Wade W Chien

Associate Professor

20052020

Research output per year

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Research Output

2020

Adeno-associated virus gene replacement for recessive inner ear dysfunction: Progress and challenges

Askew, C. & Chien, W. W., Jan 1 2020, (Accepted/In press) In : Hearing Research. 107947.

Research output: Contribution to journalReview article

2019

AAV2.7m8 is a powerful viral vector for inner ear gene therapy

Isgrig, K., McDougald, D. S., Zhu, J., Wang, H. J., Bennett, J. & Chien, W. W., Dec 1 2019, In : Nature Communications. 10, 1, 427.

Research output: Contribution to journalArticle

Sex differences in HPV immunity among adults without cancer

Windon, M. J., Waterboer, T., Hillel, A. T., Chien, W. W., Best, S. R., Stewart, C. M., Akst, L. M., Troy, T., Bender, N., Miles, B., Ryan, W. R., Mandal, R., Pitman, K., Eisele, D. W., Fakhry, C. & D'Souza, G., Jan 1 2019, In : Human Vaccines and Immunotherapeutics.

Research output: Contribution to journalArticle

SLC26A4-linked CEVA haplotype correlates with phenotype in patients with enlargement of the vestibular aqueduct

Chao, J. R., Chattaraj, P., Munjal, T., Honda, K., King, K. A., Zalewski, C. K., Chien, W. W., Brewer, C. C. & Griffith, A. J., Jul 2 2019, In : BMC Medical Genetics. 20, 1, 118.

Research output: Contribution to journalArticle

Open Access

Surgical methods for inner ear gene delivery in neonatal mouse

Isgrig, K. & Chien, W. W., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 221-226 6 p. (Methods in Molecular Biology; vol. 1937).

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

A CEP290 C-Terminal Domain Complements the Mutant CEP290 of Rd16 Mice In Trans and Rescues Retinal Degeneration

Mookherjee, S., Chen, H. Y., Isgrig, K., Yu, W., Hiriyanna, S., Levron, R., Li, T., Colosi, P., Chien, W. W., Swaroop, A. & Wu, Z., Oct 16 2018, In : Cell Reports. 25, 3, p. 611-623.e6

Research output: Contribution to journalArticle

A CRISPR way to restore hearing

Chien, W. W., Mar 29 2018, In : New England Journal of Medicine. 378, 13, p. 1255-1256 2 p.

Research output: Contribution to journalShort survey

Posterior semicircular canal approach for inner ear gene delivery in neonatal mouse

Isgrig, K. & Chien, W. W., Mar 2 2018, In : Journal of Visualized Experiments. 2018, 133, e56648.

Research output: Contribution to journalArticle

2017

A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome

Moebius Syndrome Research Consortium, Jul 6 2017, In : Nature Communications. 8, 16077.

Research output: Contribution to journalArticle

Gene Therapy Restores Balance and Auditory Functions in a Mouse Model of Usher Syndrome

Isgrig, K., Shteamer, J. W., Belyantseva, I. A., Drummond, M. C., Fitzgerald, T. S., Vijayakumar, S., Jones, S. M., Griffith, A. J., Friedman, T. B., Cunningham, L. L. & Chien, W. W., Mar 1 2017, In : Molecular Therapy. 25, 3, p. 780-791 12 p.

Research output: Contribution to journalArticle

Hearing Loss after Round Window Surgery in Mice Is due to Middle Ear Effusion

Zhu, B. Z., Saleh, J., Isgrig, K. T., Cunningham, L. L. & Chien, W. W., Jan 10 2017, (Accepted/In press) In : Audiology and Neurotology. p. 356-364 9 p.

Research output: Contribution to journalArticle

2016

A genotypic ascertainment approach to refute the association of MYO1A variants with non-syndromic deafness

Patton, J., Brewer, C., Chien, W., Johnston, J. J., Griffith, A. J. & Biesecker, L. G., Oct 19 2016, (Accepted/In press) In : European Journal of Human Genetics.

Research output: Contribution to journalArticle

Atypical patterns of segregation of familial enlargement of the vestibular aqueduct

Muskett, J. A., Chattaraj, P., Heneghan, J. F., Reimold, F. R., Shmukler, B. E., Brewer, C. C., King, K. A., Zalewski, C. K., Shawker, T. H., Butman, J. A., Kenna, M. A., Chien, W. W., Alper, S. L. & Griffith, A. J., Jul 1 2016, In : Laryngoscope. 126, 7, p. E240-E247

Research output: Contribution to journalArticle

GATA3 haploinsufficiency does not block allergic sensitization or atopic disease

Lawrence, M. G., Leiding, J. W., Lyons, J. J., Hsu, A. P., Nelson, C. C., Jones, N., Fitzgerald, A., Chien, W. W., Workman, L., Platts-Mills, T. A., Brewer, C., Gafni, R. I., Stone, K. D., Milner, J. D. & Holland, S. M., Feb 1 2016, In : Journal of Allergy and Clinical Immunology. 137, 2, p. 627-629.e2

Research output: Contribution to journalArticle

Gene therapy restores hair cell stereocilia morphology in inner ears of deaf whirler mice

Chien, W. W., Isgrig, K., Roy, S., Belyantseva, I. A., Drummond, M. C., May, L. A., Fitzgerald, T. S., Friedman, T. B. & Cunningham, L. L., Feb 1 2016, In : Molecular Therapy. 24, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Hearing loss associated with enlarged vestibular aqueduct and zero or one mutant allele of SLC26A4

Rose, J., Muskett, J. A., King, K. A., Zalewski, C. K., Chattaraj, P., Butman, J. A., Kenna, M. A., Chien, W. W., Brewer, C. C. & Griffith, A. J., 2016, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Racial differences of pigmentation in the human vestibular organs

Erbele, I. D., Lin, F., Agrawal, Y., Francis, H. W., Carey, J. P. & Chien, W. W., Sep 1 2016, In : Otolaryngology - Head and Neck Surgery. 155, 3, p. 479-484 6 p.

Research output: Contribution to journalArticle

Research Techniques Made Simple: The Application of CRISPR-Cas9 and Genome Editing in Investigative Dermatology

Guitart, J. R., Johnson, J. L. & Chien, W. W., Sep 1 2016, In : Journal of Investigative Dermatology. 136, 9, p. e87-e93

Research output: Contribution to journalShort survey

Use of pericranial flap coverage in cochlear implantation of the radical cavity: Rationale, technique, and experience

Nieman, C., Weinreich, H. M., Sharon, J. D., Chien, W. W. & Francis, H. W., Sep 1 2016, In : Otolaryngology - Head and Neck Surgery. 155, 3, p. 533-537 5 p.

Research output: Contribution to journalArticle

2015

Cochlear gene transfer mediated by adeno-associated virus: Comparison of two surgical approaches

Chien, W. W., McDougald, D. S., Roy, S., Fitzgerald, T. S. & Cunningham, L. L., Nov 2015, In : Laryngoscope. 125, 11, p. 2557-2564 8 p.

Research output: Contribution to journalArticle

Gene therapy for sensorineural hearing loss

Chien, W. W., Monzack, E. L., McDougald, D. S. & Cunningham, L. L., Jan 3 2015, In : Ear and Hearing. 36, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Restoration of middle-ear input in fluid-filled middle ears by controlled introduction of air or a novel air-filled implant

Ravicz, M. E., Chien, W. W. & Rosowski, J. J., Dec 3 2015, In : Hearing Research. 328, p. 8-23 16 p.

Research output: Contribution to journalArticle

Vestibular Dysfunction in Patients with Enlarged Vestibular Aqueduct

Zalewski, C. K., Chien, W. W., King, K. A., Muskett, J. A., Baron, R. E., Butman, J. A., Griffith, A. J. & Brewer, C. C., Aug 25 2015, In : Otolaryngology - Head and Neck Surgery (United States). 153, 2, p. 257-262 6 p.

Research output: Contribution to journalArticle

2014

3D optical coherence tomography image registration for guiding cochlear implant insertion

Cheon, G. W., Jeong, H. W., Chalasani, P., Chien, W. W., Iordachita, I., Taylor, R., Niparko, J. & Kang, J. U., Jan 1 2014, Photonic Therapeutics and Diagnostics X. SPIE, 89261Z. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 8926).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Auditory and vestibular phenotypes associated with GATA3 mutation

Chien, W. W. D., Leiding, J. W., Hsu, A. P., Zalewski, C., King, K., Holland, S. M. & Brewer, C., Apr 2014, In : Otology and Neurotology. 35, 4, p. 577-581 5 p.

Research output: Contribution to journalArticle

Evaluation of virtual fixtures for robot-assisted cochlear implant insertion

Wilkening, P., Chien, W., Gonenc, B., Niparko, J., Kang, J. U., Iordachita, I. & Taylor, R. H., Sep 30 2014, "2014 5th IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics, BioRob 2014. Carloni, R., Masia, L., Sabater-Navarro, J. M., Ackermann, M., Agrawal, S., Ajoudani, A., Artemiadis, P., Bianchi, M., Lanari Bo, A. P., Casadio, M., Cleary, K., Deshpande, A., Formica, D., Fumagalli, M., Garcia-Aracil, N., Godfrey, S. B., Khalil, I. S. M., Lambercy, O., Loureiro, R. C. V., Mattos, L., Munoz, V., Park, H-S., Rodriguez Cheu, L. E., Saltaren, R., Siqueira, A. A. G., Squeri, V., Stienen, A. H. A., Tsagarakis, N., Van der Kooij, H., Vanderborght, B., Vitiello, N., Zariffa, J. & Zollo, L. (eds.). IEEE Computer Society, p. 332-338 7 p. 6913798. (Proceedings of the IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Introduction

Chien, W., Dec 1 2014, In : Operative Techniques in Otolaryngology - Head and Neck Surgery. 25, 4, 1 p.

Research output: Contribution to journalEditorial

Racial difference in cochlear pigmentation is associated with hearing loss risk

Sun, D. Q., Zhou, X., Lin, F. R., Francis, H. W., Carey, J. P. & Chien, W. W., Jan 1 2014, In : Otology and Neurotology. 35, 9, p. 1509-1514 6 p.

Research output: Contribution to journalArticle

Robot-assisted three-dimensional registration for cochlear implant surgery using a common-path swept-source optical coherence tomography probe

Gurbani, S. S., Wilkening, P., Zhao, M., Gonenc, B., Cheon, G. W., Iordachita, I. I., Chien, W., Taylor, R. H., Niparko, J. K. & Kang, J. U., May 2014, In : Journal of biomedical optics. 19, 5, 057004.

Research output: Contribution to journalArticle

Techniques in cochlear implantation

Weinreich, H. M., Francis, H. W., Niparko, J. K. & Chien, W. W., Dec 1 2014, In : Operative Techniques in Otolaryngology - Head and Neck Surgery. 25, 4, p. 312-320 9 p.

Research output: Contribution to journalArticle

2013

Perception of pure tones and iterated rippled noise for normal hearing and cochlear implant users

Penninger, R. T., Chien, W. W., Jiradejvong, P., Boeke, E., Carver, C. L. & Limb, C. J., Mar 2013, In : Trends in Amplification. 17, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

Sensing and three-dimensional imaging of cochlea and surrounding temporal bone using swept source high-speed optical coherence tomography

Zhao, M., Chien, W. W., Taylor, R., Iordachita, I., Huang, Y., Niparko, J. & Kang, J. U., May 22 2013, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII. 857121. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 8571).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sensing and three-dimensional OCT imaging of the cochlea and temporal bone: Image-guided cochlear implantation

Zhao, M., Chien, W. W., Iordachita, I., Huang, Y., Taylor, R., Niparko, J. & Kang, J. U., May 30 2013, Photonic Therapeutics and Diagnostics IX. 85651U. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 8565).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Serial suture ligation glossectomy for squamous cell carcinoma in the setting of a massive lymphovascular malformation

Chien, W., Lin, H. W. & Deschler, D. G., May 1 2013, In : Head and Neck. 35, 5, p. E157-E160

Research output: Contribution to journalArticle

Use of SLC26A4 mutation testing for unilateral enlargement of the vestibular aqueduct

Chattaraj, P., Reimold, F. R., Muskett, J. A., Shmukler, B. E., Chien, W. W., Madeo, A. C., Pryor, S. P., Zalewski, C. K., Butman, J. A., Brewer, C. C., Kenna, M. A., Alper, S. L. & Griffith, A. J., Sep 2013, In : JAMA Otolaryngology - Head and Neck Surgery. 139, 9, p. 907-913 7 p.

Research output: Contribution to journalArticle

2012

Cochlear implantation in older adults

Lin, F. R., Chien, W. W., Li, L., Clarrett, D. M., Niparko, J. K. & Francis, H. W., Sep 1 2012, In : Medicine (United States). 91, 5, p. 229-241 13 p.

Research output: Contribution to journalArticle

Evaluation, optimization, and verification of the wrist mechanism of a new cooperatively controlled bimanual ENT microsurgery robot

He, C., Olds, K., Akst, L. M., Ishii, M., Chien, W. W., Iordachita, I. & Taylor, R., Dec 1 2012, ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012. p. 155-164 10 p. (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hearing Prosthetics: Surgical Techniques

Chien, W. W., Francis, H. & Niparko, J. K., Mar 1 2012, Schmidek and Sweet Operative Neurosurgical Techniques: Indications, Methods, and Results: Sixth Edition. Elsevier Inc., Vol. 1. p. 588-596 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Magnetic resonance imaging findings in meningitis

Markman, T., Aygun, N. & Chien, W. W., Sep 1 2012, In : Otology and Neurotology. 33, 7, p. e57-e58

Research output: Contribution to journalComment/debate

Otopathology in osteogenesis imperfecta

Santos, F., McCall, A. A., Chien, W. & Merchant, S., Dec 1 2012, In : Otology and Neurotology. 33, 9, p. 1562-1566 5 p.

Research output: Contribution to journalArticle

Prevalence of hearing aid use among older adults in the United States

Chien, W. & Lin, F. R., Feb 13 2012, In : Archives of internal medicine. 172, 3, p. 292-293 2 p.

Research output: Contribution to journalArticle

Risk factors for vagal palsy following cerebellopontine angle surgery

Best, S. R., Starmer, H. M., Agrawal, Y., Ward, B. K., Hillel, A. T., Chien, W. W., Francis, H. W., Tamargo, R. J. & Akst, L. M., Aug 1 2012, In : Otolaryngology - Head and Neck Surgery (United States). 147, 2, p. 364-368 5 p.

Research output: Contribution to journalReview article

Superior canal dehiscence size: Multivariate assessment of clinical impact

Chien, W. W., Janky, K., Minor, L. B. & Carey, J. P., Jul 1 2012, In : Otology and Neurotology. 33, 5, p. 810-815 6 p.

Research output: Contribution to journalArticle

Technical skills improve after practice on virtual-reality temporal bone simulator

Francis, H. W., Malik, M. U., Diaz Voss Varela, D. A., Barffour, M. A., Chien, W. W., Carey, J. P., Niparko, J. K. & Bhatti, N. I., Jun 1 2012, In : Laryngoscope. 122, 6, p. 1385-1391 7 p.

Research output: Contribution to journalArticle

2011

Canal dehiscence

Chien, W. W., Carey, J. P. & Minor, L. B., Feb 1 2011, In : Current opinion in neurology. 24, 1, p. 25-31 7 p.

Research output: Contribution to journalReview article

Using a virtual reality temporal bone simulator to enhance surgical competency in procedural tasks: A pilot study

Malik, M. U., Diaz Voss Varela, D. A., Francis, H. W., Pandian, V., Chien, W. W., Agrawal, Y., Niparko, J. K. & Bhatti, N. I., Jan 1 2011, In : Laryngoscope. 121, SUPPL. 4, p. S186

Research output: Contribution to journalArticle

2009

Anatomy of the distal incus in humans

Chien, W., Northrop, C., Levine, S., Pilch, B. Z., Peake, W. T., Rosowski, J. J. & Merchant, S. N., Dec 1 2009, In : JARO - Journal of the Association for Research in Otolaryngology. 10, 4, p. 485-496 12 p.

Research output: Contribution to journalArticle

Measurements of stapes velocity in live human ears

Chien, W., Rosowski, J. J., Ravicz, M. E., Rauch, S. D., Smullen, J. & Merchant, S. N., Mar 2009, In : Hearing Research. 249, 1-2, p. 54-61 8 p.

Research output: Contribution to journalArticle