Tracy Murray Stewart

Research Associate

19982020

Research output per year

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Research Output

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2020

(R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder-Robinson syndrome

Stewart, T. M., Khomutov, M., Foley, J. R., Guo, X., Holbert, C. E., Dunston, T. T., Schwartz, C. E., Gabrielson, K., Khomutov, A. & Casero, R. A., Mar 6 2020, In : Journal of Biological Chemistry. 295, 10, p. 3247-3256 10 p.

Research output: Contribution to journalArticle

2019

Dual inhibitors of LSD1 and spermine oxidase

Holshouser, S., Dunworth, M., Murray Stewart, T., Peterson, Y. K., Burger, P., Kirkpatrick, J., Chen, H. H., Casero, R. A. & Woster, P. M., Jan 1 2019, In : MedChemComm. 10, 5, p. 778-790 13 p.

Research output: Contribution to journalArticle

2018

Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies

Murray Stewart, T., Dunworth, M., Lui, Y., Giardiello, F. M., Woster, P. M. & Casero, R. A., Aug 1 2018, In : PLoS One. 13, 8, e0202677.

Research output: Contribution to journalArticle

Polyamine metabolism and cancer: treatments, challenges and opportunities

Casero, R. A., Murray Stewart, T. & Pegg, A. E., Jan 1 2018, (Accepted/In press) In : Nature Reviews Cancer.

Research output: Contribution to journalArticle

Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features

Jain, V., Raina, S., Gheware, A. P., Singh, R., Rehman, R., Negi, V., Murray Stewart, T., Mabalirajan, U., Mishra, A. K., Casero, R. A., Agrawal, A. & Ghosh, B., Oct 1 2018, In : Allergy: European Journal of Allergy and Clinical Immunology. 73, 10, p. 2033-2045 13 p.

Research output: Contribution to journalArticle

2017

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano 11047

Murray Stewart, T., Ferrari, E., Xie, Y., Yu, F., Marton, L. J., Oupicky, D. & Casero, R. A., Apr 1 2017, In : PLoS One. 12, 4, e0175917.

Research output: Contribution to journalArticle

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy

Xie, Y., Murray Stewart, T., Wang, Y., Yu, F., Li, J., Marton, L. J., Casero, R. A. & Oupický, D., Jan 28 2017, In : Journal of Controlled Release. 246, p. 110-119 10 p.

Research output: Contribution to journalArticle

Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth

Liu, Y., Murray Stewart, T., Casero, R. A., Kagiampakis, I., Jin, L., Jiawen, Z., Huihui, W., Che, Q., Huan, T., Ke, J., Feizhou, J., Fangyuan, W. & Wan, X., Jun 1 2017, In : International Journal of Oncology. 50, 6, p. 2011-2023 13 p.

Research output: Contribution to journalArticle

2016

Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer

Murray Stewart, T., Sierra, J. C., Piazuelo, M. B., Mera, R. M., Chaturvedi, R., Bravo, L. E., Correa, P., Schneider, B. G., Wilson, K. T. & Casero, R. A., Apr 4 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

2015
2014

Polyamine catabolism in carcinogenesis: Potential targets for chemotherapy and chemoprevention

Battaglia, V., DeStefano Shields, C., Murray Stewart, T. & Casero, R. A., 2014, In : Amino Acids. 46, 3, p. 511-519 9 p.

Research output: Contribution to journalArticle

Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury

Zahedi, K., Barone, S., Wang, Y., Murray Stewart, T., Roy-Chaudhury, P., Smith, R. D., Casero, R. A. & Soleimani, M., Nov 12 2014, In : PLoS One. 9, 11, e110161.

Research output: Contribution to journalArticle

2013

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism

Murray Stewart, T., Hanigan, C. L., Woster, P. M., Marton, L. J. & Casero, R. A., Oct 2013, In : Molecular Cancer Therapeutics. 12, 10, p. 2088-2099 12 p.

Research output: Contribution to journalArticle

2012

Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes

Wu, Y., Steinbergs, N., Murray Stewart, T., Marton, L. J. & Casero, R. A., Mar 15 2012, In : Biochemical Journal. 442, 3, p. 693-701 9 p.

Research output: Contribution to journalArticle

Polyamine-based small molecule epigenetic modulators

Sharma, S. K., Hazeldine, S., Crowley, M. L., Hanson, A., Beattie, R., Varghese, S., Senanayake, T. M. D., Hirata, A., Hirata, F., Huang, Y., Wu, Y., Steinbergs, N., Murray Stewart, T., Bytheway, I., Casero, R. A. & Woster, P. M., 2012, In : MedChemComm. 3, 1, p. 14-21 8 p.

Research output: Contribution to journalArticle

2010

Polyamine catabolism is enhanced after traumatic brain injury

Zahedi, K., Huttinger, F., Morrison, R., Murray Stewart, T., Casero, R. A. & Strauss, K. I., Mar 1 2010, In : Journal of Neurotrauma. 27, 3, p. 515-525 11 p.

Research output: Contribution to journalArticle

2008

Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors

Varghese, S., Senanayake, T., Murray Stewart, T., Doering, K., Fraser, A., Casero, R. A. & Woster, P. M., Apr 24 2008, In : Journal of Medicinal Chemistry. 51, 8, p. 2447-2456 10 p.

Research output: Contribution to journalArticle

2007

Inflammation and polyamine catabolism: The good, the bad and the ugly

Babbar, N., Murray Stewart, T. & Casero, R. A., Apr 2007, In : Biochemical Society Transactions. 35, 2, p. 300-304 5 p.

Research output: Contribution to journalArticle

2005
2003

Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

Wang, Y., Murray Stewart, T., Devereux, W., Hacker, A., Frydman, B., Woster, P. M. & Casero, R. A., May 16 2003, In : Biochemical and Biophysical Research Communications. 304, 4, p. 605-611 7 p.

Research output: Contribution to journalArticle

Spermidine/spermine N1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct

Murray Stewart, T., Applegren, N. B., Devereux, W., Hacker, A., Smith, R., Wang, Y. & Casero, R. A., Jul 15 2003, In : Biochemical Journal. 373, 2, p. 629-634 6 p.

Research output: Contribution to journalArticle

The role of polyamine catabolism in anti-tumour drug response

Casero, R. A., Wang, Y., Murray Stewart, T., Devereux, W., Hacker, A., Wang, Y., Smith, R. & Woster, P. M., Apr 2003, In : Biochemical Society Transactions. 31, 2, p. 361-365 5 p.

Research output: Contribution to journalArticle

2002
2001

Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure

Wang, Y., Devereux, W., Woster, P. M., Murray Stewart, T., Hacker, A. & Casero, R. A., Jul 15 2001, In : Cancer Research. 61, 14, p. 5370-5373 4 p.

Research output: Contribution to journalArticle

1998