Todd D Armstrong

Research Associate

1992 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Nanoparticle interactions with immune cells dominate tumor retention and induce T cell–mediated tumor suppression in models of breast cancer

Korangath, P., Barnett, J. D., Sharma, A., Henderson, E. T., Stewart, J., Yu, S. H., Kandala, S. K., Yang, C. T., Caserto, J. S., Hedayati, M., Armstrong, T. D., Jaffee, E., Gruettner, C., Zhou, X. C., Fu, W., Hu, C., Sukumar, S., Simons, B. W. & Ivkov, R., Jan 1 2020, In : Science Advances. 6, 13, eaay1601.

Research output: Contribution to journalArticle

Open Access
2019

A CD40 Agonist and PD-1 Antagonist Antibody Reprogram the Microenvironment of Nonimmunogenic Tumors to Allow T-cell–Mediated Anticancer Activity

Ma, H. S., Poudel, B., Torres, E. R., Sidhom, J. W., Robinson, T. M., Christmas, B., Scott, B., Cruz, K., Woolman, S., Wall, V. Z., Armstrong, T. & Jaffee, E. M., Mar 1 2019, In : Cancer Immunology Research. 7, 3, p. 428-442 15 p.

Research output: Contribution to journalArticle

Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies

Kim, V. M., Blair, A. B., Lauer, P., Foley, K., Che, X., Soares, K., Xia, T., Muth, S. T., Kleponis, J., Armstrong, T. D., Wolfgang, C., Jaffee, E., Brockstedt, D. & Zheng, L., May 22 2019, In : Journal for immunotherapy of cancer. 7, 1, 132.

Research output: Contribution to journalArticle

Open Access

Dissecting the stromal signalingandregulation of myeloid cells and memory effector T cells in pancreatic cancer

Blair, A. B., Kim, V. M., Muth, S. T., Saung, M. T., Lokker, N., Blouw, B., Armstrong, T. D., Jaffee, E. M., Tsujikawa, T., Coussens, L. M., He, J., Burkhart, R. A., Wolfgang, C. L. & Zheng, L., Sep 1 2019, In : Clinical Cancer Research. 25, 17, p. 5351-5363 13 p.

Research output: Contribution to journalArticle

MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity

Yarchoan, M., Mohan, A. A., Dennison, L., Vithayathil, T., Ruggieri, A., Lesinski, G. B., Armstrong, T. D., Azad, N. S. & Jaffee, E. M., Oct 2019, In : PloS one. 14, 10, e0224600.

Research output: Contribution to journalArticle

Open Access
2018

Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer

Kinkead, H. L., Hopkins, A., Lutz, E., Wu, A. A., Yarchoan, M., Cruz, K., Woolman, S., Vithayathil, T., Glickman, L. H., Ndubaku, C. O., McWhirter, S. M., Dubensky, T. W., Armstrong, T. D., Jaffee, E. & Zaidi, N., Oct 18 2018, In : JCI insight. 3, 20

Research output: Contribution to journalArticle

Open Access

Entinostat converts immune-resistant breast and pancreatic cancers into checkpoint-responsive tumors by reprogramming tumor-infiltrating MDSCs

Christmas, B. J., Rafie, C. I., Hopkins, A. C., Scott, B. A., Ma, H. S., Cruz, K. A., Woolman, S., Armstrong, T. D., Connolly, R., Azad, N., Jaffee, E. & Roussos Torres, E., Dec 1 2018, In : Cancer immunology research. 6, 12, p. 1561-1577 17 p.

Research output: Contribution to journalArticle

2017

A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice

Foote, J. B., Kok, M., Leatherman, J. M., Armstrong, T. D., Marcinkowski, B. C., Ojalvo, L. S., Kanne, D. B., Jaffee, E., Dubensky, T. W. & Emens, L. A., Jun 1 2017, In : Cancer immunology research. 5, 6, p. 468-479 12 p.

Research output: Contribution to journalArticle

GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer

Pelosof, L., Yerram, S., Armstrong, T. D., Chu, N., Danilova, L. V., Yanagisawa, B., Hidalgo, M., Azad, N. & Herman, J. G., Jul 3 2017, (Accepted/In press) In : Epigenetics. p. 1-11 11 p.

Research output: Contribution to journalArticle

Sorafenib combined with HER-2 targeted vaccination can promote effective T cell immunity in vivo

Sunay, M. M. E., Foote, J. B., Leatherman, J. M., Edwards, J. P., Armstrong, T. D., Nirschl, C. J., Hicks, J. & Emens, L. A., May 1 2017, In : International Immunopharmacology. 46, p. 112-123 12 p.

Research output: Contribution to journalArticle

2015

Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival

De Remigis, A., De Gruijl, T. D., Uram, J. N., Tzou, S. C., Iwama, S., Talor, M. V., Armstrong, T. D., Santegoets, S. J. A. M., Slovin, S. F., Zheng, L., Laheru, D. A., Jaffee, E. M., Gerritsen, W. R., Van Den Eertwegh, A. J. M., Le, D. T. & Caturegli, P., Jan 1 2015, In : International Journal of Cancer. 136, 1, p. 127-137 11 p.

Research output: Contribution to journalArticle

Galectin-3 shapes antitumor immune responses by suppressing CD8 T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

Kouo, T., Huang, L., Pucsek, A. B., Cao, M., Solt, S., Armstrong, T. D. & Jaffee, E., Apr 1 2015, In : Cancer immunology research. 3, 4, p. 412-423 12 p.

Research output: Contribution to journalArticle

Special conference on tumor immunology and immunotherapy: A new chapter

Byrne, K. T., Vonderheide, R. H., Jaffee, E. & Armstrong, T. D., Jun 1 2015, In : Cancer immunology research. 3, 6, p. 590-597 8 p.

Research output: Contribution to journalArticle

2014

A listeria vaccine and depletion of t-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice

Keenan, B. P., Saenger, Y., Kafrouni, M. I., Leubner, A., Lauer, P., Maitra, A., Rucki, A. A., Gunderson, A. J., Coussens, L. M., Brockstedt, D. G., Dubensky, T. W., Hassan, R., Armstrong, T. D. & Jaffee, E. M., Jun 2014, In : Gastroenterology. 146, 7, p. 1784-1794.e6

Research output: Contribution to journalArticle

2013

Peptidases released by necrotic cells control CD8+ T cell cross-priming

Gamrekelashvili, J., Kapanadze, T., Han, M., Wissing, J., Ma, C., Jaensch, L., Manns, M. P., Armstrong, T., Jaffee, E., White, A. O., Citrin, D. E., Korangy, F. & Greten, T. F., Nov 1 2013, In : Journal of Clinical Investigation. 123, 11, p. 4755-4768 14 p.

Research output: Contribution to journalArticle

Tumor immunology: multidisciplinary science driving basic and clinical advances

Keenan, B. P., Jaffee, E. M. & Armstrong, T. D., Jul 1 2013, In : Cancer Immunology Research. 1, 1, p. 16-23 8 p.

Research output: Contribution to journalArticle

Open Access
2012

Targeting the right regulatory t-cell population for tumor immunotherapy

Weiss, V. L., Lee, T. H., Jaffee, E. M. & Armstrong, T. D., Dec 1 2012, In : OncoImmunology. 1, 7, p. 1191-1193 3 p.

Research output: Contribution to journalArticle

Trafficking of high avidity HER-2/neu-specific T cells into HER-2/neu-expressing tumors after depletion of effector/memory-like regulatory T cells

Weiss, V. L., Lee, T. H., Song, H., Kouo, T. S., Black, C. M., Sgouros, G., Jaffee, E. M. & Armstrong, T. D., Feb 16 2012, In : PloS one. 7, 2, e31962.

Research output: Contribution to journalArticle

2011

CD8+Foxp3+ tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response

Le, D. T., Ladle, B. H., Lee, T., Weiss, V., Yao, X., Leubner, A., Armstrong, T. D. & Jaffee, E. M., Aug 1 2011, In : International Journal of Cancer. 129, 3, p. 636-647 12 p.

Research output: Contribution to journalArticle

Nondominant CD8+ T cells are active players in the vaccine-induced antitumor immune response

Uram, J. N., Black, C. M., Flynn, E., Huang, L., Armstrong, T. D. & Jaffee, E. M., Apr 1 2011, In : Journal of Immunology. 186, 7, p. 3847-3857 11 p.

Research output: Contribution to journalArticle

2010

Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice

Pfannenstiel, L. W., Lam, S. S. K., Emens, L. A., Jaffee, E. M. & Armstrong, T. D., Mar 25 2010, In : Cellular Immunology. 263, 1, p. 79-87 9 p.

Research output: Contribution to journalArticle

2008

Antibody association with HER-2/neu-targeted vaccine enhances CD8 + T cell responses in mice through Fc-mediated activation of DCs

Kim, P. S., Armstrong, T. D., Song, H., Wolpoe, M. E., Weiss, V., Manning, E. A., Huang, L. Q., Murata, S., Sgouros, G., Emens, L. A., Reilly, R. T. & Jaffee, E. M., May 1 2008, In : Journal of Clinical Investigation. 118, 5, p. 1700-1711 12 p.

Research output: Contribution to journalArticle

Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: efficacy of the vaccine in a pre-barrett's esophagus setting

Miyashita, T., Shah, F. A., Marti, G., Wang, J., Armstrong, T., Bonde, P., Gibson, M. K., Yoshimura, K., Montgomery, E. A., Duncan, M. D., Jaffee, E. M. & Harmon, J. W., Jan 1 2008, In : Journal of Gastrointestinal Surgery. 12, 1, p. 2-9 8 p.

Research output: Contribution to journalArticle

Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: Efficacy of the vaccine in a post-barrett's esophagus setting

Miyashita, T., Shah, F. A., Marti, G. P., Armstrong, T. D., Wang, J., Bonde, P., Gibson, M. K., Yoshimura, K., Montgomery, E. A., Duncan, M., Jaffee, E. M. & Harmon, J. W., Nov 1 2008, In : Digestive diseases and sciences. 53, 11, p. 2858-2867 10 p.

Research output: Contribution to journalArticle

2007

A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism

Manning, E. A., Ullman, J. G. M., Leatherman, J. M., Asquith, J. M., Hansen, T. R., Armstrong, T. D., Hicklin, D. J., Jaffee, E. M. & Emens, L. A., Jul 1 2007, In : Clinical Cancer Research. 13, 13, p. 3951-3959 9 p.

Research output: Contribution to journalArticle

2006

OX40 costimulation synergizes with GM-CSF whole-cell vaccination to overcome established CD8+ T cell tolerance to an endogenous tumor antigen

Murata, S., Ladle, B. H., Kim, P. S., Lutz, E. R., Wolpoe, M. E., Ivie, S. E., Smith, H. M., Armstrong, T. D., Emens, L. A., Jaffee, E. M. & Reilly, R. T., Jan 15 2006, In : Journal of Immunology. 176, 2, p. 974-983 10 p.

Research output: Contribution to journalArticle

Open Access
2005

Recruitment of latent pools of high-avidity CD8+ T cells to the antitumor immune response

Ercolini, A. M., Ladle, B. H., Manning, E. A., Pfannenstiel, L. W., Armstrong, T. D., Machiels, J. P. H., Bieler, J. G., Emens, L. A., Reilly, R. T. & Jaffee, E. M., May 16 2005, In : Journal of Experimental Medicine. 201, 10, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

2004

Mesothelin-specific CD8+ T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients

Thomas, A. M., Santarsiero, L. M., Lutz, E. R., Armstrong, T. D., Chen, Y. C., Huang, L. Q., Laheru, D. A., Goggins, M., Hruban, R. H. & Jaffee, E. M., Aug 2 2004, In : Journal of Experimental Medicine. 200, 3, p. 297-306 10 p.

Research output: Contribution to journalArticle

1998

Class II-transfected tumor cells directly present endogenous antigen to CD4+ T cells in vitro and are APCs for tumor-encoded antigens in vivo

Armstrong, T. D., Clements, V. K. & Ostrand-Rosenberg, S., Jan 1 1998, In : Journal of Immunotherapy. 21, 3, p. 218-224 7 p.

Research output: Contribution to journalArticle

Immunotherapy of established tumor with MHC class II and B7.1 cell-based tumor vaccines

Ostrand-Rosenberg, S., Pulaski, B. A., Armstrong, T. D. & Clements, V. K., Dec 1 1998, In : Advances in experimental medicine and biology. 451, p. 259-264 6 p.

Research output: Contribution to journalArticle

MHC class II-transfected tumor cells directly present antigen to tumor- specific CD4+ T lymphocytes

Armstrong, T. D., Clements, V. K. & Ostrand-Rosenberg, S., Jan 15 1998, In : Journal of Immunology. 160, 2, p. 661-666 6 p.

Research output: Contribution to journalArticle

Tumor antigen presentation: Changing the rules

Armstrong, T. D., Pulaski, B. A. & Ostrand-Rosenberg, S., May 1 1998, In : Cancer Immunology Immunotherapy. 46, 2, p. 70-74 5 p.

Research output: Contribution to journalArticle

1997

Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity

Armstrong, T. D., Clements, V. K., Martin, B. K., Ting, J. P. Y. & Ostrand-Rosenberg, S., Jun 24 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 13, p. 6886-6891 6 p.

Research output: Contribution to journalArticle

1992

Invariant chain alters the malignant phenotype of MHC class II+ tumor cells

Clements, V. K., Baskar, S., Armstrong, T. D. & Ostrand-Rosenberg, S., Jan 1 1992, In : Journal of Immunology. 149, 7, p. 2391-2396 6 p.

Research output: Contribution to journalArticle