Tzyy Choou Wu

Professor

1986 …2020

Research output per year

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Research Output

2013

Intra-Peritoneal Hyperthermia Combining α-Galactosylceramide in the Treatment of Ovarian Cancer

Wu, C. C., Chuang, Y. T., Hsu, Y. T., Huang, J. T., Wu, T. C., Hung, C. F., Yang, Y. C. & Chang, C. L., Jul 23 2013, In : PloS one. 8, 7, e69336.

Research output: Contribution to journalArticle

Intratumoral injection of therapeutic HPV vaccinia vaccine following cisplatin enhances HPV-specific antitumor effects

Lee, S. Y., Kang, T. H., Knoff, J., Huang, Z., Soong, R. S., Alvarez, R. D., Hung, C. F. & Wu, T. C., Jul 2013, In : Cancer Immunology, Immunotherapy. 62, 7, p. 1175-1185 11 p.

Research output: Contribution to journalArticle

Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine

Peng, S., Lyford-Pike, S., Akpeng, B., Wu, A., Hung, C. F., Hannaman, D., Saunders, J. R., Wu, T. C. & Pai, S. I., Jan 2013, In : Cancer Immunology, Immunotherapy. 62, 1, p. 171-182 12 p.

Research output: Contribution to journalArticle

Mucosal imprinting of vaccine-induced CD8+ T cells is crucial to inhibit the growth of mucosal tumors

Sandoval, F., Terme, M., Nizard, M., Badoual, C., Bureau, M. F., Freyburger, L., Clement, O., Marcheteau, E., Gey, A., Fraisse, G., Bouguin, C., Merillon, N., Dransart, E., Tran, T., Quintin-Colonna, F., Autret, G., Thiebaud, M., Suleman, M., Riffault, S., Wu, T. C. & 8 others, Launay, O., Danel, C., Taieb, J., Richardson, J., Zitvogel, L., Fridman, W. H., Johannes, L. & Tartour, E., Feb 13 2013, In : Science translational medicine. 5, 172, 172ra20.

Research output: Contribution to journalArticle

Targeted coating with antigenic peptide renders tumor cells susceptible to CD8 + T Cell-mediated killing

Kang, T. H., Ma, B., Wang, C., Wu, T. C. & Hung, C. F., Mar 2013, In : Molecular Therapy. 21, 3, p. 542-553 12 p.

Research output: Contribution to journalArticle

Xenogeneic Human p53 DNA Vaccination by Electroporation Breaks Immune Tolerance to Control Murine Tumors Expressing Mouse p53

Soong, R. S., Trieu, J., Lee, S. Y., He, L., Tsai, Y. C., Wu, T. C. & Hung, C. F., Feb 15 2013, In : PloS one. 8, 2, e56912.

Research output: Contribution to journalArticle

2014

Cancer immunotherapy employing an innovative strategy to enhance CD4T cell help in the tumor microenvironment

Song, L., Yang, M. C., Knoff, J., Wu, T. C., Hung, C. F. & Van Hall, T., Dec 22 2014, In : PloS one. 9, 12, e115711.

Research output: Contribution to journalArticle

Cancer immunotherapy using a potent immunodominant CTL epitope

Song, L., Yang, M. C., Knoff, J., Sun, Z. Y., Wu, T. C. & Hung, C. F., Oct 21 2014, In : Vaccine. 32, 46, p. 6039-6048 10 p.

Research output: Contribution to journalArticle

Control of HPV-associated tumors by innovative therapeutic HPV DNA vaccine in the absence of CD4+ T cells

Peng, S., Song, L., Knoff, J., Wang, J. W., Chang, Y. N., Hannaman, D., Wu, T. C., Alvarez, R. D., Roden, R. B. S. & Hung, C. F., Mar 4 2014, In : Cell and Bioscience. 4, 1, 11.

Research output: Contribution to journalArticle

Control of HPV infection and related cancer through vaccination

Tran, N. P., Hung, C. F., Roden, R. & Wu, T. C., Jan 1 2014, Viruses and Human Cancer: From Basic Science to Clinical Prevention. Springer New York LLC, p. 149-171 23 p. (Recent Results in Cancer Research; vol. 193).

Research output: Chapter in Book/Report/Conference proceedingChapter

Direct T cell activation via CD40 ligand generates high avidity CD8 + T cells capable of breaking immunological tolerance for the control of tumors

Soong, R. S., Song, L., Trieu, J., Lee, S. Y., He, L., Tsai, Y. C., Wu, T. C. & Hung, C. F., Mar 24 2014, In : PloS one. 9, 3, e93162.

Research output: Contribution to journalArticle

DNA vaccine for cancer immunotherapy

Yang, B., Jeang, J., Yang, A., Wu, T. C. & Hung, C. F., Nov 1 2014, In : Human Vaccines and Immunotherapeutics. 10, 11, p. 3153-3164 12 p.

Research output: Contribution to journalArticle

Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors

Wu, C. Y., Yang, L. H., Yang, H. Y., Knoff, J., Peng, S., Lin, Y. H., Wang, C., Alvarez, R. D., Pai, S. I., Roden, R. B. S., Hung, C. F. & Wu, T. C., 2014, In : Clinical Cancer Research. 20, 3, p. 644-657 14 p.

Research output: Contribution to journalArticle

Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by mycobacterium tuberculosis heat shock protein X

Jung, I. D., Shin, S. J., Lee, M. G., Kang, T. H., Han, H. D., Lee, S. J., Kim, W. S., Kim, H. M., Park, W. S., Kim, H. W., Yun, C. H., Lee, E. K., Wu, T. C. & Park, Y. M., Aug 1 2014, In : Journal of Immunology. 193, 3, p. 1233-1245 13 p.

Research output: Contribution to journalArticle

Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

Mao, C. P., Wu, T. C., Song, K. H. & Kim, T. W., 2014, In : OncoImmunology. 3, 7, e947871.

Research output: Contribution to journalArticle

Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model

Yang, M., Yu, T., Wood, J., Wang, Y. Y., Tang, B. C., Zeng, Q., Simons, B. W., Fu, J., Chuang, C. M., Lai, S. K., Wu, T. C., Hung, C. F. & Hanes, J., Apr 2014, In : Drug Delivery and Translational Research. 4, 2, p. 203-209 7 p.

Research output: Contribution to journalArticle

Sequential treatment of HPV E6 and E7-expressing TC-1 cells with bortezomib and celecoxib promotes apoptosis through p-p38 MAPK-mediated downregulation of cyclin D1 and CDK2

Kim, J. E., Lee, J. I., Jin, D. H., Lee, W. J., Park, G. B., Kim, S., Kim, Y. S., Wu, T. C., Hur, D. Y. & Kim, D., May 2014, In : Oncology reports. 31, 5, p. 2429-2437 9 p.

Research output: Contribution to journalArticle

Studies of inactivation mechanism of non-enveloped icosahedral virus by a visible ultrashort pulsed laser

Tsen, S. W. D., Kingsley, D. H., Poweleit, C., Achilefu, S., Soroka, D. S., Wu, T. C. & Tsen, K. T., Feb 5 2014, In : Virology Journal. 11, 1, 20.

Research output: Contribution to journalArticle

Toll-like receptor agonist imiquimod facilitates antigen-specific CD8+ T-cell accumulation in the genital tract leading to tumor control through IFNγ

Soong, R. S., Song, L., Trieu, J., Knoff, J., He, L., Tsai, Y. C., Huh, W., Chang, Y. N., Cheng, W. F., Roden, R. B. S., Wu, T. C., Trimble, C. L. & Hung, C. F., Nov 1 2014, In : Clinical Cancer Research. 20, 21, p. 5456-5467 12 p.

Research output: Contribution to journalArticle

Treatment of tumors with vitamin e suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects

Kang, T. H., Knoff, J., Yeh, W. H., Yang, B., Wang, C., Kim, Y. S., Kim, T. W., Wu, T. C. & Hung, C. F., Jul 29 2014, In : PloS one. 9, 7, e103562.

Research output: Contribution to journalArticle

Vaccination: Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions

Maldonado, L., Teague, J. E., Morrow, M. P., Jotova, I., Wu, T. C., Wang, C., Desmarais, C., Boyer, J. D., Tycko, B., Robins, H. S., Clark, R. A. & Trimble, C. L., Jan 29 2014, In : Science translational medicine. 6, 221, p. 221ra13

Research output: Contribution to journalArticle

Vaginal Delivery of Paclitaxel via Nanoparticles with Non-Mucoadhesive Surfaces Suppresses Cervical Tumor Growth

Yang, M., Yu, T., Wang, Y. Y., Lai, S. K., Zeng, Q., Miao, B., Tang, B. C., Simons, B. W., Ensign, L. M., Liu, G., Chan, K. W. Y., Juang, C. Y., Mert, O., Wood, J., Fu, J., Mcmahon, M. T., Wu, T. C., Hung, C. F. & Hanes, J., Jul 2014, In : Advanced Healthcare Materials. 3, 7, p. 1044-1052 9 p.

Research output: Contribution to journalArticle

2015

Chemical-free inactivated whole influenza virus vaccine prepared by ultrashort pulsed laser treatment

Tsen, S. W. D., Donthi, N., La, V., Hsieh, W. H., Li, Y. D., Knoff, J., Chen, A., Wu, T. C., Hung, C. F., Achilefu, S. & Tsen, K. T., May 1 2015, In : Journal of biomedical optics. 20, 5, 051008.

Research output: Contribution to journalArticle

Gain of HIF-1α under normoxia in cancer mediates immune adaptation through the AKT/ERK and VEGFA axes

Lee, Y. H., Bae, H. C., Noh, K. H., Song, K. H., Ye, S. K., Mao, C. P., Lee, K. M., Wu, T. C. & Kim, T. W., Mar 15 2015, In : Clinical Cancer Research. 21, 6, p. 1438-1446 9 p.

Research output: Contribution to journalArticle

Intravaginal HPV DNA vaccination with electroporation induces local CD8+ T-cell immune responses and antitumor effects against cervicovaginal tumors

Sun, Y., Peng, S., Qiu, J., Miao, J., Yang, B., Jeang, J., Hung, C. F. & Wu, T. C., Jul 3 2015, In : Gene Therapy. 22, 7, p. 528-535 8 p.

Research output: Contribution to journalArticle

Local administration of granulocyte macrophage colony-stimulating factor induces local accumulation of dendritic cells and antigen-specific CD8+ T cells and enhances dendritic cell cross-presentation

Lee, S. J., Song, L., Yang, M. C., Mao, C. P., Yang, B., Yang, A., Jeang, J., Peng, S., Wu, T. C. & Hung, C. F., Mar 24 2015, In : Vaccine. 33, 13, p. 1549-1555 7 p.

Research output: Contribution to journalArticle

Nanoparticle-induced intraperitoneal hyperthermia and targeted photoablation in treating ovarian cancer

Wu, C. C., Yang, Y. C., Hsu, Y. T., Wu, T. C., Hung, C. F., Huang, J. T. & Chang, C. L., 2015, In : Oncotarget. 6, 29, p. 26861-26875 15 p.

Research output: Contribution to journalArticle

Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4

Kang, T. H., Kim, Y. S., Kim, S., Yang, B., Lee, J. J., Lee, H. J., Lee, J., Jung, I. D., Han, H. D., Lee, S. H., Koh, S. S., Wu, T. C. & Park, Y. M., 2015, In : Oncotarget. 6, 29, p. 27751-27762 12 p.

Research output: Contribution to journalArticle

Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer

Peng, S., Wang, J. W., Karanam, B., Wang, C., Huh, W. K., Alvarez, R. D., Pai, S. I., Hung, C. F., Wu, T. C. & Roden, R. B. S., Jan 5 2015, In : PloS one. 10, 1, e116389.

Research output: Contribution to journalArticle

2016

Annexin A5 increases survival in murine sepsis model by inhibiting HMGB1-mediated proinflammation and coagulation

Park, J. H., Jang, J. H., Choi, E. J., Kim, Y. S., Lee, E. J., Jung, I. D., Han, H. D., Wu, T. C., Hung, C. F., Kang, T. H. & Park, Y. M., 2016, In : Molecular Medicine. 22, p. 424-436 13 p.

Research output: Contribution to journalArticle

A pilot study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16 + cervical intraepithelial neoplasia 2/3 (CIN2/3)

Alvarez, R. D., Huh, W. K., Bae, S., Lamb, L. S., Conner, M. G., Boyer, J., Wang, C., Hung, C. F., Sauter, E., Paradis, M., Adams, E. A., Hester, S., Jackson, B. E., Wu, T. C. & Trimble, C. L., 2016, In : Gynecologic oncology. 140, 2, p. 245-252 8 p.

Research output: Contribution to journalArticle

Buccal injection of synthetic HPV long peptide vaccine induces local and systemic antigen-specific CD8+ T-cell immune responses and antitumor effects without adjuvant

Yang, M. C., Yang, A., Qiu, J., Yang, B., He, L., Tsai, Y. C., Jeang, J., Wu, T. C. & Hung, C-F., Mar 3 2016, In : Cell and Bioscience. 6, 1, 17.

Research output: Contribution to journalArticle

Current state in the development of candidate therapeutic HPV vaccines

Yang, A., Jeang, J., Cheng, K., Cheng, T., Yang, B., Wu, T. C. & Hung, C. F., Aug 2 2016, In : Expert review of vaccines. 15, 8, p. 989-1007 19 p.

Research output: Contribution to journalArticle

Identification of the murine H-2Db and human HLA-A*0201 MHC class I-restricted HPV6 E7-specific cytotoxic T lymphocyte epitopes

Peng, S., Mattox, A., Best, S. R., Barbu, A. M., Burns, J. A., Akpeng, B., Jeang, J., Yang, B., Ishida, E., Hung, C. F., Wu, T. C. & Pai, S. I., Mar 1 2016, In : Cancer Immunology, Immunotherapy. 65, 3, p. 261-271 11 p.

Research output: Contribution to journalArticle

Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell-Mediated Tumor Control in the Genital Tract

Sun, Y. Y., Peng, S., Han, L., Qiu, J., Song, L., Tsai, Y., Yang, B., Roden, R. B. S., Trimble, C. L., Hung, C. F. & Wu, T. C., Feb 1 2016, In : Clinical Cancer Research. 22, 3, p. 657-669 13 p.

Research output: Contribution to journalArticle

Perspectives for therapeutic HPV vaccine development

Yang, A., Farmer, E., Wu, T. C. & Hung, C-F., Nov 4 2016, In : Journal of Biomedical Science. 23, 1, p. 1-19 19 p.

Research output: Contribution to journalArticle

2017

Characterization of HPV18 E6-specific T cell responses and establishment of HPV18 E6-expressing tumor model

Ma, Y., Yang, A., Peng, S., Qiu, J., Farmer, E., Hung, C. F. & Wu, T. C., Jul 5 2017, In : Vaccine. 35, 31, p. 3850-3858 9 p.

Research output: Contribution to journalArticle

Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation

Sun, Y., Peng, S., Yang, A., Farmer, E., Wu, T. C. & Hung, C. F., Jul 1 2017, In : Gene Therapy. 24, 7, p. 408-415 8 p.

Research output: Contribution to journalArticle

Enhancing antitumor immunogenicity of HPV16-E7 DNA vaccine by fusing DNA encoding E7-antigenic peptide to DNA encoding capsid protein L1 of Bovine papillomavirus

Yang, A., Peng, S., Farmer, E., Zeng, Q., Cheng, M. A., Pang, X., Wu, T. C. & Hung, C. F., Aug 23 2017, In : Cell and Bioscience. 7, 1, 46.

Research output: Contribution to journalArticle

HDAC1 upregulation by NANOG promotes multidrug resistance and a stem-like phenotype in immune edited tumor cells

Song, K. H., Choi, C. H., Lee, H. J., Oh, S. J., Woo, S. R., Hong, S. O., Noh, K. H., Cho, H., Chung, E. J., Kim, J. H., Chung, J. Y., Hewitt, S. M., Baek, S., Lee, K. M., Yee, C., Son, M., Mao, C. P., Wu, T. C. & Kim, T. W., Sep 15 2017, In : Cancer Research. 77, 18, p. 5039-5053 15 p.

Research output: Contribution to journalArticle

Immunologic responses to a novel DNA vaccine targeting human papillomavirus-11 E6E7

Ahn, J., Peng, S., Hung, C-F., Roden, R. S., Wu, T. C. & Best, S. R., 2017, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Metabolomic characterization of experimental ovarian cancer ascitic fluid

Bharti, S. K., Wildes, F., Hung, C. F., Wu, T. C., Bhujwalla, Z. M. & Penet, M. F., Oct 1 2017, In : Metabolomics. 13, 10, 113.

Research output: Contribution to journalArticle

The current state of therapeutic and T cell-based vaccines against human papillomaviruses

Yang, A., Farmer, E., Lin, J., Wu, T. C. & Hung, C. F., Mar 2 2017, In : Virus Research. 231, p. 148-165 18 p.

Research output: Contribution to journalReview article

2018

A novel function of API5 (apoptosis inhibitor 5), TLR4-dependent activation of antigen presenting cells

Kim, Y. S., Park, H. J., Park, J. H., Hong, E. J., Jang, G. Y., Jung, I. D., Han, H. D., Lee, S. H., Vo, M. C., Lee, J. J., Yang, A., Farmer, E., Wu, T. C., Kang, T. H. & Park, Y. M., Oct 3 2018, In : OncoImmunology. 7, 10, e1472187.

Research output: Contribution to journalArticle