Thomas Louis

Professor Emeritus

1971 …2020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1971 2020

1971

Sequential treatment allocation in clinical trials

Flehinger, B. J. & Louis, T., Dec 1971, In : Biometrika. 58, 3, p. 419-426 8 p.

Research output: Contribution to journalArticle

Clinical Trials
clinical trials
Survival Time
Assignment
Therapeutics
1972

Reducing the number of inferior treatments in clinical trials.

Flehinger, B. J., Louis, T., Robbins, H. & Singer, B. H., Oct 1972, In : Proceedings of the National Academy of Sciences of the United States of America. 69, 10, p. 2993-2994 2 p.

Research output: Contribution to journalArticle

Research Design
Theoretical Models
Clinical Trials
Therapeutics
1975

Optimal allocation in sequential tests comparing the means of two gaussian populations

Louis, T., Aug 1975, In : Biometrika. 62, 2, p. 359-369 11 p.

Research output: Contribution to journalArticle

Sequential Test
Optimal Allocation
Testing
Average Sample number
Sequential Probability Ratio Test
1976

'Optimal allocation in sequential tests comparing the means of two gaussian population'

Louis, T., 1976, In : Biometrika. 63, 1, p. 218 1 p.

Research output: Contribution to journalComment/debate

Sequential Test
Optimal Allocation
Population
testing
Sequential test
1977

Sequential allocation in clinical trials comparing two exponential survival curves

Louis, T., 1977, In : Biometrics. 33, 4, p. 627-634 8 p.

Research output: Contribution to journalArticle

Clinical Trials
clinical trials
Curve
Survival
medical treatment
1978

Screening for the early detection of cancer- I. The temporal natural history of a progressive disease state

Albert, A., Gertman, P. M. & Louis, T., 1978, In : Mathematical Biosciences. 40, 1-2, p. 1-59 59 p.

Research output: Contribution to journalArticle

Early Detection of Cancer
Screening
cancer
Cancer
screening

Screening for the early detection of cancer- II. The impact of screening on the natural history of the disease

Albert, A., Gertman, P. M., Louis, T. & Liu, S. I., 1978, In : Mathematical Biosciences. 40, 1-2, p. 61-109 49 p.

Research output: Contribution to journalArticle

Early Detection of Cancer
Uterine Cervical Neoplasms
Screening
cancer
Cancer

Screening for the early detection of cancer- III. Estimation of disease natural history

Louis, T., Albert, A. & Heghinian, S., 1978, In : Mathematical Biosciences. 40, 1-2, p. 111-144 34 p.

Research output: Contribution to journalArticle

Natural History
Early Detection of Cancer
natural history
Screening
cancer
1981

Confidence intervals for a binomial parameter after observing no successes

Louis, T., 1981, In : American Statistician. 35, 3, p. 154 1 p.

Research output: Contribution to journalArticle

Confidence interval
Percent
Sample Size
Proportion
Experiment

Nonparametric analysis of an accelerated failure time model

Louis, T., Aug 1981, In : Biometrika. 68, 2, p. 381-390 10 p.

Research output: Contribution to journalArticle

Accelerated Failure Time Model
Survival Distribution
Proportional Hazards Model
Proportional Hazards Models
Hazards

Unstable angina pectoris: National cooperative study group to compare medical and surgical therapy. IV. Results in patients with left anterior descending coronary artery disease

Russell, R. O., Moraski, R. E., Kouchoukos, N. T., Karp, R. B., Mantle, J. A., Rogers, W. J., Rackley, C. E., Resnekov, L., Falicov, R. E., Al-Sadir, J., Brooks, H., Anagnostopoulos, C. E., Lamberti, J., Wolk, M., Gay, W., Killip, T., Rosati, R. A., Oldham, H. N., Wagner, G. S., Peter, R. H. & 28 others, Conti, C. R., Curry, R. C., Daicoff, G., Becker, L., Plotnick, G., Gott, V. L., Brawley, R. K., Donahoo, J. S., Ross, R. S., Hutter, A. M., Desanctis, R. W., Gold, H. K., Leinbach, R. C., Buckley, M. J., Austin, W. G., Biddle, T. L., N.Yu, P., DeWeese, J. A., Schroeder, J., Stinson, E., Silverman, J., Kaplan, E. M., Gilbert, J. P., Hutter, A. M., Louis, T., Mosteller, D. F., Mock, M. B. & Frommer, P. L., 1981, In : The American Journal of Cardiology. 48, 3, p. 517-524 8 p.

Research output: Contribution to journalArticle

Work Capacity Evaluation
Variant Angina Pectoris
Unstable Angina
Angina Pectoris
Random Allocation
1982

Radiation effects [5]

Louis, T., 1982, In : Science. 215, 4532, p. 458 1 p.

Research output: Contribution to journalLetter

Timely topics in statistical methods for clinical trials.

Louis, T., Mosteller, F. & McPeek, B., 1982, In : Annual Review of Biophysics and Bioengineering. 11, p. 81-104 24 p.

Research output: Contribution to journalReview article

Random Allocation
Research Design
Clinical Trials
1983

Critical issues in the conduct and interpretation of clinical trials.

Louis, T. & Shapiro, S. H., 1983, In : Annual Review of Public Health. 4, p. 25-46 22 p.

Research output: Contribution to journalArticle

Medical Ethics
Patient Selection
Research Design
Clinical Trials

Designs for experiments. Parallel comparisons of treatment

Lavori, P. W., Louis, T., Bailar, J. C. & Polansky, M., 1983, In : New England Journal of Medicine. 309, 21, p. 1291-1299 9 p.

Research output: Contribution to journalArticle

Control Groups
Therapeutics
Random Allocation
Clinical Trials

Effects of selection in a prospective study of forced expiratory volume in Vermont granite workers

Eisen, E. A., Wegman, D. H. & Louis, T., 1983, In : American Review of Respiratory Disease. 128, 4, p. 587-591 5 p.

Research output: Contribution to journalArticle

Lost to Follow-Up
Respiratory Function Tests
Forced Expiratory Volume
Industry
Regression Analysis

Statistical problems in environmental research

Ware, J. H. & Louis, T., 1983, In : Canadian Journal of Statistics. 11, 1, p. 51-68 18 p.

Research output: Contribution to journalArticle

Bioassay
Air Pollution
Pollutants
Risk Assessment
Hazard
1984

A classification for biomedical research reports

Bailar, J. C., Louis, T., Lavori, P. W. & Polansky, M., 1984, In : New England Journal of Medicine. 311, 23, p. 1482-1487 6 p.

Research output: Contribution to journalArticle

Biomedical Research
New England
Research
Research Personnel
Medicine

Crossover and self-controlled designs in clinical research

Louis, T., Lavori, P. W., Bailar, J. C. & Polansky, M., 1984, In : New England Journal of Medicine. 310, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

Cross-Over Studies
Research
Therapeutics
Clinical Trials

Editorial Collaborators

Aroian, L. A., Basu, A. K., Bather, J. A., Bechhofer, R. E., Bednarski, T., Cohen, A., DeLong, D., Eisenberg, B., Gardiner, J. C., Ghosh, B. K., Ghosh, J. K., Ghosh, M., Hall, W. J., Huang, W. M., Johnson, N. L., Jurekova, J., Khan, R. A., Kulkarni, R., Lai, T. L., Louis, T. & 14 others, Martinsek, A. T., Mukhopadhyay, N., Miller-Funk, U., Neuhaus, G., Nickerson, D., Rehalia, M., Reynolds, M. R., Sen, P. K., Simons, G., Wei, C. Z., Wetherill, G. B., Wijsman, R. A., Woodroofe, M. B. & Zacks, S., Jan 1 1984, In : Sequential Analysis. 3, 3-4, p. 273-274 2 p.

Research output: Contribution to journalArticle

Empirical Bayes Method
Bayes
Estimate
Histogram
Sample variance

Estimation of Long Term Dust Exposures in the Vermont Granite Sheds

Eisen, E. A., Smith, T. J., Wegman, D. H., Louis, T. & Froines, J., Feb 1 1984, In : American Industrial Hygiene Association Journal. 45, 2, p. 89-94 6 p.

Research output: Contribution to journalArticle

Dust
Analysis of Variance
granite
Industry
Weights and Measures

Statistical consulting in clinical research: The two‐way street

Moses, L. & Louis, T., 1984, In : Statistics in Medicine. 3, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Statistical Data Interpretation
Research
Planning
Interaction
Interpretation

Studies without internal controls

Bailar, J. C., Louis, T., Lavori, P. W. & Polansky, M., 1984, In : New England Journal of Medicine. 311, 3, p. 156-162 7 p.

Research output: Contribution to journalArticle

Research Personnel
Therapeutics
Clinical Studies
1985

A randomized controlled trial of quality assurance in sixteen ambulatory care practices

Palmer, R. H., Louis, T., Hsu, L. N., Peterson, H. F., Rothrock, J. K., Strain, R., Thompson, M. S. & Wright, E. A., 1985, In : Medical Care. 23, 6, p. 751-770 20 p.

Research output: Contribution to journalArticle

Ambulatory Care
quality assurance
Group Practice
group practice
Randomized Controlled Trials

Findings for public health from meta-analyses.

Louis, T., Fineberg, H. V. & Mosteller, F., 1985, In : Annual Review of Public Health. 6, p. 1-20 20 p.

Research output: Contribution to journalArticle

Epidemiologic Methods
Attitude to Health
Behavior Therapy
Dental Caries
Patient Education
1986

Explaining discrepancies between longitudinal and cross-sectional models

Louis, T., Robins, J., Dockery, D. W., Spiro, A. & Ware, J. H., 1986, In : Journal of Chronic Diseases. 39, 10, p. 831-839 9 p.

Research output: Contribution to journalArticle

Age Distribution
Longitudinal Studies
Cohort Effect
Prospective Studies
Lung

Policy on monitoring and reporting results.

Louis, T., Bouffioux, C., Tazaki, H., Acosta-Otero, A., Khoury, S., Kopp, J., Mazeman, E., Obata, K., Tagnon, H. & Wittes, R. E., 1986, In : Progress in Clinical and Biological Research. 221, p. 33-48 16 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Clinical Trials
1987

Empirical Bayes confidence intervals based on bootstrap samples

Laird, N. M. & Louis, T., 1987, In : Journal of the American Statistical Association. 82, 399, p. 739-750 12 p.

Research output: Contribution to journalArticle

Empirical Bayes
Bootstrap
Confidence interval
Bayes
Posterior distribution

Influence analysis of generalized least squares estimators

De Gruttola, V., Ware, J. H. & Louis, T., 1987, In : Journal of the American Statistical Association. 82, 399, p. 911-917 7 p.

Research output: Contribution to journalArticle

Influence Analysis
Generalized Least Squares Estimator
Deletion
Covariance matrix
Regression Diagnostics

Inter-laboratory variability in Ames assay results

Knuiman, M. W., Laird, N. M. & Louis, T., 1987, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 180, 2, p. 171-182 12 p.

Research output: Contribution to journalArticle

Temperature
Liver

Rejoinder

Laird, N. M. & Louis, T., 1987, In : Journal of the American Statistical Association. 82, 399, p. 756-757 2 p.

Research output: Contribution to journalComment/debate

1988

Cumulative and reversible effects of lifetime smoking on simple tests of lung function in adults

Dockery, D. W., Speizer, F. E., Ferris, B. G., Ware, J. H., Louis, T. & Spiro, A., 1988, In : American Review of Respiratory Disease. 137, 2, p. 286-292 7 p.

Research output: Contribution to journalArticle

Respiratory Function Tests
Smoking
Lung
Smoking Cessation
Tobacco Products

General methods for analysing repeated measures

Louis, T., 1988, In : Statistics in Medicine. 7, 1-2, p. 29-45 17 p.

Research output: Contribution to journalArticle

Repeated Measures
Regression Analysis
Regression Diagnostics
Continuous random variable
Covariance Structure

UNFAVOURABLE OUTCOMES OF DRUG THERAPY—SUBJECTIVE PROBABILITY VERSUS CONFIDENCE INTERVALS

Manu, P., Louis, T., Lane, T. J., Gottlieb, L., Engel, P. & Rippey, R. M., 1988, In : Journal of Clinical Pharmacy and Therapeutics. 13, 3, p. 213-217 5 p.

Research output: Contribution to journalArticle

Biostatistics
Confidence Intervals
Students
Pharmaceutical Preparations
Sample Size
1989

Analysis of a random sample of 2-year carcinogen bioassays from the nci data base

Louis, T., Feb 1989, In : Toxicological Sciences. 12, 2, p. 222-231 10 p.

Research output: Contribution to journalArticle

Bioassay
Biological Assay
Carcinogens
Databases
Risk assessment

An assessment of publication bias using a sample of published clinical trials

Berlin, J. A., Begg, C. B. & Louis, T., 1989, In : Journal of the American Statistical Association. 84, 406, p. 381-392 12 p.

Research output: Contribution to journalArticle

Publication Bias
Clinical Trials
Sample Size
Treatment Effects
Alternatives

Empirical Bayes confidence intervals for a series of related experiments

Laird, N. M. & Louis, T., 1989, In : Biometrics. 45, 2, p. 481-495 15 p.

Research output: Contribution to journalArticle

Empirical Bayes
Confidence interval
confidence interval
Confidence Intervals
Bootstrap

REPLY

Louis, T. & Manu, P., 1989, In : Journal of Clinical Pharmacy and Therapeutics. 14, 6, p. 481-482 2 p.

Research output: Contribution to journalLetter

1990

Controlling error rates using prior information and marginal totals to select tumor sites

Louis, T. & Bailey, J. K., 1990, In : Journal of Statistical Planning and Inference. 24, 3, p. 297-316 20 p.

Research output: Contribution to journalArticle

Prior Information
Error Rate
Bioassay
Tumors
Tumor

Diet, plasma levels of beta-carotene and alpha-tocopherol, and risk of malignant melanoma

Stryker, W. S., Stampfer, M. J., Stein, E. A., Kaplan, L., Louis, T., Sober, A. & Willett, W. C., Apr 1990, In : American Journal of Epidemiology. 131, 4, p. 597-611 15 p.

Research output: Contribution to journalArticle

beta Carotene
alpha-Tocopherol
Melanoma
Diet
Odds Ratio

Longitudinal and cross-sectional estimates of pulmonary function decline in never-smoking adults

Ware, J. H., Dockery, D. W., Louis, T., Xu, X., Ferris, B. G. & Speizer, F. E., Oct 1990, In : American Journal of Epidemiology. 132, 4, p. 685-700 16 p.

Research output: Contribution to journalArticle

Longitudinal Studies
Smoking
Lung
Air Pollution
Appointments and Schedules

Performance quality, gender, and professional role: A study of physicians and nonphysicians in 16 ambulatory care practices

Hall, J. A., Palmer, R. H., John Orav, E., Hargraves, J. L., Wright, E. A. & Louis, T., 1990, In : Medical Care. 28, 6, p. 489-501 13 p.

Research output: Contribution to journalArticle

Professional Role
Ambulatory Care
Physicians
Early Detection of Cancer
Urinary Tract Infections
1991

Assessing, accommodating, and interpreting the influences of heterogeneity

Louis, T., 1991, In : Environmental Health Perspectives. 90, p. 215-222 8 p.

Research output: Contribution to journalArticle

Small-Area Analysis
Statistical Models
Measurement errors
Risk assessment
Meta-Analysis

Forecasting the number of future disabled elderly using Markovian and mathematical models

Boult, C., Kane, R. L., Louis, T. & Ibrahim, J. G., 1991, In : Journal of Clinical Epidemiology. 44, 9, p. 973-980 8 p.

Research output: Contribution to journalArticle

Theoretical Models
Health Status
Longitudinal Studies
Morbidity
Mortality

Smoothing the non-parametric estimate of a prior distribution by roughening. A computational study

Laird, N. M. & Louis, T., 1991, In : Computational Statistics and Data Analysis. 12, 1, p. 27-37 11 p.

Research output: Contribution to journalArticle

Empirical Bayes
Prior distribution
Smoothing
Treatment Effects
Empirical Bayes Method

Using empirical bayes methods in biopharmaceutical research

Louis, T., 1991, In : Statistics in Medicine. 10, 6, p. 811-829 19 p.

Research output: Contribution to journalArticle

Empirical Bayes Method
Bayes Theorem
Treatment Effects
Empirical Bayes
Multicenter Studies

Variance components and their implications for statistical information in medical data

Orav, E. J., Louis, T., Palmer, R. H. & Wright, E. A., 1991, In : Statistics in Medicine. 10, 4, p. 599-616 18 p.

Research output: Contribution to journalArticle

Variance Components
Sample Size
Cluster Analysis
Effective Sample Size
Variance Component Model
1992

Comment

Louis, T., 1992, In : Journal of the American Statistical Association. 87, 419, p. 626-628 3 p.

Research output: Contribution to journalComment/debate

Comment

Louis, T., 1992, In : Journal of the American Statistical Association. 87, 418, p. 576-579 4 p.

Research output: Contribution to journalComment/debate