Wan-Yee Tang

Associate Professor

20042019
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Research Output 2004 2019

2019

Can social support during pregnancy affect maternal DNA methylation? Findings from a cohort of African-Americans

Surkan, P. J., Hong, X., Zhang, B., Nawa, N., Ji, H., Tang, W. Y., Ji, Y., Kimmel, M. C., Wang, G., Pearson, C. & Wang, X., Jan 1 2019, In : Pediatric research.

Research output: Contribution to journalArticle

DNA Methylation
Social Support
African Americans
Mothers
Pregnancy

Estrogen down regulates COMT transcription via promoter DNA methylation in human breast cancer cells

Wu, Q., Odwin-Dacosta, S., Cao, S., Yager, J. D. & Tang, W-Y., Mar 15 2019, In : Toxicology and Applied Pharmacology. 367, p. 12-22 11 p.

Research output: Contribution to journalArticle

Catechol O-Methyltransferase
DNA Methylation
Transcription
Estrogens
Down-Regulation

Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body

Shin, M. K., Eraso, C. C., Mu, Y. P., Gu, C., Yeung, B. H. Y., Kim, L. J., Liu, X. R., Wu, Z. J., Paudel, O., Pichard, L. E., Shirahata, M., Tang, W. Y., Sham, J. S. K. & Polotsky, V. Y., Nov 8 2019, In : Circulation research. 125, 11, p. 989-1002 14 p.

Research output: Contribution to journalArticle

Carotid Body
Leptin
Hypertension
Inbred C57BL Mouse
Transient Receptor Potential Channels

Mitochondria are a substrate of cellular memory

Cheikhi, A., Wallace, C., St Croix, C., Cohen, C., Tang, W-Y., Wipf, P., Benos, P. V., Ambrosio, F. & Barchowsky, A., Jan 1 2019, In : Free Radical Biology and Medicine. 130, p. 528-541 14 p.

Research output: Contribution to journalArticle

Mitochondria
Data storage equipment
Substrates
Epigenomics
Stem Cells
2018

Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration

Sahu, A., Mamiya, H., Shinde, S. N., Cheikhi, A., Winter, L. L., Vo, N. V., Stolz, D., Roginskaya, V., Tang, W-Y., St Croix, C., Sanders, L. H., Franti, M., Van Houten, B., Rando, T. A., Barchowsky, A. & Ambrosio, F., Nov 19 2018, In : Nature Communications. 9, 1, 1 p.

Research output: Contribution to journalArticle

muscles
regeneration
Muscle
Regeneration
Stem Cells

Biological sex affects vaccine efficacy and protection against influenza in mice

Fink, A. L., Engle, K., Ursin, R. L., Tang, W-Y. & Klein, S. L., Dec 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 49, p. 12477-12482 6 p.

Research output: Contribution to journalArticle

Human Influenza
Vaccines
Antibody Formation
Antibody Affinity
Antibodies

In silico epigenetics of metal exposure and subclinical atherosclerosis in middle aged men: Pilot results from the aragon workers health study

Riffo-Campos, A. L., Fuentes-Trillo, A., Tang, W-Y., Soriano, Z., De Marco, G., Rentero-Garrido, P., Adam-Felici, V., Lendinez-Tortajada, V., Francesconi, K., Goessler, W., Ladd-Acosta, C. M., Leon-Latre, M., Casasnovas, J. A., Chaves, F. J., Navas Acien, A., Guallar, E. & Tellez-Plaza, M., Jun 5 2018, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1748, 20170084.

Research output: Contribution to journalArticle

middle-aged adults
health care workers
atherosclerosis
Epigenomics
epigenetics

Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response

Caballero-Eraso, C., Shin, M-K., Pho, H., Kim, L. J., Pichard, L. E., Wu, Z. J., Gu, C., Berger, S., Pham, L., Yeung, H. Y. B., Shirahata, M., Schwartz, A. R., Tang, W-Y., Sham, J. & Polotsky, V., Jan 1 2018, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Carotid Body
Wakefulness
Leptin
Ventilation
Sleep

Maternal smoking during pregnancy and cord blood DNA methylation: new insight on sex differences and effect modification by maternal folate levels

Zhang, B., Hong, X., Ji, H. K., Tang, W-Y., Kimmel, M., Ji, Y., Pearson, C., Zuckerman, B., Surkan, P. & Wang, X., Jan 1 2018, (Accepted/In press) In : Epigenetics.

Research output: Contribution to journalArticle

DNA Methylation
Fetal Blood
Folic Acid
Sex Characteristics
Smoking

The NIEHS TaRGET II Consortium and environmental epigenomics

TaRGET II Consortium, Mar 6 2018, In : Nature Biotechnology. 36, 3, p. 225-227 3 p.

Research output: Contribution to journalLetter

National Institute of Environmental Health Sciences (U.S.)
Environmental Exposure
Epigenomics
Genes
Genome
2017

Paternal involvement and support and risk of preterm birth: findings from the Boston birth cohort

Surkan, P., Dong, L., Ji, Y., Hong, X., Ji, H. K., Kimmel, M., Tang, W-Y. & Wang, X., Nov 14 2017, (Accepted/In press) In : Journal of Psychosomatic Obstetrics and Gynecology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Premature Birth
Gestational Age
Parturition
Pregnancy
Fathers
2016

Aberrant DNA methylation of phosphodiestarase 4D alters airway smooth muscle cell phenotypes

Lin, A. H. Y., Shang, Y., Mitzner, W. A., Sham, J. & Tang, W-Y., Feb 1 2016, In : American Journal of Respiratory Cell and Molecular Biology. 54, 2, p. 241-249 9 p.

Research output: Contribution to journalArticle

Type 4 Cyclic Nucleotide Phosphodiesterase
DNA Methylation
Smooth Muscle Myocytes
Muscle
Cells

An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma

An, S., Mitzner, W. A., Tang, W-Y., Ahn, K., Yoon, A. R., Huang, J., Kilic, O., Yong, H. M., Fahey, J. W., Kumar, S., Biswal, S., Holgate, S. T., Panettieri, R. A., Solway, J. & Liggett, S. B., 2016, (Accepted/In press) In : The Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk

Cheong, A., Zhang, X., Cheung, Y. Y., Tang, W-Y., Chen, J., Ye, S. H., Medvedovic, M., Leung, Y. K., Prins, G. S. & Ho, S. M., Sep 8 2016, (Accepted/In press) In : Epigenetics. p. 1-16 16 p.

Research output: Contribution to journalArticle

Environmental Exposure
Prostatic Neoplasms
DNA
Genes
Methylation
2015

Aberrant 5′-CpG methylation of cord blood TNFα associated with maternal exposure to polybrominated diphenyl ethers

Dao, T., Hong, X., Wang, X. & Tang, W-Y., Sep 25 2015, In : PLoS One. 10, 9, e0138815.

Research output: Contribution to journalArticle

Halogenated Diphenyl Ethers
polybrominated diphenyl ethers
Maternal Exposure
Methylation
Fetal Blood

A short-term fasting in neonates induces breathing instability and epigenetic modification in the carotid body

Shirahata, M., Tang, W-Y. & Kostuk, E. W., 2015, In : Advances in Experimental Medicine and Biology. 860, p. 187-193 7 p.

Research output: Contribution to journalArticle

Carotid Body
Epigenomics
Respiratory System
Fasting
Respiration

Elusive inheritance: Transgenerational effects and epigenetic inheritance in human environmental disease

Martos, S. N., Tang, W-Y. & Wang, Z., Jul 1 2015, In : Progress in Biophysics and Molecular Biology. 118, 1-2, p. 44-54 11 p.

Research output: Contribution to journalArticle

Epigenomics
Mammals
Histone Code
Phenotype
Untranslated RNA

Environmental chemicals and DNA methylation in adults: A systematic review of the epidemiologic evidence

Ruiz-Hernandez, A., Kuo, C. C., Rentero-Garrido, P., Tang, W-Y., Redon, J., Ordovas, J. M., Navas Acien, A. & Tellez-Plaza, M., 2015, In : Clinical Epigenetics. 7, 1, 55.

Research output: Contribution to journalReview article

DNA Methylation
Methylation
Long Interspersed Nucleotide Elements
Alu Elements
Antimony

Is the Carotid Body a Metabolic Monitor?

Shirahata, M., Tang, W-Y., Shin, M-K. & Polotsky, V., 2015, In : Advances in Experimental Medicine and Biology. 860, p. 153-159 7 p.

Research output: Contribution to journalArticle

Carotid Body
Carotid Sinus
Glucose
Leptin
Transient Receptor Potential Channels
2014

Alterations of the lung methylome in allergic airway hyper-responsiveness

Cheng, R. Y., Shang, Y., Limjunyawong, N., Dao, T., Das, S., Rabold, R., Sham, J., Mitzner, W. A. & Tang, W-Y., Apr 2014, In : Environmental and Molecular Mutagenesis. 55, 3, p. 244-255 12 p.

Research output: Contribution to journalArticle

Respiratory Hypersensitivity
Pyroglyphidae
Asthma
Lung
Airway Remodeling

Association of global DNA methylation and global DNA hydroxymethylation with metals and other exposures in human blood DNA samples

Tellez-Plaza, M., Tang, W-Y., Shang, Y., Umans, J. G., Francesconi, K. A., Goessler, W., Ledesma, M., Leon, M., Laclaustra, M., Pollak, J., Guallar, E., Cole, S. A., Fallin, D. D. & Navas Acien, A., 2014, In : Environmental Health Perspectives. 122, 9, p. 946-954 9 p.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
5-Methylcytosine
Metals
DNA

Differential methylation of the arsenic (III) methyltransferase promoter according to arsenic exposure

Gribble, M. O., Tang, W-Y., Shang, Y., Pollak, J., Umans, J. G., Francesconi, K. A., Goessler, W., Silbergeld, E., Guallar, E., Cole, S. A., Fallin, D. D. & Navas Acien, A., Feb 2014, In : Archives of Toxicology. 88, 2, p. 275-282 8 p.

Research output: Contribution to journalArticle

Methylation
Methyltransferases
Arsenic
Epigenomics
Genes

Increased understanding of the impact of environmental exposures on the epigenome

O'Hagan, H. M. & Tang, W-Y., Apr 2014, In : Environmental and Molecular Mutagenesis. 55, 3, p. 151-154 4 p.

Research output: Contribution to journalArticle

Genetic Epigenesis
Small Untranslated RNA
CpG Islands
Environmental Exposure
DNA Methylation
2013

Effects of ozone and particulate matter on cardiac mechanics: Role of the atrial natriuretic peptide gene

Tankersley, C. G., Georgakopoulos, D., Tang, W-Y., Abston, E., Bierman, A. & Sborz, N., Jan 2013, In : Toxicological Sciences. 131, 1, p. 95-107 13 p.

Research output: Contribution to journalArticle

Particulate Matter
Ozone
Air Pollution
Atrial Natriuretic Factor
Mechanics

Epigenetic alterations by DNA methylation in house dust mite-induced airway hyperresponsiveness

Shang, Y., Das, S., Rabold, R., Sham, J., Mitzner, W. A. & Tang, W-Y., Aug 2013, In : American Journal of Respiratory Cell and Molecular Biology. 49, 2, p. 279-287 9 p.

Research output: Contribution to journalArticle

Pyroglyphidae
DNA Methylation
Epigenomics
Dust
Inflammation
2012

Environment, Epigenetics, and Diseases

Cheng, R. Y. S. & Tang, W-Y., Aug 8 2012, Toxicology and Epigenetics. John Wiley and Sons, p. 5-24 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epigenomics

Maternal exposure to polycyclic aromatic hydrocarbons and 5'-CpG methylation of interferon-γ in cord white blood cells

Tang, W-Y., Levin, L., Talaska, G., Cheung, Y. Y., Herbstman, J., Tang, D., Miller, R. L., Perera, F. & Ho, S. M., Aug 2012, In : Environmental Health Perspectives. 120, 8, p. 1195-1200 6 p.

Research output: Contribution to journalArticle

Maternal Exposure
Polycyclic Aromatic Hydrocarbons
Fetal Blood
Interferons
Methylation

Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the ratprostate gland throughout life

Tang, W-Y., Morey, L. M., Cheung, Y. Y., Birch, L., Prins, G. S. & Ho, S. M., Jan 2012, In : Endocrinology. 153, 1, p. 42-55 14 p.

Research output: Contribution to journalArticle

Hippocalcin
Nucleosomes
Methylation
Estradiol
Carrier Proteins
2011

P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells

Tsang, T. Y., Tang, W-Y., Chan, J. Y. W., Co, N. N., Au Yeung, C. L., Yau, P. L., Kong, S. K., Fung, K. P. & Kwok, T. T., May 2011, In : Apoptosis. 16, 5, p. 524-535 12 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Cell death
Hepatocellular Carcinoma
Cell Death
Cells
2009

Mechanistic study on growth suppression and apoptosis induction by targeting Hepatoma-derived growth factor in human Hepatocellular Carcinoma HepG2 cells

Tsang, T. Y., Tang, W-Y., Tsang, W. P., Co, N. N., Kong, S. K. & Kwok, T. T., 2009, In : Cellular Physiology and Biochemistry. 24, 3-4, p. 253-262 10 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Hepatocellular Carcinoma
Apoptosis
Growth
hepatoma-derived growth factor

Relation of DNA methylation of 5′-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma

Perera, F., Tang, W-Y., Herbstman, J., Tang, D., Levin, L., Miller, R. & Ho, S. M., Feb 16 2009, In : PLoS One. 4, 2, e4488.

Research output: Contribution to journalArticle

Maternal-Fetal Exchange
long-chain-fatty-acid-CoA ligase
Coenzyme A Ligases
CpG Islands
Polycyclic Aromatic Hydrocarbons
2008

Developmental exposure to bisphenol A increases prostate cancer susceptibility in adult rats: epigenetic mode of action is implicated

Prins, G. S., Tang, W-Y., Belmonte, J. & Ho, S. M., Feb 2008, In : Fertility and Sterility. 89, 2 SUPPL.

Research output: Contribution to journalArticle

Occupational Air Pollutants
Genetic Epigenesis
Phenols
Age Factors
Epigenomics

Downregulation of hepatoma-derived growth factor activates the Bad-mediated apoptotic pathway in human cancer cells

Tsang, T. Y., Tang, W-Y., Tsang, W. P., Co, N. N., Kong, S. K. & Kwok, T. T., Sep 2008, In : Apoptosis. 13, 9, p. 1135-1147 13 p.

Research output: Contribution to journalArticle

Down-Regulation
Cells
Neoplasms
Hep G2 Cells
Growth

Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis

Prins, G. S., Tang, W-Y., Belmonte, J. & Ho, S. M., Feb 2008, In : Basic and Clinical Pharmacology and Toxicology. 102, 2, p. 134-138 5 p.

Research output: Contribution to journalArticle

Prostate
Estradiol
Carcinogenesis
Aging of materials
Estrogens

Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein

Tang, W-Y., Newbold, R., Mardilovich, K., Jefferson, W., Cheng, R. Y. S., Medvedovic, M. & Ho, S. M., Dec 2008, In : Endocrinology. 149, 12, p. 5922-5931 10 p.

Research output: Contribution to journalArticle

HMGN Proteins
Diethylstilbestrol
Genistein
Uterus
CpG Islands
2007

Developmental estrogen exposures predispose to prostate carcinogenesis with aging

Prins, G. S., Birch, L., Tang, W-Y. & Ho, S. M., Apr 2007, In : Reproductive Toxicology. 23, 3, p. 374-382 9 p.

Research output: Contribution to journalArticle

Prostate
Estradiol
Estrogens
Carcinogenesis
Aging of materials

Epigenetic reprogramming and imprinting in origins of disease

Tang, W-Y. & Ho, S. M., Jun 2007, In : Reviews in Endocrine and Metabolic Disorders. 8, 2, p. 173-182 10 p.

Research output: Contribution to journalArticle

Epigenomics
Phenotype
Histone Code
X Chromosome Inactivation
Gene-Environment Interaction
DNA Methylation
Methylation
Genes
Epigenomics
Histone Code
2006

Apigenin suppresses cancer cell growth through ERβ

Mak, P., Leung, Y. K., Tang, W-Y., Harwood, C. & Ho, S. M., Nov 2006, In : Neoplasia. 8, 11, p. 896-904 9 p.

Research output: Contribution to journalArticle

Apigenin
Estrogen Receptors
Genistein
Growth
Neoplasms

Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4

Ho, S. M., Tang, W-Y., Belmonte De Frausto, J. & Prins, G. S., Jun 1 2006, In : Cancer Research. 66, 11, p. 5624-5632 9 p.

Research output: Contribution to journalArticle

Type 4 Cyclic Nucleotide Phosphodiesterase
Prostate
Estradiol
Carcinogenesis
Estrogens
2004

The role of Raf-1 in radiation resistance of human hepatocellular carcinoma Hep G2 cells

Tang, W-Y., Chau, S. P. Y., Tsang, W. P., Kong, S. K. & Kwok, T. T., Dec 2004, In : Oncology Reports. 12, 6, p. 1349-1354 6 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Hepatocellular Carcinoma
Radiation
L 744832
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one