Tzyy Choou Wu

Professor

1986 …2020

Research output per year

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Research Output

A broad survey of cathepsin k immunoreactivity in human neoplasms

Zheng, G., Martignoni, G., Antonescu, C., Montgomery, E., Eberhart, C., Netto, G., Taube, J., Westra, W., Epstein, J. I., Lotan, T., Maitra, A., Gabrielson, E., Torbenson, M., Iacobuzio-Donahue, C., Demarzo, A., Shih, I. M., Illei, P., Wu, T. C. & Argani, P., Feb 1 2013, In : American journal of clinical pathology. 139, 2, p. 151-159 9 p.

Research output: Contribution to journalReview article

A combination of DNA vaccines targeting human papillomavirus type 16 E6 and E7 generates potent antitumor effects

Peng, S., Tomson, T. T., Trimble, C., He, L., Hung, C. F. & Wu, T. C., Feb 1 2006, In : Gene Therapy. 13, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

Activation of Akt as a mechanism for tumor immune evasion

Noh, K. H., Kang, T. H., Kim, J. H., Pai, S. I., Lin, K. Y., Hung, C. F., Wu, T. C. & Kim, T. W., Jan 1 2009, In : Molecular Therapy. 17, 3, p. 439-447 9 p.

Research output: Contribution to journalArticle

Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery

Best, S. R., Peng, S., Juang, C. M., Hung, C. F., Hannaman, D., Saunders, J. R., Wu, T. C. & Pai, S. I., Sep 4 2009, In : Vaccine. 27, 40, p. 5450-5459 10 p.

Research output: Contribution to journalArticle

A DNA vaccine co-expressing antigen and an anti-apoptotic molecule further enhances the antigen-specific CD8+ T-cell immune response

Kim, T. W., Hung, C. F., Zheng, M., Boyd, D. A. K., He, L., Pai, S. I. & Wu, T. C., Jun 15 2004, In : Journal of biomedical science. 11, 4, p. 493-499 7 p.

Research output: Contribution to journalArticle

A DNA vaccine encoding a single-chain trimer of HLA-A2 linked to human mesothelin peptide generates anti-tumor effects against human mesothelin-expressing tumors

Hung, C. F., Calizo, R., Tsai, Y. C., He, L. & Wu, T. C., Jan 2 2007, In : Vaccine. 25, 1, p. 127-135 9 p.

Research output: Contribution to journalArticle

Open Access

Annexin A5 increases survival in murine sepsis model by inhibiting HMGB1-mediated proinflammation and coagulation

Park, J. H., Jang, J. H., Choi, E. J., Kim, Y. S., Lee, E. J., Jung, I. D., Han, H. D., Wu, T. C., Hung, C. F., Kang, T. H. & Park, Y. M., Jan 1 2016, In : Molecular Medicine. 22, p. 424-436 13 p.

Research output: Contribution to journalArticle

A novel function of API5 (apoptosis inhibitor 5), TLR4-dependent activation of antigen presenting cells

Kim, Y. S., Park, H. J., Park, J. H., Hong, E. J., Jang, G. Y., Jung, I. D., Han, H. D., Lee, S. H., Vo, M. C., Lee, J. J., Yang, A., Farmer, E., Wu, T. C., Kang, T. H. & Park, Y. M., Jan 1 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

A Novel Mr 32,000 Nuclear Phosphoprotein is Selectively Expressed in Cells Competent for Self-Renewal

Walensky, L. D., Coffey, D. S., Chen, T. H., Wu, T. C. & Pasternack, G. R., Oct 1993, In : Cancer Research. 53, 19, p. 4720-4726 7 p.

Research output: Contribution to journalArticle

Anti-gene padlocks eliminate Escherichia coli based on their genotype

Shi, C., Parker, A. R., Hua, L., Morrell, C. N., Lee, S. C., Bandaru, V., Dumler, J. S., Wu, T. C. & Eshleman, J. R., Feb 1 2008, In : Journal of Antimicrobial Chemotherapy. 61, 2, p. 262-272 11 p.

Research output: Contribution to journalArticle

Antigen-Specific Cancer Immunotherapy: HPV-Associated Cervical Cancer as a Model System

Tsen, S. W. D., Hung, C. F. & Wu, T. C., Mar 1 2007, Cancer Vaccines and Tumor Immunity. John Wiley and Sons, p. 79-94 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Antigen-specific cancer immunotherapy using a GM-CSF secreting allogeneic tumor cell-based vaccine

Chang, E. Y., Chen, C. H., Ji, H., Wang, T. L., Hung, K., Lee, B. P., Huang, A. Y. C., Kurman, R. J., Pardoll, D. M. & Wu, T. C., May 19 2000, In : International Journal of Cancer. 86, 5, p. 725-730 6 p.

Research output: Contribution to journalArticle

Antigen-specific immunotherapy for human papillomavirus 16 E7-expressing tumors grown in the liver

Chen, C. H., Suh, K. W., Ji, H., Choti, M. A., Pardoll, D. M. & Wu, T. C., Jul 2000, In : Journal of Hepatology. 33, 1, p. 91-98 8 p.

Research output: Contribution to journalArticle

Antigen-specific immunotherapy for murine lung metastatic tumors expressing human papillomavirus type 16 E7 oncoprotein

Ji, H., Chang, E. Y., Lin, K. Y., Kurman, R. J., Pardoll, D. M. & Wu, T. C., Sep 3 1998, In : International Journal of Cancer. 78, 1, p. 41-45 5 p.

Research output: Contribution to journalArticle

Antigen-specific immunotherapy of cervical and ovarian cancer

Hung, C. F., Wu, T. C., Monie, A. & Roden, R., Apr 1 2008, In : Immunological reviews. 222, 1, p. 43-69 27 p.

Research output: Contribution to journalReview article

A phase I trial of a human papillomavirus DNA vaccine for HPV16+Cervical intraepithelial neoplasia 2/3

Trimble, C. L., Peng, S., Kos, F., Gravitt, P., Viscidi, R., Sugar, E., Pardoll, D. & Wu, T. C., Jan 1 2009, In : Clinical Cancer Research. 15, 1, p. 361-367 7 p.

Research output: Contribution to journalArticle

A pilot study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16 + cervical intraepithelial neoplasia 2/3 (CIN2/3)

Alvarez, R. D., Huh, W. K., Bae, S., Lamb, L. S., Conner, M. G., Boyer, J., Wang, C., Hung, C. F., Sauter, E., Paradis, M., Adams, E. A., Hester, S., Jackson, B. E., Wu, T. C. & Trimble, C. L., Jan 1 2016, In : Gynecologic oncology. 140, 2, p. 245-252 8 p.

Research output: Contribution to journalArticle

A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression

Bins, A. D., Jorritsma, A., Wolkers, M. C., Hung, C. F., Wu, T. C., Schumacher, T. N. M. & Haanen, J. B. A. G., Aug 1 2005, In : Nature medicine. 11, 8, p. 899-904 6 p.

Research output: Contribution to journalArticle

A reassessment of the role of B7-1 expression in tumor rejection

Wu, T. C., Huang, A. Y. C., Jaffee, E. M., Levitsky, H. I. & Pardoll, D. M., Nov 1 1995, In : Journal of Experimental Medicine. 182, 5, p. 1415-1421 7 p.

Research output: Contribution to journalArticle

Ascites volumes and the ovarian cancer microenvironment

Penet, M. F., Krishnamachary, B., Wildes, F. B., Mironchik, Y., Hung, C. F., Wu, T. C. & Bhujwalla, Z. M., Jan 1 2018, In : Frontiers in Oncology. 8, DEC, 595.

Research output: Contribution to journalArticle

Open Access

Association of human papillomavirus with nasal neoplasia

Wu, T. C., Trujillo, J. M., Mounts, P. & Kashima, H. K., Feb 27 1993, In : The Lancet. 341, 8844, p. 522-524 3 p.

Research output: Contribution to journalArticle

Atypical oral presentation of herpes simplex virus infection in a patient after orthotopic liver transplantation

Burke, E. M., Karp, D. L., Wu, T. C. & Corio, R. L., Aug 1 1994, In : European Archives of Oto-Rhino-Laryngology. 251, 5, p. 301-303 3 p.

Research output: Contribution to journalArticle

Boosting with recombinant vaccinia increases HPV-16 E7-specific T cell precursor frequencies and antitumor effects of HPV-16 E7-expressing sindbis virus replicon particles

Lin, C. T., Hung, C. F., Juang, J., He, L., Lin, K. Y., Kim, T. W. & Wu, T. C., Oct 2003, In : Molecular Therapy. 8, 4, p. 559-566 8 p.

Research output: Contribution to journalArticle

Bortezomib enhances antigen-specific cytotoxic T cell responses against immune-resistant cancer cells generated by STAT3-ablated dendritic cells

Kim, J. E., Jin, D. H., Lee, W. J., Hur, D., Wu, T. C. & Kim, D., May 1 2013, In : Pharmacological Research. 71, p. 23-33 11 p.

Research output: Contribution to journalArticle

Buccal injection of synthetic HPV long peptide vaccine induces local and systemic antigen-specific CD8+ T-cell immune responses and antitumor effects without adjuvant

Yang, M. C., Yang, A., Qiu, J., Yang, B., He, L., Tsai, Y. C., Jeang, J., Wu, T. C. & Hung, C-F., Mar 3 2016, In : Cell and Bioscience. 6, 1, 17.

Research output: Contribution to journalArticle

Cancer immunotherapy employing an innovative strategy to enhance CD4T cell help in the tumor microenvironment

Song, L., Yang, M. C., Knoff, J., Wu, T. C., Hung, C. F. & Van Hall, T., Dec 22 2014, In : PloS one. 9, 12, e115711.

Research output: Contribution to journalArticle

Cancer immunotherapy using adjuvant-free, fusion protein encoding M. bovis BCG HSP65 and HPV16 E7

Chu, N. R., Bantroch, S., Wu, H. B., Boux, L., Wu, T. C., Siegel, M. & Mizzen, L. A., Mar 20 1998, In : FASEB Journal. 12, 5, p. A909

Research output: Contribution to journalArticle

Cancer immunotherapy using a DNA vaccine encoding a single-chain trimer of MHC class I linked to an HPV-16 E6 immunodominant CTL epitope

Huang, C. H., Peng, S., He, L., Tsai, Y. C., Boyd, D. A. K., Hansen, T. H., Wu, T. C. & Hung, C. F., Aug 1 2005, In : Gene Therapy. 12, 15, p. 1180-1186 7 p.

Research output: Contribution to journalArticle

Cancer immunotherapy using a DNA vaccine encoding the translocation domain of a bacterial toxin linked to a tumor antigen

Hung, C. F., Cheng, W. F., Hsu, K. F., Chai, C. Y., He, L., Ling, M. & Wu, T. C., May 1 2001, In : Cancer Research. 61, 9, p. 3698-3703 6 p.

Research output: Contribution to journalArticle

Cancer immunotherapy using a potent immunodominant CTL epitope

Song, L., Yang, M. C., Knoff, J., Sun, Z. Y., Wu, T. C. & Hung, C. F., Oct 21 2014, In : Vaccine. 32, 46, p. 6039-6048 10 p.

Research output: Contribution to journalArticle

Cancer immunotherapy using irradiated tumor cells secreting heat shock protein 70

Chang, C. L., Tsai, Y. C., He, L., Wu, T. C. & Hung, C. F., Oct 15 2007, In : Cancer Research. 67, 20, p. 10047-10057 11 p.

Research output: Contribution to journalArticle

Cancer immunotherapy using sindbis virus replicon particles encoding a VP22-antigen fusion

Cheng, W. F., Hung, C. F., Hsu, K. F., Chai, C. Y., He, L., Polo, J. M., Slater, L. A., Ling, M. & Wu, T. C., Mar 1 2002, In : Human gene therapy. 13, 4, p. 553-568 16 p.

Research output: Contribution to journalArticle

Cancer vaccination drives nanog-dependent evolution of tumor cells toward an immune-resistant and stem-like phenotype

Noh, K. H., Lee, Y. H., Jeon, J. H., Kang, T. H., Mao, C. P., Wu, T. C. & Kim, T. W., Apr 1 2012, In : Cancer Research. 72, 7, p. 1717-1727 11 p.

Research output: Contribution to journalArticle

Carcinoma ex-papilloma: Histologic and virologic studies in whole-organ sections of the larynx

Kashima, H., Wu, T. C., Mounts, P., Heffner, D., Cachay, A. & Hyams, V., Jun 1988, In : Laryngoscope. 98, 6, p. 619-624 6 p.

Research output: Contribution to journalArticle

Carrageenan as an adjuvant to enhance peptide-based vaccine potency

Zhang, Y. Q., Tsai, Y. C., Monie, A., Hung, C. F. & Wu, T. C., Jul 1 2010, In : Vaccine. 28, 32, p. 5212-5219 8 p.

Research output: Contribution to journalArticle

CD8+ T cells, NK cells and IFN-γ are important for control of tumor with downregulated MHC class I expression by DNA vaccination

Cheng, W. F., Hung, C. F., Lin, K. Y., Ling, M., Juang, J., He, L., Lin, C. T. & Wu, T. C., Aug 1 2003, In : Gene Therapy. 10, 16, p. 1311-1320 10 p.

Research output: Contribution to journalReview article

Cellular proliferation, estrogen receptor, progesterone receptor, and bcl-2 expression in GnRH agonist-treated uterine leiomyomas

Vu, K., Greenspan, D. L., Wu, T. C., Zacur, H. A. & Kurman, R. J., Jan 1 1998, In : Human pathology. 29, 4, p. 359-363 5 p.

Research output: Contribution to journalArticle

Cervarix™:A vaccine for the prevention of HPV 16, 18-associated cervical cancer

Monie, A., Hung, C. F., Roden, R. & Wu, T. C., Dec 1 2008, In : Biologics: Targets and Therapy. 2, 1, p. 107-113 7 p.

Research output: Contribution to journalReview article

Characterization of DNA vaccines encoding the domains of calreticulin for their ability to elicit tumor-specific immunity and antiangiogenesis

Cheng, W. F., Hung, C. F., Chen, C. A., Lee, C. N., Su, Y. N., Chai, C. Y., Boyd, D. A. K., Hsieh, C. Y. & Wu, T. C., May 31 2005, In : Vaccine. 23, 29, p. 3864-3874 11 p.

Research output: Contribution to journalArticle

Characterization of HLA-A2-restricted HPV-16 E7-specific CD8+ T-cell immune responses induced by DNA vaccines in HLA-A2 transgenic mice

Peng, S., Trimble, C., He, L., Tsai, Y. C., Lin, C. T., Boyd, D. A. K., Pardoll, D., Hung, C. F. & Wu, T. C., Jan 1 2006, In : Gene Therapy. 13, 1, p. 67-77 11 p.

Research output: Contribution to journalArticle

Characterization of HPV-16 E6 DNA vaccines employing intracellular targeting and intercellular spreading strategies

Peng, S., Trimble, C., Ji, H., He, L., Tsai, Y. C., Macaes, B., Hung, C. F. & Wu, T. C., Oct 1 2005, In : Journal of biomedical science. 12, 5, p. 689-700 12 p.

Research output: Contribution to journalArticle

Characterization of HPV18 E6-specific T cell responses and establishment of HPV18 E6-expressing tumor model

Ma, Y., Yang, A., Peng, S., Qiu, J., Farmer, E., Hung, C. F. & Wu, T. C., Jul 5 2017, In : Vaccine. 35, 31, p. 3850-3858 9 p.

Research output: Contribution to journalArticle

Characterization of human papillomavirus type 11-specific immune responses in a preclinical model

Peng, S., Best, S. R., Hung, C. F., Loyo, M., Lyford-Pike, S., Flint, P. W., Tunkel, D. E., Saunders, J. R., Wu, T. C. & Pai, S. I., Mar 1 2010, In : Laryngoscope. 120, 3, p. 504-510 7 p.

Research output: Contribution to journalArticle

Chemical-free inactivated whole influenza virus vaccine prepared by ultrashort pulsed laser treatment

Tsen, S. W. D., Donthi, N., La, V., Hsieh, W. H., Li, Y. D., Knoff, J., Chen, A., Wu, T. C., Hung, C. F., Achilefu, S. & Tsen, K. T., May 1 2015, In : Journal of biomedical optics. 20, 5, 051008.

Research output: Contribution to journalArticle

Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity

Kang, T. H., Mao, C. P., Lee, S. Y., Chen, A., Lee, J. H., Kim, T. W., Alvarez, R. D., Roden, R. B. S., Pardoll, D., Hung, C. F. & Wu, T. C., Apr 15 2013, In : Cancer Research. 73, 8, p. 2493-2504 12 p.

Research output: Contribution to journalArticle