Timothy Osborne

Professor

1981 …2021

Research activity per year

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Search results

  • 2021

    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

    Esquejo, R. M., Roqueta-Rivera, M., Shao, W., Phelan, P. E., Seneviratne, U., am Ende, C. W., Hershberger, P. M., Machamer, C. E., Espenshade, P. J. & Osborne, T. F., Feb 18 2021, In: Cell Chemical Biology. 28, 2, p. 169-179.e7

    Research output: Contribution to journalArticlepeer-review

  • 2020

    Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

    Che, L., Chi, W., Qiao, Y., Zhang, J., Song, X., Liu, Y., Li, L., Jia, J., Pilo, M. G., Wang, J., Cigliano, A., Ma, Z., Kuang, W., Tang, Z., Zhang, Z., Shui, G., Ribback, S., Dombrowski, F., Evert, M., Pascale, R. M. & 6 others, Cossu, C., Pes, G. M., Osborne, T. F., Calvisi, D. F., Chen, X. & Chen, L., Jan 1 2020, In: Gut. 69, 1, p. 177-186 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Correction: Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue (Experimental & Molecular Medicine, (2020), 52, 2, (238-252), 10.1038/s12276-020-0379-z)

    Lee, J. H., Go, Y., Kim, D. Y., Lee, S. H., Kim, O. H., Jeon, Y. H., Kwon, T. K., Bae, J. H., Song, D. K., Rhyu, I. J., Lee, I. K., Shong, M., Oh, B. C., Petucci, C., Park, J. W., Osborne, T. F. & Im, S. S., Jun 1 2020, In: Experimental and Molecular Medicine. 52, 6, p. 988 1 p.

    Research output: Contribution to journalComment/debatepeer-review

    Open Access
  • Fat Distribution in Women Is Associated with Depot-Specific Transcriptomic Signatures and Chromatin Structure

    Divoux, A., Sandor, K., Bojcsuk, D., Yi, F., Hopf, M. E., Smith, J. S., Balint, B. L., Osborne, T. F. & Smith, S. R., May 15 2020, In: Journal of the Endocrine Society. 4, 6, bvaa042.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Inflammation triggers liver X receptor-dependent lipogenesis

    Liebergall, S. R., Angdisen, J., Chan, S. H., Chang, Y. J., Osborne, T. F., Koeppel, A. F., Turner, S. D. & Schulman, I. G., Jan 1 2020, In: Molecular and cellular biology. 40, 2, e00364-19.

    Research output: Contribution to journalArticlepeer-review

  • Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

    Lee, J. H., Go, Y., Kim, D. Y., Lee, S. H., Kim, O. H., Jeon, Y. H., Kwon, T. K., Bae, J. H., Song, D. K., Rhyu, I. J., Lee, I. K., Shong, M., Oh, B. C., Petucci, C., Park, J. W., Osborne, T. F. & Im, S. S., Feb 1 2020, In: Experimental and Molecular Medicine. 52, 2, p. 238-252 15 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • 2019

    Estrogen-related receptor γ controls sterol regulatory element-binding protein-1c expression and alcoholic fatty liver

    Kim, D. K., Kim, Y. H., Lee, J. H., Jung, Y. S., Kim, J., Feng, R., Jeon, T. I., Lee, I. K., Cho, S. J., Im, S. S., Dooley, S., Osborne, T. F., Lee, C. H. & Choi, H. S., Dec 2019, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 12, 158521.

    Research output: Contribution to journalArticlepeer-review

  • 2018

    Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

    Esquejo, R. M., Salatto, C. T., Delmore, J., Albuquerque, B., Reyes, A., Shi, Y., Moccia, R., Cokorinos, E., Peloquin, M., Monetti, M., Barricklow, J., Bollinger, E., Smith, B. K., Day, E. A., Nguyen, C., Geoghegan, K. F., Kreeger, J. M., Opsahl, A., Ward, J., Kalgutkar, A. S. & 8 others, Tess, D., Butler, L., Shirai, N., Osborne, T. F., Steinberg, G. R., Birnbaum, M. J., Cameron, K. O. & Miller, R. A., May 2018, In: EBioMedicine. 31, p. 122-132 11 p.

    Research output: Contribution to journalArticlepeer-review

  • Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: Primary outcomes

    Divoux, A., Sandor, K., Bojcsuk, D., Talukder, A., Li, X., Balint, B. L., Osborne, T. F. & Smith, S. R., Nov 26 2018, In: Clinical Epigenetics. 10, 1, 148.

    Research output: Contribution to journalArticlepeer-review

  • Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch

    Abe, Y., Fujiwara, Y., Takahashi, H., Matsumura, Y., Sawada, T., Jiang, S., Nakaki, R., Uchida, A., Nagao, N., Naito, M., Kajimura, S., Kimura, H., Osborne, T. F., Aburatani, H., Kodama, T., Inagaki, T. & Sakai, J., Dec 1 2018, In: Nature communications. 9, 1, 1566.

    Research output: Contribution to journalArticlepeer-review

  • Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance

    Costford, S. R., Brouwers, B., Hopf, M. E., Sparks, L. M., Dispagna, M., Gomes, A. P., Cornnell, H. H., Petucci, C., Phelan, P., Xie, H., Yi, F., Walter, G. A., Osborne, T. F., Sinclair, D. A., Mynatt, R. L., Ayala, J. E., Gardell, S. J. & Smith, S. R., Jan 2018, In: Molecular Metabolism. 7, p. 1-11 11 p.

    Research output: Contribution to journalArticlepeer-review

  • SREBP-1a–stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1

    Lee, J. H., Phelan, P., Shin, M., Oh, B. C., Han, X., Im, S. S. & Osborne, T. F., Dec 26 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. E12228-E12234

    Research output: Contribution to journalArticlepeer-review

  • T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways

    Smith, K., Karimian Azari, E., LaMoia, T. E., Hussain, T., Vargova, V., Karolyi, K., Veldhuis, P. P., Arnoletti, J. P., de la Fuente, S. G., Pratley, R. E., Osborne, T. F. & Kyriazis, G. A., Nov 2018, In: Molecular Metabolism. 17, p. 98-111 14 p.

    Research output: Contribution to journalArticlepeer-review

  • 2017

    Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis

    Key, C. C. C., Liu, M., Kurtz, C. L., Chung, S., Boudyguina, E., Dinh, T. A., Bashore, A., Phelan, P. E., Freedman, B. I., Osborne, T. F., Zhu, X., Ma, L., Sethupathy, P., Biddinger, S. B. & Parks, J. S., Jun 6 2017, In: Cell Reports. 19, 10, p. 2116-2129 14 p.

    Research output: Contribution to journalArticlepeer-review

  • Inhibition of sweet chemosensory receptors alters insulin responses during glucose ingestion in healthy adults: A randomized crossover interventional study

    Azari, E. K., Smith, K. R., Yi, F., Osborne, T. F., Bizzotto, R., Mari, A., Pratley, R. E. & Kyriazis, G. A., Apr 1 2017, In: American Journal of Clinical Nutrition. 105, 4, p. 1001-1009 9 p.

    Research output: Contribution to journalArticlepeer-review

  • 2016

    miRNA and cholesterol homeostasis

    Jeon, T. I. & Osborne, T. F., Dec 1 2016, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1861, 12, p. 2041-2046 6 p.

    Research output: Contribution to journalReview articlepeer-review

  • SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation

    Roqueta-Rivera, M., Esquejo, R. M., Phelan, P. E., Sandor, K., Daniel, B., Foufelle, F., Ding, J., Li, X., Khorasanizadeh, S. & Osborne, T. F., Sep 13 2016, In: Cell Metabolism. 24, 3, p. 474-484 11 p.

    Research output: Contribution to journalArticlepeer-review

  • SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy

    Kim, K. Y., Jang, H. J., Yang, Y. R., Park, K. I., Seo, J. K., Shin, I. W., Jeon, T. I., Ahn, S. C., Suh, P. G., Osborne, T. F. & Seo, Y. K., Oct 21 2016, In: Scientific reports. 6, 35732.

    Research output: Contribution to journalArticlepeer-review

  • SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression

    Vergnes, L., Chin, R. G., De Vallim, T. A., Fong, L. G., Osborne, T. F., Young, S. G. & Reue, K., Mar 2016, In: Journal of Lipid Research. 57, 3, p. 410-421 12 p.

    Research output: Contribution to journalArticlepeer-review

  • 2015

    H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation

    Matsumura, Y., Nakaki, R., Inagaki, T., Yoshida, A., Kano, Y., Kimura, H., Tanaka, T., Tsutsumi, S., Nakao, M., Doi, T., Fukami, K., Osborne, T. F., Kodama, T., Aburatani, H. & Sakai, J., Nov 19 2015, In: Molecular cell. 60, 4, p. 584-596 13 p.

    Research output: Contribution to journalArticlepeer-review

  • JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis

    Abe, Y., Rozqie, R., Matsumura, Y., Kawamura, T., Nakaki, R., Tsurutani, Y., Tanimura-Inagaki, K., Shiono, A., Magoori, K., Nakamura, K., Ogi, S., Kajimura, S., Kimura, H., Tanaka, T., Fukami, K., Osborne, T. F., Kodama, T., Aburatani, H., Inagaki, T. & Sakai, J., May 7 2015, In: Nature communications. 6, 7052.

    Research output: Contribution to journalArticlepeer-review

  • The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis

    Inagaki, T., Iwasaki, S., Matsumura, Y., Kawamura, T., Tanaka, T., Abe, Y., Yamasaki, A., Tsurutani, Y., Yoshida, A., Chikaoka, Y., Nakamura, K., Magoori, K., Nakaki, R., Osborne, T. F., Fukami, K., Aburatani, H., Kodama, T. & Sakai, J., Feb 13 2015, In: Journal of Biological Chemistry. 290, 7, p. 4163-4177 15 p.

    Research output: Contribution to journalArticlepeer-review

  • 2014

    Lipid-cell cycle nexus: SREBP regulates microRNAs targeting Fbxw7

    Esquejo, R. M., Jeon, T. I. & Osborne, T. F., Feb 1 2014, In: Cell Cycle. 13, 3, p. 339-340 2 p.

    Research output: Contribution to journalEditorialpeer-review

  • Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism

    Masri, S., Rigor, P., Cervantes, M., Ceglia, N., Sebastian, C., Xiao, C., Roqueta-Rivera, M., Deng, C., Osborne, T. F., Mostoslavsky, R., Baldi, P. & Sassone-Corsi, P., Jul 31 2014, In: Cell. 158, 3, p. 659-672 14 p.

    Research output: Contribution to journalArticlepeer-review

  • Response to gerlic et al.

    Im, S. S., Young, S. G., Raffatellu, M. & Osborne, T. F., Mar 4 2014, In: Cell Metabolism. 19, 3, p. 346-347 2 p.

    Research output: Contribution to journalLetterpeer-review

  • 2013

    An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis

    Jeon, T. I., Esquejo, R. M., Roqueta-Rivera, M., Phelan, P. E., Moon, Y. A., Govindarajan, S. S., Esau, C. C. & Osborne, T. F., Jul 2 2013, In: Cell Metabolism. 18, 1, p. 51-61 11 p.

    Research output: Contribution to journalArticlepeer-review

  • Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

    Kidani, Y., Elsaesser, H., Hock, M. B., Vergnes, L., Williams, K. J., Argus, J. P., Marbois, B. N., Komisopoulou, E., Wilson, E. B., Osborne, T. F., Graeber, T. G., Reue, K., Brooks, D. G. & Bensinger, S. J., May 2013, In: Nature Immunology. 14, 5, p. 489-499 11 p.

    Research output: Contribution to journalArticlepeer-review

  • 2012

    Genome-wide analysis of FoxO1 binding in hepatic chromatin: Potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis

    Shin, D. J., Joshi, P., Hong, S. H., Mosure, K., Shin, D. G. & Osborne, T. F., Dec 2012, In: Nucleic acids research. 40, 22, p. 11499-11509 11 p.

    Research output: Contribution to journalArticlepeer-review

  • Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR

    Chong, H. K., Biesinger, J., Seo, Y. K., Xie, X. & Osborne, T. F., Feb 1 2012, In: BMC genomics. 13, 1, 51.

    Research output: Contribution to journalArticlepeer-review

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L., Alegre-Abarrategui, J. & 1,249 others, Aleo, M. F., Alirezaei, M., Almasan, A., Almonte-Becerril, M., Amano, A., Amaravadi, R., Amarnath, S., Amer, A. O., Andrieu-Abadie, N., Anantharam, V., Ann, D. K., Anoopkumar-Dukie, S., Aoki, H., Apostolova, N., Arancia, G., Aris, J. P., Asanuma, K., Asare, N. Y. O., Ashida, H., Askanas, V., Askew, D. S., Auberger, P., Baba, M., Backues, S. K., Baehrecke, E. H., Bahr, B. A., Bai, X. Y., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Bamber, B. A., Bampton, E. T. W., Bánhegyi, G., Bartholomew, C. R., Bassham, D. C., Bast, R. C., Batoko, H., Bay, B. H., Beau, I., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Bernassola, F., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Boise, L. H., Bonaldo, P., Boone, D. L., Bornhauser, B. C., Bortoluci, K. R., Bossis, I., Bost, F., Bourquin, J. P., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Brenman, J. E., Brennand, A., Bresnick, E. H., Brest, P., Bridges, D., Bristol, M. L., Brookes, P. S., Brown, E. J., Brumell, J. H., Brunetti-Pierri, N., Brunk, U. T., Bulman, D. E., Bultman, S. J., Bultynck, G., Burbulla, L. F., Bursch, W., Butchar, J. P., Buzgariu, W., Bydlowski, S. P., Cadwell, K., Cahová, M., Cai, D., Cai, J., Cai, Q., Calabretta, B., Calvo-Garrido, J., Camougrand, N., Campanella, M., Campos-Salinas, J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Carew, J. S., Carlin, C. R., Carmignac, V., Carneiro, L. A. M., Carra, S., Caruso, R. A., Casari, G., Casas, C., Castino, R., Cebollero, E., Cecconi, F., Celli, J., Chaachouay, H., Chae, H. J., Chai, C. Y., Chan, D. C., Chan, E. Y., Chang, R. C. C., Che, C. M., Chen, C. C., Chen, G. C., Chen, G. Q., Chen, M., Chen, Q., Chen, S. S. L., Chen, W. L., Chen, X., Chen, X., Chen, X., Chen, Y. G., Chen, Y., Chen, Y., Chen, Y. J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Cheong, H., Cheong, J. H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H. L., Chiarelli, R., Chiba, T., Chin, L. S., Chiou, S. H., Chisari, F. V., Cho, C. H., Cho, D. H., Choi, A. M. K., Choi, D. S., Choi, K. S., Choi, M. E., Chouaib, S., Choubey, D., Choubey, V., Chu, C. T., Chuang, T. H., Chueh, S. H., Chun, T., Chwae, Y. J., Chye, M. L., Ciarcia, R., Ciriolo, M. R., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Clarke, R., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condello, M., Condorelli, F., Cookson, M. R., Coombs, G. H., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M., Cullen, J. J., Czaja, M. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., De Groot, J. F., De Haan, C. A. M., De Martino, L., De Milito, A., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Deng, Y. Z., Dengjel, J., Dent, P., Denton, D., Deretic, V., Desai, S. D., Devenish, R. J., Di Gioacchino, M., Di Paolo, G., Di Pietro, C., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Diaz-Nido, J., Dikic, I., Dinesh-Kumar, S. P., Ding, W. X., Distelhorst, C. W., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Dorsey, F. C., Dosenko, V., Dowling, J. J., Doxsey, S., Dreux, M., Drew, M. E., Duan, Q., Duchosal, M. A., Duff, K., Dugail, I., Durbeej, M., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Eissa, N. T., Ekmekcioglu, S., El-Deiry, W. S., Elazar, Z., Elgendy, M., Ellerby, L. M., Er Eng, K., Engelbrecht, A. M., Engelender, S., Erenpreisa, J., Escalante, R., Esclatine, A., Eskelinen, E. L., Espert, L., Espina, V., Fan, H., Fan, J., Fan, Q. W., Fan, Z., Fang, S., Fang, Y., Fanto, M., Fanzani, A., Farkas, T., Farré, J. C., Faure, M., Fechheimer, M., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Fiorito, F., Fisher, E. A., Fisher, P. B., Flajolet, M., Florez-McClure, M. L., Florio, S., Fon, E. A., Fornai, F., Fortunato, F., Fotedar, R., Fowler, D. H., Fox, H. S., Franco, R., Frankel, L. B., Fransen, M., Fuentes, J. M., Fueyo, J., Fujii, J., Fujisaki, K., Fujita, E., Fukuda, M., Furukawa, R. H., Gaestel, M., Gailly, P., Gajewska, M., Galliot, B., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F. B., Gao, G. F., Gao, J., Garcia, L., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Gautel, M., Gawriluk, T. R., Gegg, M. E., Geng, J., Germain, M., Gestwicki, J. E., Gewirtz, D. A., Ghavami, S., Ghosh, P., Giammarioli, A. M., Giatromanolaki, A. N., Gibson, S. B., Gilkerson, R. W., Ginger, M. L., Ginsberg, H. N., Golab, J., Goligorsky, M. S., Golstein, P., Gomez-Manzano, C., Goncu, E., Gongora, C., Gonzalez, C. D., Gonzalez, R., González-Estévez, C., González-Polo, R. A., Gonzalez-Rey, E., Gorbunov, N. V., Gorski, S., Goruppi, S., Gottlieb, R. A., Gozuacik, D., Granato, G. E., Grant, G. D., Green, K. N., Gregorc, A., Gros, F., Grose, C., Grunt, T. W., Gual, P., Guan, J. L., Guan, K. L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Gustafsson, A. B., Halayko, A. J., Hale, A. N., Halonen, S. K., Hamasaki, M., Han, F., Han, T., Hancock, M. K., Hansen, M., Harada, H., Harada, M., Hardt, S. E., Harper, J. W., Harris, A. L., Harris, J., Harris, S. D., Hashimoto, M., Haspel, J. A., Hayashi, S. I., Hazelhurst, L. A., He, C., He, Y. W., Hébert, M. J., Heidenreich, K. A., Helfrich, M. H., Helgason, G. V., Henske, E. P., Herman, B., Herman, P. K., Hetz, C., Hilfiker, S., Hill, J. A., Hocking, L. J., Hofman, P., Hofmann, T. G., Höhfeld, J., Holyoake, T. L., Hong, M. H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Høyer-Hansen, M., Hu, B., Hu, C. A. A., Hu, H. M., Hua, Y., Huang, C., Huang, J., Huang, S., Huang, W. P., Huber, T. B., Huh, W. K., Hung, T. H., Hupp, T. R., Hur, G. M., Hurley, J. B., Hussain, S. N. A., Hussey, P. J., Hwang, J. J., Hwang, S., Ichihara, A., Ilkhanizadeh, S., Inoki, K., Into, T., Iovane, V., Iovanna, J. L., Ip, N. Y., Isaka, Y., Ishida, H., Isidoro, C., Isobe, K. I., Iwasaki, A., Izquierdo, M., Izumi, Y., Jaakkola, P. M., Jäättelä, M., Jackson, G. R., Jackson, W. T., Janji, B., Jendrach, M., Jeon, J. H., Jeung, E. B., Jiang, H., Jiang, H., Jiang, J. X., Jiang, M., Jiang, Q., Jiang, X., Jiménez, A., Jin, M., Jin, S., Joe, C. O., Johansen, T., Johnson, D. E., Johnson, G. V. W., Jones, N. L., Joseph, B., Joseph, S. K., Joubert, A. M., Juhász, G., Juillerat-Jeanneret, L., Jung, C. H., Jung, Y. K., Kaarniranta, K., Kaasik, A., Kabuta, T., Kadowaki, M., Kagedal, K., Kamada, Y., Kaminskyy, V. O., Kampinga, H. H., Kanamori, H., Kang, C., Kang, K. B., Il Kang, K., Kang, R., Kang, Y. A., Kanki, T., Kanneganti, T. D., Kanno, H., Kanthasamy, A. G., Kanthasamy, A., Karantza, V., Kaushal, G. P., Kaushik, S., Kawazoe, Y., Ke, P. Y., Kehrl, J. H., Kelekar, A., Kerkhoff, C., Kessel, D. H., Khalil, H., Kiel, J. A. K. W., Kiger, A. A., Kihara, A., Kim, D. R., Kim, D. H., Kim, D. H., Kim, E. K., Kim, H. R., Kim, J. S., Kim, J. H., Kim, J. C., Kim, J. K., Kim, P. K., Kim, S. W., Kim, Y. S., Kim, Y., Kimchi, A., Kimmelman, A. C., King, J. S., Kinsella, T. J., Kirkin, V., Kirshenbaum, L. A., Kitamoto, K., Kitazato, K., Klein, L., Klimecki, W. 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L., Li, L., Li, S., Li, W., Li, X. J., Li, Y. B., Li, Y. P., Liang, C., Liang, Q., Liao, Y. F., Liberski, P. P., Lieberman, A., Lim, H. J., Lim, K. L., Lim, K., Lin, C. F., Lin, F. C., Lin, J., Lin, J. D., Lin, K., Lin, W. W., Lin, W. C., Lin, Y. L., Linden, R., Lingor, P., Lippincott-Schwartz, J., Lisanti, M. P., Liton, P. B., Liu, B., Liu, C. F., Liu, K., Liu, L., Liu, Q. A., Liu, W., Liu, Y. C., Liu, Y., Lockshin, R. A., Lok, C. N., Lonial, S., Loos, B., Lopez-Berestein, G., López-Otín, C., Lossi, L., Lotze, M. T., Lõw, P., Lu, B., Lu, B., Lu, B., Lu, Z., Luciano, F., Lukacs, N. W., Lund, A. H., Lynch-Day, M. A., Ma, Y., Macian, F., MacKeigan, J. P., Macleod, K. F., Madeo, F., Maiuri, L., Maiuri, M. C., Malagoli, D., Malicdan, M. C. V., Malorni, W., Man, N., Mandelkow, E. M., Manon, S., Manov, I., Mao, K., Mao, X., Mao, Z., Marambaud, P., Marazziti, D., Marcel, Y. L., Marchbank, K., Marchetti, P., Marciniak, S. J., Marcondes, M., Mardi, M., Marfe, G., Mariño, G., Markaki, M., Marten, M. R., Martin, S. J., Martinand-Mari, C., Martinet, W., Martinez-Vicente, M., Masini, M., Matarrese, P., Matsuo, S., Matteoni, R., Mayer, A., Mazure, N. M., McConkey, D. J., McConnell, M. J., McDermott, C., McDonald, C., McInerney, G. M., McKenna, S. L., McLaughlin, B. A., McLean, P. J., McMaster, C. R., McQuibban, G. A., Meijer, A. J., Meisler, M. H., Meléndez, A., Melia, T. J., Melino, G., Mena, M. A., Menendez, J. A., Menna-Barreto, R. F. S., Menon, M. B., Menzies, F. M., Mercer, C. A., Merighi, A., Merry, D. E., Meschini, S., Meyer, C. G., Meyer, T. F., Miao, C. Y., Miao, J. Y., Michels, P. A. M., Michiels, C., Mijaljica, D., Milojkovic, A., Minucci, S., Miracco, C., Miranti, C. K., Mitroulis, I., Miyazawa, K., Mizushima, N., Mograbi, B., Mohseni, S., Molero, X., Mollereau, B., Mollinedo, F., Momoi, T., Monastyrska, I., Monick, M. M., Monteiro, M. J., Moore, M. N., Mora, R., Moreau, K., Moreira, P. I., Moriyasu, Y., Moscat, J., Mostowy, S., Mottram, J. C., Motyl, T., Moussa, C. E. H., Müller, S., Muller, S., Münger, K., Münz, C., Murphy, L. O., Murphy, M. E., Musarò, A., Mysorekar, I., Nagata, E., Nagata, K., Nahimana, A., Nair, U., Nakagawa, T., Nakahira, K., Nakano, H., Nakatogawa, H., Nanjundan, M., Naqvi, N. I., Narendra, D. P., Narita, M., Navarro, M., Nawrocki, S. T., Nazarko, T. Y., Nemchenko, A., Netea, M. G., Neufeld, T. P., Ney, P. A., Nezis, I. P., Nguyen, H. P., Nie, D., Nishino, I., Nislow, C., Nixon, R. A., Noda, T., Noegel, A. A., Nogalska, A., Noguchi, S., Notterpek, L., Novak, I., Nozaki, T., Nukina, N., Nürnberger, T., Nyfeler, B., Obara, K., Oberley, T. D., Oddo, S., Ogawa, M., Ohashi, T., Okamoto, K., Oleinick, N. L., Oliver, F. J., Olsen, L. J., Olsson, S., Opota, O., Osborne, T. F., Ostrander, G. K., Otsu, K., Ou, J. H. J., Ouimet, M., Overholtzer, M., Ozpolat, B., Paganetti, P., Pagnini, U., Pallet, N., Palmer, G. E., Palumbo, C., Pan, T., Panaretakis, T., Pandey, U. B., Papackova, Z., Papassideri, I., Paris, I., Park, J., Park, O. K., Parys, J. B., Parzych, K. R., Patschan, S., Patterson, C., Pattingre, S., Pawelek, J. M., Peng, J., Perlmutter, D. H., Perrotta, I., Perry, G., Pervaiz, S., Peter, M., Peters, G. J., Petersen, M., Petrovski, G., Phang, J. M., Piacentini, M., Pierre, P., Pierrefite-Carle, V., Pierron, G., Pinkas-Kramarski, R., Piras, A., Piri, N., Platanias, L. C., Pöggeler, S., Poirot, M., Poletti, A., Poüs, C., Pozuelo-Rubio, M., Prætorius-Ibba, M., Prasad, A., Prescott, M., Priault, M., Produit-Zengaffinen, N., Progulske-Fox, A., Proikas-Cezanne, T., Przedborski, S., Przyklenk, K., Puertollano, R., Puyal, J., Qian, S. B., Qin, L., Qin, Z. H., Quaggin, S. E., Raben, N., Rabinowich, H., Rabkin, S. W., Rahman, I., Rami, A., Ramm, G., Randall, G., Randow, F., Rao, V. A., Rathmell, J. C., Ravikumar, B., Ray, S. K., Reed, B. H., Reed, J. C., Reggiori, F., Régnier-Vigouroux, A., Reichert, A. S., Reiners, J. J., Reiter, R. J., Ren, J., Revuelta, J. L., Rhodes, C. J., Ritis, K., Rizzo, E., Robbins, J., Roberge, M., Roca, H., Roccheri, M. C., Rocchi, S., Rodemann, H. P., De Córdoba, S. R., Rohrer, B., Roninson, I. B., Rosen, K., Rost-Roszkowska, M. M., Rouis, M., Rouschop, K. M. A., Rovetta, F., Rubin, B. P., Rubinsztein, D. C., Ruckdeschel, K., Rucker, E. B., Rudich, A., Rudolf, E., Ruiz-Opazo, N., Russo, R., Rusten, T. E., Ryan, K. M., Ryter, S. W., Sabatini, D. M., Sadoshima, J., Saha, T., Saitoh, T., Sakagami, H., Sakai, Y., Salekdeh, G. H., Salomoni, P., Salvaterra, P. M., Salvesen, G., Salvioli, R., Sanchez, A. M. J., Sánchez-Alcázar, J. A., Sánchez-Prieto, R., Sandri, M., Sankar, U., Sansanwal, P., Santambrogio, L., Saran, S., Sarkar, S., Sarwal, M., Sasakawa, C., Sasnauskiene, A., Sass, M., Sato, K., Sato, M., Schapira, A. H. V., Scharl, M., Schätzl, H. M., Scheper, W., Schiaffino, S., Schneider, C., Schneider, M. E., Schneider-Stock, R., Schoenlein, P. V., Schorderet, D. F., Schüller, C., Schwartz, G. K., Scorrano, L., Sealy, L., Seglen, P. O., Segura-Aguilar, J., Seiliez, I., Seleverstov, O., Sell, C., Seo, J. B., Separovic, D., Setaluri, V., Setoguchi, T., Settembre, C., Shacka, J. J., Shanmugam, M., Shapiro, I. M., Shaulian, E., Shaw, R. J., Shelhamer, J. H., Shen, H. M., Shen, W. C., Sheng, Z. H., Shi, Y., Shibuya, K., Shidoji, Y., Shieh, J. J., Shih, C. M., Shimada, Y., Shimizu, S., Shintani, T., Shirihai, O. S., Shore, G. C., Sibirny, A. A., Sidhu, S. B., Sikorska, B., Silva-Zacarin, E. C. M., Simmons, A., Simon, A. K., Simon, H. U., Simone, C., Simonsen, A., Sinclair, D. A., Singh, R., Sinha, D., Sinicrope, F. A., Sirko, A., Siu, P. M., Sivridis, E., Skop, V., Skulachev, V. P., Slack, R. S., Smaili, S. S., Smith, D. R., Soengas, M. S., Soldati, T., Song, X., Sood, A. K., Soong, T. W., Sotgia, F., Spector, S. A., Spies, C. D., Springer, W., Srinivasula, S. M., Stefanis, L., Steffan, J. S., Stendel, R., Stenmark, H., Stephanou, A., Stern, S. T., Sternberg, C., Stork, B., Strålfors, P., Subauste, C. S., Sui, X., Sulzer, D., Sun, J., Sun, S. Y., Sun, Z. J., Sung, J. J. Y., Suzuki, K., Suzuki, T., Swanson, M. S., Swanton, C., Sweeney, S. T., Sy, L. K., Szabadkai, G., Tabas, I., Taegtmeyer, H., Tafani, M., Takács-Vellai, K., Takano, Y., Takegawa, K., Takemura, G., Takeshita, F., Talbot, N. J., Tan, K. S. W., Tanaka, K., Tanaka, K., Tang, D., Tang, D., Tanida, I., Tannous, B. A., Tavernarakis, N., Taylor, G. S., Taylor, G. A., Taylor, J. P., Terada, A. S., Terman, A., Tettamanti, G., Thevissen, K., Thompson, C. B., Thorburn, A., Thumm, M., Tian, F. F., Tian, Y., Tocchini-Valentini, G., Tolkovsky, A. M., Tomino, Y., Tönges, L., Tooze, S. A., Tournier, C., Tower, J., Towns, R., Trajkovic, V., Travassos, L. H., Tsai, T. F., Tschan, M. P., Tsubata, T., Tsung, A., Turk, B., Turner, L. S., Tyagi, S. C., Uchiyama, Y., Ueno, T., Umekawa, M., Umemiya-Shirafuji, R., Unni, V. K., Vaccaro, M. I., Valente, E. M., Van Den Berghe, G., Van Der Klei, I. J., Van Doorn, W. G., Van Dyk, L. F., Van Egmond, M., Van Grunsven, L. A., Vandenabeele, P., Vandenberghe, W. P., Vanhorebeek, I., Vaquero, E. C., Velasco, G., Vellai, T., Vicencio, J. M., Vierstra, R. D., Vila, M., Vindis, C., Viola, G., Viscomi, M. T., Voitsekhovskaja, O. V., Von Haefen, C., Votruba, M., Wada, K., Wade-Martins, R., Walker, C. L., Walsh, C. M., Walter, J., Wan, X. B., Wang, A., Wang, C., Wang, D., Wang, F., Wang, F., Wang, G., Wang, H., Wang, H. G., Wang, H. D., Wang, J., Wang, K., Wang, M., Wang, R. C., Wang, X., Wang, X., Wang, Y. J., Wang, Y., Wang, Z., Wang, Z. C., Wang, Z., Wansink, D. G., Ward, D. M., Watada, H., Waters, S. L., Webster, P., Wei, L., Weihl, C. C., Weiss, W. A., Welford, S. M., Wen, L. P., Whitehouse, C. A., Whitton, J. L., Whitworth, A. J., Wileman, T., Wiley, J. W., Wilkinson, S., Willbold, D., Williams, R. L., Williamson, P. R., Wouters, B. G., Wu, C., Wu, D. C., Wu, W. K. K., Wyttenbach, A., Xavier, R. J., Xi, Z., Xia, P., Xiao, G., Xie, Z., Xie, Z., Xu, D. Z., Xu, J., Xu, L., Xu, X., Yamamoto, A., Yamamoto, A., Yamashina, S., Yamashita, M., Yan, X., Yanagida, M., Yang, D. S., Yang, E., Yang, J. M., Yang, S. Y., Yang, W., Yang, W. Y., Yang, Z., Yao, M. C., Yao, T. P., Yeganeh, B., Yen, W. L., Yin, J. J., Yin, X. M., Yoo, O. J., Yoon, G., Yoon, S. Y., Yorimitsu, T., Yoshikawa, Y., Yoshimori, T., Yoshimoto, K., You, H. J., Youle, R. J., Younes, A., Yu, L., Yu, L., Yu, S. W., Yu, W. H., Yuan, Z. M., Yue, Z., Yun, C. H., Yuzaki, M., Zabirnyk, O., Silva-Zacarin, E., David Zacks, E., Zacksenhaus, L., Zaffaroni, N., Zakeri, Z., Zeh, H. J., Zeitlin, S. O., Zhang, H., Zhang, H. L., Zhang, J., Zhang, J. P., Zhang, L., Zhang, L., Zhang, M. Y., Zhang, X. D., Zhao, M., Zhao, Y. F., Zhao, Y., Zhao, Z. J., Zheng, X., Zhivotovsky, B., Zhong, Q., Zhou, C. Z., Zhu, C., Zhu, W. G., Zhu, X. F., Zhu, X., Zhu, Y., Zoladek, T., Zong, W. X., Zorzano, A., Zschocke, J. & Zuckerbraun, B., Apr 2012, In: Autophagy. 8, 4, p. 445-544 100 p.

    Research output: Contribution to journalReview articlepeer-review

  • Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

    Freed-Pastor, W. A., Mizuno, H., Zhao, X., Langerød, A., Moon, S. H., Rodriguez-Barrueco, R., Barsotti, A., Chicas, A., Li, W., Polotskaia, A., Bissell, M. J., Osborne, T. F., Tian, B., Lowe, S. W., Silva, J. M., Børresen-Dale, A. L., Levine, A. J., Bargonetti, J. & Prives, C., Jan 20 2012, In: Cell. 148, 1-2, p. 244-258 15 p.

    Research output: Contribution to journalArticlepeer-review

  • SREBPs: Metabolic integrators in physiology and metabolism

    Jeon, T. I. & Osborne, T. F., Feb 2012, In: Trends in Endocrinology and Metabolism. 23, 2, p. 65-72 8 p.

    Research output: Contribution to journalReview articlepeer-review

  • 2011

    Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy

    Seo, Y. K., Jeon, T. I., Chong, H. K., Biesinger, J., Xie, X. & Osborne, T. F., Apr 6 2011, In: Cell Metabolism. 13, 4, p. 367-375 9 p.

    Research output: Contribution to journalArticlepeer-review

  • Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK

    Jeon, T. I., Seo, Y. K. & Osborne, T. F., Aug 15 2011, In: Biochemical Journal. 438, 1, p. 33-37 5 p.

    Research output: Contribution to journalArticlepeer-review

  • Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis

    Blanc, M., Hsieh, W. Y., Robertson, K. A., Watterson, S., Shui, G., Lacaze, P., Khondoker, M., Dickinson, P., Sing, G., Rodríguez-Martín, S., Phelan, P., Forster, T., Strobl, B., Müller, M., Riemersma, R., Osborne, T., Wenk, M. R., Angulo, A. & Ghazal, P., Mar 2011, In: PLoS biology. 9, 3, e1000598.

    Research output: Contribution to journalArticlepeer-review

  • Integrated expression profiling and Genome-Wide analysis of ChREBP targets reveals the dual role for ChREBP in Glucose-Regulated gene expression

    Jeong, Y. S., Kim, D., Lee, Y. S., Kim, H. J., Han, J. Y., Im, S. S., Chong, H. K., Kwon, J. K., Cho, Y. H., Kim, W. K., Osborne, T. F., Horton, J. D., Jun, H. S., Ahn, Y. H., Ahn, S. M. & Cha, J. Y., 2011, In: PloS one. 6, 7, e22544.

    Research output: Contribution to journalArticlepeer-review

  • Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a

    Im, S. S., Yousef, L., Blaschitz, C., Liu, J. Z., Edwards, R. A., Young, S. G., Raffatellu, M. & Osborne, T. F., May 4 2011, In: Cell Metabolism. 13, 5, p. 540-549 10 p.

    Research output: Contribution to journalArticlepeer-review

  • Liver X receptors in atherosclerosis and inflammation

    Im, S. S. & Osborne, T. F., Apr 15 2011, In: Circulation research. 108, 8, p. 996-1001 6 p.

    Research output: Contribution to journalReview articlepeer-review

  • Sterols for oxygen: The metabolic burden of microbial SREBP

    Osborne, T. F., Oct 21 2011, In: Molecular cell. 44, 2, p. 172-174 3 p.

    Research output: Contribution to journalShort surveypeer-review

  • 2010

    Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity

    Lee, F. Y., Vallim, T. Q. D. A., Chong, H. K., Zhang, Y., Liu, Y., Jones, S. A., Osborne, T. F. & Edwards, P. A., Aug 2010, In: Molecular Endocrinology. 24, 8, p. 1626-1636 11 p.

    Research output: Contribution to journalArticlepeer-review

  • A feed-forward loop amplifies nutritional regulation of PNPLA3

    Huang, Y., He, S., Li, J. Z., Seo, Y. K., Osborne, T. F., Cohen, J. C. & Hobbs, H. H., Apr 27 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 17, p. 7892-7897 6 p.

    Research output: Contribution to journalArticlepeer-review

  • Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1

    Chong, H. K., Infante, A. M., Seo, Y. K., Jeon, T. I., Zhang, Y., Edwards, P. A., Xie, X. & Osborne, T. F., May 18 2010, In: Nucleic acids research. 38, 18, p. 6007-6017 11 p., gkq397.

    Research output: Contribution to journalArticlepeer-review

  • 2009

    COUP-TFII acts downstream of Wnt/β-catenin signal to silence PPARγ gene expression and repress adipogenesis

    Okamura, M., Kudo, H., Wakabayashi, K. I., Tanaka, T., Nonaka, A., Uchida, A., Tsutsumi, S., Sakakibara, I., Naito, M., Osborne, T. F., Hamakubo, T., Ito, S., Aburatani, H., Yanagisawa, M., Kodama, T. & Sakai, J., Apr 7 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 14, p. 5819-5824 6 p.

    Research output: Contribution to journalArticlepeer-review

  • Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: What a long, strange tRIP it's been

    Osborne, T. F. & Espenshade, P. J., Nov 15 2009, In: Genes and Development. 23, 22, p. 2578-2591 14 p.

    Research output: Contribution to journalReview articlepeer-review

  • FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action

    Shin, D. J. & Osborne, T. F., Apr 24 2009, In: Journal of Biological Chemistry. 284, 17, p. 11110-11120 11 p.

    Research output: Contribution to journalArticlepeer-review

  • Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif

    Seo, Y. K., Hansook, K. C., Infante, A. M., Im, S. S., Xie, X. & Osborne, T. F., Aug 18 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 33, p. 13765-13769 5 p.

    Research output: Contribution to journalArticlepeer-review

  • Regulation of steroid 5-α reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin

    Seo, Y. K., Zhu, B., Jeon, T. I. & Osborne, T. F., Nov 1 2009, In: Experimental cell research. 315, 18, p. 3133-3139 7 p.

    Research output: Contribution to journalArticlepeer-review

  • Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2

    Im, S. S., Hammond, L. E., Yousef, L., Nugas-Selby, C., Shin, D. J., Seo, Y. K., Fong, L. G., Young, S. G. & Osborne, T. F., Sep 2009, In: Molecular and cellular biology. 29, 17, p. 4864-4872 9 p.

    Research output: Contribution to journalArticlepeer-review

  • Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2 (Molecular and Cellular Biology (2009) 29, 17, (4864-4872))

    Im, S. S., Hammond, L. E., Yousef, L., Nugas-Selby, C., Shin, D. J., Seo, Y. K., Fong, L. G., Young, S. G. & Osborne, T. F., Nov 2009, In: Molecular and cellular biology. 29, 21, p. 5974 1 p.

    Research output: Contribution to journalComment/debatepeer-review