Tracy Murray Stewart

Research Associate

19982019
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Research Output 1998 2019

2019

Dual inhibitors of LSD1 and spermine oxidase

Holshouser, S., Dunworth, M., Murray Stewart, T., Peterson, Y. K., Burger, P., Kirkpatrick, J., Chen, H. H., Casero, R. A. & Woster, P. M., Jan 1 2019, In : MedChemComm. 10, 5, p. 778-790 13 p.

Research output: Contribution to journalArticle

Tumors
Monoamine Oxidase
Histone Demethylases
Cells
Neoplasms
2018

Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies

Murray Stewart, T., Dunworth, M., Lui, Y., Giardiello, F. M., Woster, P. M. & Casero, R. A., Aug 1 2018, In : PLoS One. 13, 8, e0202677.

Research output: Contribution to journalArticle

Curcumin
Gastrointestinal Neoplasms
curcumin
Polyamines
polyamines

Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis

Cruz-Correa, M., Hylind, L. M., Marrero, J. H., Zahurak, M. L., Murray Stewart, T., Casero, R. A., Montgomery, E. A., Iacobuzio-Donahue, C., Brosens, L. A., Offerhaus, G. J., Umar, A., Rodriguez, L. M. & Giardiello, F. M., Sep 1 2018, In : Gastroenterology. 155, 3, p. 668-673 6 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Curcumin
Adenoma
Safety
Polyps

Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex

McKenna, J., Kapfhamer, D., Kinchen, J. M., Wasek, B., Dunworth, M., Murray Stewart, T., Bottiglieri, T., Casero, R. A. & Gambello, M. J., Jun 15 2018, In : Human Molecular Genetics. 27, 12, p. 2113-2124 12 p.

Research output: Contribution to journalArticle

Tuberous Sclerosis
Metabolomics
Polyamines
Methylation
Putrescine

Polyamine catabolism and oxidative damage

Murray Stewart, T., Dunston, T. T., Woster, P. M. & Casero, R. A., Jan 1 2018, In : Journal of Biological Chemistry. 293, 48, p. 18736-18745 10 p.

Research output: Contribution to journalReview article

Polyamines
Yeast
Amines
Homeostasis
Maintenance

Polyamine metabolism and cancer: treatments, challenges and opportunities

Casero, R. A., Murray Stewart, T. & Pegg, A. E., Jan 1 2018, (Accepted/In press) In : Nature Reviews Cancer.

Research output: Contribution to journalArticle

Polyamines
Neoplasms
Therapeutics
Carcinogenesis
Clinical Trials

Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features

Jain, V., Raina, S., Gheware, A. P., Singh, R., Rehman, R., Negi, V., Murray Stewart, T., Mabalirajan, U., Mishra, A. K., Casero, R. A., Agrawal, A. & Ghosh, B., Oct 1 2018, In : Allergy: European Journal of Allergy and Clinical Immunology. 73, 10, p. 2033-2045 13 p.

Research output: Contribution to journalArticle

Spermine
Polyamines
Asthma
Epithelial Cells
Apoptosis
2017

Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury

Zahedi, K., Barone, S., Destefano-Shields, C., Brooks, M., Murray Stewart, T., Dunworth, M., Li, W., Doherty, J. R., Hall, M. A., Smith, R. D., Cleveland, J. L., Casero, R. A. & Soleimani, M., Sep 1 2017, In : PLoS One. 12, 9, e0184570.

Research output: Contribution to journalArticle

cisplatin
Endoplasmic Reticulum Stress
Polyamines
polyamines
Acute Kidney Injury

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano 11047

Murray Stewart, T., Ferrari, E., Xie, Y., Yu, F., Marton, L. J., Oupicky, D. & Casero, R. A., Apr 1 2017, In : PLoS One. 12, 4, e0175917.

Research output: Contribution to journalArticle

Polyamines
polyamines
Metabolism
Tumors
metabolism

Correction: Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047 (PLoS ONE (2017) 12:4 (e0175917) DOI: 10.1371/journal.pone.0175917)

Murray-Stewart, T., Ferrari, E., Xie, Y., Yu, F., Marton, L. J., Oupicky, D. & Casero, R. A., May 1 2017, In : PLoS One. 12, 5, e0178102.

Research output: Contribution to journalComment/debate

Polyamines
polyamines
Isomers
Molecules
4-iodo-2,5-dimethoxyphenylisopropylamine

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy

Xie, Y., Murray Stewart, T., Wang, Y., Yu, F., Li, J., Marton, L. J., Casero, R. A. & Oupický, D., Jan 28 2017, In : Journal of Controlled Release. 246, p. 110-119 10 p.

Research output: Contribution to journalArticle

Polyamines
MicroRNAs
Nanoparticles
Neoplasms
Antineoplastic Combined Chemotherapy Protocols

Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth

Liu, Y., Murray Stewart, T., Casero, R. A., Kagiampakis, I., Jin, L., Jiawen, Z., Huihui, W., Che, Q., Huan, T., Ke, J., Feizhou, J., Fangyuan, W. & Wan, X., Jun 1 2017, In : International Journal of Oncology. 50, 6, p. 2011-2023 13 p.

Research output: Contribution to journalArticle

Hexokinase
Uterine Cervical Neoplasms
Glycolysis
Growth
Neoplasms
2016

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection

Hardbower, D. M., Asim, M., Murray Stewart, T., Casero, R. A., Verriere, T., Lewis, N. D., Chaturvedi, R., Piazuelo, M. B. & Wilson, K. T., Apr 13 2016, (Accepted/In press) In : Amino Acids. p. 1-14 14 p.

Research output: Contribution to journalArticle

Arginase
Macrophage Activation
Macrophages
Polyamines
Helicobacter Infections

Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer

Murray Stewart, T., Sierra, J. C., Piazuelo, M. B., Mera, R. M., Chaturvedi, R., Bravo, L. E., Correa, P., Schneider, B. G., Wilson, K. T. & Casero, R. A., Apr 4 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Epigenomics
Helicobacter pylori
Stomach Neoplasms
Gastritis
DNA Damage
DNA Methylation
Epigenomics
Histones
Co-Repressor Proteins
Neoplasms
2015

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase

Chaturvedi, R., De Sablet, T., Asim, M., Piazuelo, M. B., Barry, D. P., Verriere, T. G., Sierra, J. C., Hardbower, D. M., Delgado, A. G., Schneider, B. G., Israel, D. A., Romero-Gallo, J., Nagy, T. A., Morgan, D. R., Murray Stewart, T., Bravo, L. E., Peek, R. M., Fox, J. G., Woster, P. M., Casero, R. A. & 2 others, Correa, P. & Wilson, K. T., Jun 27 2015, In : Oncogene. 34, 26, p. 3429-3440 12 p.

Research output: Contribution to journalArticle

Colombia
Helicobacter pylori
Stomach Neoplasms
DNA Damage
Stomach

Mammalian polyamine catabolism

Murray Stewart, T. & Casero, R. A., Jan 1 2015, Polyamines: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer Japan, p. 61-76 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Polyamines
Spermidine
Oxidation
Spermine
Poisons
2014

Polyamine catabolism in carcinogenesis: Potential targets for chemotherapy and chemoprevention

Battaglia, V., DeStefano Shields, C., Murray Stewart, T. & Casero, R. A., 2014, In : Amino Acids. 46, 3, p. 511-519 9 p.

Research output: Contribution to journalArticle

Chemotherapy
Chemoprevention
Polyamines
Spermidine
Spermine

Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury

Zahedi, K., Barone, S., Wang, Y., Murray Stewart, T., Roy-Chaudhury, P., Smith, R. D., Casero, R. A. & Soleimani, M., Nov 12 2014, In : PLoS One. 9, 11, e110161.

Research output: Contribution to journalArticle

proximal tubules
acetyltransferases
Acetyltransferases
Spermidine
Spermine
Polyamines
Myeloid Cells
Cadherins
Acute Myeloid Leukemia
Histones
2013

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism

Murray Stewart, T., Hanigan, C. L., Woster, P. M., Marton, L. J. & Casero, R. A., Oct 2013, In : Molecular Cancer Therapeutics. 12, 10, p. 2088-2099 12 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Polyamines
MicroRNAs
Drug Resistance
Spermine
2012

Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes

Wu, Y., Steinbergs, N., Murray Stewart, T., Marton, L. J. & Casero, R. A., Mar 15 2012, In : Biochemical Journal. 442, 3, p. 693-701 9 p.

Research output: Contribution to journalArticle

Eflornithine
Tumor Suppressor Genes
Lysine
Tumors
Polyamines

Polyamine-based small molecule epigenetic modulators

Sharma, S. K., Hazeldine, S., Crowley, M. L., Hanson, A., Beattie, R., Varghese, S., Senanayake, T. M. D., Hirata, A., Hirata, F., Huang, Y., Wu, Y., Steinbergs, N., Murray Stewart, T., Bytheway, I., Casero, R. A. & Woster, P. M., 2012, In : MedChemComm. 3, 1, p. 14-21 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Polyamines
Epigenomics
Modulators
Histone Demethylases
2011
Polyamines
Enzymes
Pharmaceutical Preparations
Luminescent Measurements
Luminol

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

Goodwin, A. C., Destefano Shields, C. E., Wu, S., Huso, D. L., Wu, X., Murray Stewart, T., Hacker-Prietz, A., Rabizadeh, S., Woster, P. M., Sears, C. L. & Casero, R. A., Sep 13 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 37, p. 15354-15359 6 p.

Research output: Contribution to journalArticle

Bacteroides fragilis
Polyamines
Colon
Carcinogenesis
Inflammation
2010

Polyamine catabolism is enhanced after traumatic brain injury

Zahedi, K., Huttinger, F., Morrison, R., Murray Stewart, T., Casero, R. A. & Strauss, K. I., Mar 1 2010, In : Journal of Neurotrauma. 27, 3, p. 515-525 11 p.

Research output: Contribution to journalArticle

Spermine
Polyamines
Wounds and Injuries
Spermidine
Putrescine
2009

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes

Huang, Y., Murray Stewart, T., Wu, Y., Baylin, S. B., Marton, L. J., Perkins, B., Jones, R. J., Woster, P. M. & Casero, R. A., Dec 1 2009, In : Clinical Cancer Research. 15, 23, p. 7217-7228 12 p.

Research output: Contribution to journalArticle

Lysine
Genes
Methyltransferases
Methylation
Chromatin
2008

Nuclear localization of human spermine oxidase isoforms - Possible implications in drug response and disease etiology

Murray Stewart, T., Wang, Y., Goodwin, A., Hacker, A., Meeker, A. K. & Casero, R. A., Jun 2008, In : FEBS Journal. 275, 11, p. 2795-2806 12 p.

Research output: Contribution to journalArticle

Protein Isoforms
Spermine
Polyamines
Pharmaceutical Preparations
Oxidation

Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors

Varghese, S., Senanayake, T., Murray Stewart, T., Doering, K., Fraser, A., Casero, R. A. & Woster, P. M., Apr 24 2008, In : Journal of Medicinal Chemistry. 51, 8, p. 2447-2456 10 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Histone Deacetylases
Protein Isoforms
decitabine
Polyamines
2007

Inflammation and polyamine catabolism: The good, the bad and the ugly

Babbar, N., Murray Stewart, T. & Casero, R. A., Apr 2007, In : Biochemical Society Transactions. 35, 2, p. 300-304 5 p.

Research output: Contribution to journalArticle

Polyamines
Inflammation
Spermidine
Spermine
Tumors
Histone Code
Polyamines
Lysine
Chromatin
Gene Expression
2006

Recent advances in the understanding of mammalian polyamine catabolism the regulation and potential role of polyamine catabolism in drug response and disease processes

Casero, R. A., Fraser, A. V., Murray Stewart, T., Hacker, A., Babbar, N., Fleischer, J. & Wang, Y., 2006, Polyamine Cell Signaling: Polyamine Cell Signaling. Humana Press, p. 205-232 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Polyamines
Pharmaceutical Preparations
Acetyltransferases
Spermine
Oxidoreductases
2005

Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein

Wang, Y., Hacker, A., Murray Stewart, T., Fleischer, J. G., Woster, P. M. & Casero, R. A., Mar 15 2005, In : Biochemical Journal. 386, 3, p. 543-547 5 p.

Research output: Contribution to journalArticle

Stabilization
Polyamines
Enzyme activity
Messenger RNA
Half-Life

Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): Potential role in determining drug sensitivity

Wang, Y., Hacker, A., Murray Stewart, T., Frydman, B., Valasinas, A., Fraser, A. V., Woster, P. M. & Casero, R. A., Jul 2005, In : Cancer Chemotherapy and Pharmacology. 56, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

Polyamines
Oxidoreductases
Pharmaceutical Preparations
Spermine
Cloning
Polyamines
Antineoplastic Agents
Ornithine Decarboxylase
Enzymes
Neoplasms
2003

Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells

Devereux, W., Wang, Y., Murray Stewart, T., Hacker, A., Smith, R., Frydman, B., Valasinas, A. L., Reddy, V. K., Marton, L. J., Ward, T. D., Woster, P. M. & Casero, R. A., Nov 2003, In : Cancer Chemotherapy and Pharmacology. 52, 5, p. 383-390 8 p.

Research output: Contribution to journalArticle

Polyamines
Cells
Carcinoma
Lung
Spermine

Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

Wang, Y., Murray Stewart, T., Devereux, W., Hacker, A., Frydman, B., Woster, P. M. & Casero, R. A., May 16 2003, In : Biochemical and Biophysical Research Communications. 304, 4, p. 605-611 7 p.

Research output: Contribution to journalArticle

Spermine
Polyamines
Spermidine
Corrosion inhibitors
Enzymes

Spermidine/spermine N1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct

Murray Stewart, T., Applegren, N. B., Devereux, W., Hacker, A., Smith, R., Wang, Y. & Casero, R. A., Jul 15 2003, In : Biochemical Journal. 373, 2, p. 629-634 6 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Small Cell Lung Carcinoma
Human Activities

The role of polyamine catabolism in anti-tumour drug response

Casero, R. A., Wang, Y., Murray Stewart, T., Devereux, W., Hacker, A., Wang, Y., Smith, R. & Woster, P. M., Apr 2003, In : Biochemical Society Transactions. 31, 2, p. 361-365 5 p.

Research output: Contribution to journalArticle

Polyamines
Tumors
Spermine
Acetyltransferases
Spermidine
2002
Cloning
Polyamines
Isoenzymes
Organism Cloning
Metabolic Networks and Pathways
Polyamines
Arabidopsis
Gene expression
NF-E2-Related Factor 2
Gene Expression
2001
NF-E2-Related Factor 2
Acetyltransferases
Spermidine
Spermine
Polyamines

Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure

Wang, Y., Devereux, W., Woster, P. M., Murray Stewart, T., Hacker, A. & Casero, R. A., Jul 15 2001, In : Cancer Research. 61, 14, p. 5370-5373 4 p.

Research output: Contribution to journalArticle

Polyamines
Organism Cloning
Clone Cells
polyamine oxidase
Complementary DNA
1999
Acetyltransferases
Spermidine
Spermine
Cloning
Polyamines
1998
X-Linked Genes
Spermine
Polyamines
Lung Neoplasms
Cell Line