Todd T Brown

Professor

20022019
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Research Output 2002 2019

2019

A novel density-volume calcium score by non-contrast CT predicts coronary plaque burden on coronary CT angiography: Results from the MACS (Multicenter AIDS cohort study)

Nakanishi, R., Delaney, J. A., Post, W. S., Dailing, C., Blaha, M., Palella, F., Witt, M., Brown, T. T., Kingsley, L. A., Osawa, K., Ceponiene, I., Nezarat, N., Rahmani, S., Kanisawa, M., Jacobson, L. P. & Budoff, M. J., Jan 1 2019, (Accepted/In press) In : Journal of cardiovascular computed tomography.

Research output: Contribution to journalArticle

Coronary Angiography
Acquired Immunodeficiency Syndrome
Cohort Studies
Calcium
Coronary Vessels

Association Between HIV Infection and Mitochondrial DNA Copy Number in Peripheral Blood: A Population-Based, Prospective Cohort Study

Sun, J., Longchamps, R. J., Piggott, D. A., Castellani, C. A., Sumpter, J. A., Brown, T. T., Mehta, S. H., Arking, D. & Kirk, G. D., Apr 8 2019, In : The Journal of infectious diseases. 219, 8, p. 1285-1293 9 p.

Research output: Contribution to journalArticle

Virus Diseases
Mitochondrial DNA
Cohort Studies
HIV
Prospective Studies
Prediabetic State
Asthma
Hemoglobins
Obesity
Confidence Intervals

Association of Fibroblast Growth Factor-23 (FGF-23) With Incident Frailty in HIV-Infected and HIV-Uninfected Individuals

Wang, R., Shlipak, M. G., Ix, J. H., Brown, T. T., Jacobson, L. P., Palella, F. J., Lake, J. E., Koletar, S. L., Semba, R. D. & Estrella, M. M., Jan 1 2019, In : Journal of acquired immune deficiency syndromes (1999). 80, 1, p. 118-125 8 p.

Research output: Contribution to journalArticle

HIV
Confidence Intervals
fibroblast growth factor 23
Bone and Bones
Proportional Hazards Models

Associations between lipids and subclinical coronary atherosclerosis

Whelton, S., Deal, J. A., Zikusoka, M., Jacobson, L. P., Sarkar, S., Palella, F. J., Kingsley, L., Budoff, M., Witt, M. D., Brown, T. T. & Post, W. S., May 1 2019, In : AIDS (London, England). 33, 6, p. 1053-1061 9 p.

Research output: Contribution to journalArticle

Coronary Artery Disease
HIV
Lipids
HDL Cholesterol
Coronary Vessels

Associations between QT interval subcomponents, HIV serostatus, and inflammation

Wu, K. C., Bhondoekhan, F., Haberlen, S. A., Ashikaga, H., Brown, T. T., Budoff, M. J., D'Souza, G., Magnani, J. W., Kingsley, L. A., Palella, F. J., Margolick, J. B., Martínez-Maza, O., Altekruse, S. F., Soliman, E. Z. & Post, W. S., Jan 1 2019, (Accepted/In press) In : Annals of Noninvasive Electrocardiology. e12705.

Research output: Contribution to journalArticle

Open Access
HIV
Inflammation
Interleukin-6
HIV Seropositivity
Left Ventricular Hypertrophy
Body Composition
Weight Loss
Gastric Bypass
Intra-Abdominal Fat
Stomach

CT Fat Density Accurately Reflects Histologic Fat Quality in Adults With HIV On and Off Antiretroviral Therapy

Lake, J. E., Moser, C., Johnston, L., Magyar, C., Nelson, S. D., Erlandson, K. M., Brown, T. T. & McComsey, G. A., Oct 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 10, p. 4857-4864 8 p.

Research output: Contribution to journalArticle

Biopsy
Adipocytes
T-cells
Fats
HIV

Effect of Testosterone Use on Bone Mineral Density in HIV-Infected Men

Grant, P. M., Li, X., Jacobson, L. P., Palella, F. J., Kingsley, L. A., Margolick, J. B., Dobs, A. S., Lake, J. E., Althoff, K. & Brown, T. T., Jan 1 2019, In : AIDS Research and Human Retroviruses. 35, 1, p. 75-80 6 p.

Research output: Contribution to journalArticle

Bone Density
Testosterone
HIV
Spine
Hip

Gait speed decline is associated with hemoglobin a1c, neurocognitive impairment, and black race in persons with HIV

Masters, M. C., Perez, J., Tassiopoulos, K., Andrade, A., Ellis, R., Yang, J., Brown, T. T., Palella, F. J. & Erlandson, K. M., Nov 1 2019, In : AIDS research and human retroviruses. 35, 11-12, p. 1065-1073 9 p.

Research output: Contribution to journalArticle

Gait
Hemoglobins
HIV
Odds Ratio
Confidence Intervals

GCH1 haplotypes and cardiovascular risk in HIV

Slaven, J. E., Haas, D. W., Liu, Z., Stein, J. H., Brown, T. T. & Gupta, S. K., Aug 1 2019, In : AIDS. 33, 10, p. 1669-1671 3 p.

Research output: Contribution to journalArticle

Haplotypes
HIV
Inflammation
Carotid Intima-Media Thickness
Dilatation

GlycA, a novel inflammatory marker, is associated with subclinical coronary disease

Tibuakuu, M., Fashanu, O. E., Zhao, D., Otvos, J. D., Brown, T. T., Haberlen, S., Guallar, E., Budoff, M. J., Palella, F. J., Martinson, J. J., Akinkuolie, A. O., Mora, S., Post, W. S. & Michos, E. D., Mar 1 2019, In : AIDS (London, England). 33, 3, p. 547-557 11 p.

Research output: Contribution to journalArticle

Coronary Disease
HIV
Cardiovascular Diseases
Biomarkers
Coronary Artery Disease

Inflammation status in HIV-positive individuals correlates with changes in bone tissue quality after initiation of ART

Lerma-Chippirraz, E., Pineda-Moncusí, M., González-Mena, A., Soldado-Folgado, J., Knobel, H., Trenchs-Rodríguez, M., Díez-Pérez, A., Brown, T. T., García-Giralt, N. & Güerri-Fernández, R., Jan 1 2019, In : Journal of Antimicrobial Chemotherapy. 74, 5, p. 1381-1388 8 p., dkz014.

Research output: Contribution to journalArticle

HIV
Inflammation
Bone and Bones
Tenofovir
Bone Remodeling

Lean mass declines consistently over 10 years in people living with HIV on antiretroviral therapy, with patterns differing by sex

Debroy, P., Lake, J. E., Sim, M., Erlandson, K. M., Falutz, J., Prado, C. M., Brown, T. T., Guaraldi, G. & Metabolic Cohort Team, T. M. H., Jan 1 2019, In : Antiviral therapy. 24, 5, p. 383-387 5 p.

Research output: Contribution to journalArticle

Tenofovir
Integrase Inhibitors
HIV
Photon Absorptiometry
Therapeutics

Limited correlation between systemic biomarkers and neurocognitive performance before and during HIV treatment

Robertson, K., Landay, A., Miyahara, S., Vecchio, A., Masters, M. C., Brown, T. T. & Taiwo, B. O., Jan 1 2019, (Accepted/In press) In : Journal of neurovirology.

Research output: Contribution to journalArticle

HLA-DR Antigens
Tenofovir
Biomarkers
HIV
Neuropsychological Tests

Lower pretreatment gut integrity is independently associated with fat gain on antiretroviral therapy

El Kamari, V., Moser, C., Hileman, C. O., Currier, J. S., Brown, T. T., Johnston, L., Hunt, P. W. & McComsey, G. A., Apr 8 2019, In : Clinical Infectious Diseases. 68, 8, p. 1394-1401 8 p.

Research output: Contribution to journalArticle

Fats
Ritonavir
Tenofovir
Nonparametric Statistics
Insulin Resistance

Midlife adiposity predicts cognitive decline in the prospective Multicenter AIDS Cohort Study

Rubin, L. H., Gustafson, D., Hawkins, K. L., Zhang, L., Jacobson, L. P., Becker, J. T., Munro, C. A., Lake, J. E., Martin, E., Levine, A., Brown, T. T., Sacktor, N. & Erlandson, K. M., Jul 16 2019, In : Neurology. 93, 3, p. e261-e271

Research output: Contribution to journalArticle

Adiposity
Acquired Immunodeficiency Syndrome
Cohort Studies
HIV
HIV Infections

Peripheral blood mitochondrial DNA copy number obtained from genome-wide genotype data is associated with neurocognitive impairment in persons with chronic HIV infection

Hulgan, T., Kallianpur, A. R., Guo, Y., Barnholtz-Sloan, J. S., Gittleman, H., Brown, T. T., Ellis, R., Letendre, S., Heaton, R. K. & Samuels, D. C., Apr 1 2019, In : Journal of Acquired Immune Deficiency Syndromes. 80, 4, p. E95-E102

Research output: Contribution to journalArticle

Mitochondrial DNA
HIV Infections
Genotype
Genome
HIV

Plasma cathelicidin and longitudinal lung function in current and former smokers

Burkes, R. M., Astemborski, J., Lambert, A. A., Brown, T. T., Wise, R. A., Kirk, G. D. & Drummond, M. B., Feb 1 2019, In : PloS one. 14, 2, e0212628.

Research output: Contribution to journalArticle

Open Access
lung function
vitamin D
Plasmas
Lung
risk groups
Cystatin C
Odds Ratio
HIV
Therapeutics
AIDS Dementia Complex

Progressive increases in fat mass occur in adults living with HIV on antiretroviral therapy, but patterns differ by sex and anatomic depot

Debroy, P., Sim, M., Erlandson, K. M., Falutz, J., Prado, C. M., Brown, T. T., Guaraldi, G. & Lake, J. E., Apr 1 2019, In : The Journal of antimicrobial chemotherapy. 74, 4, p. 1028-1034 7 p.

Research output: Contribution to journalArticle

Fats
HIV
Leg
Tenofovir
Photon Absorptiometry

Proteinuria Is Associated With Increased Risk of Fragility Fracture in Men With or at Risk of HIV Infection

Gonciulea, A., Wang, R., Althoff, K., Estrella, M. M., Sellmeyer, D. E., Palella, F. J., Lake, J. E., Kingsley, L. A. & Brown, T. T., Jul 1 2019, In : Journal of acquired immune deficiency syndromes (1999). 81, 3, p. e85-e91

Research output: Contribution to journalArticle

Proteinuria
HIV Infections
HIV
Tenofovir
Bone Fractures
Open Access
Acquired Immunodeficiency Syndrome
Cohort Studies
HIV
Integrases
Confidence Intervals

Relationships Between Adipose Mitochondrial Function, Serum Adiponectin, and Insulin Resistance in Persons With HIV After 96 Weeks of Antiretroviral Therapy

Hulgan, T., Ramsey, B. S., Koethe, J. R., Samuels, D. C., Gerschenson, M., Libutti, D. E., Sax, P. E., Daar, E. S., McComsey, G. A. & Brown, T. T., Mar 1 2019, In : Journal of acquired immune deficiency syndromes (1999). 80, 3, p. 358-366 9 p.

Research output: Contribution to journalArticle

Adiponectin
Insulin Resistance
HIV
Mitochondrial DNA
Serum

Risk Factors for Falls, Falls With Injury, and Falls With Fracture Among Older Men With or at Risk of HIV Infection

Erlandson, K. M., Zhang, L., Ng, D., Althoff, K., Palella, F. J., Kingsley, L. A., Jacobson, L. P., Margolick, J. B., Lake, J. E. & Brown, T. T., Aug 1 2019, In : Journal of acquired immune deficiency syndromes (1999). 81, 4, p. e117-e126

Research output: Contribution to journalArticle

efavirenz
HIV Infections
HIV
Wounds and Injuries
Street Drugs

The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV

Adrian, S., Scherzinger, A., Sanyal, A., Lake, J. E., Falutz, J., Dubé, M. P., Stanley, T., Grinspoon, S., Mamputu, J. C., Marsolais, C., Brown, T. T. & Erlandson, K. M., Jan 1 2019, In : The Journal of frailty & aging. 8, 3, p. 154-159 6 p.

Research output: Contribution to journalArticle

Growth Hormone-Releasing Hormone
Fats
HIV
Muscles
Intra-Abdominal Fat
Open Access
Tenofovir
Transgender Persons
Fumarates
Estrogens
HIV

Validation of the Use of Electronic Medical Records for Identification of Post-gastric Bypass Hypoglycemia Cases

Lee, C., Wood, G. C., Bressler, N., Govina, T., Lazo-Elizondo, M., Brown, T. T., Clark, J., Still, C. & Benotti, P., Jan 1 2019, In : Obesity Surgery.

Research output: Contribution to journalArticle

Gastric Bypass
Electronic Health Records
Hypoglycemia
Bariatric Surgery
Epidemiology

Vitamin D does not modulate immune-mediated bone loss during ART initiation

A5280 Study Team, Jan 1 2019, In : Antiviral therapy. 24, 5, p. 355-362 8 p.

Research output: Contribution to journalArticle

Vitamin D
Pelvic Bones
Bone Density
RANK Ligand
Calcium
2018

Abdominal obesity, sarcopenia, and osteoporosis are associated with frailty in men living with and without HIV

Hawkins, K. L., Zhang, L., Ng, D., Althoff, K., Palella, F. J., Kingsley, L. A., Jacobson, L. P., Margolick, J. B., Lake, J. E., Brown, T. T. & Erlandson, K. M., Jun 19 2018, In : AIDS. 32, 10, p. 1257-1266 10 p.

Research output: Contribution to journalArticle

Sarcopenia
Abdominal Obesity
Osteoporosis
HIV
Body Composition

Alterations in the oral microbiome in HIV-infected participants after antiretroviral therapy administration are influenced by immune status

Presti, R. M., Handley, S. A., Droit, L., Ghannoum, M., Jacobson, M., Shiboski, C. H., Webster-Cyriaque, J., Brown, T. T., Yin, M. T. & Overton, E. T., Jun 19 2018, In : AIDS. 32, 10, p. 1279-1287 9 p.

Research output: Contribution to journalArticle

Microbiota
CD4 Lymphocyte Count
HIV
T-Lymphocytes
Saliva

Bone density, microarchitecture, and tissue quality after 1 year of treatment with tenofovir disoproxil fumarate

Güerri-Fernández, R., Lerma-Chippirraz, E., Fernandez Marron, A., García-Giralt, N., Villar-García, J., Soldado-Folgado, J., González-Mena, A., Trenchs-Rodríguez, M., Guelar, A., Díez-Pérez, A., Brown, T. T. & Knobel, H., Apr 24 2018, In : AIDS. 32, 7, p. 913-920 8 p.

Research output: Contribution to journalArticle

Tenofovir
Bone Density
Bone and Bones
Photon Absorptiometry
Therapeutics

Bone Mineral Density Declines Twice as Quickly Among HIV-Infected Women Compared With Men

Erlandson, K. M., Lake, J. E., Sim, M., Falutz, J., Prado, C. M., Domingues da Silva, A. R., Brown, T. T. & Guaraldi, G., Mar 1 2018, In : Journal of acquired immune deficiency syndromes (1999). 77, 3, p. 288-294 7 p.

Research output: Contribution to journalArticle

Bone Density
HIV
Femur Neck
Tenofovir
Photon Absorptiometry

Brief report: Circulating markers of fibrosis are associated with immune reconstitution status in HIV-infected men

Tobolowsky, F. A., Wada, N., Martinez-Maza, O., Magpantay, L., Koletar, S. L., Palella, F. J., Brown, T. T. & Lake, J. E., Jan 1 2018, In : PLoS One. 13, 1, e0191606.

Research output: Contribution to journalArticle

Hyaluronic Acid
fibrosis
hyaluronic acid
Fibrosis
HIV

Changes in plasma RANKL-osteoprotegerin in a prospective, randomized clinical trial of initial antiviral therapy: A5260s

Kelesidis, T., Moser, C. B., Johnston, E., Stein, J. H., Dube, M. P., Yang, O. O., McComsey, G. A., Currier, J. S. & Brown, T. T., Jan 1 2018, In : Journal of Acquired Immune Deficiency Syndromes. 78, 3, p. 362-366 5 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteoprotegerin
Antiviral Agents
Randomized Controlled Trials
Pelvic Bones

Changes in waist circumference in HIV-infected individuals initiating a raltegravir or protease inhibitor regimen: Effects of sex and race

Bhagwat, P., Ofotokun, I., McComsey, G. A., Brown, T. T., Moser, C., Sugar, C. A. & Currier, J. S., Jan 1 2018, In : Open Forum Infectious Diseases. 5, 11

Research output: Contribution to journalArticle

Waist Circumference
Protease Inhibitors
Ritonavir
HIV
Abdominal Fat

Human immunodeficiency virus and bone

Yin, M. T. & Brown, T. T., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 474-481 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Viruses
Bone
HIV
Bone and Bones
Osteoporosis

Impact of glycemic status on longitudinal cognitive performance in men with and without HIV infection

Yang, J., Jacobson, L. P., Becker, J. T., Levine, A., Martin, E. M., Munro, C., Palella, F. J., Lake, J. E., Sacktor, N. & Brown, T. T., Jan 1 2018, In : AIDS. 32, 13, p. 1849-1860 12 p.

Research output: Contribution to journalArticle

HIV Infections
HIV
Diabetes Mellitus
Glucose
Cognition

Increased risk of depression in non-depressed HIV infected men with sleep disturbance: Prospective findings from the Multicenter AIDS Cohort Study

Irwin, M. R., Archer, G., Olmstead, R., Brown, T. T., Teplin, L. A., Patel, S. R., Abraham, A. G. & Breen, E. C., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Sleep
Acquired Immunodeficiency Syndrome
Cohort Studies
HIV
Depression

Low thigh muscle mass is associated with coronary artery stenosis among HIV-infected and HIV-uninfected men: The Multicenter AIDS Cohort Study (MACS)

Tibuakuu, M., Zhao, D., Saxena, A., Brown, T. T., Jacobson, L. P., Palella, F. J., Witt, M. D., Koletar, S. L., Margolick, J. B., Guallar, E., Korada, S. K. C., Budoff, M. J., Post, W. S. & Michos, E. D., Jan 1 2018, (Accepted/In press) In : Journal of Cardiovascular Computed Tomography.

Research output: Contribution to journalArticle

Coronary Stenosis
Thigh
Acquired Immunodeficiency Syndrome
Cohort Studies
HIV

Metabolic health across the BMI spectrum in HIV-infected and HIV-uninfected men

Lake, J. E., Li, X., Palella, F. J., Erlandson, K. M., Wiley, D., Kingsley, L., Jacobson, L. P. & Brown, T. T., Jan 2 2018, In : AIDS. 32, 1, p. 49-57 9 p.

Research output: Contribution to journalArticle

HIV
Health
Stavudine
Reverse Transcriptase Inhibitors
Zidovudine

Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: Rationale and design

Nakanishi, R., Post, W. S., Osawa, K., Jayawardena, E., Kim, M., Sheidaee, N., Nezarat, N., Rahmani, S., Kim, N., Hathiramani, N., Susarla, S., Palella, F., Witt, M., Blaha, M., Brown, T. T., Kingsley, L., Haberlen, S., Dailing, C. & Budoff, M. J., Jan 1 2018, In : Coronary Artery Disease. 29, 1, p. 23-29 7 p.

Research output: Contribution to journalArticle

Acquired Immunodeficiency Syndrome
Cohort Studies
HIV
Coronary Artery Disease
Multicenter Studies

Physical function improvements with moderate or high-intensity exercise among older adults with or without HIV infection

Erlandson, K. M., MaWhinney, S., Wilson, M., Gross, L., McCandless, S. A., Campbell, T. B., Kohrt, W. M., Schwartz, R., Brown, T. T. & Jankowski, C. M., Oct 23 2018, In : AIDS (London, England). 32, 16, p. 2317-2326 10 p.

Research output: Contribution to journalArticle

HIV Infections
HIV
Leg
Confidence Intervals

Predictors of electrocardiographic QT interval prolongation in men with HIV

Wu, K. C-C., Zhang, L., Haberlen, S., Ashikaga, H., Brown, T. T., Budoff, M. J., D'Souza, G., Kingsley, L. A., Palella, F. J., Margolick, J. B., Martínez-Maza, O., Soliman, E. Z. & Post, W. S., Jan 1 2018, (Accepted/In press) In : Heart.

Research output: Contribution to journalArticle

HIV
Sudden Cardiac Death
Biomarkers
B-Cell Activating Factor
Intercellular Adhesion Molecule-1

Regional coronary endothelial dysfunction is related to the degree of local epicardial fat in people with HIV

Iantorno, M., Soleimanifard, S., Schar, M., Brown, T. T., Bonanno, G., Barditch-Crovo, P., Mathews, L., Lai, S., Gerstenblith, G., Weiss, R. G. & Hays, A., Nov 1 2018, In : Atherosclerosis. 278, p. 7-14 8 p.

Research output: Contribution to journalArticle

Coronary Artery Disease
Fats
HIV
Adipose Tissue
Exercise

Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men

Monczor, A. N., Li, X., Palella, F. J., Erlandson, K. M., Wiley, D., Kingsley, L. A., Post, W. S., Jacobson, L. P., Brown, T. T. & Lake, J. E., Jan 1 2018, In : Mediators of Inflammation. 2018, 1 p.

Research output: Contribution to journalArticle

HIV
Inflammation
Health
Adiponectin
Insulin Resistance
Bariatric Surgery
Hypoglycemia
Incidence
Gastric Bypass
Hypoglycemic Agents

The Role of Mitochondrial DNA Variation in Age-Related Decline in Gait Speed among Older Men Living with Human Immunodeficiency Virus

Sun, J., Brown, T. T., Samuels, D. C., Hulgan, T., D'Souza, G., Jamieson, B. D., Erlandson, K. M., Martinson, J., Palella, F. J., Margolick, J. B., Kirk, G. D. & Schrack, J. A., Aug 16 2018, In : Clinical Infectious Diseases. 67, 5, p. 778-784 7 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
HIV
Logistic Models
Gait
Acquired Immunodeficiency Syndrome

To T or not to T: Differences in Testosterone Use and Discontinuation by HIV Serostatus among Men who Have Sex with Men

Haberlen, S., Jacobson, L. P., Palella, F. J., Dobs, A. S., Plankey, M., Lake, J. E., Kingsley, L. A., Stall, R., Post, W. S. & Brown, T. T., Oct 1 2018, In : HIV Medicine. 19, 9, p. 634-644 11 p.

Research output: Contribution to journalArticle

Testosterone
HIV
Cardiovascular Diseases
Therapeutics
Los Angeles