Timothy Osborne

Professor

1981 …2019
If you made any changes in Pure, your changes will be visible here soon.

Fingerprint Dive into the research topics where Timothy Osborne is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 11 Similar Profiles
Sterol Regulatory Element Binding Proteins Medicine & Life Sciences
Sterols Medicine & Life Sciences
Sterol Regulatory Element Binding Protein 1 Medicine & Life Sciences
Genes Chemical Compounds
Cholesterol Medicine & Life Sciences
Sterol Regulatory Element Binding Protein 2 Medicine & Life Sciences
Fatty Acid Synthases Medicine & Life Sciences
Liver Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1981 2019

Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

Che, L., Chi, W., Qiao, Y., Zhang, J., Song, X., Liu, Y., Li, L., Jia, J., Pilo, M. G., Wang, J., Cigliano, A., Ma, Z., Kuang, W., Tang, Z., Zhang, Z., Shui, G., Ribback, S., Dombrowski, F., Evert, M., Pascale, R. M. & 6 others, Cossu, C., Pes, G. M., Osborne, T., Calvisi, D. F., Chen, X. & Chen, L., Jan 1 2019, In : Gut.

Research output: Contribution to journalArticle

Open Access
Fatty Acid Synthases
Hepatocellular Carcinoma
Cholesterol
Growth
Knockout Mice

Estrogen-related receptor γ controls sterol regulatory element-binding protein-1c expression and alcoholic fatty liver

Kim, D. K., Kim, Y. H., Lee, J. H., Jung, Y. S., Kim, J., Feng, R., Jeon, T. I., Lee, I. K., Cho, S. J., Im, S. S., Dooley, S., Osborne, T., Lee, C. H. & Choi, H. S., Dec 1 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 12, 158521.

Research output: Contribution to journalArticle

Alcoholic Fatty Liver
Sterol Regulatory Element Binding Protein 1
Estrogen Receptors
Lipogenesis
Alcohols

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

Esquejo, R. M., Salatto, C. T., Delmore, J., Albuquerque, B., Reyes, A., Shi, Y., Moccia, R., Cokorinos, E., Peloquin, M., Monetti, M., Barricklow, J., Bollinger, E., Smith, B. K., Day, E. A., Nguyen, C., Geoghegan, K. F., Kreeger, J. M., Opsahl, A., Ward, J., Kalgutkar, A. S. & 8 others, Tess, D., Butler, L., Shirai, N., Osborne, T., Steinberg, G. R., Birnbaum, M. J., Cameron, K. O. & Miller, R. A., May 1 2018, In : EBioMedicine. 31, p. 122-132 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Liver
Primates
Rodentia
Chemical activation

Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: Primary outcomes

Divoux, A., Sandor, K., Bojcsuk, D., Talukder, A., Li, X., Balint, B. L., Osborne, T. & Smith, S. R., Nov 26 2018, In : Clinical Epigenetics. 10, 1, 148.

Research output: Contribution to journalArticle

Chromatin
Transposases
Fats
Genes
Chromatin Immunoprecipitation

Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch

Abe, Y., Fujiwara, Y., Takahashi, H., Matsumura, Y., Sawada, T., Jiang, S., Nakaki, R., Uchida, A., Nagao, N., Naito, M., Kajimura, S., Kimura, H., Osborne, T., Aburatani, H., Kodama, T., Inagaki, T. & Sakai, J., Dec 1 2018, In : Nature Communications. 9, 1, 1566.

Research output: Contribution to journalArticle

Histone Demethylases
adipose tissues
Brown Adipose Tissue
adrenergics
Adipogenesis