Todd Matthew Kolb

Assistant Professor

20022019
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Research Output 2002 2019

2019

A nonapoptotic endothelial barrier-protective role for caspase-3

Suresh, K., Carino, K., Johnston, L., Servinsky, L., Machamer, C. E., Kolb, T. M., Lam, H., Dudek, S. M., An, S., Rane, M. J., Shimoda, L. & Damarla, M., Jun 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 6, p. L1118-L1126

Research output: Contribution to journalArticle

Caspase 3
Thrombin
Caspases
Electric Impedance
Endothelial Cells

Disconnect between fibrotic response and right ventricular dysfunction

Crnkovic, S., Egemnazarov, B., Damico, R., Marsh, L. M., Nagy, B. M., Douschan, P., Atsina, K., Kolb, T. M., Mathai, S. C., Hooper, J. E., Ghanim, B., Klepetko, W., Fruhwald, F., Lassner, D., Olschewski, A., Olschewski, H., Hassoun, P. M. & Kwapiszewska, G., Jun 15 2019, In : American journal of respiratory and critical care medicine. 199, 12, p. 1550-1560 11 p.

Research output: Contribution to journalArticle

Right Ventricular Dysfunction
Heart Ventricles
Galectin 3
Fibrosis
Pulmonary Hypertension
Open Access
Systemic Scleroderma
Uric Acid
Pulmonary Hypertension
Survival
Serum

SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model

Peloquin, G. L., Johnston, L., Damarla, M., Damico, R. L., Hassoun, P. M. & Kolb, T. M., Jun 17 2019, In : Respiratory research. 20, 1, 123.

Research output: Contribution to journalArticle

Open Access
Pulmonary Hypertension
Endothelial Cells
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor-2
Cell Proliferation

Validation of the REVEAL Prognostic Equation and Risk Score Calculator in Incident Systemic Sclerosis–Associated Pulmonary Arterial Hypertension

on behalf of the PHAROS Investigators, Jan 1 2019, (Accepted/In press) In : Arthritis and Rheumatology.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Systemic Scleroderma
Calibration
Survival
Brain Natriuretic Peptide

Ventricular mass as a prognostic imaging biomarker in incident pulmonary arterial hypertension

Simpson, C. E., Damico, R. L., Kolb, T. M., Mathai, S., Khair, R. M., Sato, T., Bourji, K., Tedford, R. J., Zimmerman, S. & Hassoun, P. M., Apr 1 2019, In : The European respiratory journal. 53, 4

Research output: Contribution to journalLetter

Open Access
Pulmonary Hypertension
Biomarkers
2018

Assessment of right ventricular function in the research setting: Knowledge gaps and pathways forward an official American thoracic society research statement

Lahm, T., Douglas, I. S., Archer, S. L., Bogaard, H. J., Chesler, N. C., Haddad, F., Hemnes, A. R., Kawut, S. M., Kline, J. A., Kolb, T. M., Mathai, S. C., Mercier, O., Michelakis, E. D., Naeije, R., Tuder, R. M., Ventetuolo, C. E., Vieillard-Baron, A., Voelkel, N. F., Vonk-Noordegraaf, A. & Hassoun, P. M., Aug 15 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 4, p. e15-e43

Research output: Contribution to journalReview article

Right Ventricular Function
Thorax
Research
Pulmonary Circulation
Patient Rights

Challenges in pulmonary hypertension: Controversies in treating the tip of the iceberg a joint national institutes of health clinical center and pulmonary hypertension association symposium report

Elinoff, J. M., Agarwal, R., Barnett, C. F., Benza, R. L., Cuttica, M. J., Gharib, A. M., Gray, M. P., Hassoun, P. M., Hemnes, A. R., Humbert, M., Kolb, T. M., Lahm, T., Leopold, J. A., Mathai, S., McLaughlin, V. V., Preston, I. R., Rosenzweig, E. B., Shlobin, O. A., Steen, V. D., Zamanian, R. T. & 1 others, Solomon, M. A., Jul 15 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 2, p. 166-174 9 p.

Research output: Contribution to journalReview article

National Institutes of Health (U.S.)
Pulmonary Hypertension
Joints

Improvement in right ventricular strain with ambrisentan and tadalafil upfront therapy in scleroderma-associated pulmonary arterial hypertension

Mercurio, V., Mukherjee, M., Tedford, R. J., Zamanian, R. T., Khair, R. M., Sato, T., Minai, O. A., Torres, F., Girgis, R. E., Chin, K., Damico, R. L., Kolb, T. M., Mathai, S. & Hassoun, P. M., Feb 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 3, p. 388-391 4 p.

Research output: Contribution to journalLetter

Pulmonary Hypertension
Therapeutics
ambrisentan
Tadalafil

Pulmonary arterial hypertension and atrial arrhythmias: incidence, risk factors, and clinical impact

Mercurio, V., Peloquin, G., Bourji, K. I., Diab, N., Sato, T., Enobun, B., Housten-Harris, T., Damico, R. L., Kolb, T. M., Mathai, S., Tedford, R. J., Tocchetti, C. G. & Hassoun, P. M., Apr 1 2018, In : Pulmonary Circulation. 8, 2

Research output: Contribution to journalArticle

Pulmonary Hypertension
Cardiac Arrhythmias
Systemic Scleroderma
Incidence
Mortality

Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease

Tampakakis, E., Shah, S. J., Borlaug, B. A., Leary, P. J., Patel, H. H., Miller, W. L., Kelemen, B. W., Houston, B. A., Kolb, T. M., Damico, R. L., Mathai, S., Kasper, E. K., Hassoun, P. M., Kass, D. A. & Tedford, R. J., Apr 1 2018, In : Circulation: Heart Failure. 11, 4, e004436.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Heart Diseases
Lung
Lung Compliance
Vascular Resistance

Reply: Can treprostinil-induced early gastrointestinal side effects serve as predictors of pulmonary arterial hypertension prognosis?

Leary, P. J., Kolb, T. M., Maron, B. A., Tedford, R. J. & Zamanian, R. T., Aug 1 2018, In : International Journal of Cardiology. 264, 1 p.

Research output: Contribution to journalLetter

Pulmonary Hypertension
treprostinil

Right ventricular myofilament functional differences in humans with systemic sclerosis-associated versus idiopathic pulmonary arterial hypertension

Hsu, S., Kokkonen-Simon, K. M., Kirk, J. A., Kolb, T. M., Damico, R. L., Mathai, S., Mukherjee, M., Shah, A., Wigley, F., Margulies, K. B., Hassoun, P. M., Halushka, M. K., Tedford, R. J. & Kass, D. A., Jan 1 2018, In : Circulation. 137, 22, p. 2360-2370 11 p.

Research output: Contribution to journalArticle

Myofibrils
Systemic Scleroderma
Pulmonary Hypertension
Muscle Cells
Calcium
Pulmonary Hypertension
Right Ventricular Dysfunction
Pulmonary Hypertension
Heart Ventricles
Blood Vessels
Economics

The impact of ambrisentan and tadalafil upfront combination therapy on cardiac function in scleroderma associated pulmonary arterial hypertension patients: cardiac magnetic resonance feature tracking study

Sato, T., Ambale Venkatesh, B., Lima, J., Zimmerman, S., Tedford, R. J., Fujii, T., Hulme, O. L., Pullins, E. H., Corona Villalobos, C., Zamanian, R. T., Minai, O. A., Girgis, R. E., Chin, K., Khair, R., Damico, R. L., Kolb, T. M., Mathai, S. & Hassoun, P. M., Feb 1 2018, In : Pulmonary Circulation. 8, 1

Research output: Contribution to journalArticle

Pulmonary Hypertension
Right Ventricular Function
Magnetic Resonance Spectroscopy
Left Ventricular Function
Systemic Scleroderma
2017

Evaluation of criteria for exerciseinduced pulmonary hypertension in patients with resting pulmonary hypertension

Mullin, C. J., Hsu, S., Amancherla, K., Wand, A., Rhodes, P., Leary, P. J., Mukherjee, M., Damico, R. L., Kolb, T. M., Mathai, S., Hassoun, P. M. & Tedford, R. J., Sep 1 2017, In : European Respiratory Journal. 50, 3, 00784.

Research output: Contribution to journalLetter

Pulmonary Hypertension

Poor survival in patients with scleroderma and pulmonary hypertension due to heart failure with preserved ejection fraction

Bourji, K. I., Kelemen, B. W., Mathai, S., Damico, R. L., Kolb, T. M., Mercurio, V., Cozzi, F., Tedford, R. J. & Hassoun, P. M., 2017, In : Pulmonary Circulation. 7, 2, p. 409-420 12 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Pulmonary Hypertension
Heart Failure
Survival
Cardiac Catheterization
Systemic Scleroderma
Familial Primary Pulmonary Hypertension

Use of thermodilution cardiac output overestimates diagnoses of exercise-induced pulmonary hypertension

Hsu, S., Brusca, S. B., Rhodes, P. S., Kolb, T. M., Mathai, S. & Tedford, R. J., Jan 1 2017, In : Pulmonary Circulation. 7, 1, p. 253-255 3 p.

Research output: Contribution to journalLetter

Thermodilution
Pulmonary Hypertension
Cardiac Output
Exercise

What's in a side effect? The association between pulmonary vasodilator adverse drug events and clinical outcomes in patients with pulmonary arterial hypertension

Leary, P. J., Kang, S., Kolb, T. M., Maron, B. A., Ralph, D. D., Rao, Y., Tedford, R. J. & Zamanian, R. T., Jan 23 2017, (Accepted/In press) In : International Journal of Cardiology.

Research output: Contribution to journalArticle

Drug-Related Side Effects and Adverse Reactions
Vasodilator Agents
Pulmonary Hypertension
Lung
Mortality
Xanthine Dehydrogenase
Lipopolysaccharides
Sepsis
Lung
Survival
2016
Hyper-IgM Immunodeficiency Syndrome
Common Variable Immunodeficiency
Lymphoid Tissue
Bronchi
Kabuki syndrome

Health-related quality of life and survival in pulmonary arterial hypertension

Mathai, S., Suber, T., Khair, R. M., Kolb, T. M., Damico, R. L. & Hassoun, P. M., Jan 1 2016, In : Annals of the American Thoracic Society. 13, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Quality of Life
Survival
Proportional Hazards Models
Hemodynamics

Heart rate dependence of the pulmonary resistance x compliance (rc) time and impact on right ventricular load

Metkus, T., Mullin, C. J., Grandin, E. W., Rame, J. E., Tampakakis, E., Hsu, S., Kolb, T. M., Damico, R. L., Hassoun, P. M., Kass, D. A., Mathai, S. & Tedford, R. J., Nov 1 2016, In : PLoS One. 11, 11, e0166463.

Research output: Contribution to journalArticle

compliance
Compliance
heart rate
Heart Rate
lungs
MAP Kinase Kinase Kinase 5
Xanthine Dehydrogenase
Macrophage Migration-Inhibitory Factors
Smoke
Tobacco Products
Lung Compliance
Adult Respiratory Distress Syndrome
Catheters
Vascular Resistance
Survivors

Right Ventricular Functional Reserve in Pulmonary Arterial Hypertension

Hsu, S., Houston, B. A., Tampakakis, E., Bacher, A. C., Rhodes, P. S., Mathai, S., Damico, R. L., Kolb, T. M., Hummers, L., Shah, A., McMahan, Z., Corona Villalobos, C., Zimmerman, S., Wigley, F., Hassoun, P. M., Kass, D. A. & Tedford, R. J., May 12 2016, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Ergometry
Right Ventricular Function
Systemic Scleroderma
Recycling

The minimal important difference in borg dyspnea score in pulmonary arterial hypertension

Khair, R. M., Nwaneri, C., Damico, R. L., Kolb, T. M., Hassoun, P. M. & Mathai, S., Jun 1 2016, In : Annals of the American Thoracic Society. 13, 6, p. 842-849 8 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Dyspnea
Fatigue
Therapeutics
Baltimore
2015

Ambrisentan and tadalafil up-front combination therapy in scleroderma-associated pulmonary arterial hypertension

Hassoun, P. M., Zamanian, R. T., Damico, R. L., Lechtzin, N., Khair, R., Kolb, T. M., Tedford, R. J., Hulme, O. L., Housten, T., Pisanello, C., Sato, T., Pullins, E. H., Corona Villalobos, C., Zimmerman, S., Gashouta, M. A., Minai, O. A., Torres, F., Girgis, R. E., Chin, K. & Mathai, S., Nov 1 2015, In : American Journal of Respiratory and Critical Care Medicine. 192, 9, p. 1102-1110 9 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Brain Natriuretic Peptide
Therapeutics
Rare Diseases
Vascular Resistance

Association between serum concentrations of hypoxia inducible factor responsive proteins and excessive erythrocytosis in high altitude Peru

Painschab, M. S., Malpartida, G. E., Dávila-Roman, V. G., Gilman, R. H., Kolb, T. M., León-Velarde, F., Miranda, J. J. & Checkley, W., Mar 1 2015, In : High Altitude Medicine and Biology. 16, 1, p. 26-33 8 p.

Research output: Contribution to journalArticle

Polycythemia
Peru
Serum
Vascular Endothelial Growth Factor Receptor
Proteins
Right Ventricular Function
Pulmonary Hypertension
Magnetic Resonance Imaging
Survival
Proportional Hazards Models

Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia

Kim, B. S., Serebreni, L., Fallica, J., Hamdan, O., Wang, L., Johnston, L., Kolb, T. M., Damarla, M., Damico, R. L. & Hassoun, P. M., Apr 1 2015, In : PLoS One. 10, 4, e0124189.

Research output: Contribution to journalArticle

Xanthine Dehydrogenase
Cyclin-Dependent Kinase 5
xanthine
cyclin-dependent kinase
Cyclin-Dependent Kinases

Pulmonary Hypertension Associated with Respiratory Disease

Kolb, T. M. & Hassoun, P. M., Jan 1 2015, PanVascular Medicine, Second Edition. Springer Berlin Heidelberg, p. 4211-4231 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pulmonary diseases
Pulmonary Hypertension
Chronic Disease
Epidemiology
Vasodilator Agents

Right Ventricular Angiogenesis is an Early Adaptive Response to Chronic Hypoxia-Induced Pulmonary Hypertension

Kolb, T. M., Peabody, J., Baddoura, P., Fallica, J., Mock, J. R., Singer, B. D., D'Alessio, F., Damarla, M., Damico, R. L. & Hassoun, P. M., Nov 1 2015, In : Microcirculation. 22, 8, p. 724-736 13 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Hypertrophy
Gene Expression
Muscle Cells
Flow Cytometry

Right ventricular remodeling in idiopathic and scleroderma-associated pulmonary arterial hypertension: Two distinct phenotypes

Kelemen, B. W., Mathai, S., Tedford, R. J., Damico, R. L., Corona Villalobos, C., Kolb, T. M., Chaisson, N. F., Harris, T. H., Zimmerman, S., Kamel, I. R., Kass, D. A. & Hassoun, P. M., Jun 1 2015, In : Pulmonary Circulation. 5, 2, p. 327-334 8 p.

Research output: Contribution to journalArticle

Ventricular Remodeling
Pulmonary Hypertension
Heart Ventricles
Phenotype
Vascular Resistance

Serum endostatin is a genetically determined predictor of survival in pulmonary arterial hypertension

Damico, R. L., Kolb, T. M., Valera, L., Wang, L., Housten, T., Tedford, R. J., Kass, D. A., Rafaels, N., Gao, L., Barnes, K. C., Benza, R. L., Rand, J. L., Hamid, R., Loyd, J. E., Robbins, I. M., Hemnes, A. R., Chung, W. K., Austin, E. D., Drummond, M. B., Mathai, S. & 1 others, Hassoun, P. M., Jan 15 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 2, p. 208-218 11 p.

Research output: Contribution to journalArticle

Endostatins
Pulmonary Hypertension
Survival
Serum
Mortality

Vascular receptor autoantibodies in pulmonary arterial hypertension

Bourji, K. I., Khair, R. M., Damico, R. L., Kolb, T. M., Mathai, S. & Hassoun, P. M., Mar 1 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 5, p. 602 1 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Pulmonary Hypertension
Autoantibodies
Pulmonary Artery
Blood Vessels
2014

Macrophage migration inhibitory factor is a novel determinant of cigarette smoke-induced lung damage

Fallica, J., Boyer, L., Kim, B. S., Serebreni, L., Varela, L., Hamdan, O., Wang, L., Simms, T., Damarla, M., Kolb, T. M., Bucala, R., Mitzner, W. A., Hassoun, P. M. & Damico, R. L., 2014, In : American Journal of Respiratory Cell and Molecular Biology. 51, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Smoke
Tobacco Products
Lung
Endothelial cells

Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3

Damarla, M., Parniani, A. R., Johnston, L., Maredia, H., Serebreni, L., Hamdan, O., Sidhaye, V., Shimoda, L., Myers, A. C., Crow, M. T., Schmidt, E. P., Machamer, C. E., Gaestel, M., Rane, M. J., Kolb, T. M., Kim, B. S., Damico, R. L. & Hassoun, P. M., 2014, In : American Journal of Respiratory Cell and Molecular Biology. 50, 5, p. 932-941 10 p.

Research output: Contribution to journalArticle

Capillary Permeability
Mitogen-Activated Protein Kinases
Caspase 3
Protein Kinases
Apoptosis
Pulmonary Wedge Pressure
Pulmonary Hypertension
Pulmonary Artery
Vascular Resistance
Transplants
Cyclic GMP-Dependent Protein Kinases
Oxidants
Protein-Tyrosine Kinases
Endothelial Cells
Antioxidants

Severity of systemic sclerosis-associated pulmonary arterial hypertension in African Americans

Blanco, I., Mathai, S., Shafiq, M., Boyce, D., Kolb, T. M., Chami, H., Hummers, L., Housten, T., Chaisson, N., Zaiman, A. L., Wigley, F., Tedford, R. J., Kass, D. A., Damico, R. L., Girgis, R. E. & Hassoun, P. M., Jul 1 2014, In : Medicine (United States). 93, 5, p. 177-185 9 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Pulmonary Hypertension
African Americans
Diffuse Scleroderma
Hemodynamics
2013

A 32-year-old woman with dyspnea, lung cysts, and previous pneumothoraces

Kolb, T. M., King, L. S. & Pearse, D. B., Dec 2013, In : Chest. 144, 6, p. 1964-1968 5 p.

Research output: Contribution to journalArticle

Birt-Hogg-Dube Syndrome
X Ray Computed Tomography
Estrone
Pneumothorax
Dyspnea
2012

Dieulafoy's disease of the bronchus

Kolb, T. M., Gilbert, C., Fishman, E. K., Terry, P. B., Pearse, D. B., Feller-Kopman, D. & Yarmus, L., Dec 1 2012, In : American Journal of Respiratory and Critical Care Medicine. 186, 11, p. 1191 1 p.

Research output: Contribution to journalArticle

Bronchial Diseases
Therapeutic Embolization
Bronchial Arteries
X Ray Computed Tomography
Hemoptysis

Right Ventricular Dysfunction in Chronic Lung Disease

Kolb, T. M. & Hassoun, P. M., May 2012, In : Cardiology Clinics. 30, 2, p. 243-256 14 p.

Research output: Contribution to journalArticle

Right Ventricular Dysfunction
Lung Diseases
Chronic Disease
Pulmonary Gas Exchange
Right Ventricular Hypertrophy

Schnitzler's syndrome associated with pancreatitis: A disease of IL-1 dysregulation

Larocca, C. A., McEvoy, J. W., Ellis, C. L., Junkins-Hopkins, J., Kolb, T. M., Baer, A. & Garibaldi, B. T., Jan 2012, In : Clinical Rheumatology. 31, 1, p. 169-174 6 p.

Research output: Contribution to journalArticle

Schnitzler Syndrome
Interleukin-1
Pancreatitis
Paraproteinemias
Leukocytosis

Treatment of pulmonary hypertension

Kolb, T. M. & Hassoun, P. M., Jan 1 2012, Scleroderma: From Pathogenesis to Comprehensive Management. Springer US, p. 437-445 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Systemic Scleroderma
Pulmonary Hypertension
Therapeutics
Mortality
Lung
2011
Ketone Oxidoreductases
Inflammation Mediators
Pulmonary Hypertension
Tumor Necrosis Factor-alpha
Inflammation