Tzyy Choou Wu

Professor

1986 …2020

Research output per year

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Research Output

2014

Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by mycobacterium tuberculosis heat shock protein X

Jung, I. D., Shin, S. J., Lee, M. G., Kang, T. H., Han, H. D., Lee, S. J., Kim, W. S., Kim, H. M., Park, W. S., Kim, H. W., Yun, C. H., Lee, E. K., Wu, T. C. & Park, Y. M., Aug 1 2014, In : Journal of Immunology. 193, 3, p. 1233-1245 13 p.

Research output: Contribution to journalArticle

Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

Mao, C. P., Wu, T. C., Song, K. H. & Kim, T. W., Jan 1 2014, In : OncoImmunology. 3, 7, e947871.

Research output: Contribution to journalArticle

Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model

Yang, M., Yu, T., Wood, J., Wang, Y. Y., Tang, B. C., Zeng, Q., Simons, B. W., Fu, J., Chuang, C. M., Lai, S. K., Wu, T. C., Hung, C. F. & Hanes, J., Apr 2014, In : Drug Delivery and Translational Research. 4, 2, p. 203-209 7 p.

Research output: Contribution to journalArticle

Sequential treatment of HPV E6 and E7-expressing TC-1 cells with bortezomib and celecoxib promotes apoptosis through p-p38 MAPK-mediated downregulation of cyclin D1 and CDK2

Kim, J. E., Lee, J. I., Jin, D. H., Lee, W. J., Park, G. B., Kim, S., Kim, Y. S., Wu, T. C., Hur, D. Y. & Kim, D., May 2014, In : Oncology reports. 31, 5, p. 2429-2437 9 p.

Research output: Contribution to journalArticle

Studies of inactivation mechanism of non-enveloped icosahedral virus by a visible ultrashort pulsed laser

Tsen, S. W. D., Kingsley, D. H., Poweleit, C., Achilefu, S., Soroka, D. S., Wu, T. C. & Tsen, K. T., Feb 5 2014, In : Virology Journal. 11, 1, 20.

Research output: Contribution to journalArticle

Toll-like receptor agonist imiquimod facilitates antigen-specific CD8+ T-cell accumulation in the genital tract leading to tumor control through IFNγ

Soong, R. S., Song, L., Trieu, J., Knoff, J., He, L., Tsai, Y. C., Huh, W., Chang, Y. N., Cheng, W. F., Roden, R. B. S., Wu, T. C., Trimble, C. L. & Hung, C. F., Nov 1 2014, In : Clinical Cancer Research. 20, 21, p. 5456-5467 12 p.

Research output: Contribution to journalArticle

Treatment of tumors with vitamin e suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects

Kang, T. H., Knoff, J., Yeh, W. H., Yang, B., Wang, C., Kim, Y. S., Kim, T. W., Wu, T. C. & Hung, C. F., Jul 29 2014, In : PloS one. 9, 7, e103562.

Research output: Contribution to journalArticle

Vaccination: Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions

Maldonado, L., Teague, J. E., Morrow, M. P., Jotova, I., Wu, T. C., Wang, C., Desmarais, C., Boyer, J. D., Tycko, B., Robins, H. S., Clark, R. A. & Trimble, C. L., Jan 29 2014, In : Science translational medicine. 6, 221, p. 221ra13

Research output: Contribution to journalArticle

Vaginal Delivery of Paclitaxel via Nanoparticles with Non-Mucoadhesive Surfaces Suppresses Cervical Tumor Growth

Yang, M., Yu, T., Wang, Y. Y., Lai, S. K., Zeng, Q., Miao, B., Tang, B. C., Simons, B. W., Ensign, L. M., Liu, G., Chan, K. W. Y., Juang, C. Y., Mert, O., Wood, J., Fu, J., Mcmahon, M. T., Wu, T. C., Hung, C. F. & Hanes, J., Jul 2014, In : Advanced Healthcare Materials. 3, 7, p. 1044-1052 9 p.

Research output: Contribution to journalArticle

2013

A broad survey of cathepsin k immunoreactivity in human neoplasms

Zheng, G., Martignoni, G., Antonescu, C., Montgomery, E., Eberhart, C., Netto, G., Taube, J., Westra, W., Epstein, J. I., Lotan, T., Maitra, A., Gabrielson, E., Torbenson, M., Iacobuzio-Donahue, C., Demarzo, A., Shih, I. M., Illei, P., Wu, T. C. & Argani, P., Feb 1 2013, In : American journal of clinical pathology. 139, 2, p. 151-159 9 p.

Research output: Contribution to journalReview article

Bortezomib enhances antigen-specific cytotoxic T cell responses against immune-resistant cancer cells generated by STAT3-ablated dendritic cells

Kim, J. E., Jin, D. H., Lee, W. J., Hur, D., Wu, T. C. & Kim, D., May 1 2013, In : Pharmacological Research. 71, p. 23-33 11 p.

Research output: Contribution to journalArticle

Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity

Kang, T. H., Mao, C. P., Lee, S. Y., Chen, A., Lee, J. H., Kim, T. W., Alvarez, R. D., Roden, R. B. S., Pardoll, D., Hung, C. F. & Wu, T. C., Apr 15 2013, In : Cancer Research. 73, 8, p. 2493-2504 12 p.

Research output: Contribution to journalArticle

Control of spontaneous ovarian tumors by CD8+ T cells through NKG2D-targeted delivery of antigenic peptide

Kang, T. H., Knoff, J., Yang, B., Tsai, Y. C., He, L., Hung, C. F. & Wu, T. C., Dec 20 2013, In : Cell and Bioscience. 3, 1, 48.

Research output: Contribution to journalArticle

Dose-dense chemotherapy improves mechanisms of antitumor immune response

Chang, C. L., Hsu, Y. T., Wu, C. C., Lai, Y. Z., Wang, C., Yang, Y. C., Wu, T. C. & Hung, C. F., Jan 1 2013, In : Cancer Research. 73, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

Erratum: Mucosal imprinting of vaccine-induced CD8+ T cells is crucial to inhibit the growth of mucosal tumors (Science Translational Medicine (2013) 5 (178er2))

Sandoval, F., Terme, M., Nizard, M., Badoual, C., Bureau, M. F., Freyburger, L., Clement, O., Marcheteau, E., Gey, A., Fraisse, G., Bouguin, C., Merillon, N., Dransart, E., Tran, T., Quintin-Colonna, F., Autret, G., Thiebaud, M., Suleman, M., Riffault, S., Wu, T. C. & 8 others, Launay, O., Danel, C., Taieb, J., Richardson, J., Zitvogel, L., Fridman, W. H., Johannes, L. & Tartour, E., Mar 27 2013, In : Science translational medicine. 5, 178, 178er2.

Research output: Contribution to journalComment/debate

Open Access

Histone deacetylase inhibitor AR-42 enhances E7-specific CD8+ T cell-mediated antitumor immunity induced by therapeutic HPV DNA vaccination

Lee, S. Y., Huang, Z., Kang, T. H., Soong, R. S., Knoff, J., Axenfeld, E., Wang, C., Alvarez, R. D., Chen, C. S., Hung, C. F. & Wu, T. C., Oct 1 2013, In : Journal of Molecular Medicine. 91, 10, p. 1221-1231 11 p.

Research output: Contribution to journalArticle

In memoriam: Kuan-Teh Jeang, MD PhD (1958-2013)

Jin, D. Y., Shi, Y. B. & Wu, T. C., Feb 28 2013, In : Cell and Bioscience. 3, 1, 13.

Research output: Contribution to journalArticle

Innovative DNA vaccine to break immune tolerance against tumor self-antigen

Kang, T. H., Mao, C. P., La, V., Chen, A., Hung, C. F. & Wu, T. C., Feb 1 2013, In : Human gene therapy. 24, 2, p. 181-188 8 p.

Research output: Contribution to journalArticle

Intra-Peritoneal Hyperthermia Combining α-Galactosylceramide in the Treatment of Ovarian Cancer

Wu, C. C., Chuang, Y. T., Hsu, Y. T., Huang, J. T., Wu, T. C., Hung, C. F., Yang, Y. C. & Chang, C. L., Jul 23 2013, In : PloS one. 8, 7, e69336.

Research output: Contribution to journalArticle

Intratumoral injection of therapeutic HPV vaccinia vaccine following cisplatin enhances HPV-specific antitumor effects

Lee, S. Y., Kang, T. H., Knoff, J., Huang, Z., Soong, R. S., Alvarez, R. D., Hung, C. F. & Wu, T. C., Jul 1 2013, In : Cancer Immunology, Immunotherapy. 62, 7, p. 1175-1185 11 p.

Research output: Contribution to journalArticle

Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine

Peng, S., Lyford-Pike, S., Akpeng, B., Wu, A., Hung, C. F., Hannaman, D., Saunders, J. R., Wu, T. C. & Pai, S. I., Jan 1 2013, In : Cancer Immunology, Immunotherapy. 62, 1, p. 171-182 12 p.

Research output: Contribution to journalArticle

Mucosal imprinting of vaccine-induced CD8+ T cells is crucial to inhibit the growth of mucosal tumors

Sandoval, F., Terme, M., Nizard, M., Badoual, C., Bureau, M. F., Freyburger, L., Clement, O., Marcheteau, E., Gey, A., Fraisse, G., Bouguin, C., Merillon, N., Dransart, E., Tran, T., Quintin-Colonna, F., Autret, G., Thiebaud, M., Suleman, M., Riffault, S., Wu, T. C. & 8 others, Launay, O., Danel, C., Taieb, J., Richardson, J., Zitvogel, L., Fridman, W. H., Johannes, L. & Tartour, E., Feb 13 2013, In : Science translational medicine. 5, 172, 172ra20.

Research output: Contribution to journalArticle

Targeted coating with antigenic peptide renders tumor cells susceptible to CD8 + T Cell-mediated killing

Kang, T. H., Ma, B., Wang, C., Wu, T. C. & Hung, C. F., Mar 2013, In : Molecular Therapy. 21, 3, p. 542-553 12 p.

Research output: Contribution to journalArticle

Xenogeneic Human p53 DNA Vaccination by Electroporation Breaks Immune Tolerance to Control Murine Tumors Expressing Mouse p53

Soong, R. S., Trieu, J., Lee, S. Y., He, L., Tsai, Y. C., Wu, T. C. & Hung, C. F., Feb 15 2013, In : PloS one. 8, 2, e56912.

Research output: Contribution to journalArticle

2012

Cancer vaccination drives nanog-dependent evolution of tumor cells toward an immune-resistant and stem-like phenotype

Noh, K. H., Lee, Y. H., Jeon, J. H., Kang, T. H., Mao, C. P., Wu, T. C. & Kim, T. W., Apr 1 2012, In : Cancer Research. 72, 7, p. 1717-1727 11 p.

Research output: Contribution to journalArticle

Development of a DNA vaccine targeting Merkel cell polyomavirus

Zeng, Q., Gomez, B. P., Viscidi, R. P., Peng, S., He, L., Ma, B., Wu, T. C. & Hung, C. F., Feb 8 2012, In : Vaccine. 30, 7, p. 1322-1329 8 p.

Research output: Contribution to journalArticle

Emerging human papillomavirus vaccines

Ma, B., Maraj, B., Tran, N. P., Knoff, J., Chen, A., Alvarez, R. D., Hung, C. F. & Wu, T. C., Dec 1 2012, In : Expert Opinion on Emerging Drugs. 17, 4, p. 469-492 24 p.

Research output: Contribution to journalReview article

Immune mechanism of the antitumor effects generated by bortezomib

Chang, C. L., Hsu, Y. T., Wu, C. C., Yang, Y. C., Wang, C., Wu, T. C. & Hung, C. F., Sep 15 2012, In : Journal of Immunology. 189, 6, p. 3209-3220 12 p.

Research output: Contribution to journalArticle

LAH4 enhances CD8+ T cell immunity of protein/peptide-based vaccines

Zhang, T. T., Kang, T. H., Ma, B., Xu, Y., Hung, C. F. & Wu, T. C., Jan 17 2012, In : Vaccine. 30, 4, p. 784-793 10 p.

Research output: Contribution to journalArticle

Nanog signaling in cancer promotes stem-like phenotype and immune evasion

Noh, K. H., Kim, B. W., Song, K. H., Cho, H., Lee, Y. H., Kim, J. H., Chung, J. Y., Kim, J. H., Hewitt, S. M., Seong, S. Y., Mao, C. P., Wu, T. C. & Kim, T. W., Nov 1 2012, In : Journal of Clinical Investigation. 122, 11, p. 4077-4093 17 p.

Research output: Contribution to journalArticle

OGDHL Is a Modifier of AKT-Dependent Signaling and NF-κB Function

Sen, T., Sen, N., Noordhuis, M. G., Ravi, R., Wu, T. C., Ha, P. K., Sidransky, D. & Hoque, M. O., Nov 12 2012, In : PloS one. 7, 11, e48770.

Research output: Contribution to journalArticle

Ovarian cancer gene therapy using HPV-16 Pseudovirion carrying the HSV-tk gene

Hung, C. F., Chiang, A. J., Tsai, H. H., Pomper, M. G., Kang, T. H., Roden, R. R. & Wu, T. C., Jul 17 2012, In : PloS one. 7, 7, e40983.

Research output: Contribution to journalArticle

Prospects for a novel ultrashort pulsed laser technology for pathogen inactivation

Tsen, S. W. D., Wu, T. C., Kiang, J. G. & Tsen, K. T., Jul 10 2012, In : Journal of biomedical science. 19, 1, 62.

Research output: Contribution to journalReview article

Side-by-side comparison of gene-based smallpox vaccine with MVA in nonhuman primates

Golden, J. W., Josleyn, M., Mucker, E. M., Hung, C. F., Loudon, P. T., Wu, T. C. & Hooper, J. W., Jul 31 2012, In : PloS one. 7, 7, e42353.

Research output: Contribution to journalArticle

Strategies to improve DNA vaccine potency: HPV-associated cervical cancer as a model system

Hung, C. F., Ma, B., Xu, Y. & Wu, T. C., Mar 1 2012, Gene Vaccines. Springer-Verlag Wien, Vol. 9783709104392. p. 37-65 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tumor-targeted delivery of IL-2 by NKG2D leads to accumulation of antigen-specific CD8+ T cells in the tumor loci and enhanced anti-tumor effects

Kang, T. H., Mao, C. P., He, L., Tsai, Y. C., Liu, K., La, V., Wu, T. C. & Hung, C. F., Apr 16 2012, In : PloS one. 7, 4, e35141.

Research output: Contribution to journalArticle

2011

Control of cervicovaginal HPV-16 E7-expressing tumors by the combination of therapeutic HPV vaccination and vascular disrupting agents

Zeng, Q., Peng, S., Monie, A., Yang, M., Pang, X., Hung, C. F. & Wu, T. C., Jul 1 2011, In : Human gene therapy. 22, 7, p. 809-819 11 p.

Research output: Contribution to journalArticle

Enforced expression of miR-101 inhibits prostate cancer cell growth by modulating the COX-2 pathway in vivo

Hao, Y., Gu, X., Zhao, Y., Greene, S., Sha, W., Smoot, D. T., Califano, J., Wu, T. C. & Pang, X., Jul 1 2011, In : Cancer Prevention Research. 4, 7, p. 1073-1083 11 p.

Research output: Contribution to journalArticle

Enhancement of protein vaccine potency by in vivo electroporation mediated intramuscular injection

Kang, T. H., Monie, A., Wu, L. S. F., Pang, X., Hung, C. F. & Wu, T. C., Jan 29 2011, In : Vaccine. 29, 5, p. 1082-1089 8 p.

Research output: Contribution to journalArticle

HPV pseudovirions as DNA delivery vehicles

Ma, B., Roden, R. B. S., Hung, C. F. & Wu, T. C., Apr 1 2011, In : Therapeutic Delivery. 2, 4, p. 427-430 4 p.

Research output: Contribution to journalEditorial

Improvement of prostate cancer detection by integrating the PSA test with miRNA expression profiling

Hao, Y., Zhao, Y., Zhao, X., He, C., Pang, X., Wu, T. C., Califano, J. A. & Gu, X., May 1 2011, In : Cancer Investigation. 29, 4, p. 318-324 7 p.

Research output: Contribution to journalArticle

Intraperitoneal administration of poly(I:C) with polyethylenimine leads to significant antitumor immunity against murine ovarian tumors

Wu, C. Y., Yang, H. Y., Monie, A., Ma, B., Tsai, H. H., Wu, T. C. & Hung, C. F., Aug 1 2011, In : Cancer Immunology, Immunotherapy. 60, 8, p. 1085-1096 12 p.

Research output: Contribution to journalArticle

In vivo microRNA-155 expression influences antigen-specific T cell-mediated immune responses generated by DNA vaccination

Mao, C. P., He, L., Tsai, Y. C., Peng, S., Kang, T. H., Pang, X., Monie, A., Hung, C. F. & Wu, T. C., Jan 18 2011, In : Cell and Bioscience. 1, 1, 3.

Research output: Contribution to journalArticle

Molecular pathogenesis, detection and clinical management of pre-invasive cervical lesions

Chen, W. C., Ma, B., Mao, C. P. & Wu, T. C., Dec 1 2011, Pre-Invasive Disease: Pathogenesis and Clinical Management. Springer New York, p. 437-466 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Perspectives on therapeutic HPV vaccines: Where are we now?

Wang, C., Ma, B., Chen, A., Hung, C. F. & Wu, T. C., Sep 1 2011, HPV and Cervical Cancer: Achievements in Prevention and Future Prospects. Springer New York, p. 341-389 49 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes

Heaphy, C. M., Subhawong, A. P., Hong, S. M., Goggins, M. G., Montgomery, E. A., Gabrielson, E., Netto, G. J., Epstein, J. I., Lotan, T. L., Westra, W. H., Shih, I. M., Iacobuzio-Donahue, C. A., Maitra, A., Li, Q. K., Eberhart, C. G., Taube, J. M., Rakheja, D., Kurman, R. J., Wu, T. C., Roden, R. B. & 5 others, Argani, P., De Marzo, A. M., Terracciano, L., Torbenson, M. & Meeker, A. K., Oct 1 2011, In : American Journal of Pathology. 179, 4, p. 1608-1615 8 p.

Research output: Contribution to journalArticle