Wade W Chien

Associate Professor

20052019
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Research Output 2005 2019

2019

AAV2.7m8 is a powerful viral vector for inner ear gene therapy

Isgrig, K., McDougald, D. S., Zhu, J., Wang, H. J., Bennett, J. & Chien, W. W., Dec 1 2019, In : Nature Communications. 10, 1, 427.

Research output: Contribution to journalArticle

gene therapy
Gene therapy
hair
ear
Inner Ear

Sex differences in HPV immunity among adults without cancer

Windon, M. J., Waterboer, T., Hillel, A. T., Chien, W. W., Best, S. R., Stewart, C. M., Akst, L. M., Troy, T., Bender, N., Miles, B., Ryan, W. R., Mandal, R., Pitman, K., Eisele, D. W., Fakhry, C. & D'Souza, G., Jan 1 2019, In : Human Vaccines and Immunotherapeutics.

Research output: Contribution to journalArticle

Seroepidemiologic Studies
Sex Characteristics
Sexual Partners
Immunity
Neoplasms

SLC26A4-linked CEVA haplotype correlates with phenotype in patients with enlargement of the vestibular aqueduct

Chao, J. R., Chattaraj, P., Munjal, T., Honda, K., King, K. A., Zalewski, C. K., Chien, W. W., Brewer, C. C. & Griffith, A. J., Jul 2 2019, In : BMC Medical Genetics. 20, 1, 118.

Research output: Contribution to journalArticle

Open Access
Vestibular Aqueduct
Haplotypes
Phenotype
Alleles
Mutation

Surgical methods for inner ear gene delivery in neonatal mouse

Isgrig, K. & Chien, W. W., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 221-226 6 p. (Methods in Molecular Biology; vol. 1937).

Research output: Chapter in Book/Report/Conference proceedingChapter

Inner Ear
Genetic Therapy
Genes
Ear Round Window
Semicircular Canals
2018

A CEP290 C-Terminal Domain Complements the Mutant CEP290 of Rd16 Mice In Trans and Rescues Retinal Degeneration

Mookherjee, S., Chen, H. Y., Isgrig, K., Yu, W., Hiriyanna, S., Levron, R., Li, T., Colosi, P., Chien, W. W., Swaroop, A. & Wu, Z., Oct 16 2018, In : Cell Reports. 25, 3, p. 611-623.e6

Research output: Contribution to journalArticle

Retinal Degeneration
Leber Congenital Amaurosis
Gene therapy
Mutation
Fibroblasts

A CRISPR way to restore hearing

Chien, W. W., Mar 29 2018, In : New England Journal of Medicine. 378, 13, p. 1255-1256 2 p.

Research output: Contribution to journalShort survey

Clustered Regularly Interspaced Short Palindromic Repeats
Hearing

Posterior semicircular canal approach for inner ear gene delivery in neonatal mouse

Isgrig, K. & Chien, W. W., Mar 2 2018, In : Journal of Visualized Experiments. 2018, 133, e56648.

Research output: Contribution to journalArticle

Semicircular Canals
Canals
Inner Ear
Gene therapy
Genes
2017

A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome

Moebius Syndrome Research Consortium, Jul 6 2017, In : Nature Communications. 8, 16077.

Research output: Contribution to journalArticle

Myotonia Congenita
Genetic Databases
Cell Fusion
Myoblasts
Zebrafish

Gene Therapy Restores Balance and Auditory Functions in a Mouse Model of Usher Syndrome

Isgrig, K., Shteamer, J. W., Belyantseva, I. A., Drummond, M. C., Fitzgerald, T. S., Vijayakumar, S., Jones, S. M., Griffith, A. J., Friedman, T. B., Cunningham, L. L. & Chien, W. W., Mar 1 2017, In : Molecular Therapy. 25, 3, p. 780-791 12 p.

Research output: Contribution to journalArticle

Usher Syndromes
Stereocilia
Genetic Therapy
Hearing Disorders
Dizziness

Hearing Loss after Round Window Surgery in Mice Is due to Middle Ear Effusion

Zhu, B. Z., Saleh, J., Isgrig, K. T., Cunningham, L. L. & Chien, W. W., Jan 10 2017, (Accepted/In press) In : Audiology and Neurotology. p. 356-364 9 p.

Research output: Contribution to journalArticle

Otitis Media with Effusion
Hearing Loss
Otoscopy
Punctures
Brain Stem Auditory Evoked Potentials
2016

A genotypic ascertainment approach to refute the association of MYO1A variants with non-syndromic deafness

Patton, J., Brewer, C., Chien, W., Johnston, J. J., Griffith, A. J. & Biesecker, L. G., Oct 19 2016, (Accepted/In press) In : European Journal of Human Genetics.

Research output: Contribution to journalArticle

Sensorineural Hearing Loss
Deafness
Hearing Loss
Bilateral Hearing Loss
Audiology

Atypical patterns of segregation of familial enlargement of the vestibular aqueduct

Muskett, J. A., Chattaraj, P., Heneghan, J. F., Reimold, F. R., Shmukler, B. E., Brewer, C. C., King, K. A., Zalewski, C. K., Shawker, T. H., Butman, J. A., Kenna, M. A., Chien, W. W., Alper, S. L. & Griffith, A. J., Jul 1 2016, In : Laryngoscope. 126, 7, p. E240-E247

Research output: Contribution to journalArticle

Vestibular Aqueduct
Alleles
Hearing Loss
Mutation
Genotype

GATA3 haploinsufficiency does not block allergic sensitization or atopic disease

Lawrence, M. G., Leiding, J. W., Lyons, J. J., Hsu, A. P., Nelson, C. C., Jones, N., Fitzgerald, A., Chien, W. W., Workman, L., Platts-Mills, T. A., Brewer, C., Gafni, R. I., Stone, K. D., Milner, J. D. & Holland, S. M., Feb 1 2016, In : The Journal of Allergy and Clinical Immunology. 137, 2, p. 617-629 13 p.

Research output: Contribution to journalArticle

GATA3 Transcription Factor
Haploinsufficiency
Immediate Hypersensitivity
T-Lymphocyte Subsets
Skin Tests

Gene therapy restores hair cell stereocilia morphology in inner ears of deaf whirler mice

Chien, W. W., Isgrig, K., Roy, S., Belyantseva, I. A., Drummond, M. C., May, L. A., Fitzgerald, T. S., Friedman, T. B. & Cunningham, L. L., Feb 1 2016, In : Molecular Therapy. 24, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Stereocilia
Deafness
Inner Ear
Inner Auditory Hair Cells
Genetic Therapy

Hearing loss associated with enlarged vestibular aqueduct and zero or one mutant allele of SLC26A4

Rose, J., Muskett, J. A., King, K. A., Zalewski, C. K., Chattaraj, P., Butman, J. A., Kenna, M. A., Chien, W. W., Brewer, C. C. & Griffith, A. J., 2016, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Hearing Loss
Alleles
Ear
Cochlear Implants
Cochlear Implantation

Racial differences of pigmentation in the human vestibular organs

Erbele, I. D., Lin, F., Agrawal, Y., Francis, H. W., Carey, J. P. & Chien, W. W., Sep 1 2016, In : Otolaryngology - Head and Neck Surgery. 155, 3, p. 479-484 6 p.

Research output: Contribution to journalArticle

Melanins
Pigmentation
Temporal Bone
African Americans
Endolymphatic Duct

Research Techniques Made Simple: The Application of CRISPR-Cas9 and Genome Editing in Investigative Dermatology

Guitart, J. R., Johnson, J. L. & Chien, W. W., Sep 1 2016, In : Journal of Investigative Dermatology. 136, 9, p. e87-e93

Research output: Contribution to journalShort survey

CRISPR-Associated Proteins
Dermatology
Research Design
Genes
Technology

Use of pericranial flap coverage in cochlear implantation of the radical cavity: Rationale, technique, and experience

Nieman, C., Weinreich, H. M., Sharon, J. D., Chien, W. W. & Francis, H. W., Sep 1 2016, In : Otolaryngology - Head and Neck Surgery. 155, 3, p. 533-537 5 p.

Research output: Contribution to journalArticle

Cochlear Implantation
Mastoid
Ear Canal
Cochlear Implants
Cholesteatoma
2015

Cochlear gene transfer mediated by adeno-associated virus: Comparison of two surgical approaches

Chien, W. W., McDougald, D. S., Roy, S., Fitzgerald, T. S. & Cunningham, L. L., Nov 1 2015, In : Laryngoscope. 125, 11, p. 2557-2564 8 p.

Research output: Contribution to journalArticle

Dependovirus
Cochlea
Hearing
Genes
Virus Diseases

Gene therapy for sensorineural hearing loss

Chien, W. W., Monzack, E. L., McDougald, D. S. & Cunningham, L. L., Jan 3 2015, In : Ear and Hearing. 36, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Sensorineural Hearing Loss
Genetic Therapy
Hearing Loss
Cochlea
Hearing

Restoration of middle-ear input in fluid-filled middle ears by controlled introduction of air or a novel air-filled implant

Ravicz, M. E., Chien, W. W. & Rosowski, J. J., Dec 3 2015, In : Hearing Research. 328, p. 8-23 16 p.

Research output: Contribution to journalArticle

Middle Ear
Air
Ossicular Prosthesis
Tympanic Membrane
Conductive Hearing Loss

Vestibular Dysfunction in Patients with Enlarged Vestibular Aqueduct

Zalewski, C. K., Chien, W. W., King, K. A., Muskett, J. A., Baron, R. E., Butman, J. A., Griffith, A. J. & Brewer, C. C., Aug 25 2015, In : Otolaryngology - Head and Neck Surgery. 153, 2, p. 257-262 6 p.

Research output: Contribution to journalArticle

Signs and Symptoms
Craniocerebral Trauma
Vestibular Evoked Myogenic Potentials
Enlarged Vestibular Aqueduct
National Institutes of Health (U.S.)
2014

3D optical coherence tomography image registration for guiding cochlear implant insertion

Cheon, G. W., Jeong, H. W., Chalasani, P., Chien, W. W., Iordachita, I., Taylor, R. H., Niparko, J. & Kang, J. U., 2014, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. SPIE, Vol. 8926. 89261Z

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cochlear implants
Cochlear Implants
Optical tomography
Cochlea
Image registration

Auditory and vestibular phenotypes associated with GATA3 mutation

Chien, W. W., Leiding, J. W., Hsu, A. P., Zalewski, C., King, K., Holland, S. M. & Brewer, C., 2014, In : Otology and Neurotology. 35, 4, p. 577-581 5 p.

Research output: Contribution to journalArticle

Phenotype
Mutation
Brain Stem Auditory Evoked Potentials
Hearing Loss
Outer Auditory Hair Cells

Evaluation of virtual fixtures for robot-assisted cochlear implant insertion

Wilkening, P., Chien, W. W., Gonenc, B., Niparko, J., Kang, J. U., Iordachita, I. & Taylor, R. H., Sep 30 2014, "2014 5th IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics, BioRob 2014. IEEE Computer Society, p. 332-338 7 p. 6913798

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cochlear implants
Robots
Electrodes
Audition
Robotics

Introduction

Chien, W., Dec 1 2014, In : Operative Techniques in Otolaryngology - Head and Neck Surgery. 25, 4, p. 311 1 p.

Research output: Contribution to journalArticle

Racial difference in cochlear pigmentation is associated with hearing loss risk

Sun, D., Zhou, X., Lin, F., Francis, H. W., Carey, J. P. & Chien, W. W., 2014, In : Otology and Neurotology. 35, 9, p. 1509-1514 6 p.

Research output: Contribution to journalArticle

Cochlea
Pigmentation
Hearing Loss
Melanins
African Americans

Robot-assisted three-dimensional registration for cochlear implant surgery using a common-path swept-source optical coherence tomography probe

Gurbani, S. S., Wilkening, P., Zhao, M., Gonenc, B., Cheon, G. W., Iordachita, I. I., Chien, W. W., Taylor, R. H., Niparko, J. K. & Kang, J. U., 2014, In : Journal of Biomedical Optics. 19, 5, 057004.

Research output: Contribution to journalArticle

Cochlear implants
cochlea
Optical tomography
robots
surgery

Techniques in cochlear implantation

Weinreich, H. M., Francis, H. W., Niparko, J. K. & Chien, W. W., Dec 1 2014, In : Operative Techniques in Otolaryngology - Head and Neck Surgery. 25, 4, p. 312-320 9 p.

Research output: Contribution to journalArticle

Cochlear Implantation
Hearing
Cochlea
Hearing Loss
Epithelium
2013

Perception of pure tones and iterated rippled noise for normal hearing and cochlear implant users

Penninger, R. T., Chien, W. W., Jiradejvong, P., Boeke, E., Carver, C. & Limb, C. J., Mar 2013, In : Trends in Amplification. 17, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

Cochlear Implants
Hearing
Noise
Aptitude

Sensing and three-dimensional imaging of cochlea and surrounding temporal bone using swept source high-speed optical coherence tomography

Zhao, M., Chien, W. W., Taylor, R. H., Iordachita, I., Huang, Y., Niparko, J. & Kang, J. U., 2013, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8571. 857121

Research output: Chapter in Book/Report/Conference proceedingConference contribution

cochlea
Three-Dimensional Imaging
Temporal Bone
Optical tomography
Cochlea

Sensing and three-dimensional OCT imaging of the cochlea and temporal bone: Image-guided cochlear implantation

Zhao, M., Chien, W. W., Iordachita, I., Huang, Y., Taylor, R. H., Niparko, J. & Kang, J. U., 2013, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8565. 85651U

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cochlear Implantation
cochlea
Temporal Bone
Optical tomography
Cochlea

Serial suture ligation glossectomy for squamous cell carcinoma in the setting of a massive lymphovascular malformation

Chien, W. W., Lin, H. W. & Deschler, D. G., May 2013, In : Head and Neck. 35, 5

Research output: Contribution to journalArticle

Glossectomy
Tongue
Sutures
Ligation
Squamous Cell Carcinoma

Use of SLC26A4 mutation testing for unilateral enlargement of the vestibular aqueduct

Chattaraj, P., Reimold, F. R., Muskett, J. A., Shmukler, B. E., Chien, W. W., Madeo, A. C., Pryor, S. P., Zalewski, C. K., Butman, J. A., Brewer, C. C., Kenna, M. A., Alper, S. L. & Griffith, A. J., Sep 2013, In : JAMA Otolaryngology - Head and Neck Surgery. 139, 9, p. 907-913 7 p.

Research output: Contribution to journalArticle

Vestibular Aqueduct
Mutation
Alleles
Genotype
Unilateral Hearing Loss
2012
Skin Pigmentation
Hearing Loss
Hearing
Hispanic Americans
Skin

Cochlear implantation in older adults

Lin, F., Chien, W. W., Li, L., Clarrett, D. M., Niparko, J. K. & Francis, H. W., Sep 2012, In : Medicine (United States). 91, 5, p. 229-241 13 p.

Research output: Contribution to journalArticle

Cochlear Implantation
Cochlear Implants
Hearing Loss
Language
Population

Evaluation, optimization, and verification of the wrist mechanism of a new cooperatively controlled bimanual ENT microsurgery robot

He, C., Olds, K., Akst, L. M., Ishii, M., Chien, W. W., Iordachita, I. & Taylor, R. H., 2012, ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE). Vol. 2. p. 155-164 10 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Robots
Surgery
Kinematics
Stiffness
Experiments

Hearing Prosthetics: Surgical Techniques

Chien, W. W., Francis, H. & Niparko, J. K., Mar 2012, Schmidek and Sweet Operative Neurosurgical Techniques: Indications, Methods, and Results: Sixth Edition. Elsevier Inc., Vol. 1. p. 588-596 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hearing

Magnetic resonance imaging findings in meningitis

Markman, T., Aygun, N. & Chien, W. W., Sep 2012, In : Otology and Neurotology. 33, 7

Research output: Contribution to journalArticle

Cerebellar Neoplasms
Pneumococcal Meningitis
Cerebellopontine Angle
Sensorineural Hearing Loss
Meningioma

Otopathology in osteogenesis imperfecta

Santos, F., McCall, A. A., Chien, W. W. & Merchant, S., Dec 2012, In : Otology and Neurotology. 33, 9, p. 1562-1566 5 p.

Research output: Contribution to journalArticle

Osteogenesis Imperfecta
Hearing Loss
Temporal Bone
Cochlea
Otosclerosis
Cerebellopontine Angle
Deglutition Disorders
Deglutition
Facial Nerve
Referral and Consultation

Prevalence of hearing aid use among older adults in the United States

Chien, W. W. & Lin, F., Feb 13 2012, In : Archives of Internal Medicine. 172, 3, p. 292-293 2 p.

Research output: Contribution to journalArticle

Hearing Aids

Risk factors for vagal palsy following cerebellopontine angle surgery

Best, S. R., Starmer, H. M., Agrawal, Y., Ward, B., Hillel, A. T., Chien, W. W., Francis, H. W., Tamargo, R. J. & Akst, L. M., Aug 2012, In : Otolaryngology - Head and Neck Surgery. 147, 2, p. 364-368 5 p.

Research output: Contribution to journalArticle

Cerebellopontine Angle
Paralysis
Vocal Cords
Deglutition
Length of Stay

Superior canal dehiscence size: Multivariate assessment of clinical impact

Chien, W. W., Janky, K., Minor, L. B. & Carey, J. P., Jul 2012, In : Otology and Neurotology. 33, 5, p. 810-815 6 p.

Research output: Contribution to journalArticle

Semicircular Canals
Vestibular Evoked Myogenic Potentials
Bone Conduction
Air
Bone and Bones

Technical skills improve after practice on virtual-reality temporal bone simulator

Francis, H. W., Malik, M. U., Diaz Voss Varela, D. A., Barffour, M. A., Chien, W. W., Carey, J. P., Niparko, J. K. & Bhatti, N. I., Jun 2012, In : Laryngoscope. 122, 6, p. 1385-1391 7 p.

Research output: Contribution to journalArticle

Temporal Bone
Sigmoid Colon
Mastoid
Dissection
Operating Rooms
2011

Canal dehiscence

Chien, W. W., Carey, J. P. & Minor, L. B., Feb 2011, In : Current Opinion in Neurology. 24, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

Semicircular Canals
Otitis Media
Inner Ear
Cholesteatoma
Vertigo

Using a virtual reality temporal bone simulator to enhance surgical competency in procedural tasks: A pilot study

Malik, M. U., Diaz Voss Varela, D. A., Francis, H. W., Pandian, V., Chien, W. W., Agrawal, Y., Niparko, J. K. & Bhatti, N. I., 2011, In : Laryngoscope. 121, SUPPL. 4

Research output: Contribution to journalArticle

Temporal Bone
Otolaryngology
Operating Rooms
Mandrillus
Sigmoid Colon
2009

Anatomy of the distal incus in humans

Chien, W. W., Northrop, C., Levine, S., Pilch, B. Z., Peake, W. T., Rosowski, J. J. & Merchant, S. N., Dec 2009, In : JARO - Journal of the Association for Research in Otolaryngology. 10, 4, p. 485-496 12 p.

Research output: Contribution to journalArticle

Incus
Anatomy
Osteocytes
Temporal Bone
Bone Resorption

Measurements of stapes velocity in live human ears

Chien, W. W., Rosowski, J. J., Ravicz, M. E., Rauch, S. D., Smullen, J. & Merchant, S. N., 2009, In : Hearing Research. 249, 1-2, p. 54-61 8 p.

Research output: Contribution to journalArticle

Stapes
Ear
Middle Ear
Accidental Falls
Cochlear Implantation
2008

Isolated fracture of the manubrium of the malleus

Chien, W. W., McKenna, M. J., Rosowski, J. J. & Merchant, S. N., Sep 2008, In : Journal of Laryngology and Otology. 122, 9, p. 898-904 7 p.

Research output: Contribution to journalArticle

Manubrium
Malleus
Acoustic Impedance Tests
Audiometry
Ear Canal