Wade W Chien

ASSOCIATE PROFESSOR

20052019
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Research Output 2005 2019

AAV2.7m8 is a powerful viral vector for inner ear gene therapy

Isgrig, K., McDougald, D. S., Zhu, J., Wang, H. J., Bennett, J. & Chien, W. W., Dec 1 2019, In : Nature communications. 10, 1, 427.

Research output: Contribution to journalArticle

gene therapy
Gene therapy
hair
ear
Inner Ear

A CEP290 C-Terminal Domain Complements the Mutant CEP290 of Rd16 Mice In Trans and Rescues Retinal Degeneration

Mookherjee, S., Chen, H. Y., Isgrig, K., Yu, W., Hiriyanna, S., Levron, R., Li, T., Colosi, P., Chien, W. W., Swaroop, A. & Wu, Z., Oct 16 2018, In : Cell Reports. 25, 3, p. 611-623.e6

Research output: Contribution to journalArticle

Retinal Degeneration
Leber Congenital Amaurosis
Gene therapy
Mutation
Fibroblasts

A CRISPR way to restore hearing

Chien, W. W., Mar 29 2018, In : New England Journal of Medicine. 378, 13, p. 1255-1256 2 p.

Research output: Contribution to journalShort survey

Clustered Regularly Interspaced Short Palindromic Repeats
Hearing

Posterior semicircular canal approach for inner ear gene delivery in neonatal mouse

Isgrig, K. & Chien, W. W., Mar 2 2018, In : Journal of Visualized Experiments. 2018, 133, e56648.

Research output: Contribution to journalArticle

Semicircular Canals
Canals
Inner Ear
Gene therapy
Genes

A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome

Moebius Syndrome Research Consortium, Jul 6 2017, In : Nature Communications. 8, 16077.

Research output: Contribution to journalArticle

Myotonia Congenita
Genetic Databases
Cell Fusion
Myoblasts
Zebrafish