Victor E Velculescu

Professor

1993 …2019
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Research Output 1993 2019

2019

Addressing the dichotomy between individual and societal approaches to personalised medicine in oncology

the IBCD-Faculty, Jun 1 2019, In : European Journal of Cancer. 114, p. 128-136 9 p.

Research output: Contribution to journalArticle

Precision Medicine
Neoplasms
Delivery of Health Care
Tumor Biomarkers
Industry

Combined MEK and Bcl-2/X L inhibition is effective in high-grade serous ovarian cancer patient–derived xenograft models and BIM levels are predictive of responsiveness

Iavarone, C., Zervantonakis, I. K., Selfors, L. M., Palakurthi, S., Liu, J. F., Drapkin, R., Matulonis, U. A., Hallberg, D., Velculescu, V. E., Leverson, J. D., Sampath, D., Mills, G. B. & Brugge, J. S., Mar 1 2019, In : Molecular cancer therapeutics. 18, 3, p. 642-655 14 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Heterografts
Ovarian Neoplasms
MAP Kinase Signaling System
Drug Combinations

Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1 (Journal for Immuno Therapy of Cancer (2019) 7 (40) DOI: 10.1186/s40425-018-0492-x)

Smith, K., Llosa, N., Cottrell, T. R., Siegel, N., Fan, H., Suri, P., Chan, H. Y., Guo, H., Oke, T., Awan, A. H., Verde, F., Danilova, L. V., Anagnostou, V., Tam, A. J., Luber, B. S., Bartlett, B. R., Aulakh, L. K., Sidhom, J. W., Zhu, Q., Sears, C. L. & 21 others, Cope, L., Sharfman, W., Thompson, E., Riemer, J., Marrone, K., Naidoo, J., Velculescu, V. E., Forde, P., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Durham, J. N., Wang, H., Le, D., Justesen, S., Taube, J. M., Diaz, L. A., Brahmer, J., Pardoll, A. M., Anders, R. A. & Housseau, F., Mar 6 2019, In : Journal for immunotherapy of cancer. 7, 1, 7.

Research output: Contribution to journalComment/debate

Consultants
Oncogenes
T-Lymphocytes
Conflict of Interest
Organized Financing

Dynamics of tumor and immune responses during immune checkpoint blockade in non–small cell lung cancer

Anagnostou, V., Forde, P. M., White, J. R., Niknafs, N., Hruban, C., Naidoo, J., Marrone, K., Ashok Sivakumar, I. K., Bruhm, D. C., Rosner, S., Phallen, J., Leal, A., Adleff, V., Smith, K. N., Cottrell, T. R., Rhymee, L., Palsgrove, D. N., Hann, C. L., Levy, B., Feliciano, J. & 16 others, Georgiades, C., Verde, F., Illei, P., Li, Q. K., Gabrielson, E., Brock, M. V., Isbell, J. M., Sauter, J. L., Taube, J., Scharpf, R. B., Karchin, R., Pardoll, D. M., Chaft, J. E., Hellmann, M. D., Brahmer, J. R. & Velculescu, V. E., Jan 1 2019, In : Cancer Research. 79, 6, p. 1214-1225 12 p.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
DNA
Neoplasms
Therapeutics
Confidence Intervals

Early noninvasive detection of response to targeted therapy in non–small cell lung cancer

Phallen, J., Leal, A., Woodward, B. D., Forde, P., Naidoo, J., Marrone, K., Brahmer, J., Fiksel, J., Medina, J. E., Cristiano, S., Palsgrove, D. N., Gocke, C., Bruhm, D. C., Keshavarzian, P., Adleff, V., Weihe, E., Anagnostou, V., Scharpf, R. B., Velculescu, V. E. & Husain, H., Jan 1 2019, In : Cancer Research. 79, 6, p. 1204-1213 10 p.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
DNA
Neoplasms
Circulating Neoplastic Cells
Therapeutics

Genome-wide cell-free DNA fragmentation in patients with cancer

Cristiano, S., Leal, A., Phallen, J., Fiksel, J., Adleff, V., Bruhm, D. C., Jensen, S. Ø., Medina, J. E., Hruban, C., White, J. R., Palsgrove, D. N., Niknafs, N., Anagnostou, V., Forde, P., Naidoo, J., Marrone, K., Brahmer, J., Woodward, B. D., Husain, H., van Rooijen, K. L. & 16 others, Ørntoft, M. B. W., Madsen, A. H., van de Velde, C. J. H., Verheij, M., Cats, A., Punt, C. J. A., Vink, G. R., van Grieken, N. C. T., Koopman, M., Fijneman, R. J. A., Johansen, J. S., Nielsen, H. J., Meijer, G. A., Andersen, C. L., Scharpf, R. B. & Velculescu, V. E., Jun 20 2019, In : Nature. 570, 7761, p. 385-389 5 p.

Research output: Contribution to journalLetter

DNA Fragmentation
Genome
DNA
Neoplasms
Bile Duct Neoplasms

Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types

Mathios, D., Hwang, T., Xia, Y., Phallen, J., Rui, Y., See, A. P., Maxwell, R., Belcaid, Z., Casaos, J., Burger, P. C., McDonald, K. L., Gallia, G. L., Cope, L., Kai, M., Brem, H., Pardoll, A. M., Ha, P., Green, J., Velculescu, V. E., Bettegowda, C. & 2 others, Park, C. K. & Lim, M., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

DNA Methylation
Glioblastoma
Genome
Genes
Neoplasms

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Smith, K., Llosa, N., Cottrell, T. R., Siegel, N., Fan, H., Suri, P., Chan, H. Y., Guo, H., Oke, T., Awan, A. H., Verde, F., Danilova, L. V., Anagnostou, V., Tam, A. J., Luber, B. S., Bartlett, B. R., Aulakh, L. K., Sidhom, J. W., Zhu, Q., Sears, C. L. & 21 others, Cope, L., Sharfman, W., Thompson, E., Riemer, J., Marrone, K., Naidoo, J., Velculescu, V. E., Forde, P., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Durham, J. N., Wang, H., Le, D., Justesen, S., Taube, J. M., Diaz, L. A., Brahmer, J., Pardoll, A. M., Anders, R. A. & Housseau, F., Feb 11 2019, In : Journal for immunotherapy of cancer. 7, 1, 40.

Research output: Contribution to journalArticle

Open Access
Oncogenes
T-Lymphocytes
Biomarkers
DNA Mismatch Repair
Neoplasms
2018

A machine learning approach for somatic mutation discovery

Wood, D. E., White, J. R., Georgiadis, A., Van Emburgh, B., Parpart-Li, S., Mitchell, J., Anagnostou, V., Niknafs, N., Karchin, R., Papp, E., McCord, C., LoVerso, P., Riley, D., Diaz, L. A., Jones, S., Sausen, M., Velculescu, V. E. & Angiuoli, S. V., Sep 5 2018, In : Science Translational Medicine. 10, 457, aar7939.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Atlases
Genome
Exome

Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines

Papp, E., Hallberg, D., Konecny, G. E., Bruhm, D. C., Adleff, V., Noë, M., Kagiampakis, I., Palsgrove, D., Conklin, D., Kinose, Y., White, J. R., Press, M. F., Drapkin, R., Easwaran, H., Baylin, S. B., Slamon, D., Velculescu, V. E. & Scharpf, R. B., Nov 27 2018, In : Cell Reports. 25, 9, p. 2617-2633 17 p.

Research output: Contribution to journalArticle

Epigenomics
Ovarian Neoplasms
Tumors
Mitogen-Activated Protein Kinase Kinases
Cells

Ipilimumab plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer

Boudadi, K., Suzman, D. L., Anagnostou, V., Fu, W., Luber, B., Wang, H., Niknafs, N., White, J. R., Silberstein, J. L., Sullivan, R., Dowling, D., Harb, R., Nirschl, T. R., Veeneman, B. A., Tomlins, S. A., Wang, Y., Jendrisak, A., Graf, R. P., Dittamore, R., Carducci, M. A. & 8 others, Eisenberger, M., Haffner, M. C., Meeker, A. K., Eshleman, J., Luo, J., Velculescu, V. E., Drake, C. G. & Antonarakis, E., Jun 19 2018, In : Oncotarget. 9, 47, p. 28561-28571 11 p.

Research output: Contribution to journalArticle

DNA Repair
Disease-Free Survival
Prostatic Neoplasms
Survival
Circulating Neoplastic Cells

Neoadjuvant PD-1 blockade in resectable lung cancer

Forde, P., Chaft, J. E., Smith, K., Anagnostou, V., Cottrell, T. R., Hellmann, M. D., Zahurak, M., Broderick, S., Yang, S. C., Jones, D. R., Battafarano, R. J., Velez, M. J., Rekhtman, N., Olah, Z., Verde, F., Naidoo, J., Marrone, K., Guo, H., Sidhom, J. W., Zhang, J. & 15 others, Caushi, J. X., Chan, H. Y., Scharpf, R. B., White, J., Gabrielson, E., Wang, H., Rosner, G., Rusch, V., Wolchok, J. D., Merghoub, T., Taube, J. M., Velculescu, V. E., Topalian, S., Brahmer, J. & Pardoll, A. M., May 24 2018, In : New England Journal of Medicine. 378, 21, p. 1976-1986 11 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Clone Cells
Neoplasms
Non-Small Cell Lung Carcinoma
T-Lymphocytes

Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: A proposal for quantitative immune-related pathologic response criteria (irPRC)

Cottrell, T. R., Thompson, E., Forde, P., Stein, J. E., Duffield, A. S., Anagnostou, V., Rekhtman, N., Anders, R. A., Cuda, J. D., Illei, P. B., Gabrielson, E., Askin, F. B., Niknafs, N., Smith, K., Velez, M. J., Sauter, J. L., Isbell, J. M., Jones, D. R., Battafarano, R. J., Yang, S. C. & 10 others, Danilova, L. V., Wolchok, J. D., Topalian, S., Velculescu, V. E., Pardoll, A. M., Brahmer, J., Hellmann, M. D., Chaft, J. E., Cimino-Mathews, A. M. & Taube, J. M., Jan 1 2018, In : Annals of Oncology. 29, 8, p. 1853-1860 8 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Non-Small Cell Lung Carcinoma
Neoplasms
Tumor-Infiltrating Lymphocytes
Neoadjuvant Therapy

The mutation-associated neoantigen functional expansion of specific T cells (MANAFEST) assay: A sensitive platform for monitoring antitumor immunity

Danilova, L. V., Anagnostou, V., Caushi, J. X., Sidhom, J. W., Guo, H., Chan, H. Y., Suri, P., Tam, A., Zhang, J., Asmar, M. E., Marrone, K., Naidoo, J., Brahmer, J., Forde, P., Baras, A., Cope, L., Velculescu, V. E., Pardoll, A. M., Housseau, F. & Smith, K., Aug 1 2018, In : Cancer immunology research. 6, 8, p. 888-899 12 p.

Research output: Contribution to journalArticle

Immunity
T-Lymphocytes
Mutation
Antigens
Cytokines
2017

AACR project genie: Powering precision medicine through an international consortium

The AACR Project GENIE Consortium, 2017, In : Cancer Discovery. 7, 8, p. 818-831 14 p.

Research output: Contribution to journalArticle

Precision Medicine
Neoplasms
Information Dissemination
Genie
Biomarkers

Cancer DNA in the circulation: The liquid biopsy

Husain, H. & Velculescu, V. E., Oct 3 2017, In : JAMA - Journal of the American Medical Association. 318, 13, p. 1272-1273 2 p.

Research output: Contribution to journalArticle

Neoplasm DNA
DNA Sequence Analysis
Biopsy
Polymerase Chain Reaction
DNA

Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations

Vaz, M., Hwang, S. Y., Kagiampakis, I., Phallen, J., Patil, A., O'Hagan, H. M., Murphy, L., Zahnow, C., Gabrielson, E., Velculescu, V. E., Easwaran, H. & Baylin, S. B., Sep 11 2017, In : Cancer Cell. 32, 3, p. 360-376 17 p.

Research output: Contribution to journalArticle

Oncogenes
Epigenomics
Smoke
Tobacco Products
Epithelial Cells

Circulating Tumor DNA for Mutation Detection and Identification of Mechanisms of Resistance in Non-Small Cell Lung Cancer

Yeung, K. T., More, S., Woodward, B., Velculescu, V. E. & Husain, H., Mar 24 2017, (Accepted/In press) In : Molecular Diagnosis and Therapy. p. 1-10 10 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Mutation
DNA
Neoplasms
Circulating Neoplastic Cells

Clinical study of genomic drivers in pancreatic ductal adenocarcinoma

Barrett, M. T., Deiotte, R., Lenkiewicz, E., Malasi, S., Holley, T., Evers, L., Posner, R. G., Jones, T., Han, H., Sausen, M., Velculescu, V. E., Drebin, J., O'Dwyer, P., Jameson, G., Ramanathan, R. K. & Von Hoff, D. D., Aug 8 2017, In : British Journal of Cancer. 117, 4, p. 572-582 11 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Genome
Neoplasms
DNA Repair-Deficiency Disorders
Clinical Trials

Direct detection of early-stage cancers using circulating tumor DNA

Phallen, J., Sausen, M., Adleff, V., Leal, A., Hruban, C., White, J., Anagnostou, V., Fiksel, J., Cristiano, S., Papp, E., Speir, S., Reinert, T., Orntoft, M. B. W., Woodward, B. D., Murphy, D., Parpart-Li, S., Riley, D., Nesselbush, M., Sengamalay, N., Georgiadis, A. & 17 others, Li, Q. K., Madsen, M. R., Mortensen, F. V., Huiskens, J., Punt, C., Van Grieken, N., Fijneman, R., Meijer, G., Husain, H., Scharpf, R. B., Diaz, L. A., Jones, S., Angiuoli, S., Ørntoft, T., Nielsen, H. J., Andersen, C. L. & Velculescu, V. E., Aug 16 2017, In : Science Translational Medicine. 9, 403, eaan2415.

Research output: Contribution to journalArticle

Early Detection of Cancer
DNA
Neoplasms
High-Throughput Nucleotide Sequencing
Mutation

Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

Topper, M. J., Vaz, M., Chiappinelli, K. B., DeStefano Shields, C. E., Niknafs, N., Yen, R-W., Wenzel, A., Hicks, J., Ballew, M., Stone, M., Tran, P. T., Zahnow, C., Hellmann, M. D., Anagnostou, V., Strissel, P. L., Strick, R., Velculescu, V. E. & Baylin, S. B., Nov 30 2017, In : Cell. 171, 6, p. 1284-1300.e21

Research output: Contribution to journalArticle

Immune Evasion
T-cells
Epigenomics
Non-Small Cell Lung Carcinoma
Lung Neoplasms

Establishment of patient-derived tumor xenograft models of epithelial ovarian cancer for preclinical evaluation of novel therapeutics

Liu, J. F., Palakurthi, S., Zeng, Q., Zhou, S., Ivanova, E., Huang, W., Zervantonakis, I. K., Selfors, L. M., Shen, Y., Pritchard, C. C., Zheng, M., Adleff, V., Papp, E., Piao, H., Novak, M., Fotheringham, S., Wulf, G. M., English, J., Kirschmeier, P. T., Velculescu, V. E. & 6 others, Paweletz, C., Mills, G. B., Livingston, D. M., Brugge, J. S., Matulonis, U. A. & Drapkin, R., Mar 1 2017, In : Clinical Cancer Research. 23, 5, p. 1263-1273 11 p.

Research output: Contribution to journalArticle

Heterografts
Neoplasms
Therapeutics
Tumor Burden
Ovarian Neoplasms

Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer

Anagnostou, V., Smith, K., Forde, P., Niknafs, N., Bhattacharya, R., White, J., Zhang, T., Adleff, V., Phallen, J., Wali, N., Hruban, C., Guthrie, V. B., Rodgers, K., Naidoo, J., Kang, H., Sharfman, W., Georgiades, C. S., Verde, F., Illei, P. B., Li, Q. K. & 9 others, Gabrielson, E., Brock, M. V., Zahnow, C., Baylin, S. B., Scharpf, R. B., Brahmer, J., Karchin, R., Pardoll, A. M. & Velculescu, V. E., Mar 1 2017, In : Cancer Discovery. 7, 3, p. 264-276 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasms
T-Lymphocytes
Mutation
T-Cell Antigen Receptor

High grade serous ovarian carcinomas originate in the fallopian tube

Labidi-Galy, S. I., Papp, E., Hallberg, D., Niknafs, N., Adleff, V., Noe, M., Bhattacharya, R., Novak, M., Jones, S., Phallen, J., Hruban, C. A., Hirsch, M. S., Lin, D. I., Schwartz, L., Maire, C. L., Tille, J. C., Bowden, M., Ayhan, A., Wood, L. D., Scharpf, R. B. & 6 others, Kurman, R. J., Wang, T-L., Shih, I. M., Karchin, R., Drapkin, R. & Velculescu, V. E., Dec 1 2017, In : Nature Communications. 8, 1, 1093.

Research output: Contribution to journalArticle

Fallopian Tubes
Carcinoma in Situ
Tumors
grade
cancer

Precancer atlas to drive precision prevention trials

Spira, A., Yurgelun, M. B., Alexandrov, L., Rao, A., Bejar, R., Polyak, K., Giannakis, M., Shilatifard, A., Finn, O. J., Dhodapkar, M., Kay, N. E., Braggio, E., Vilar, E., Mazzilli, S. A., Rebbeck, T. R., Garber, J. E., Velculescu, V. E., Disis, M. L., Wallace, D. C. & Lippman, S. M., 2017, In : Cancer Research. 77, 7, p. 1510-1541 32 p.

Research output: Contribution to journalReview article

Atlases
Neoplasms
Immunity
Clone Cells
Drive

The effect of preservative and temperature on the analysis of circulating tumor DNA

Parpart-Li, S., Bartlett, B., Popoli, M., Adleff, V., Tucker, L., Steinberg, R., Georgiadis, A., Phallen, J., Brahmer, J., Azad, N., Browner, I., Laheru, D., Velculescu, V. E., Sausen, M. & Diaz, L. A., May 15 2017, In : Clinical Cancer Research. 23, 10, p. 2471-2477 7 p.

Research output: Contribution to journalArticle

Temperature
DNA
Neoplasms
Serum
Edetic Acid
2016

Genomic and immunological tumor profiling identifies targetable pathways and extensive CD8+/PDL1+ immune infiltration in inflammatory breast cancer tumors

Hamm, C. A., Moran, D., Rao, K., Trusk, P. B., Pry, K., Sausen, M., Jones, S., Velculescu, V. E., Cristofanilli, M. & Bacus, S., Jul 1 2016, In : Molecular Cancer Therapeutics. 15, 7, p. 1746-1756 11 p.

Research output: Contribution to journalArticle

Inflammatory Breast Neoplasms
Breast Neoplasms
Neoplasms
DNA Mismatch Repair
Mutation Rate

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Hao, Y., Samuels, Y., Li, Q., Krokowski, D., Guan, B. J., Wang, C., Jin, Z., Dong, B., Cao, B., Feng, X., Xiang, M., Xu, C., Fink, S., Meropol, N. J., Xu, Y., Conlon, R. A., Markowitz, S., Kinzler, K. W., Velculescu, V. E., Brunengraber, H. & 6 others, Willis, J. E., Laframboise, T., Hatzoglou, M., Zhang, G. F., Vogelstein, B. & Wang, Z., Jun 20 2016, In : Nature Communications. 7, 11971.

Research output: Contribution to journalArticle

glutamine
metabolism
mutations
Glutamine
Metabolism
2015

Beyond genomics: Critical evaluation of cell line utility for ovarian cancer research

Elias, K. M., Emori, M. M., Papp, E., Macduffie, E., Konecny, G. E., Velculescu, V. E. & Drapkin, R., Oct 1 2015, In : Gynecologic Oncology. 139, 1, p. 97-103 7 p.

Research output: Contribution to journalArticle

Genomics
Ovarian Neoplasms
Atlases
Cell Line
Research

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

Sausen, M., Phallen, J., Adleff, V., Jones, S., Leary, R. J., Barrett, M. T., Anagnostou, V., Parpart-Li, S., Murphy, D., Li, Q. K., Hruban, C. A., Scharpf, R. B., White, J. R., O'Dwyer, P. J., Allen, P. J., Eshleman, J., Thompson, C. B., Klimstra, D. S., Linehan, D. C., Maitra, A. & 6 others, Hruban, R. H., Diaz, L. A., Von Hoff, D. D., Johansen, J. S., Drebin, J. A. & Velculescu, V. E., Jul 7 2015, In : Nature Communications. 6, 7686.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Tumors
tumors
cancer
Neoplasms

Notch1 mutations are drivers of oral tumorigenesis

Izumchenko, E., Sun, K., Jones, S., Brait Rodrigues De Oliveira, M., Agrawal, N., Koch, W. M., McCord, C. L., Riley, D. R., Angiuoli, S. V., Velculescu, V. E., Jiang, W. W. & Sidransky, D., Apr 1 2015, In : Cancer Prevention Research. 8, 4, p. 277-286 10 p.

Research output: Contribution to journalArticle

Carcinogenesis
Mutation
Squamous Cell Carcinoma
Oral Leukoplakia
Population

Personalized genomic analyses for cancer mutation discovery and interpretation

Jones, S., Anagnostou, V., Lytle, K., Parpart-Li, S., Nesselbush, M., Riley, D. R., Shukla, M., Chesnick, B., Kadan, M., Papp, E., Galens, K. G., Murphy, D., Zhang, T., Kann, L., Sausen, M., Angiuoli, S. V., Diaz, L. A. & Velculescu, V. E., Apr 15 2015, In : Science Translational Medicine. 7, 283, 283ra53.

Research output: Contribution to journalArticle

Mutation
Exome
Neoplasms
Neoplasm Genes
Genes

The genomic landscape of response to EGFR blockade in colorectal cancer

Bertotti, A., Papp, E., Jones, S., Adleff, V., Anagnostou, V., Lupo, B., Sausen, M., Phallen, J., Hruban, C. A., Tokheim, C., Niknafs, N., Nesselbush, M., Lytle, K., Sassi, F., Cottino, F., Migliardi, G., Zanella, E. R., Ribero, D., Russolillo, N., Mellano, A. & 15 others, Muratore, A., Paraluppi, G., Salizzoni, M., Marsoni, S., Kragh, M., Lantto, J., Cassingena, A., Li, Q. K., Karchin, R., Scharpf, R. B., Sartore-Bianchi, A., Siena, S., Diaz, L. A., Trusolino, L. & Velculescu, V. E., Oct 8 2015, In : Nature. 526, 7572, p. 263-267 5 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Colorectal Neoplasms
Neoplasms
Therapeutics
Transplants
2014

Blood-based analyses of cancer: Circulating tumor cells and circulating tumor DNA

Haber, D. A. & Velculescu, V. E., 2014, In : Cancer Discovery. 4, 6, p. 650-661 12 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
DNA
Neoplasms
Therapeutics
Drug Resistance
Tumor Burden
Melanoma
DNA
Neoplasms
Mutation

Detection of circulating tumor DNA in early- and late-stage human malignancies

Bettegowda, C., Sausen, M., Leary, R. J., Kinde, I., Wang, Y., Agrawal, N., Bartlett, B. R., Wang, H., Luber, B., Alani, R. M., Antonarakis, E., Azad, N., Bardelli, A., Brem, H., Cameron, J. L., Lee, C. C., Fecher, L. A., Gallia, G. L., Gibbs, P., Le, D. & 43 others, Giuntoli, R. L., Goggins, M. S., Hogarty, M. D., Holdhoff, M., Hong, S. M., Jiao, Y., Juhl, H. H., Kim, J. J., Siravegna, G., Laheru, D., Lauricella, C., Lim, M., Lipson, E., Marie, S. K. N., Netto, G. J., Oliner, K. S., Olivi, A., Olsson, L., Riggins, G. J., Sartore-Bianchi, A., Schmidt, K., Shih, I. M., Oba-Shinjo, S. M., Siena, S., Theodorescu, D., Tie, J., Harkins, T. T., Veronese, S., Wang, T-L., Weingart, J. D., Wolfgang, C., Wood, L. D., Xing, D., Hruban, R. H., Wu, J., Allen, P. J., Schmidt, C. M., Choti, M. A., Velculescu, V. E., Kinzler, K. W., Vogelstein, B., Papadopoulos, N. & Diaz, L. A., Feb 19 2014, In : Science Translational Medicine. 6, 224, 224ra24.

Research output: Contribution to journalArticle

DNA
Neoplasms
Colorectal Neoplasms
Biomarkers
Circulating Neoplastic Cells

Ganitumab (AMG 479) inhibits IGF-II-dependent ovarian cancer growth and potentiates platinum-based chemotherapy

Beltran, P. J., Calzone, F. J., Mitchell, P., Chung, Y. A., Cajulis, E., Moody, G., Belmontes, B., Li, C. M., Vonderfecht, S., Velculescu, V. E., Yang, G., Qi, J., Slamon, D. J. & Konecny, G. E., Jun 1 2014, In : Clinical Cancer Research. 20, 11, p. 2947-2958 12 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor II
Platinum
Ovarian Neoplasms
Drug Therapy
Growth

Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes

Jones, S., Stransky, N., McCord, C. L., Cerami, E., Lagowski, J., Kelly, D., Angiuoli, S. V., Sausen, M., Kann, L., Shukla, M., Makar, R., Wood, L. D., Diaz, L. A., Lengauer, C. & Velculescu, V. E., 2014, In : Nature Communications. 5, 5006.

Research output: Contribution to journalArticle

Carcinosarcoma
chromatin
Chromatin Assembly and Disassembly
mutations
genes

Integrated next-generation sequencing and avatar mouse models for personalized cancer treatment

Garralda, E., Paz, K., López-Casas, P. P., Jones, S., Katz, A., Kann, L. M., López-Rios, F., Sarno, F., Al-Shahrour, F., Vasquez, D., Bruckheimer, E., Angiuoli, S. V., Calles, A., Diaz, L. A., Velculescu, V. E., Valencia, A., Sidransky, D. & Hidalgo, M., May 1 2014, In : Clinical Cancer Research. 20, 9, p. 2476-2484 9 p.

Research output: Contribution to journalArticle

Neoplasms
Exome
Mutation
Therapeutics
Heterografts

Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer

Guerrero-Preston, R., Michailidi, C., Marchionni, L., Pickering, C. R., Frederick, M. J., Myers, J. N., Yegnasubramanian, S., Hadar, T., Noordhuis, M. G., Zizkova, V., Fertig, E., Agrawal, N., Westra, W., Koch, W. M., Califano, J., Velculescu, V. E. & Sidransky, D., Jan 5 2014, In : Epigenetics. 9, 7, p. 1031-1046 16 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Tumor Suppressor Genes
Methylation
Mutation
Epigenomics
2013

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

Bardelli, A., Corso, S., Bertotti, A., Hobor, S., Valtorta, E., Siravegna, G., Sartore-Bianchi, A., Scala, E., Cassingena, A., Zecchin, D., Apicella, M., Migliardi, G., Galimi, F., Lauricella, C., Zanon, C., Perera, T., Veronese, S., Corti, G., Amatu, A., Gambacorta, M. & 8 others, Diaz, L. A., Sausen, M., Velculescu, V. E., Comoglio, P., Trusolino, L., Di Nicolantonio, F., Giordano, S. & Siena, S., 2013, In : Cancer Discovery. 3, 6, p. 658-673 16 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Colorectal Neoplasms
Proto-Oncogenes
Therapeutics
Mutation

Cancer detection using whole-genome sequencing of cell free DNA

Leary, R. J., Sausen, M., Diaz, L. A. & Velculescu, V. E., 2013, In : Oncotarget. 4, 8, p. 1119-1120 2 p.

Research output: Contribution to journalArticle

Neoplasm DNA
Human Genome
Tumor Biomarkers
DNA Sequence Analysis
Early Detection of Cancer

Cancer genome landscapes

Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A. & Kinzler, K. W., Mar 29 2013, In : Science. 340, 6127, p. 1546-1558 13 p.

Research output: Contribution to journalArticle

Genome
Neoplasms
Genes
Mutation
Cell Survival

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

Jiao, Y., Pawlik, T. M., Anders, R. A., Selaru, F., Streppel, M. M., Lucas, D. J., Niknafs, N., Guthrie, V. B., Maitra, A., Argani, P., Offerhaus, G. J. A., Roa, J. C., Roberts, L. R., Gores, G. J., Popescu, I., Alexandrescu, S. T., Dima, S., Fassan, M., Simbolo, M., Mafficini, A. & 16 others, Capelli, P., Lawlor, R. T., Ruzzenente, A., Guglielmi, A., Tortora, G., De Braud, F., Scarpa, A., Jarnagin, W., Klimstra, D., Karchin, R., Velculescu, V. E., Hruban, R. H., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Wood, L. D., Dec 2013, In : Nature Genetics. 45, 12, p. 1470-1473 4 p.

Research output: Contribution to journalArticle

Exome
Cholangiocarcinoma
Mutation
Chromatin Assembly and Disassembly
Genes

Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS

Agrawal, N., Jiao, Y., Sausen, M., Leary, R., Bettegowda, C., Roberts, N., Bhan, S., Ho, A. S., Khan, Z., Bishop, J., Westra, W. H., Wood, L. D., Hruban, R. H., Tufano, R. P., Robinson, B., Dralle, H., Toledo, S. P. A., Toledo, R. A., Morris, L. G. T., Ghossein, R. A. & 8 others, Fagin, J. A., Chan, T. A., Velculescu, V. E., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Nelkin, B. D. & Ball, D. W., Feb 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 2

Research output: Contribution to journalArticle

Genes
Tumors
Mutation
Exons
Exome

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA

Diaz, L. A., Sausen, M., Fisher, G. A. & Velculescu, V. E., Oct 2013, In : Oncotarget. 4, 10, p. 1856-1857 2 p.

Research output: Contribution to journalArticle

Neoplasm DNA
Neoplasm Drug Resistance
Antibodies, Monoclonal, Humanized
Genome-Wide Association Study
Human Genome

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

Sausen, M., Leary, R. J., Jones, S., Wu, J., Reynolds, C. P., Liu, X., Blackford, A., Parmigiani, G., Diaz, L. A., Papadopoulos, N., Vogelstein, B., Kinzler, K. W., Velculescu, V. E. & Hogarty, M. D., Jan 2013, In : Nature Genetics. 45, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

Neuroblastoma
Chromatin Assembly and Disassembly
Neoplasms
Genome
Genes

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

Killela, P. J., Reitman, Z. J., Jiao, Y., Bettegowda, C., Agrawal, N., Diaz, L. A., Friedman, A. H., Friedman, H., Gallia, G. L., Giovanella, B. C., Grollman, A. P., He, T. C., He, Y., Hruban, R. H., Jallo, G., Mandahl, N., Meeker, A. K., Mertens, F., Netto, G. J., Ahmed Rasheed, B. & 17 others, Riggins, G. J., Rosenquist, T. A., Schiffman, M., Shih, I. M., Theodorescu, D., Torbenson, M. S., Velculescu, V. E., Wang, T-L., Wentzensen, N., Wood, L. D., Zhang, M., McLendon, R. E., Bigner, D. D., Kinzler, K. W., Vogelstein, B., Papadopoulos, N. & Yan, H., Apr 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. 6021-6026 6 p.

Research output: Contribution to journalArticle

Telomerase
Glioma
Telomere
Mutation
Neoplasms

Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer

Ihnen, M., Eulenburg, C. Z., Kolarova, T., Qi, J. W., Manivong, K., Chalukya, M., Dering, J., Anderson, L., Ginther, C., Meuter, A., Winterhoff, B., Jones, S., Velculescu, V. E., Venkatesan, N., Rong, H. M., Dandekar, S., Udar, N., Jänicke, F., Los, G., Slamon, D. J. & 1 others, Konecny, G. E., Jun 2013, In : Molecular Cancer Therapeutics. 12, 6, p. 1002-1015 14 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Drug Therapy
Topotecan
Therapeutics
DNA Fragmentation
2012

ATM mutations in patients with hereditary pancreatic cancer

Roberts, N., Jiao, Y., Yu, J., Kopelovich, L., Petersen, G. M., Bondy, M. L., Gallinger, S., Schwartz, A. G., Syngal, S., Cote, M. L., Axilbund, J., Schulick, R., Ali, S. Z., Eshleman, J., Velculescu, V. E., Goggins, M. S., Vogelstein, B., Papadopoulos, N., Hruban, R. H., Kinzler, K. W. & 1 others, Klein, A., Jan 2012, In : Cancer Discovery. 2, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Pancreatic Neoplasms
Mutation
Genes
Adenocarcinoma