Valina Dawson

Research output

Research output per year 1988 1996 1998 1999 2001 2003 2004 2005 2006 2007 2009 2010 2011 2012 2014 2016 2017 2018 2020 2021 2022 2024

• 309 Article
• 73 Review article
• 31 Chapter
• 8 Short survey
• 17 More
  • 7 Comment/debate
  • 4 Editorial
  • 4 Letter
  • 2 Conference contribution

Research output per year

Research output per year

Search results

• 2024

  Blocking the Self-Destruct Program of Dopamine Neurons through Macrophage Migration Inhibitory Factor Nuclease Inhibition

  Patel, J., Dawson, V. L. & Dawson, T., 2024, (Accepted/In press) In: Movement Disorders.

  Research output: Contribution to journal › Article › peer-review

  • Parthanatos 100%
  • Macrophage Migration-Inhibitory Factors 74%
  • Dopaminergic Neurons 56%
  • Parkinson Disease 36%
  • Apoptosis Inducing Factor 30%

• Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency

  Wang, H., Yin, X., Xu, J., Chen, L., Karuppagounder, S., Xu, E., Mao, X., Dawson, V. L. & Dawson, T., Jan 9 2024, In: Stem Cell Reports. 19, 1, p. 54-67 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chimerism 100%
  • Human Embryonic Stem Cells 96%
  • Dopaminergic Neurons 83%
  • Dopamine 74%
  • Tyrosine 72%

• Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission

  Chen, C., Kumbhar, R., Wang, H., Yang, X., Gadhave, K., Rastegar, C., Kimura, Y., Behensky, A., Kotha, S., Kuo, G., Katakam, S., Jeong, D., Wang, L., Wang, A., Chen, R., Zhang, S., Jin, L., Workman, C. J., Vignali, D. A. A., Pletinkova, O., & 10 othersJia, H., Peng, W., Nauen, D., Wong, P., Redding-Ochoa, J., Troncoso, J., Ying, M., Dawson, V., Dawson, T. & Mao, X., 2024, (Accepted/In press) In: Advanced Science.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Poly(ADP-ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation

  Hossain, M. I., Lee, J. H., Gagné, J. P., Khan, J., Poirier, GG., King, P. H., Dawson, V. L., Dawson, T. & Andrabi, S. A., Mar 31 2024, In: FASEB Journal. 38, 6, e23556.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Protein Translation in the Pathogenesis of Parkinson’s Disease

  Ashraf, D., Khan, M. R., Dawson, T. M. & Dawson, V. L., Feb 2024, In: International journal of molecular sciences. 25, 4, 2393.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Parkinson disease 100%
  • pathogenesis 98%
  • Protein Biosynthesis 69%
  • Proteins 57%
  • Proteostasis 55%
• 2023

  Apoptotic cell death in disease—Current understanding of the NCCD 2023

  Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Aqeilan, R. I., Arama, E., Baehrecke, E. H., Balachandran, S., Bano, D., Barlev, N. A., Bartek, J., Bazan, N. G., & 208 othersBecker, C., Bernassola, F., Bertrand, M. J. M., Bianchi, M. E., Blagosklonny, M. V., Blander, J. M., Blandino, G., Blomgren, K., Borner, C., Bortner, C. D., Bove, P., Boya, P., Brenner, C., Broz, P., Brunner, T., Damgaard, R. B., Calin, G. A., Campanella, M., Candi, E., Carbone, M., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chen, G. Q., Chen, Q., Chen, Y. H., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Ciliberto, G., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D’Angiolella, V., Daugaard, M., Dawson, T. M., Dawson, V. L., De Maria, R., De Strooper, B., Debatin, K. M., Deberardinis, R. J., Degterev, A., Del Sal, G., Deshmukh, M., Di Virgilio, F., Diederich, M., Dixon, S. J., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Engeland, K., Fimia, G. M., Galassi, C., Ganini, C., Garcia-Saez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Gerlic, M., Ghosh, S., Green, D. R., Greene, L. A., Gronemeyer, H., Häcker, G., Hajnóczky, G., Hardwick, J. M., Haupt, Y., He, S., Heery, D. M., Hengartner, M. O., Hetz, C., Hildeman, D. A., Ichijo, H., Inoue, S., Jäättelä, M., Janic, A., Joseph, B., Jost, P. J., Kanneganti, T. D., Karin, M., Kashkar, H., Kaufmann, T., Kelly, G. L., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Kluck, R., Krysko, D. V., Kulms, D., Kumar, S., Lavandero, S., Lavrik, I. N., Lemasters, J. J., Liccardi, G., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Luedde, T., MacFarlane, M., Madeo, F., Malorni, W., Manic, G., Mantovani, R., Marchi, S., Marine, J. C., Martin, S. J., Martinou, J. C., Mastroberardino, P. G., Medema, J. P., Mehlen, P., Meier, P., Melino, G., Melino, S., Miao, E. A., Moll, U. M., Muñoz-Pinedo, C., Murphy, D. J., Niklison-Chirou, M. V., Novelli, F., Núñez, G., Oberst, A., Ofengeim, D., Opferman, J. T., Oren, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pentimalli, F., Pereira, D. M., Pervaiz, S., Peter, M. E., Pinton, P., Porta, G., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rajalingam, K., Ravichandran, K. S., Rehm, M., Ricci, J. E., Rizzuto, R., Robinson, N., Rodrigues, C. M. P., Rotblat, B., Rothlin, C. V., Rubinsztein, D. C., Rudel, T., Rufini, A., Ryan, K. M., Sarosiek, K. A., Sawa, A., Sayan, E., Schroder, K., Scorrano, L., Sesti, F., Shao, F., Shi, Y., Sica, G. S., Silke, J., Simon, H. U., Sistigu, A., Stephanou, A., Stockwell, B. R., Strapazzon, F., Strasser, A., Sun, L., Sun, E., Sun, Q., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Troy, C. M., Turk, B., Urbano, N., Vandenabeele, P., Vanden Berghe, T., Vander Heiden, M. G., Vanderluit, J. L., Verkhratsky, A., Villunger, A., von Karstedt, S., Voss, A. K., Vousden, K. H., Vucic, D., Vuri, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, R., Wang, Y., Weber, A., Wood, W., Yamazaki, T., Yang, H. T., Zakeri, Z., Zawacka-Pankau, J. E., Zhang, L., Zhang, H., Zhivotovsky, B., Zhou, W., Piacentini, M., Kroemer, G. & Galluzzi, L., May 2023, In: Cell death and differentiation. 30, 5, p. 1097-1154 58 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Terminology 100%
  • Cell Death 75%
  • Apoptosis 60%
  • Regulated Cell Death 51%
  • Homeostasis 48%

• Bi-allelic TTI1 variants cause an autosomal-recessive neurodevelopmental disorder with microcephaly

  Serey-Gaut, M., Cortes, M., Makrythanasis, P., Suri, M., Taylor, A. M. R., Sullivan, J. A., Asleh, A. N., Mitra, J., Dar, M. A., McNamara, A., Shashi, V., Dugan, S., Song, X., Rosenfeld, J. A., Cabrol, C., Iwaszkiewicz, J., Zoete, V., Pehlivan, D., Akdemir, Z. C., Roeder, E. R., & 29 othersLittlejohn, R. O., Dibra, H. K., Byrd, P. J., Stewart, G. S., Geckinli, B. B., Posey, J., Westman, R., Jungbluth, C., Eason, J., Sachdev, R., Evans, C. A., Lemire, G., VanNoy, G. E., O'Donnell-Luria, A., Mau-Them, F. T., Juven, A., Piard, J., Nixon, C. Y., Zhu, Y., Ha, T., Buckley, M. F., Thauvin, C., Essien Umanah, G. K., Van Maldergem, L., Lupski, J. R., Roscioli, T., Dawson, V. L., Dawson, T. M. & Antonarakis, S. E., Mar 2 2023, In: American journal of human genetics. 110, 3, p. 499-515 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microcephaly 100%
  • Neurodevelopmental Disorders 96%
  • Telomere 54%
  • Movement Disorders 36%
  • Maintenance 34%

• DNA Methylation Signature of Aging: Potential Impact on the Pathogenesis of Parkinson's Disease

  Yazar, V., Dawson, V. L., Dawson, T. M. & Kang, S. U., 2023, In: Journal of Parkinson's Disease. 13, 2, p. 145-164 20 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • DNA Methylation 100%
  • Parkinson Disease 84%
  • Epigenome 63%
  • Methylation 30%
  • Longevity 30%

• Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson’s disease

  Khan, M. R., Yin, X., Kang, S. U., Mitra, J., Wang, H., Ryu, T., Brahmachari, S., Karuppagounder, S. S., Kimura, Y., Jhaldiyal, A., Kim, H. H., Gu, H., Chen, R., Redding-Ochoa, J., Troncoso, J., Na, C. H., Ha, T., Dawson, V. L. & Dawson, T. M., 2023, In: Science translational medicine. 15, 724, eadd0499.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins 100%
  • Parkinson Disease 55%
  • Animal Models 47%
  • Tuberous Sclerosis Complex 2 Protein 35%
  • TOR Serine-Threonine Kinases 24%

• Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate

  Bae, J. H., Jo, A., Cho, S. C., Lee, Y. II., Kam, T. I., You, C. L., Jeong, H. J., Kim, H., Jeong, M. H., Jeong, Y., Ha, Y. W., Kim, Y. S., Kim, J., Woo, S. H., Kim, M. S., Shin, E. S., Song, S. O., Kang, H., Khang, R., Park, S., & 6 othersPark, J., Dawson, V. L., Dawson, T. M., Park, S. C., Shin, J. H. & Kang, J. S., 2023, In: Science translational medicine. 15, 711, eabh3489.

  Research output: Contribution to journal › Article › peer-review

  • Farnesol 100%
  • Prenylation 87%
  • Muscle Weakness 66%
  • Muscles 37%
  • parkin protein 11%

• Inhibition of host PARP1 contributes to the anti-inflammatory and antitubercular activity of pyrazinamide

  Krug, S., Gupta, M., Kumar, P., Feller, L., Ihms, E. A., Kang, B. G., Srikrishna, G., Dawson, T. M., Dawson, V. L. & Bishai, W. R., Dec 2023, In: Nature communications. 14, 1, 8161.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • tuberculosis 100%
  • ribose 96%
  • Poly (ADP-Ribose) Polymerase-1 83%
  • Poly(ADPribose) 82%
  • adenosine diphosphate 81%

• PARIS undergoes liquid–liquid phase separation and poly(ADP-ribose)-mediated solidification

  Kang, H., Park, S., Jo, A., Mao, X., Kumar, M., Park, C. H., Ahn, J. Y., Lee, Y., Choi, J. Y., Lee, Y. S., Dawson, V. L., Dawson, T. M., Kam, T. I. & Shin, J. H., Nov 6 2023, In: EMBO Reports. 24, 11, e56166.

  Research output: Contribution to journal › Article › peer-review

  • Poly Adenosine Diphosphate Ribose 100%
  • Poly(ADPribose) 96%
  • Solidification 77%
  • Phase Separation 61%
  • Prions 43%

• The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson’s disease

  Karuppagounder, S. S., Wang, H., Kelly, T., Rush, R., Nguyen, R., Bisen, S., Yamashita, Y., Sloan, N., Dang, B., Sigmon, A., Lee, H. W., Lee, S. M., Watkins, L., Kim, E., Brahmachari, S., Kumar, M., Werner, M. H., Dawson, T. M. & Dawson, V. L., Jan 18 2023, In: Science translational medicine. 15, 679, eabp9352.

  Research output: Contribution to journal › Article › peer-review

  • Parkinson Disease 100%
  • Synucleins 67%
  • Dopaminergic Neurons 31%
  • Pathology 28%
  • Animal Models 21%

• The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives

  Gharagozloo, M., Galleguillos, D., Jank, L., Sotirchos, E. S., Smith, M. D., Garton, T., Kumar, S., Hussein, O., Potluri, S., Taylor, M., Siu, C., Mace, J. W., Dawson, T., Dawson, V. L., Lee, S. & Calabresi, P. A., Jul 2023, In: Neurotherapeutics. 20, 4, p. 1229-1240 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cuprizone 100%
  • Remyelination 83%
  • Glucagon-Like Peptide-1 Receptor 81%
  • Demyelinating Diseases 66%
  • Oligodendroglia 29%
• 2022

  AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1

  Umanah, G., Abalde-Atristain, L., Khan, M. R., Mitra, J., Dar, M. A., Chang, M., Tangella, K., McNamara, A., Bennett, S., Chen, R., Aggarwal, V., Cortes, M., Worley, P. F., Ha, T., Dawson, T. M. & Dawson, V. L., Dec 2022, In: Nature communications. 13, 1, 4836.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ATPases Associated with Diverse Cellular Activities 100%
  • Mechanistic Target of Rapamycin Complex 1 84%
  • Sirolimus 71%
  • Raptors 29%
  • Metabolic 27%

• ADP-ribosyltransferases, an update on function and nomenclature

  Lüscher, B., Ahel, I., Altmeyer, M., Ashworth, A., Bai, P., Chang, P., Cohen, M., Corda, D., Dantzer, F., Daugherty, M. D., Dawson, T. M., Dawson, V. L., Deindl, S., Fehr, A. R., Feijs, K. L. H., Filippov, D. V., Gagné, J. P., Grimaldi, G., Guettler, S., Hoch, N. C., & 27 othersHottiger, M. O., Korn, P., Kraus, W. L., Ladurner, A., Lehtiö, L., Leung, A. K. L., Lord, C. J., Mangerich, A., Matic, I., Matthews, J., Moldovan, G. L., Moss, J., Natoli, G., Nielsen, M. L., Niepel, M., Nolte, F., Pascal, J., Paschal, B. M., Pawłowski, K., Poirier, G. G., Smith, S., Timinszky, G., Wang, Z. Q., Yélamos, J., Yu, X., Zaja, R. & Ziegler, M., Dec 2022, In: FEBS Journal. 289, 23, p. 7399-7410 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ADP Ribose Transferases 100%
  • ADP-Ribosylation 91%
  • Terminology 67%
  • Poly ADP-ribosylation 58%
  • ADP-ribosylarginine hydrolase 53%

• A high-affinity cocaine binding site associated with the brain acid soluble protein 1

  Harraz, M. M., Malla, A. P., Semenza, E. R., Shishikura, M., Singh, M., Hwang, Y., Kang, I. G., Song, Y. J., Snowman, A. M., Cortés, P., Karuppagounder, S. S., Dawson, T. M., Dawson, V. L. & Snyder, S. H., Apr 19 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 16, 2200545119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cocaine 100%
  • Binding Sites 76%
  • Acids 75%
  • Dopamine Plasma Membrane Transport Proteins 61%
  • cocaine receptor 61%

• Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin

  Kam, T. I., Park, H., Chou, S. C., Van Vranken, J. G., Mittenbuhler, M. J., Kim, H., Mu, A., Choi, Y. R., Biswas, D., Wang, J., Shin, Y., Loder, A., Karuppagounder, S. S., Wrann, C. D., Dawson, V. L., Spiegelman, B. M. & Dawson, T. M., Sep 6 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 36, e2204835119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Parkinson Disease 55%
  • Tandem Mass Spectrometry 24%
  • Hand Strength 23%
  • Dopaminergic Neurons 23%

• Cell Biology of Parkin: Clues to the Development of New Therapeutics for Parkinson’s Disease

  Patel, J., Panicker, N., Dawson, V. L. & Dawson, T. M., Dec 2022, In: CNS Drugs. 36, 12, p. 1249-1267 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Biology 100%
  • Parkinson Disease 96%
  • parkin protein 39%
  • Combat Disorders 39%
  • Ligases 25%

• CYFIP1 Dosages Exhibit Divergent Behavioral Impact via Diametric Regulation of NMDA Receptor Complex Translation in Mouse Models of Psychiatric Disorders

  Kim, N. S., Ringeling, F. R., Zhou, Y., Nguyen, H. N., Temme, S. J., Lin, Y. T., Eacker, S., Dawson, V. L., Dawson, T. M., Xiao, B., Hsu, K. S., Canzar, S., Li, W., Worley, P., Christian, K. M., Yoon, K. J., Song, H. & Ming, G. L., Nov 15 2022, In: Biological psychiatry. 92, 10, p. 815-826 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • N-Methyl-D-Aspartate Receptors 100%
  • Mental Disorders 80%
  • Gene Dosage 47%
  • RNA Sequence Analysis 44%
  • Protein Biosynthesis 43%

• Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson’s disease

  Pirooznia, S. K., Wang, H., Panicker, N., Kumar, M., Neifert, S., Dar, M. A., Lau, E., Kang, B. G., Redding-Ochoa, J., Troncoso, J. C., Dawson, V. L. & Dawson, T. M., Apr 2022, In: Science Advances. 8, 13, 1824.

  Research output: Contribution to journal › Article › peer-review

  • Deubiquitinating Enzymes 100%
  • Organelle Biogenesis 91%
  • Dopaminergic Neurons 75%
  • Parkinson Disease 60%
  • Mitochondrial Parkinson Disease 43%

• Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein

  Sterling, J. K., Kam, T. I., Guttha, S., Park, H., Baumann, B., Mehrabani-Tabari, A. A., Schultz, H., Anderson, B., Alnemri, A., Chou, S. C., Troncoso, J. C., Dawson, V. L., Dawson, T. M. & Dunaief, J. L., Feb 15 2022, In: Cell Reports. 38, 7, 110358.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deferiprone 100%
  • Synucleins 89%
  • Iron Chelator 82%
  • Iron 49%
  • Interleukin-6 45%

• Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease

  Panicker, N., Kam, T. I., Wang, H., Neifert, S., Chou, S. C., Kumar, M., Brahmachari, S., Jhaldiyal, A., Hinkle, J. T., Akkentli, F., Mao, X., Xu, E., Karuppagounder, S. S., Hsu, E. T., Kang, S. U., Pletnikova, O., Troncoso, J., Dawson, V. L. & Dawson, T. M., Aug 3 2022, In: Neuron. 110, 15, p. 2422-2437.e9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • NLR Proteins 100%
  • Inflammasomes 82%
  • Parkinson Disease 57%
  • Dopaminergic Neurons 47%
  • Proteins 25%

• PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease

  Park, H., Kam, T. I., Peng, H., Chou, S. C., Mehrabani-Tabari, A. A., Song, J. J., Yin, X., Karuppagounder, S. S., Umanah, G. K., Rao, A. V. S., Choi, Y. R., Aggarwal, A., Chang, S., Kim, H., Byun, J., Liu, J. O., Dawson, T. M. & Dawson, V. L., May 26 2022, In: Cell. 185, 11, p. 1943-1959.e21

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Parthanatos 100%
  • Cell Death 57%
  • Parkinson Disease 45%
  • Synucleins 27%
  • Apoptosis Inducing Factor 25%

• Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins

  Gao, J., Mewborne, Q. T., Girdhar, A., Sheth, U., Coyne, A. N., Punathil, R., Kang, B. G., Dasovich, M., Veire, A., DeJesus Hernandez, M., Liu, S., Shi, Z., Dafinca, R., Fouquerel, E., Talbot, K., Kam, T. I., Zhang, Y. J., Dickson, D., Petrucelli, L., van Blitterswijk, M., & 8 othersGuo, L., Dawson, T. M., Dawson, V. L., Leung, A. K. L., Lloyd, T. E., Gendron, T. F., Rothstein, J. D. & Zhang, K., Sep 14 2022, In: Science translational medicine. 14, 662, abq3215.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poly Adenosine Diphosphate Ribose 100%
  • Dipeptides 91%
  • Arginine 65%
  • Frontotemporal Dementia 59%
  • Proteins 26%

• STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy

  Hinkle, J. T., Patel, J., Panicker, N., Karuppagounder, S. S., Biswas, D., Belingon, B., Chen, R., Brahmachari, S., Pletnikova, O., Troncoso, J. C., Dawson, V. L. & Dawson, T. M., Apr 12 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 15, 2118819119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleinopathies 100%
  • Interferons 65%
  • Genes 28%
  • Parkinson Disease 23%
  • Microglia 21%

• The Absence of Parkin Does Not Promote Dopamine or Mitochondrial Dysfunction in PolgA^D257A/D257A Mitochondrial Mutator Mice

  Scott, L., Karuppagounder, S. S., Neifert, S., Kang, B. G., Wang, H., Dawson, V. L. & Dawson, T. M., Dec 7 2022, In: Journal of Neuroscience. 42, 49, p. 9263-9277 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dopamine 100%
  • Corpus Striatum 76%
  • Substantia Nigra 63%
  • Mitophagy 53%
  • Dopaminergic Neurons 41%

• Waiting for PARIS - A Biological Target in Search of a Drug

  Wyse, R. K., Stott, S. R. W., Mursaleen, L., Matthews, H., Dawson, V. L. & Dawson, T. M., 2022, In: Journal of Parkinson's Disease. 12, 1, p. 95-103 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Parkinson Disease 100%
  • Pharmaceutical Preparations 49%
  • Farnesol 47%
  • Translational Medical Research 33%
  • Research Personnel 20%
• 2021

  AIF3 splicing switch triggers neurodegeneration

  Liu, S., Zhou, M., Ruan, Z., Wang, Y., Chang, C., Sasaki, M., Rajaram, V., Lemoff, A., Nambiar, K., Wang, J. E., Hatanpaa, K. J., Luo, W., Dawson, T. M., Dawson, V. L. & Wang, Y., Dec 2021, In: Molecular neurodegeneration. 16, 1, 25.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apoptosis Inducing Factor 100%
  • Brain 17%
  • Cell Death 16%
  • Neurodegenerative Diseases 12%
  • Mitochondria 11%

• Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

  Park, J. S., Kam, T. I., Lee, S., Park, H., Oh, Y., Kwon, S. H., Song, J. J., Kim, D., Kim, H., Jhaldiyal, A., Na, D. H., Lee, K. C., Park, E. J., Pomper, M. G., Pletnikova, O., Troncoso, J. C., Ko, H. S., Dawson, V. L., Dawson, T. M. & Lee, S., Dec 2021, In: Acta Neuropathologica Communications. 9, 1, 78.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Astrocytes 100%
  • Microglia 99%
  • Alzheimer Disease 84%
  • Glucagon-Like Peptide-1 Receptor 56%
  • Neurodegenerative Diseases 18%

• Complement and Coagulation Cascades are Potentially Involved in Dopaminergic Neurodegeneration in α-Synuclein-Based Mouse Models of Parkinson's Disease

  Ma, S. X., Seo, B. A., Kim, D., Xiong, Y., Kwon, S. H., Brahmachari, S., Kim, S., Kam, T. I., Nirujogi, R. S., Kwon, S. H., Dawson, V. L., Dawson, T. M., Pandey, A., Na, C. H. & Ko, H. S., Jul 2 2021, In: Journal of proteome research. 20, 7, p. 3428-3443 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins 100%
  • Coagulation 67%
  • Parkinson Disease 55%
  • Protein 27%
  • Intrastriatal 20%

• Dysregulated mRNA translation in the G2019S LRRK2 and LRRK2 knock-out mouse brains

  Kim, J. W., Yin, X., Martin, I., Xiong, Y., Eacker, S. M., Ingolia, N. T., Dawson, T. M. & Dawson, V. L., Nov 1 2021, In: eNeuro. 8, 6, ENEURO.0310-21.2021.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Biosynthesis 100%
  • Leucine 94%
  • Knockout Mice 84%
  • Phosphotransferases 71%
  • Brain 45%

• Integrative genome-wide analysis of dopaminergic neuron-specific PARIS expression in Drosophila dissects recognition of multiple PPAR-γ associated gene regulation

  Yazar, V., Kang, S. U., Ha, S., Dawson, V. L. & Dawson, T. M., Dec 2021, In: Scientific reports. 11, 1, 21500.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • PPAR gamma 100%
  • Dopaminergic Neurons 94%
  • Drosophila 84%
  • Organelle Biogenesis 76%
  • Parkinson Disease 75%

• Intracellular Signaling: Mediators and Protective Responses

  Thompson, J. W., Xu, J., Dawson, V. L., Perez-Pinzon, M. A. & Dawson, T., Jan 1 2021, Stroke: Pathophysiology, Diagnosis, and Management. Elsevier, p. 74 and 81.e5

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Nervous System Trauma 100%
  • Therapeutics 13%

• Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

  Zhang, L., Chen, C., Fu, J., Lilley, B., Berlinicke, C., Hansen, B., Ding, D., Wang, G., Wang, T., Shou, D., Ye, Y., Mulligan, T., Emmerich, K., Saxena, M. T., Hall, K. R., Sharrock, A. V., Brandon, C., Park, H., Kam, T. I., Dawson, V. L., & 10 othersDawson, T. M., Shim, J. S., Hanes, J., Ji, H., Liu, J. O., Qian, J., Ackerley, D. F., Rohrer, B., Zack, D. J. & Mumm, J. S., Jun 2021, In: eLife. 10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zebrafish 83%
  • Neuroprotective Agents 83%
  • Neuroprotective 52%
  • Drug 43%
  • Rod Like Crystal 38%

• LRRK2 modulates the exocyst complex assembly by interacting with sec8

  Fais, M., Sanna, G., Galioto, M., Duyen Nguyen, T. T., Thi Trần, M. U., Sini, P., Carta, F., Turrini, F., Xiong, Y., Dawson, T. M., Dawson, V. L., Crosio, C. & Iaccarino, C., Feb 1 2021, In: Cells. 10, 2, p. 1-16 16 p., 203.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Parkinson Disease 100%
  • Phosphotransferases 92%
  • Secretory Vesicles 68%
  • Biological Phenomena 57%
  • Mutation 50%

• Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice

  Gu, H., Yang, X., Mao, X., Xu, E., Qi, C., Wang, H., Brahmachari, S., York, B., Sriparna, M., Li, A., Chang, M., Patel, P., Dawson, V. L. & Dawson, T. M., Mar 10 2021, In: Frontiers in Cellular Neuroscience. 15, 656426.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Synucleinopathies 92%
  • Lymphocyte Activation 70%
  • Transgenic Mice 58%
  • Lewy Bodies 34%

• Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson’s disease

  Zhang, S., Liu, Y. Q., Jia, C., Lim, Y. J., Feng, G., Xu, E., Long, H., Kimura, Y., Tao, Y., Zhao, C., Wang, C., Liu, Z., Hu, J. J., Ma, M. R., Liu, Z., Jiang, L., Li, D., Wang, R., Dawson, V. L., Dawson, T. M., & 3 othersLi, Y. M., Mao, X. & Liu, C., Jun 29 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 26, e2011196118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Amyloid 62%
  • Parkinson Disease 55%
  • Amyloid beta-Protein Precursor 50%
  • Lymphocyte Activation 46%

• Nanozyme scavenging ROS for prevention of pathologic α-synuclein transmission in Parkinson's disease

  Liu, Y. Q., Mao, Y., Xu, E., Jia, H., Zhang, S., Dawson, V. L., Dawson, T. M., Li, Y. M., Zheng, Z., He, W. & Mao, X., Feb 2021, In: Nano Today. 36, 101027.

  Research output: Contribution to journal › Article › peer-review

  • Prions 100%
  • Reactive oxygen species 94%
  • Synucleins 81%
  • Scavenging 72%
  • Spreading 56%
  6 Scopus citations

• PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease

  Jo, A., Lee, Y., Kam, T-I., Kang, S. U., Neifert, S., Karuppagounder, S., Khang, R., Kang, H., Park, H., Chou, S. C., Oh, S., Jiang, H., Swing, D. A., Ham, S., Pirooznia, S., Umanah, G., Mao, X., Kumar, M., Ko, H. S., Kang, H. C., & 15 othersLee, B. D., Lee, Y. I., Andrabi, S. A., Park, C. H., Lee, J. Y., Kim, H., Kim, H., Kim, H., Cho, J. W., Paek, S. H., Na, C. H., Tessarollo, L., Dawson, V. L., Dawson, T. M. & Shin, J. H., Jul 28 2021, In: Science translational medicine. 13, 604, eaax8891.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prenylation 100%
  • Farnesol 91%
  • Parkinson Disease 59%
  • Synucleins 21%
  • Peroxisome Proliferator-Activated Receptors 17%

• Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration

  Kim, H., Shin, J. Y., Jo, A., Kim, J. H., Park, S., Choi, J. Y., Kang, H. C., Dawson, V. L., Dawson, T. M., Shin, J. H. & Lee, Y., Dec 1 2021, In: Brain. 144, 12, p. 3674-3691 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phosphorylation 100%
  • Parkinson Disease 94%
  • Synucleins 48%
  • 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide 46%
  • Mesencephalon 33%

• Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection

  Pirooznia, S. K., Rosenthal, L. S., Dawson, V. L. & Dawson, T. M., Oct 1 2021, In: Pharmacological reviews. 73, 4, p. 1204-1268 65 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Neuroprotection 100%
  • Parkinson Disease 79%
  • Critical Pathways 8%
  • Penetrance 8%
  • Mutation 8%

• Protocol for measurement of calcium dysregulation in human induced pluripotent stem cell-derived dopaminergic neurons

  Yin, X., Kim, J. W., Liu, S., Dawson, T. M. & Dawson, V. L., Jun 18 2021, In: STAR Protocols. 2, 2, 100405.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Induced Pluripotent Stem Cells 100%
  • Dopaminergic Neurons 92%
  • Calcium(0) 67%
  • Homeostasis 64%
  • Calcium 60%

• Targeting Parthanatos in Ischemic Stroke

  Koehler, R. C., Dawson, V. L. & Dawson, T. M., May 5 2021, In: Frontiers in Neurology. 12, 662034.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Parthanatos 100%
  • Poly(ADP-ribose) Polymerase Inhibitors 71%
  • Stroke 36%
  • Apoptosis Inducing Factor 30%
  • Poly(ADP-ribose) Polymerases 25%

• The cell biology of Parkinson’s disease

  Panicker, N., Ge, P., Dawson, V. L. & Dawson, T. M., 2021, In: Journal of Cell Biology. 220, 4, e202012095.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Cell Biology 100%
  • Parkinson Disease 96%
  • Parkinson Disease Associated Proteins 71%
  • Pars Compacta 24%
  • Neurons 23%

• Therapeutic Potential of a Novel Glucagon-like Peptide-1 Receptor Agonist, NLY01, in Experimental Autoimmune Encephalomyelitis

  Gharagozloo, M., Smith, M. D., Sotirchos, E. S., Jin, J., Meyers, K., Taylor, M., Garton, T., Bannon, R., Lord, H. N., Dawson, T. M., Dawson, V. L., Lee, S. & Calabresi, P. A., Jul 2021, In: Neurotherapeutics. 18, 3, p. 1834-1848 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucagon-Like Peptide-1 Receptor 100%
  • Autoimmune Experimental Encephalomyelitis 90%
  • Central Nervous System 45%
  • Multiple Sclerosis 40%
  • Peptide Hormones 18%

• TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease

  Seo, B. A., Kim, D., Hwang, H., Kim, M. S., Ma, S. X., Kwon, S. H., Kweon, S. H., Wang, H., Yoo, J. M., Choi, S., Kwon, S. H., Kang, S. U., Kam, T. I., Kim, K., Karuppagounder, S. S., Kang, B. G., Lee, S., Park, H., Kim, S., Yan, W., & 10 othersLi, Y. S., Kuo, S. H., Redding-Ochoa, J., Pletnikova, O., Troncoso, J. C., Lee, G., Mao, X., Dawson, V. L., Dawson, T. M. & Ko, H. S., Dec 1 2021, In: Neuron. 109, 23, p. 3758-3774.e11

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • human PSMC5 protein 100%
  • Glucosylceramidase 70%
  • Ubiquitination 53%
  • Parkinson Disease 41%
  • Synucleins 27%

• USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing

  Kim, J. J., Lee, S. Y., Hwang, Y., Kim, S., Chung, J. M., Park, S., Yoon, J., Yun, H., Ji, J. H., Chae, S., Cho, H., Kim, C. G., Dawson, T. M., Kim, H., Dawson, V. L. & Kang, H. C., Nov 8 2021, In: Nucleic acids research. 49, 19, p. 11083-11102 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poly Adenosine Diphosphate Ribose 100%
  • DNA Damage 61%
  • Spliceosomes 48%
  • DNA Repair 32%
  • Deubiquitinating Enzymes 24%
• 2020

  AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF

  Umanah, G., Ghasemi, M., Yin, X., Chang, M., Kim, J. W., Zhang, J., Ma, E., Scarffe, L. A., Lee, Y. I., Chen, R., Tangella, K., McNamara, A., Abalde-Atristain, L., Dar, M. A., Bennett, S., Cortes, M., Andrabi, S. A., Doulias, P. T., Ischiropoulos, H., Dawson, T. M., & 1 othersDawson, V. L., Nov 3 2020, In: Cell Reports. 33, 5, 108329.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • AMPA Receptors 100%
  • Plastic Property 97%
  • Neuronal Plasticity 80%
  • Surface 26%

• Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons

  Kumar, M., Acevedo-Cintrón, J., Jhaldiyal, A., Wang, H., Andrabi, S. A., Eacker, S., Karuppagounder, S. S., Brahmachari, S., Chen, R., Kim, H., Ko, H. S., Dawson, V. L. & Dawson, T. M., Sep 8 2020, In: Stem Cell Reports. 15, 3, p. 629-645 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organelle Biogenesis 100%
  • Dopaminergic Neurons 82%
  • Autophagy 75%
  • Dopamine 74%
  • Parkinson Disease 39%
  6 Scopus citations