Tracy Murray Stewart

Research Associate

19982020

Research output per year

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Research Output

2020

(R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder-Robinson syndrome

Stewart, T. M., Khomutov, M., Foley, J. R., Guo, X., Holbert, C. E., Dunston, T. T., Schwartz, C. E., Gabrielson, K., Khomutov, A. & Casero, R. A., Mar 6 2020, In : Journal of Biological Chemistry. 295, 10, p. 3247-3256 10 p.

Research output: Contribution to journalArticle

2019

Dual inhibitors of LSD1 and spermine oxidase

Holshouser, S., Dunworth, M., Murray Stewart, T., Peterson, Y. K., Burger, P., Kirkpatrick, J., Chen, H. H., Casero, R. A. & Woster, P. M., Jan 1 2019, In : MedChemComm. 10, 5, p. 778-790 13 p.

Research output: Contribution to journalArticle

2018

Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies

Murray Stewart, T., Dunworth, M., Lui, Y., Giardiello, F. M., Woster, P. M. & Casero, R. A., Aug 1 2018, In : PLoS One. 13, 8, e0202677.

Research output: Contribution to journalArticle

Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis

Cruz-Correa, M., Hylind, L. M., Marrero, J. H., Zahurak, M. L., Murray Stewart, T., Casero, R. A., Montgomery, E. A., Iacobuzio-Donahue, C., Brosens, L. A., Offerhaus, G. J., Umar, A., Rodriguez, L. M. & Giardiello, F. M., Sep 1 2018, In : Gastroenterology. 155, 3, p. 668-673 6 p.

Research output: Contribution to journalArticle

Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex

McKenna, J., Kapfhamer, D., Kinchen, J. M., Wasek, B., Dunworth, M., Murray Stewart, T., Bottiglieri, T., Casero, R. A. & Gambello, M. J., Jun 15 2018, In : Human Molecular Genetics. 27, 12, p. 2113-2124 12 p.

Research output: Contribution to journalArticle

Polyamine catabolism and oxidative damage

Stewart, T. M., Dunston, T. T., Woster, P. M. & Casero, R. A., Nov 30 2018, In : Journal of Biological Chemistry. 293, 48, p. 18736-18745 10 p.

Research output: Contribution to journalReview article

Polyamine metabolism and cancer: treatments, challenges and opportunities

Casero, R. A., Murray Stewart, T. & Pegg, A. E., Jan 1 2018, (Accepted/In press) In : Nature Reviews Cancer.

Research output: Contribution to journalArticle

Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features

Jain, V., Raina, S., Gheware, A. P., Singh, R., Rehman, R., Negi, V., Murray Stewart, T., Mabalirajan, U., Mishra, A. K., Casero, R. A., Agrawal, A. & Ghosh, B., Oct 1 2018, In : Allergy: European Journal of Allergy and Clinical Immunology. 73, 10, p. 2033-2045 13 p.

Research output: Contribution to journalArticle

2017

Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury

Zahedi, K., Barone, S., Destefano-Shields, C., Brooks, M., Murray Stewart, T., Dunworth, M., Li, W., Doherty, J. R., Hall, M. A., Smith, R. D., Cleveland, J. L., Casero, R. A. & Soleimani, M., Sep 1 2017, In : PLoS One. 12, 9, e0184570.

Research output: Contribution to journalArticle

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano 11047

Murray Stewart, T., Ferrari, E., Xie, Y., Yu, F., Marton, L. J., Oupicky, D. & Casero, R. A., Apr 1 2017, In : PLoS One. 12, 4, e0175917.

Research output: Contribution to journalArticle

Correction: Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047 (PLoS ONE (2017) 12:4 (e0175917) DOI: 10.1371/journal.pone.0175917)

Murray-Stewart, T., Ferrari, E., Xie, Y., Yu, F., Marton, L. J., Oupicky, D. & Casero, R. A., May 2017, In : PloS one. 12, 5, e0178102.

Research output: Contribution to journalComment/debate

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy

Xie, Y., Murray Stewart, T., Wang, Y., Yu, F., Li, J., Marton, L. J., Casero, R. A. & Oupický, D., Jan 28 2017, In : Journal of Controlled Release. 246, p. 110-119 10 p.

Research output: Contribution to journalArticle

Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth

Liu, Y., Murray-Stewart, T., Casero, R. A., Kagiampakis, I., Jin, L., Jiawen, Z., Huihui, W., Che, Q., Huan, T., Ke, J., Feizhou, J., Fangyuan, W. & Wan, X., Jun 2017, In : International journal of oncology. 50, 6, p. 2011-2023 13 p.

Research output: Contribution to journalArticle

2016

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection

Hardbower, D. M., Asim, M., Murray-Stewart, T., Casero, R. A., Verriere, T., Lewis, N. D., Chaturvedi, R., Piazuelo, M. B. & Wilson, K. T., Oct 1 2016, In : Amino Acids. 48, 10, p. 2375-2388 14 p.

Research output: Contribution to journalArticle

Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer

Murray Stewart, T., Sierra, J. C., Piazuelo, M. B., Mera, R. M., Chaturvedi, R., Bravo, L. E., Correa, P., Schneider, B. G., Wilson, K. T. & Casero, R. A., Apr 4 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation. A Perfect Combination for Cancer Therapy.

Zahnow, C. A., Topper, M., Stone, M., Murray-Stewart, T., Li, H., Baylin, S. B. & Casero, R. A., Jan 1 2016, Advances in Cancer Research, 2016. Fisher, P. B. & Tew, K. D. (eds.). Academic Press Inc., p. 55-111 57 p. (Advances in Cancer Research; vol. 130).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2015

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase

Chaturvedi, R., De Sablet, T., Asim, M., Piazuelo, M. B., Barry, D. P., Verriere, T. G., Sierra, J. C., Hardbower, D. M., Delgado, A. G., Schneider, B. G., Israel, D. A., Romero-Gallo, J., Nagy, T. A., Morgan, D. R., Murray-Stewart, T., Bravo, L. E., Peek, R. M., Fox, J. G., Woster, P. M., Casero, R. A. & 2 others, Correa, P. & Wilson, K. T., Jun 27 2015, In : Oncogene. 34, 26, p. 3429-3440 12 p.

Research output: Contribution to journalArticle

Mammalian polyamine catabolism

Murray Stewart, T. & Casero, R. A., Jan 1 2015, Polyamines: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer Japan, p. 61-76 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Polyamine catabolism in carcinogenesis: Potential targets for chemotherapy and chemoprevention

Battaglia, V., DeStefano Shields, C., Murray-Stewart, T. & Casero, R. A., Mar 2014, In : Amino Acids. 46, 3, p. 511-519 9 p.

Research output: Contribution to journalShort survey

Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury

Zahedi, K., Barone, S., Wang, Y., Murray-Stewart, T., Roy-Chaudhury, P., Smith, R. D., Casero, R. A. & Soleimani, M., Nov 12 2014, In : PloS one. 9, 11, e110161.

Research output: Contribution to journalArticle

2013

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism

Murray-Stewart, T., Hanigan, C. L., Woster, P. M., Marton, L. J. & Casero, R. A., Oct 1 2013, In : Molecular cancer therapeutics. 12, 10, p. 2088-2099 12 p.

Research output: Contribution to journalArticle

2012

Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes

Wu, Y., Steinbergs, N., Murray-Stewart, T., Marton, L. J. & Casero, R. A., Mar 15 2012, In : Biochemical Journal. 442, 3, p. 693-701 9 p.

Research output: Contribution to journalArticle

Polyamine-based small molecule epigenetic modulators

Sharma, S. K., Hazeldine, S., Crowley, M. L., Hanson, A., Beattie, R., Varghese, S., Senanayake, T. M. D., Hirata, A., Hirata, F., Huang, Y., Wu, Y., Steinbergs, N., Murray-Stewart, T., Bytheway, I., Casero, R. A. & Woster, P. M., Jan 2012, In : MedChemComm. 3, 1, p. 14-21 8 p.

Research output: Contribution to journalArticle

2011

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

Goodwin, A. C., Destefano Shields, C. E., Wu, S., Huso, D. L., Wu, X. Q., Murray-Stewart, T. R., Hacker-Prietz, A., Rabizadeh, S., Woster, P. M., Sears, C. L. & Casero, R. A., Sep 13 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 37, p. 15354-15359 6 p.

Research output: Contribution to journalArticle

2010

Polyamine catabolism is enhanced after traumatic brain injury

Zahedi, K., Huttinger, F., Morrison, R., Murray-Stewart, T., Casero, R. A. & Strauss, K. I., Mar 1 2010, In : Journal of neurotrauma. 27, 3, p. 515-525 11 p.

Research output: Contribution to journalArticle

2009

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes

Huang, Y., Stewart, T. M., Wu, Y., Baylin, S. B., Marton, L. J., Perkins, B., Jones, R. J., Woster, P. M. & Casero, R. A., Dec 1 2009, In : Clinical Cancer Research. 15, 23, p. 7217-7228 12 p.

Research output: Contribution to journalArticle

2008

Nuclear localization of human spermine oxidase isoforms - Possible implications in drug response and disease etiology

Murray-Stewart, T., Wang, Y., Goodwin, A., Hacker, A., Meeker, A. & Casero, R. A., Jun 1 2008, In : FEBS Journal. 275, 11, p. 2795-2806 12 p.

Research output: Contribution to journalArticle

Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors

Varghese, S., Senanayake, T., Murray-Stewart, T., Doering, K., Fraser, A., Casero, R. A. & Woster, P. M., Apr 24 2008, In : Journal of medicinal chemistry. 51, 8, p. 2447-2456 10 p.

Research output: Contribution to journalArticle

2007

Inflammation and polyamine catabolism: The good, the bad and the ugly

Babbar, N., Murray-Stewart, T. & Casero, R. A., Apr 1 2007, In : Biochemical Society transactions. 35, 2, p. 300-304 5 p.

Research output: Contribution to journalArticle

2006

Recent advances in the understanding of mammalian polyamine catabolism the regulation and potential role of polyamine catabolism in drug response and disease processes

Casero, R. A., Fraser, A. V., Murray-Stewart, T., Hacker, A., Babbar, N., Fleischer, J. & Wang, Y., Dec 1 2006, Polyamine Cell Signaling: Polyamine Cell Signaling. Humana Press, p. 205-232 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2005

Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein

Wang, Y., Hacker, A., Murray-Stewart, T., Fleischer, J. G., Woster, P. M. & Casero, R. A., Mar 15 2005, In : Biochemical Journal. 386, 3, p. 543-547 5 p.

Research output: Contribution to journalArticle

Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): Potential role in determining drug sensitivity

Wang, Y., Hacker, A., Murray-Stewart, T., Frydman, B., Valasinas, A., Fraser, A. V., Woster, P. M. & Casero, R. A., Jul 1 2005, In : Cancer Chemotherapy and Pharmacology. 56, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

2003

Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells

Devereux, W., Wang, Y., Stewart, T. M., Hacker, A., Smith, R., Frydman, B., Valasinas, A. L., Reddy, V. K., Marton, L. J., Ward, T. D., Woster, P. M. & Casero, R. A., Nov 1 2003, In : Cancer Chemotherapy and Pharmacology. 52, 5, p. 383-390 8 p.

Research output: Contribution to journalArticle

Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

Wang, Y., Murray-Stewart, T., Devereux, W., Hacker, A., Frydman, B., Woster, P. M. & Casero, R. A., May 16 2003, In : Biochemical and Biophysical Research Communications. 304, 4, p. 605-611 7 p.

Research output: Contribution to journalArticle

Spermidine/spermine N1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct

Murray-Stewart, T., Applegren, N. B., Devereux, W., Hacker, A., Smith, R., Wang, Y. & Casero, R. A., Jul 15 2003, In : Biochemical Journal. 373, 2, p. 629-634 6 p.

Research output: Contribution to journalArticle

The role of polyamine catabolism in anti-tumour drug response

Casero, R. A., Wang, Y., Stewart, T. M., Devereux, W., Hacker, A., Wang, Y., Smith, R. & Woster, P. M., Apr 1 2003, In : Biochemical Society transactions. 31, 2, p. 361-365 5 p.

Research output: Contribution to journalArticle

2002
2001

Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure

Wang, Y., Devereux, W., Woster, P. M., Stewart, T. M., Hacker, A. & Casero, R. A., Jul 15 2001, In : Cancer Research. 61, 14, p. 5370-5373 4 p.

Research output: Contribution to journalArticle

1999
1998