Wade W Chien

Associate Professor

20052019

Research output per year

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Research Output

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Article
2019

AAV2.7m8 is a powerful viral vector for inner ear gene therapy

Isgrig, K., McDougald, D. S., Zhu, J., Wang, H. J., Bennett, J. & Chien, W. W., Dec 1 2019, In : Nature Communications. 10, 1, 427.

Research output: Contribution to journalArticle

Sex differences in HPV immunity among adults without cancer

Windon, M. J., Waterboer, T., Hillel, A. T., Chien, W. W., Best, S. R., Stewart, C. M., Akst, L. M., Troy, T., Bender, N., Miles, B., Ryan, W. R., Mandal, R., Pitman, K., Eisele, D. W., Fakhry, C. & D'Souza, G., Jan 1 2019, In : Human Vaccines and Immunotherapeutics.

Research output: Contribution to journalArticle

SLC26A4-linked CEVA haplotype correlates with phenotype in patients with enlargement of the vestibular aqueduct

Chao, J. R., Chattaraj, P., Munjal, T., Honda, K., King, K. A., Zalewski, C. K., Chien, W. W., Brewer, C. C. & Griffith, A. J., Jul 2 2019, In : BMC Medical Genetics. 20, 1, 118.

Research output: Contribution to journalArticle

Open Access
2018

A CEP290 C-Terminal Domain Complements the Mutant CEP290 of Rd16 Mice In Trans and Rescues Retinal Degeneration

Mookherjee, S., Chen, H. Y., Isgrig, K., Yu, W., Hiriyanna, S., Levron, R., Li, T., Colosi, P., Chien, W. W., Swaroop, A. & Wu, Z., Oct 16 2018, In : Cell Reports. 25, 3, p. 611-623.e6

Research output: Contribution to journalArticle

Posterior semicircular canal approach for inner ear gene delivery in neonatal mouse

Isgrig, K. & Chien, W. W., Mar 2 2018, In : Journal of Visualized Experiments. 2018, 133, e56648.

Research output: Contribution to journalArticle

2017

A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome

Moebius Syndrome Research Consortium, Jul 6 2017, In : Nature Communications. 8, 16077.

Research output: Contribution to journalArticle

Gene Therapy Restores Balance and Auditory Functions in a Mouse Model of Usher Syndrome

Isgrig, K., Shteamer, J. W., Belyantseva, I. A., Drummond, M. C., Fitzgerald, T. S., Vijayakumar, S., Jones, S. M., Griffith, A. J., Friedman, T. B., Cunningham, L. L. & Chien, W. W., Mar 1 2017, In : Molecular Therapy. 25, 3, p. 780-791 12 p.

Research output: Contribution to journalArticle

Hearing Loss after Round Window Surgery in Mice Is due to Middle Ear Effusion

Zhu, B. Z., Saleh, J., Isgrig, K. T., Cunningham, L. L. & Chien, W. W., Jan 10 2017, (Accepted/In press) In : Audiology and Neurotology. p. 356-364 9 p.

Research output: Contribution to journalArticle

2016

A genotypic ascertainment approach to refute the association of MYO1A variants with non-syndromic deafness

Patton, J., Brewer, C., Chien, W., Johnston, J. J., Griffith, A. J. & Biesecker, L. G., Oct 19 2016, (Accepted/In press) In : European Journal of Human Genetics.

Research output: Contribution to journalArticle

Atypical patterns of segregation of familial enlargement of the vestibular aqueduct

Muskett, J. A., Chattaraj, P., Heneghan, J. F., Reimold, F. R., Shmukler, B. E., Brewer, C. C., King, K. A., Zalewski, C. K., Shawker, T. H., Butman, J. A., Kenna, M. A., Chien, W. W., Alper, S. L. & Griffith, A. J., Jul 1 2016, In : Laryngoscope. 126, 7, p. E240-E247

Research output: Contribution to journalArticle

GATA3 haploinsufficiency does not block allergic sensitization or atopic disease

Lawrence, M. G., Leiding, J. W., Lyons, J. J., Hsu, A. P., Nelson, C. C., Jones, N., Fitzgerald, A., Chien, W. W., Workman, L., Platts-Mills, T. A., Brewer, C., Gafni, R. I., Stone, K. D., Milner, J. D. & Holland, S. M., Feb 1 2016, In : The Journal of Allergy and Clinical Immunology. 137, 2, p. 617-629 13 p.

Research output: Contribution to journalArticle

Gene therapy restores hair cell stereocilia morphology in inner ears of deaf whirler mice

Chien, W. W., Isgrig, K., Roy, S., Belyantseva, I. A., Drummond, M. C., May, L. A., Fitzgerald, T. S., Friedman, T. B. & Cunningham, L. L., Feb 1 2016, In : Molecular Therapy. 24, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Hearing loss associated with enlarged vestibular aqueduct and zero or one mutant allele of SLC26A4

Rose, J., Muskett, J. A., King, K. A., Zalewski, C. K., Chattaraj, P., Butman, J. A., Kenna, M. A., Chien, W. W., Brewer, C. C. & Griffith, A. J., 2016, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Racial differences of pigmentation in the human vestibular organs

Erbele, I. D., Lin, F., Agrawal, Y., Francis, H. W., Carey, J. P. & Chien, W. W., Sep 1 2016, In : Otolaryngology - Head and Neck Surgery. 155, 3, p. 479-484 6 p.

Research output: Contribution to journalArticle

Use of pericranial flap coverage in cochlear implantation of the radical cavity: Rationale, technique, and experience

Nieman, C., Weinreich, H. M., Sharon, J. D., Chien, W. W. & Francis, H. W., Sep 1 2016, In : Otolaryngology - Head and Neck Surgery. 155, 3, p. 533-537 5 p.

Research output: Contribution to journalArticle

2015

Cochlear gene transfer mediated by adeno-associated virus: Comparison of two surgical approaches

Chien, W. W., McDougald, D. S., Roy, S., Fitzgerald, T. S. & Cunningham, L. L., Nov 1 2015, In : Laryngoscope. 125, 11, p. 2557-2564 8 p.

Research output: Contribution to journalArticle

Gene therapy for sensorineural hearing loss

Chien, W. W., Monzack, E. L., McDougald, D. S. & Cunningham, L. L., Jan 3 2015, In : Ear and Hearing. 36, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Restoration of middle-ear input in fluid-filled middle ears by controlled introduction of air or a novel air-filled implant

Ravicz, M. E., Chien, W. W. & Rosowski, J. J., Dec 3 2015, In : Hearing Research. 328, p. 8-23 16 p.

Research output: Contribution to journalArticle

Vestibular Dysfunction in Patients with Enlarged Vestibular Aqueduct

Zalewski, C. K., Chien, W. W., King, K. A., Muskett, J. A., Baron, R. E., Butman, J. A., Griffith, A. J. & Brewer, C. C., Aug 25 2015, In : Otolaryngology - Head and Neck Surgery. 153, 2, p. 257-262 6 p.

Research output: Contribution to journalArticle

2014

Auditory and vestibular phenotypes associated with GATA3 mutation

Chien, W. W., Leiding, J. W., Hsu, A. P., Zalewski, C., King, K., Holland, S. M. & Brewer, C., 2014, In : Otology and Neurotology. 35, 4, p. 577-581 5 p.

Research output: Contribution to journalArticle

Introduction

Chien, W., Dec 1 2014, In : Operative Techniques in Otolaryngology - Head and Neck Surgery. 25, 4, p. 311 1 p.

Research output: Contribution to journalArticle

Racial difference in cochlear pigmentation is associated with hearing loss risk

Sun, D., Zhou, X., Lin, F., Francis, H. W., Carey, J. P. & Chien, W. W., 2014, In : Otology and Neurotology. 35, 9, p. 1509-1514 6 p.

Research output: Contribution to journalArticle

Robot-assisted three-dimensional registration for cochlear implant surgery using a common-path swept-source optical coherence tomography probe

Gurbani, S. S., Wilkening, P., Zhao, M., Gonenc, B., Cheon, G. W., Iordachita, I. I., Chien, W. W., Taylor, R. H., Niparko, J. K. & Kang, J. U., 2014, In : Journal of Biomedical Optics. 19, 5, 057004.

Research output: Contribution to journalArticle

Techniques in cochlear implantation

Weinreich, H. M., Francis, H. W., Niparko, J. K. & Chien, W. W., Dec 1 2014, In : Operative Techniques in Otolaryngology - Head and Neck Surgery. 25, 4, p. 312-320 9 p.

Research output: Contribution to journalArticle

2013

Perception of pure tones and iterated rippled noise for normal hearing and cochlear implant users

Penninger, R. T., Chien, W. W., Jiradejvong, P., Boeke, E., Carver, C. & Limb, C. J., Mar 2013, In : Trends in Amplification. 17, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

Serial suture ligation glossectomy for squamous cell carcinoma in the setting of a massive lymphovascular malformation

Chien, W. W., Lin, H. W. & Deschler, D. G., May 2013, In : Head and Neck. 35, 5

Research output: Contribution to journalArticle

Use of SLC26A4 mutation testing for unilateral enlargement of the vestibular aqueduct

Chattaraj, P., Reimold, F. R., Muskett, J. A., Shmukler, B. E., Chien, W. W., Madeo, A. C., Pryor, S. P., Zalewski, C. K., Butman, J. A., Brewer, C. C., Kenna, M. A., Alper, S. L. & Griffith, A. J., Sep 2013, In : JAMA Otolaryngology - Head and Neck Surgery. 139, 9, p. 907-913 7 p.

Research output: Contribution to journalArticle

2012

Cochlear implantation in older adults

Lin, F., Chien, W. W., Li, L., Clarrett, D. M., Niparko, J. K. & Francis, H. W., Sep 2012, In : Medicine (United States). 91, 5, p. 229-241 13 p.

Research output: Contribution to journalArticle

Magnetic resonance imaging findings in meningitis

Markman, T., Aygun, N. & Chien, W. W., Sep 2012, In : Otology and Neurotology. 33, 7

Research output: Contribution to journalArticle

Otopathology in osteogenesis imperfecta

Santos, F., McCall, A. A., Chien, W. W. & Merchant, S., Dec 2012, In : Otology and Neurotology. 33, 9, p. 1562-1566 5 p.

Research output: Contribution to journalArticle

Prevalence of hearing aid use among older adults in the United States

Chien, W. W. & Lin, F., Feb 13 2012, In : Archives of Internal Medicine. 172, 3, p. 292-293 2 p.

Research output: Contribution to journalArticle

Risk factors for vagal palsy following cerebellopontine angle surgery

Best, S. R., Starmer, H. M., Agrawal, Y., Ward, B., Hillel, A. T., Chien, W. W., Francis, H. W., Tamargo, R. J. & Akst, L. M., Aug 2012, In : Otolaryngology - Head and Neck Surgery. 147, 2, p. 364-368 5 p.

Research output: Contribution to journalArticle

Superior canal dehiscence size: Multivariate assessment of clinical impact

Chien, W. W., Janky, K., Minor, L. B. & Carey, J. P., Jul 2012, In : Otology and Neurotology. 33, 5, p. 810-815 6 p.

Research output: Contribution to journalArticle

Technical skills improve after practice on virtual-reality temporal bone simulator

Francis, H. W., Malik, M. U., Diaz Voss Varela, D. A., Barffour, M. A., Chien, W. W., Carey, J. P., Niparko, J. K. & Bhatti, N. I., Jun 2012, In : Laryngoscope. 122, 6, p. 1385-1391 7 p.

Research output: Contribution to journalArticle

2011

Canal dehiscence

Chien, W. W., Carey, J. P. & Minor, L. B., Feb 2011, In : Current Opinion in Neurology. 24, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

Using a virtual reality temporal bone simulator to enhance surgical competency in procedural tasks: A pilot study

Malik, M. U., Diaz Voss Varela, D. A., Francis, H. W., Pandian, V., Chien, W. W., Agrawal, Y., Niparko, J. K. & Bhatti, N. I., 2011, In : Laryngoscope. 121, SUPPL. 4

Research output: Contribution to journalArticle

2009

Anatomy of the distal incus in humans

Chien, W. W., Northrop, C., Levine, S., Pilch, B. Z., Peake, W. T., Rosowski, J. J. & Merchant, S. N., Dec 2009, In : JARO - Journal of the Association for Research in Otolaryngology. 10, 4, p. 485-496 12 p.

Research output: Contribution to journalArticle

Measurements of stapes velocity in live human ears

Chien, W. W., Rosowski, J. J., Ravicz, M. E., Rauch, S. D., Smullen, J. & Merchant, S. N., 2009, In : Hearing Research. 249, 1-2, p. 54-61 8 p.

Research output: Contribution to journalArticle

2008

Isolated fracture of the manubrium of the malleus

Chien, W. W., McKenna, M. J., Rosowski, J. J. & Merchant, S. N., Sep 2008, In : Journal of Laryngology and Otology. 122, 9, p. 898-904 7 p.

Research output: Contribution to journalArticle

2007

Investigation of the mechanics of type III stapes columella tympanoplasty using laser-Doppler vibrometry

Chien, W. W., Rosowski, J. J. & Merchant, S. N., Sep 2007, In : Otology and Neurotology. 28, 6, p. 782-787 6 p.

Research output: Contribution to journalArticle

Measurements of human middle- and inner-ear mechanics with dehiscence of the superior semicircular canal

Chien, W. W., Ravicz, M. E., Rosowski, J. J. & Merchant, S. N., Feb 2007, In : Otology and Neurotology. 28, 2, p. 250-257 8 p.

Research output: Contribution to journalArticle

Testing a method for quantifying the output of implantable middle ear hearing devices

Rosowski, J. J., Chien, W. W., Ravicz, M. E. & Merchant, S. N., Jun 2007, In : Audiology and Neurotology. 12, 4, p. 265-276 12 p.

Research output: Contribution to journalArticle

2006

Experimental assessment of the performance of an electromagnetic hearing aid in human temporal bones

Hamanishi, S., Koike, T., Chien, W. W., Ravicz, M. E., Rosowski, J. J., Merchant, S. N., Kobayashi, T. & Wada, H., Jun 15 2006, In : JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing. 48, 4, p. 529-536 8 p.

Research output: Contribution to journalArticle

Risk of second primary malignancy after radioactive iodine treatment for differentiated thyroid carcinoma

Bhattacharyya, N. & Chien, W. W., Aug 2006, In : Annals of Otology, Rhinology and Laryngology. 115, 8, p. 607-610 4 p.

Research output: Contribution to journalArticle

The effect of methodological differences in the measurement of stapes motion in live and cadaver ears

Chien, W. W., Ravicz, M. E., Merchant, S. N. & Rosowski, J. J., Apr 2006, In : Audiology and Neurotology. 11, 3, p. 183-197 15 p.

Research output: Contribution to journalArticle

Type 1 laryngeal cleft: Establishing a functional diagnostic and management algorithm

Chien, W. W., Ashland, J., Haver, K., Hardy, S. C., Curren, P. & Hartnick, C. J., Dec 2006, In : International Journal of Pediatric Otorhinolaryngology. 70, 12, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

2005

Effects of aspirin and low-dose heparin in head and neck reconstruction using microvascular free flaps

Chien, W. W., Varvares, M. A., Hadlock, T., Cheney, M. & Deschler, D. G., Jun 2005, In : Laryngoscope. 115, 6, p. 973-976 4 p.

Research output: Contribution to journalArticle

Radiology quiz case 4

Chien, W. W., Faquin, W. C., Caruso, P. A., Rabinov, J. D. & Cunningham, M. J., Nov 2005, In : Archives of Otolaryngology--Head and Neck Surgery. 131, 11

Research output: Contribution to journalArticle