Vilmos Adleff

Research output

Research output per year 2015 2017 2019 2020 2023 2024

• 19 Article

Research output per year

Research output per year

Search results

• 2024

  Genome-wide repeat landscapes in cancer and cell-free DNA

  Annapragada, A. V., Niknafs, N., White, J. R., Bruhm, D. C., Cherry, C., Medina, J. E., Adleff, V., Hruban, C., Mathios, D., Foda, Z. H., Phallen, J., Scharpf, R. B. & Velculescu, V. E., Mar 13 2024, In: Science translational medicine. 16, 738, eadj9283.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2023

  Detecting Liver Cancer Using Cell-Free DNA Fragmentomes

  Foda, Z. H., Annapragada, A. V., Boyapati, K., Bruhm, D. C., Vulpescu, N. A., Medina, J. E., Mathios, D., Cristiano, S., Niknafs, N., Luu, H. T., Goggins, M. G., Anders, R. A., Sun, J., Meta, S. H., Thomas, D. L., Kirk, G. D., Adleff, V., Phallen, J., Scharpf, R. B., Kim, A. K., & 1 othersVelculescu, V. E., Mar 1 2023, In: Cancer discovery. 13, 3, p. 616-631 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell-Free Nucleic Acids 100%
  • Liver Neoplasms 79%
  • DNA Fragmentation 63%
  • Hepatocellular Carcinoma 47%
  • Genome 26%

• Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells

  van 't Erve, I., Medina, J. E., Leal, A., Papp, E., Phallen, J., Adleff, V., Chiao, E. J., Arun, A. S., Bolhuis, K., Simmons, J. K., Karandikar, A., Valkenburg, K. C., Sausen, M., Angiuoli, S. V., Scharpf, R. B., Punt, C. J. A., Meijer, G. A., Velculescu, V. E. & Fijneman, R. J. A., Mar 1 2023, In: Clinical Cancer Research. 29, 5, p. 899-909 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Circulating Tumor DNA 100%
  • Cell-Free Nucleic Acids 87%
  • High-Throughput Nucleotide Sequencing 66%
  • Colorectal Neoplasms 55%
  • Leukocytes 55%

• Single-molecule genome-wide mutation profiles of cell-free DNA for non-invasive detection of cancer

  Bruhm, D. C., Mathios, D., Foda, Z. H., Annapragada, A. V., Medina, J. E., Adleff, V., Chiao, E. J., Ferreira, L., Cristiano, S., White, J. R., Mazzilli, S. A., Billatos, E., Spira, A., Zaidi, A. H., Mueller, J., Kim, A. K., Anagnostou, V., Phallen, J., Scharpf, R. B. & Velculescu, V. E., Aug 2023, In: Nature genetics. 55, 8, p. 1301-1310 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell-Free Nucleic Acids 100%
  • Genome 53%
  • Mutation 44%
  • Neoplasms 25%
  • Whole Genome Sequencing 18%
• 2021

  Detection and characterization of lung cancer using cell-free DNA fragmentomes

  Mathios, D., Johansen, J. S., Cristiano, S., Medina, J. E., Phallen, J., Larsen, K. R., Bruhm, D. C., Niknafs, N., Ferreira, L., Adleff, V., Chiao, J. Y., Leal, A., Noe, M., White, J. R., Arun, A. S., Hruban, C., Annapragada, A. V., Jensen, S. Ø., Ørntoft, M. B. W., Madsen, A. H., & 18 othersCarvalho, B., de Wit, M., Carey, J., Dracopoli, N. C., Maddala, T., Fang, K. C., Hartman, A. R., Forde, P. M., Anagnostou, V., Brahmer, J. R., Fijneman, R. J. A., Nielsen, H. J., Meijer, G. A., Andersen, C. L., Mellemgaard, A., Bojesen, S. E., Scharpf, R. B. & Velculescu, V. E., Dec 1 2021, In: Nature communications. 12, 1, 5060.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell-Free Nucleic Acids 100%
  • lungs 86%
  • cancer 74%
  • deoxyribonucleic acid 71%
  • Fragmentation 65%
• 2020

  Genomic characterization of malignant progression in neoplastic pancreatic cysts

  Noë, M., Niknafs, N., Fischer, C. G., Hackeng, W. M., Beleva Guthrie, V., Hosoda, W., Debeljak, M., Papp, E., Adleff, V., White, J. R., Luchini, C., Pea, A., Scarpa, A., Butturini, G., Zamboni, G., Castelli, P., Hong, S. M., Yachida, S., Hiraoka, N., Gill, A. J., & 18 othersSamra, J. S., Offerhaus, G. J. A., Hoorens, A., Verheij, J., Jansen, C., Adsay, N. V., Jiang, W., Winter, J., Albores-Saavedra, J., Terris, B., Thompson, E. D., Roberts, N. J., Hruban, R. H., Karchin, R., Scharpf, R. B., Brosens, L. A. A., Velculescu, V. E. & Wood, L. D., Dec 1 2020, In: Nature communications. 11, 1, 4085.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • neoplasms 100%
  • cysts 91%
  • Pancreatic Cyst 90%
  • progressions 70%
  • Mutation 52%
  10 Scopus citations

• Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer

  Anagnostou, V., Niknafs, N., Marrone, K., Bruhm, D. C., White, J. R., Naidoo, J., Hummelink, K., Monkhorst, K., Lalezari, F., Lanis, M., Rosner, S., Reuss, J. E., Smith, K. N., Adleff, V., Rodgers, K., Belcaid, Z., Rhymee, L., Levy, B., Feliciano, J., Hann, C. L., & 15 othersEttinger, D. S., Georgiades, C., Verde, F., Illei, P., Li, Q. K., Baras, A. S., Gabrielson, E., Brock, M. V., Karchin, R., Pardoll, D. M., Baylin, S. B., Brahmer, J. R., Scharpf, R. B., Forde, P. M. & Velculescu, V. E., Jan 1 2020, In: Nature Cancer. 1, 1, p. 99-111 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Non-Small Cell Lung Carcinoma 100%
  • Tumor Burden 45%
  • Mutation 44%
  • Immunotherapy 42%
  • Neoplasms 36%

• White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer

  Leal, A., van Grieken, N. C. T., Palsgrove, D. N., Phallen, J., Medina, J. E., Hruban, C., Broeckaert, M. A. M., Anagnostou, V., Adleff, V., Bruhm, D. C., Canzoniero, J. V., Fiksel, J., Nordsmark, M., Warmerdam, F. A. R. M., Verheul, H. M. W., van Spronsen, D. J., Beerepoot, L. V., Geenen, M. M., Portielje, J. E. A., Jansen, E. P. M., & 11 othersvan Sandick, J., Meershoek-Klein Kranenbarg, E., van Laarhoven, H. W. M., van der Peet, D. L., van de Velde, C. J. H., Verheij, M., Fijneman, R., Scharpf, R. B., Meijer, G. A., Cats, A. & Velculescu, V. E., Dec 1 2020, In: Nature communications. 11, 1, 525.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • leukocytes 100%
  • Cell-Free Nucleic Acids 90%
  • Circulating Tumor DNA 69%
  • cancer 67%
  • deoxyribonucleic acid 65%
  26 Scopus citations
• 2019

  Dynamics of tumor and immune responses during immune checkpoint blockade in non–small cell lung cancer

  Anagnostou, V., Forde, P. M., White, J. R., Niknafs, N., Hruban, C., Naidoo, J., Marrone, K., Ashok Sivakumar, I. K., Bruhm, D. C., Rosner, S., Phallen, J., Leal, A., Adleff, V., Smith, K. N., Cottrell, T. R., Rhymee, L., Palsgrove, D. N., Hann, C. L., Levy, B., Feliciano, J., & 16 othersGeorgiades, C., Verde, F., Illei, P., Li, Q. K., Gabrielson, E., Brock, M. V., Isbell, J. M., Sauter, J. L., Taube, J., Scharpf, R. B., Karchin, R., Pardoll, D. M., Chaft, J. E., Hellmann, M. D., Brahmer, J. R. & Velculescu, V. E., 2019, In: Cancer Research. 79, 6, p. 1214-1225 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Circulating Tumor DNA 100%
  • Non-Small Cell Lung Carcinoma 72%
  • Neoplasms 26%
  • T-Lymphocytes 14%
  • Confidence Intervals 13%
  61 Scopus citations

• Early noninvasive detection of response to targeted therapy in non–small cell lung cancer

  Phallen, J., Leal, A., Woodward, B. D., Forde, P. M., Naidoo, J., Marrone, K. A., Brahmer, J. R., Fiksel, J., Medina, J. E., Cristiano, S., Palsgrove, D. N., Gocke, C. D., Bruhm, D. C., Keshavarzian, P., Adleff, V., Weihe, E., Anagnostou, V., Scharpf, R. B., Velculescu, V. E. & Husain, H., 2019, In: Cancer Research. 79, 6, p. 1204-1213 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Circulating Tumor DNA 100%
  • Non-Small Cell Lung Carcinoma 62%
  • Whole Genome Sequencing 16%
  • Tumor Burden 13%
  • Genetic Therapy 12%
  31 Scopus citations

• Genome-wide cell-free DNA fragmentation in patients with cancer

  Cristiano, S., Leal, A., Phallen, J., Fiksel, J., Adleff, V., Bruhm, D. C., Jensen, S. Ø., Medina, J. E., Hruban, C., White, J. R., Palsgrove, D. N., Niknafs, N., Anagnostou, V., Forde, P., Naidoo, J., Marrone, K., Brahmer, J., Woodward, B. D., Husain, H., van Rooijen, K. L., & 16 othersØrntoft, M. B. W., Madsen, A. H., van de Velde, C. J. H., Verheij, M., Cats, A., Punt, C. J. A., Vink, G. R., van Grieken, N. C. T., Koopman, M., Fijneman, R. J. A., Johansen, J. S., Nielsen, H. J., Meijer, G. A., Andersen, C. L., Scharpf, R. B. & Velculescu, V. E., Jun 20 2019, In: Nature. 570, 7761, p. 385-389 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell-Free Nucleic Acids 100%
  • DNA Fragmentation 84%
  • Genome 53%
  • Neoplasms 25%
  • Bile Duct Neoplasms 22%
  171 Scopus citations
• 2018

  Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines

  Papp, E., Hallberg, D., Konecny, G. E., Bruhm, D. C., Adleff, V., Noë, M., Kagiampakis, I., Palsgrove, D., Conklin, D., Kinose, Y., White, J. R., Press, M. F., Drapkin, R., Easwaran, H., Baylin, S. B., Slamon, D., Velculescu, V. E. & Scharpf, R. B., Nov 27 2018, In: Cell Reports. 25, 9, p. 2617-2633 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinase) Inhibitor 100%
  • Ovarian Neoplasms 56%
  • Epigenomics 54%
  • Cell Line 36%
  • Poly(ADP-ribose) Polymerase Inhibitors 27%
  31 Scopus citations
• 2017

  Direct detection of early-stage cancers using circulating tumor DNA

  Phallen, J., Sausen, M., Adleff, V., Leal, A., Hruban, C., White, J., Anagnostou, V., Fiksel, J., Cristiano, S., Papp, E., Speir, S., Reinert, T., Orntoft, M. B. W., Woodward, B. D., Murphy, D., Parpart-Li, S., Riley, D., Nesselbush, M., Sengamalay, N., Georgiadis, A., & 17 othersLi, Q. K., Madsen, M. R., Mortensen, F. V., Huiskens, J., Punt, C., Van Grieken, N., Fijneman, R., Meijer, G., Husain, H., Scharpf, R. B., Diaz, L. A., Jones, S., Angiuoli, S., Ørntoft, T., Nielsen, H. J., Andersen, C. L. & Velculescu, V. E., Aug 16 2017, In: Science translational medicine. 9, 403, eaan2415.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Circulating Tumor DNA 100%
  • Early Detection of Cancer 65%
  • Neoplasms 22%
  • Colorectal Neoplasms 18%
  • Lung Neoplasms 18%
  376 Scopus citations

• Establishment of patient-derived tumor xenograft models of epithelial ovarian cancer for preclinical evaluation of novel therapeutics

  Liu, J. F., Palakurthi, S., Zeng, Q., Zhou, S., Ivanova, E., Huang, W., Zervantonakis, I. K., Selfors, L. M., Shen, Y., Pritchard, C. C., Zheng, M., Adleff, V., Papp, E., Piao, H., Novak, M., Fotheringham, S., Wulf, G. M., English, J., Kirschmeier, P. T., Velculescu, V. E., & 6 othersPaweletz, C., Mills, G. B., Livingston, D. M., Brugge, J. S., Matulonis, U. A. & Drapkin, R., Mar 1 2017, In: Clinical Cancer Research. 23, 5, p. 1263-1273 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ovarian Epithelial Carcinoma 100%
  • Heterografts 77%
  • Neoplasms 27%
  • Tumor Burden 18%
  • Ovarian Neoplasms 17%
  46 Scopus citations

• Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer

  Anagnostou, V., Smith, K. N., Forde, P. M., Niknafs, N., Bhattacharya, R., White, J., Zhang, T., Adleff, V., Phallen, J., Wali, N., Hruban, C., Guthrie, V. B., Rodgers, K., Naidoo, J., Kang, H., Sharfman, W., Georgiades, C., Verde, F., Illei, P., Li, Q. K., & 9 othersGabrielson, E., Brock, M. V., Zahnow, C. A., Baylin, S. B., Scharpf, R. B., Brahmer, J. R., Karchin, R., Pardoll, D. M. & Velculescu, V. E., Mar 2017, In: Cancer discovery. 7, 3, p. 264-276 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Non-Small Cell Lung Carcinoma 100%
  • Neoplasms 36%
  • T-Lymphocytes 34%
  • Mutation 31%
  • T-Cell Antigen Receptor 18%
  391 Scopus citations

• High grade serous ovarian carcinomas originate in the fallopian tube

  Labidi-Galy, S. I., Papp, E., Hallberg, D., Niknafs, N., Adleff, V., Noe, M., Bhattacharya, R., Novak, M., Jones, S., Phallen, J., Hruban, C. A., Hirsch, M. S., Lin, D. I., Schwartz, L., Maire, C. L., Tille, J. C., Bowden, M., Ayhan, A., Wood, L. D., Scharpf, R. B., & 6 othersKurman, R., Wang, T. L., Shih, I. M., Karchin, R., Drapkin, R. & Velculescu, V. E., Dec 1 2017, In: Nature communications. 8, 1, 1093.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fallopian Tubes 100%
  • grade 80%
  • cancer 77%
  • Carcinoma in Situ 75%
  • Ovarian Neoplasms 60%
  215 Scopus citations

• The effect of preservative and temperature on the analysis of circulating tumor DNA

  Parpart-Li, S., Bartlett, B., Popoli, M., Adleff, V., Tucker, L., Steinberg, R., Georgiadis, A., Phallen, J., Brahmer, J., Azad, N., Browner, I., Laheru, D., Velculescu, V. E., Sausen, M. & Diaz, L. A., May 15 2017, In: Clinical Cancer Research. 23, 10, p. 2471-2477 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Circulating Tumor DNA 100%
  • Cell-Free Nucleic Acids 87%
  • Temperature 49%
  • Edetic Acid 8%
  • Neoplasms 7%
  94 Scopus citations
• 2015

  Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

  Sausen, M., Phallen, J., Adleff, V., Jones, S., Leary, R. J., Barrett, M. T., Anagnostou, V., Parpart-Li, S., Murphy, D., Li, Q. K., Hruban, C. A., Scharpf, R., White, J. R., O'Dwyer, P. J., Allen, P. J., Eshleman, J. R., Thompson, C. B., Klimstra, D. S., Linehan, D. C., Maitra, A., & 6 othersHruban, R. H., Diaz, L. A., Von Hoff, D. D., Johansen, J. S., Drebin, J. A. & Velculescu, V. E., Jul 7 2015, In: Nature communications. 6, 7686.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • tumors 100%
  • Pancreatic Neoplasms 99%
  • cancer 97%
  • Circulating Tumor DNA 90%
  • Mutation 88%
  237 Scopus citations

• The genomic landscape of response to EGFR blockade in colorectal cancer

  Bertotti, A., Papp, E., Jones, S., Adleff, V., Anagnostou, V., Lupo, B., Sausen, M., Phallen, J., Hruban, C. A., Tokheim, C., Niknafs, N., Nesselbush, M., Lytle, K., Sassi, F., Cottino, F., Migliardi, G., Zanella, E. R., Ribero, D., Russolillo, N., Mellano, A., & 15 othersMuratore, A., Paraluppi, G., Salizzoni, M., Marsoni, S., Kragh, M., Lantto, J., Cassingena, A., Li, Q. K., Karchin, R., Scharpf, R., Sartore-Bianchi, A., Siena, S., Diaz, L. A., Trusolino, L. & Velculescu, V. E., Oct 8 2015, In: Nature. 526, 7572, p. 263-267 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ErbB Receptors 100%
  • Colorectal Neoplasms 83%
  • Neoplasms 24%
  • Transplants 17%
  • Therapeutics 17%
  251 Scopus citations