and expression profiles in tree shrew (Tupaia belangeri)
Zheng, Y., Wang, Q., Yun, C., Wang, Y., Smith, W. W. & Leng, J., Jun 2 2014, In: PloS one. 9, 6, e98552.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models
Li, T., Yang, D., Zhong, S., Thomas, J. M., Xue, F., Liu, J., Kong, L., Voulalas, P., Hassan, H. E., Park, J. S., MacKerell, A. D. & Smith, W. W., Dec 1 2014, In: Human molecular genetics. 23, 23, p. 6212-6222 11 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
Preserve common limb in duodenal-jejunal bypass surgery benefits rats with type 2-like diabetes
Zhang, S. Y., Sun, X. J., Zheng, J. B., Wang, W., Liu, D., Chen, N. Z., He, S., Huo, X. W. & Smith, W., Mar 2014, In: Obesity Surgery. 24, 3, p. 405-411 7 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Synphilin-1 binds ATP and regulates intracellular energy status
Li, T., Liu, J. & Smith, W. W., Dec 29 2014, In: PloS one. 9, 12, e115233.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2013
Enhanced Aβ1-40 Production in Endothelial Cells Stimulated with Fibrillar Aβ1-42
Rajadas, J., Sun, W., Li, H., Inayathullah, M., Cereghetti, D., Tan, A., de Mello Coelho, V., Chrest, F. J., Kusiak, J. W., Smith, W. W., Taub, D., Wu, J. C. & Rifkind, J. M., Mar 7 2013, In: PloS one. 8, 3, e58194.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Pyrroloquinoline Quinine Inhibits RANKL-Mediated Expression of NFATc1 in Part via Suppression of c-Fos in Mouse Bone Marrow Cells and Inhibits Wear Particle-Induced Osteolysis in Mice
Kong, L., Yang, C., Yu, L., Smith, W., Zhu, S., Zhu, J. & Zhu, Q., Apr 17 2013, In: PloS one. 8, 4, e61013.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2012
A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation
Zhang, Y. M., Dai, B. L., Zheng, L., Zhan, Y. Z., Zhang, J., Smith, W. W., Wang, X. L., Chen, Y. N. & He, L. C., Oct 2012, In: Cell Death and Disease. 3, 10, e406.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
A novel obesity model: Synphilin-1-induced hyperphagia and obesity in mice
Li, X., Tamashiro, K. L. K., Liu, Z., Bello, N. T., Wang, X., Aja, S., Bi, S., Ladenheim, E. E., Ross, C. A., Moran, T. H. & Smith, W. W., Sep 2012, In: International Journal of Obesity. 36, 9, p. 1215-1221 7 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
A novel taspine derivative, HMQ1611, inhibits breast cancer cell growth via estrogen receptor α and EGF receptor signaling pathways
Zhan, Y., Zhang, Y., Liu, C., Zhang, J., Smith, W. W., Wang, N., Chen, Y., Zheng, L. & He, L., Jun 2012, In: Cancer Prevention Research. 5, 6, p. 864-873 10 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin
Yang, D., Li, T., Liu, Z., Arbez, N., Yan, J., Moran, T. H., Ross, C. A. & Smith, W. W., Sep 2012, In: Neurobiology of Disease. 47, 3, p. 385-392 8 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
Roles of dorsomedial hypothalamic cholecystokinin signaling in the controls of meal patterns and glucose homeostasis
Zhu, G., Yan, J., Smith, W. W., Moran, T. H. & Bi, S., Jan 18 2012, In: Physiology and Behavior. 105, 2, p. 234-241 8 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model
Liu, J., Li, T., Yang, D., Ma, R., Moran, T. H. & Smith, W. W., Dec 2012, In: International Journal of Obesity. 36, 12, p. 1529-1536 8 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2011
Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism
Liu, Z., Yu, Y., Li, X., Ross, C. A. & Smith, W. W., May 2011, In: Pharmacological Research. 63, 5, p. 439-444 6 p.Research output: Contribution to journal › Article › peer-review
92 Scopus citations -
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
Liu, Z., Hamamichi, S., Lee, B. D., Yang, D., Ray, A., Caldwell, G. A., Caldwell, K. A., Dawson, T. M., Smith, W. W. & Dawson, V. L., Oct 2011, In: Human molecular genetics. 20, 20, p. 3933-3942 10 p., ddr312.Research output: Contribution to journal › Article › peer-review
Open Access94 Scopus citations -
Models for LRRK2-linked parkinsonism
Smith, W. W., Li, T., Yang, D., Sushchky, S. & Liu, Z., 2011, In: Parkinson's Disease. 942412.Research output: Contribution to journal › Review article › peer-review
Open Access25 Scopus citations -
2010
Baicalein reduces E46K α-synuclein aggregation in vitro and protects cells against E46K α-synuclein toxicity in cell models of familiar Parkinsonism
Jiang, M., Porat-Shliom, Y., Pei, Z., Cheng, Y., Xiang, L., Sommers, K., Li, Q., Gillardon, F., Hengerer, B., Berlinicke, C., Smith, W. W., Zack, D. J., Poirier, M. A., Ross, C. A. & Duan, W., Jul 2010, In: Journal of Neurochemistry. 114, 2, p. 419-429 11 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations