Tzyy Choou Wu

Professor

1986 …2020

Research output per year

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Research Output

2020

Coexistence of Conventional Leiomyoma, Fumarate Hydratase-deficient Atypical Leiomyoma, and Perivascular Epithelioid Cell Tumor in a Uterus: A Case Study

Liu, Y., Deleon, E. M. B., Okour, S., Vang, R., Hung, C. F., Wu, T. C., Ronnett, B. M. & Xing, D., Jan 1 2020, (Accepted/In press) In : International Journal of Gynecological Pathology.

Research output: Contribution to journalArticle

Prevalence of somatic and germline mutations of Fumarate hydratase in uterine leiomyomas from young patients

Liu, C., Dillon, J., Beavis, A. L., Liu, Y., Lombardo, K., Fader, A. N., Hung, C. F., Wu, T. C., Vang, R., Garcia, J. E. & Xing, D., Feb 1 2020, In : Histopathology. 76, 3, p. 354-365 12 p.

Research output: Contribution to journalArticle

2019

Endoplasmic reticulum stress enhances the antigen-specific T cell immune responses and therapeutic antitumor effects generated by therapeutic HPV vaccines

Lee, S. Y., Oh, J. Y., Kang, T. H., Shin, H. S., Cheng, M. A., Farmer, E., Wu, T. C. & Hung, C. F., May 27 2019, In : Journal of biomedical science. 26, 1, 41.

Research output: Contribution to journalArticle

Open Access
Open Access
Open Access

Lineage-specific alterations in gynecologic neoplasms with choriocarcinomatous differentiation: Implications for origin and therapeutics

Xing, D., Zheng, G., Pallavajjala, A., Kenneth Schoolmeester, J., Liu, Y., Haley, L., Hu, Y., Liu, L., Logan, L., Lin, Y., Pearce, K. E., Sattler, C. A., Tsai, Y. C., Vang, R., Hung, C. F., Wu, T. C. & Ronnett, B. M., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4516-4529 14 p.

Research output: Contribution to journalArticle

Recurrent genetic alterations and biomarker expression in primary and metastatic squamous cell carcinomas of the vulva

Xing, D., Liu, Y., Park, H. J., Baek, I., Tran, H., Cheang, G., Novo, J., Dillon, J., Matoso, A., Farmer, E., Cheng, M. A., Tsai, Y. C., Lombardo, K., Conner, M. G., Vang, R., Hung, C. F., Wu, T. C. & Song, W., Oct 2019, In : Human pathology. 92, p. 67-80 14 p.

Research output: Contribution to journalArticle

2018

A novel function of API5 (apoptosis inhibitor 5), TLR4-dependent activation of antigen presenting cells

Kim, Y. S., Park, H. J., Park, J. H., Hong, E. J., Jang, G. Y., Jung, I. D., Han, H. D., Lee, S. H., Vo, M. C., Lee, J. J., Yang, A., Farmer, E., Wu, T. C., Kang, T. H. & Park, Y. M., Jan 1 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Ascites volumes and the ovarian cancer microenvironment

Penet, M. F., Krishnamachary, B., Wildes, F. B., Mironchik, Y., Hung, C. F., Wu, T. C. & Bhujwalla, Z. M., Jan 1 2018, In : Frontiers in Oncology. 8, DEC, 595.

Research output: Contribution to journalArticle

Open Access

Epithelial boost enhances antigen expression by vaccinia virus for the generation of potent CD8+ T cell-mediated antitumor immunity following DNA priming vaccination

Qiu, J., Peng, S., Ma, Y., Yang, A., Farmer, E., Cheng, M. A., Roden, R. B. S., Wu, T. C., Chang, Y. N. & Hung, C. F., Dec 2018, In : Virology. 525, p. 205-215 11 p.

Research output: Contribution to journalArticle

Integration of oncogenes via sleeping beauty as a mouse model of HPV16þ oral tumors and immunologic control

Lin, Y. H., Yang, M. C., Tseng, S. H., Jiang, R., Yang, A., Farmer, E., Peng, S., Henkle, T., Chang, Y. N., Hung, C. F. & Wu, T. C., Mar 1 2018, In : Cancer Immunology Research. 6, 3, p. 305-319 15 p.

Research output: Contribution to journalArticle

Intramuscular vaccination targeting mucosal tumor draining lymph node enhances integrins-mediated CD8+ T cell infiltration to control mucosal tumor growth

Qiu, J., Peng, S., Yang, A., Ma, Y., Han, L., Cheng, M. A., Farmer, E., Hung, C. F. & Wu, T. C., Aug 3 2018, In : OncoImmunology. 7, 8, e1463946.

Research output: Contribution to journalArticle

Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance

Song, K. H., Kim, J. H., Lee, Y. H., Bae, H. C., Lee, H. J., Woo, S. R., Oh, S. J., Lee, K. M., Yee, C., Kim, B. W., Cho, H., Chung, E. J., Chung, J. Y., Hewitt, S. M., Chung, T. W., Ha, K. T., Bae, Y. K., Mao, C. P., Yang, A., Wu, T. C. & 1 others, Kim, T. W., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 4098-4114 17 p.

Research output: Contribution to journalArticle

Next-generation Sequencing Reveals Recurrent Somatic Mutations in Small Cell Neuroendocrine Carcinoma of the Uterine Cervix

Xing, D., Zheng, G., Schoolmeester, J. K., Li, Z., Pallavajjalla, A., Haley, L., Conner, M. G., Vang, R. S., Hung, C-F., Wu, T. C. & Ronnett, B. M., Jan 1 2018, In : American Journal of Surgical Pathology. 42, 6, p. 750-760 11 p.

Research output: Contribution to journalArticle

Programmed self-assembly of peptide–major histocompatibility complex for antigen-specific immune modulation

Mao, C. P., Peng, S., Yang, A., He, L., Tsai, Y. C., Hung, C-F. & Wu, T. C., Apr 24 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 17, p. E4032-E4040

Research output: Contribution to journalArticle

Therapeutic DNA Vaccines for Human Papillomavirus and Associated Diseases

Cheng, M. A., Farmer, E., Huang, C., Lin, J., Hung, C-F. & Wu, T. C., Sep 1 2018, In : Human Gene Therapy. 29, 9, p. 971-996 26 p.

Research output: Contribution to journalReview article

2017

Characterization of HPV18 E6-specific T cell responses and establishment of HPV18 E6-expressing tumor model

Ma, Y., Yang, A., Peng, S., Qiu, J., Farmer, E., Hung, C. F. & Wu, T. C., Jul 5 2017, In : Vaccine. 35, 31, p. 3850-3858 9 p.

Research output: Contribution to journalArticle

Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation

Sun, Y., Peng, S., Yang, A., Farmer, E., Wu, T. C. & Hung, C. F., Jul 1 2017, In : Gene Therapy. 24, 7, p. 408-415 8 p.

Research output: Contribution to journalArticle

Enhancing antitumor immunogenicity of HPV16-E7 DNA vaccine by fusing DNA encoding E7-antigenic peptide to DNA encoding capsid protein L1 of Bovine papillomavirus

Yang, A., Peng, S., Farmer, E., Zeng, Q., Cheng, M. A., Pang, X., Wu, T. C. & Hung, C-F., Aug 23 2017, In : Cell and Bioscience. 7, 1, 46.

Research output: Contribution to journalArticle

HDAC1 upregulation by NANOG promotes multidrug resistance and a stem-like phenotype in immune edited tumor cells

Song, K. H., Choi, C. H., Lee, H. J., Oh, S. J., Woo, S. R., Hong, S. O., Noh, K. H., Cho, H., Chung, E. J., Kim, J. H., Chung, J. Y., Hewitt, S. M., Baek, S., Lee, K. M., Yee, C., Son, M., Mao, C. P., Wu, T. C. & Kim, T. W., Sep 15 2017, In : Cancer Research. 77, 18, p. 5039-5053 15 p.

Research output: Contribution to journalArticle

Immunologic responses to a novel DNA vaccine targeting human papillomavirus-11 E6E7

Ahn, J., Peng, S., Hung, C-F., Roden, R. S., Wu, T. C. & Best, S. R., 2017, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Metabolomic characterization of experimental ovarian cancer ascitic fluid

Bharti, S. K., Wildes, F., Hung, C. F., Wu, T. C., Bhujwalla, Z. M. & Penet, M. F., Oct 1 2017, In : Metabolomics. 13, 10, 113.

Research output: Contribution to journalArticle

2016

Annexin A5 increases survival in murine sepsis model by inhibiting HMGB1-mediated proinflammation and coagulation

Park, J. H., Jang, J. H., Choi, E. J., Kim, Y. S., Lee, E. J., Jung, I. D., Han, H. D., Wu, T. C., Hung, C-F., Kang, T. H. & Park, Y. M., 2016, In : Molecular Medicine. 22, p. 424-436 13 p.

Research output: Contribution to journalArticle

A pilot study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16 + cervical intraepithelial neoplasia 2/3 (CIN2/3)

Alvarez, R. D., Huh, W. K., Bae, S., Lamb, L. S., Conner, M. G., Boyer, J., Wang, C., Hung, C-F., Sauter, E., Paradis, M., Adams, E. A., Hester, S., Jackson, B. E., Wu, T. C. & Trimble, C. L., 2016, In : Gynecologic Oncology. 140, 2, p. 245-252 8 p.

Research output: Contribution to journalArticle

Buccal injection of synthetic HPV long peptide vaccine induces local and systemic antigen-specific CD8+ T-cell immune responses and antitumor effects without adjuvant

Yang, M. C., Yang, A., Qiu, J., Yang, B., He, L., Tsai, Y. C., Jeang, J., Wu, T. C. & Hung, C-F., Mar 3 2016, In : Cell and Bioscience. 6, 1, 17.

Research output: Contribution to journalArticle

Current state in the development of candidate therapeutic HPV vaccines

Yang, A., Jeang, J., Cheng, K., Cheng, T., Yang, B., Wu, T. C. & Hung, C. F., Aug 2 2016, In : Expert review of vaccines. 15, 8, p. 989-1007 19 p.

Research output: Contribution to journalArticle

Identification of the murine H-2Db and human HLA-A*0201 MHC class I-restricted HPV6 E7-specific cytotoxic T lymphocyte epitopes

Peng, S., Mattox, A., Best, S. R., Barbu, A. M., Burns, J. A., Akpeng, B., Jeang, J., Yang, B., Ishida, E., Hung, C. F., Wu, T. C. & Pai, S. I., Mar 1 2016, In : Cancer Immunology, Immunotherapy. 65, 3, p. 261-271 11 p.

Research output: Contribution to journalArticle

Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell-Mediated Tumor Control in the Genital Tract

Sun, Y. Y., Peng, S., Han, L., Qiu, J., Song, L., Tsai, Y., Yang, B., Roden, R. B. S., Trimble, C. L., Hung, C. F. & Wu, T. C., Feb 1 2016, In : Clinical Cancer Research. 22, 3, p. 657-669 13 p.

Research output: Contribution to journalArticle

Perspectives for therapeutic HPV vaccine development

Yang, A., Farmer, E., Wu, T. C. & Hung, C-F., Nov 4 2016, In : Journal of Biomedical Science. 23, 1, p. 1-19 19 p.

Research output: Contribution to journalArticle

The current state of therapeutic and T cell-based vaccines against human papillomaviruses

Yang, A., Farmer, E., Lin, J., Wu, T. C. & Hung, C-F., Aug 31 2016, (Accepted/In press) In : Virus Research.

Research output: Contribution to journalArticle

2015

Chemical-free inactivated whole influenza virus vaccine prepared by ultrashort pulsed laser treatment

Tsen, S. W. D., Donthi, N., La, V., Hsieh, W. H., Li, Y. D., Knoff, J., Chen, A., Wu, T. C., Hung, C. F., Achilefu, S. & Tsen, K. T., May 1 2015, In : Journal of biomedical optics. 20, 5, 051008.

Research output: Contribution to journalArticle

Gain of HIF-1α under normoxia in cancer mediates immune adaptation through the AKT/ERK and VEGFA axes

Lee, Y. H., Bae, H. C., Noh, K. H., Song, K. H., Ye, S. K., Mao, C. P., Lee, K. M., Wu, T. C. & Kim, T. W., Mar 15 2015, In : Clinical Cancer Research. 21, 6, p. 1438-1446 9 p.

Research output: Contribution to journalArticle

Intravaginal HPV DNA vaccination with electroporation induces local CD8+ T-cell immune responses and antitumor effects against cervicovaginal tumors

Sun, Y., Peng, S., Qiu, J., Miao, J., Yang, B., Jeang, J., Hung, C. F. & Wu, T. C., Jul 3 2015, In : Gene Therapy. 22, 7, p. 528-535 8 p.

Research output: Contribution to journalArticle

Local administration of granulocyte macrophage colony-stimulating factor induces local accumulation of dendritic cells and antigen-specific CD8+ T cells and enhances dendritic cell cross-presentation

Lee, S. J., Song, L., Yang, M. C., Mao, C. P., Yang, B., Yang, A., Jeang, J., Peng, S., Wu, T. C. & Hung, C. F., Mar 24 2015, In : Vaccine. 33, 13, p. 1549-1555 7 p.

Research output: Contribution to journalArticle

Nanoparticle-induced intraperitoneal hyperthermia and targeted photoablation in treating ovarian cancer

Wu, C. C., Yang, Y. C., Hsu, Y. T., Wu, T. C., Hung, C. F., Huang, J. T. & Chang, C. L., Jan 1 2015, In : Oncotarget. 6, 29, p. 26861-26875 15 p.

Research output: Contribution to journalArticle

Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4

Kang, T. H., Kim, Y. S., Kim, S., Yang, B., Lee, J. J., Lee, H. J., Lee, J., Jung, I. D., Han, H. D., Lee, S. H., Koh, S. S., Wu, T. C. & Park, Y. M., Jan 1 2015, In : Oncotarget. 6, 29, p. 27751-27762 12 p.

Research output: Contribution to journalArticle

Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer

Peng, S., Wang, J. W., Karanam, B., Wang, C., Huh, W. K., Alvarez, R. D., Pai, S. I., Hung, C. F., Wu, T. C. & Roden, R. B. S., Jan 5 2015, In : PloS one. 10, 1, e116389.

Research output: Contribution to journalArticle

2014

Cancer immunotherapy employing an innovative strategy to enhance CD4T cell help in the tumor microenvironment

Song, L., Yang, M. C., Knoff, J., Wu, T. C., Hung, C. F. & Van Hall, T., Dec 22 2014, In : PloS one. 9, 12, e115711.

Research output: Contribution to journalArticle

Cancer immunotherapy using a potent immunodominant CTL epitope

Song, L., Yang, M. C., Knoff, J., Sun, Z. Y., Wu, T. C. & Hung, C. F., Oct 21 2014, In : Vaccine. 32, 46, p. 6039-6048 10 p.

Research output: Contribution to journalArticle

Control of HPV-associated tumors by innovative therapeutic HPV DNA vaccine in the absence of CD4+ T cells

Peng, S., Song, L., Knoff, J., Wang, J. W., Chang, Y. N., Hannaman, D., Wu, T. C., Alvarez, R. D., Roden, R. B. S. & Hung, C. F., Mar 4 2014, In : Cell and Bioscience. 4, 1, 11.

Research output: Contribution to journalArticle

Control of HPV infection and related cancer through vaccination

Tran, N. P., Hung, C. F., Roden, R. & Wu, T. C., Jan 1 2014, Viruses and Human Cancer: From Basic Science to Clinical Prevention. Springer New York LLC, p. 149-171 23 p. (Recent Results in Cancer Research; vol. 193).

Research output: Chapter in Book/Report/Conference proceedingChapter

Direct T cell activation via CD40 ligand generates high avidity CD8 + T cells capable of breaking immunological tolerance for the control of tumors

Soong, R. S., Song, L., Trieu, J., Lee, S. Y., He, L., Tsai, Y. C., Wu, T. C. & Hung, C. F., Mar 24 2014, In : PloS one. 9, 3, e93162.

Research output: Contribution to journalArticle

DNA vaccine for cancer immunotherapy

Yang, B., Jeang, J., Yang, A., Wu, T. C. & Hung, C. F., Nov 1 2014, In : Human Vaccines and Immunotherapeutics. 10, 11, p. 3153-3164 12 p.

Research output: Contribution to journalArticle

Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors

Wu, C. Y., Yang, L. H., Yang, H. Y., Knoff, J., Peng, S., Lin, Y. H., Wang, C., Alvarez, R. D., Pai, S. I., Roden, R. B. S., Hung, C. F. & Wu, T. C., Feb 11 2014, In : Clinical Cancer Research. 20, 3, p. 644-657 14 p.

Research output: Contribution to journalArticle