Thomas Kelly

Professor Emeritus

1968 …2019

Research output per year

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Research Output

2019

Dynamics of DNA replication in a eukaryotic cell

Kelly, T. & Callegari, A. J., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 11, p. 4973-4982 10 p.

Research output: Contribution to journalArticle

Open Access
2017

Historical perspective of eukaryotic DNA replication

Kelly, T., Jan 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 1042. p. 1-41 41 p. (Advances in Experimental Medicine and Biology; vol. 1042).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Coordination of DNA damage tolerance mechanisms with cell cycle progression in fission yeast

Callegari, A. J. & Kelly, T., Jan 17 2016, In : Cell Cycle. 15, 2, p. 261-273 13 p.

Research output: Contribution to journalArticle

2014

Geminin inhibits a late step in the formation of human pre-replicative complexes

Wu, M., Lu, W., Santos, R. E., Frattini, M. G. & Kelly, T. J., Oct 31 2014, In : Journal of Biological Chemistry. 289, 44, p. 30810-30821 12 p.

Research output: Contribution to journalArticle

2013

Nathans, Daniel

DiMaio, D. & Kelly, T., Feb 27 2013, Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., p. 6-7 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

S. pombe replication protein Cdc18 (Cdc6) interacts with Swi6 (HP1) heterochromatin protein: Region specific effects and replication timing in the centromere

Li, P. C., Chretien, L., Côté, J., Kelly, T. J. & Forsburg, S. L., Jan 15 2011, In : Cell Cycle. 10, 2, p. 323-336 14 p.

Research output: Contribution to journalArticle

2010

Postreplication gaps at UV lesions are signals for checkpoint activation

Callegari, A. J., Clark, E., Pneuman, A. & Kelly, T. J., May 4 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 18, p. 8219-8224 6 p.

Research output: Contribution to journalArticle

2009

Autoinhibition and autoactivation of the DNA replication checkpoint kinase Cds1

Xu, Y. J. & Kelly, T. J., Jun 5 2009, In : Journal of Biological Chemistry. 284, 23, p. 16016-16027 12 p.

Research output: Contribution to journalArticle

2008

Multiple mechanisms contribute to Schizosaccharomyces pombe origin recognition complex-DNA interactions

Houchens, C. R., Lu, W., Chuang, R. Y., Frattini, M. G., Fuller, A., Simancek, P. & Kelly, T. J., Oct 31 2008, In : Journal of Biological Chemistry. 283, 44, p. 30216-30224 9 p.

Research output: Contribution to journalArticle

Schizosaccharomyces pombe Noc3 is essential for ribosome biogenesis and cell division but not DNA replication

Houchens, C. R., Perreault, A., Bachand, F. & Kelly, T. J., Sep 1 2008, In : Eukaryotic Cell. 7, 9, p. 1433-1440 8 p.

Research output: Contribution to journalArticle

2007

Shedding light on the DNA damage checkpoint

Callegari, A. J. & Kelly, T. J., Mar 15 2007, In : Cell Cycle. 6, 6, p. 660-666 7 p.

Research output: Contribution to journalReview article

Open Access
2006

Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast

Xu, Y. J., Davenport, M. & Kelly, T. J., Apr 15 2006, In : Genes and Development. 20, 8, p. 990-1003 14 p.

Research output: Contribution to journalArticle

UV irradiation induces a postreplication DNA damage checkpoint

Callegari, A. J. & Kelly, T. J., Oct 24 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 43, p. 15877-15882 6 p.

Research output: Contribution to journalArticle

2005

DNA replication origins in the Schizosaccharomyces pombe genome

Dai, J., Chuang, R. Y. & Kelly, T. J., Jan 11 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 2, p. 337-342 6 p.

Research output: Contribution to journalArticle

2003

Sequence-independent DNA binding and replication initiation by the human origin recognition complex

Vashee, S., Cvetic, C., Lu, W., Simancek, P., Kelly, T. J. & Walter, J. C., Aug 1 2003, In : Genes and Development. 17, 15, p. 1894-1908 15 p.

Research output: Contribution to journalArticle

2002

Purification and characterization of the Schizosaccharomyces pombe origin recognition complex. Interaction with origin DNA and Cdc18 protein

Chuang, R. Y., Chrétien, L., Dai, J. & Kelly, T. J., May 10 2002, In : Journal of Biological Chemistry. 277, 19, p. 16920-16927 8 p.

Research output: Contribution to journalArticle

2001

Assembly of the Human Origin Recognition Complex

Vashee, S., Simancek, P., Challberg, M. D. & Kelly, T. J., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 26666-26673 8 p.

Research output: Contribution to journalArticle

Redundant control of rereplication in fission yeast

Gopalakrishnan, V., Simancek, P., Houchens, C., Snaith, H. A., Frattini, M. G., Sazer, S. & Kelly, T. J., Nov 6 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 23, p. 13114-13119 6 p.

Research output: Contribution to journalArticle

2000

Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response

Brush, G. S. & Kelly, T. J., Oct 1 2000, In : Nucleic acids research. 28, 19, p. 3725-3732 8 p.

Research output: Contribution to journalArticle

Open Access

Regulation of chromosome replication

Kelly, T. J. & Brown, G. W., Nov 2 2000, In : Annual review of biochemistry. 69, p. 829-880 52 p.

Research output: Contribution to journalReview article

1999

Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase

Brown, G. W. & Kelly, T. J., Jul 20 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 15, p. 8443-8448 6 p.

Research output: Contribution to journalArticle

1998

Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast

Brown, G. W. & Kelly, T. J., Aug 21 1998, In : Journal of Biological Chemistry. 273, 34, p. 22083-22090 8 p.

Research output: Contribution to journalArticle

1997

Cyclin-dependent kinase and initiation at eukaryotic origins: A replication switch?

Jallepalli, P. V. & Kelly, T. J., Jun 1997, In : Current Opinion in Cell Biology. 9, 3, p. 358-363 6 p.

Research output: Contribution to journalArticle

Identification of autonomously replicating sequence (ARS) elements in eukaryotic cells

Clyne, R. K. & Kelly, T. J., Nov 1997, In : Methods: A Companion to Methods in Enzymology. 13, 3, p. 221-233 13 p.

Research output: Contribution to journalArticle

Interaction of the S phase regulator Cdc18 with cyclin-dependent kinase in fission yeast

Brown, G. W., Jallepalli, P. V., Huneycutt, B. J. & Kelly, T. J., Jun 10 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 12, p. 6142-6147 6 p.

Research output: Contribution to journalArticle

Regulation of the replication initiator protein p65(cdc18) by CDK phosphorylation

Jallepalli, P. V., Brown, G. W., Muzi-Falconi, M., Tien, D. & Kelly, T. J., Nov 1 1997, In : Genes and Development. 11, 21, p. 2767-2779 13 p.

Research output: Contribution to journalArticle

Open Access

The schizosaccharomyces pombe rad11+ gene encodes the large subunit of replication protein A

Parker, A. E., Clyne, R. K., Carr, A. M. & Kelly, T. J., May 1997, In : Molecular and cellular biology. 17, 5, p. 2381-2390 10 p.

Research output: Contribution to journalArticle

Open Access
1996

cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe

Muzi-Falconi, M., Brown, G. W. & Kelly, T. J., Feb 20 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 4, p. 1566-1570 5 p.

Research output: Contribution to journalArticle

DNA polymerase III: Running rings around the fork

Herendeen, D. R. & Kelly, T. J., Jan 12 1996, In : Cell. 84, 1, p. 5-8 4 p.

Research output: Contribution to journalReview article

DNA replication: Controlling initiation during the cell cycle

Muzi-Falconi, M., Brown, G. W. & Kelly, T. J., Jan 1 1996, In : Current Biology. 6, 3, p. 229-233 5 p.

Research output: Contribution to journalArticle

Open Access

Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor

Ohtani, K., DeGregori, J., Leone, G., Herendeen, D. R., Kelly, T. J. & Nevins, J. R., Jan 1 1996, In : Molecular and cellular biology. 16, 12, p. 6977-6984 8 p.

Research output: Contribution to journalArticle

Open Access

Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe

Jallepalli, P. V. & Kelly, T. J., Mar 1 1996, In : Genes and Development. 10, 5, p. 541-552 12 p.

Research output: Contribution to journalArticle

Open Access

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast

Brush, G. S., Morrow, D. M., Hieter, P. & Kelly, T. J., Dec 24 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 26, p. 15075-15080 6 p.

Research output: Contribution to journalArticle

1995

Genetic analysis of an ARS element from the fission yeast Schizosaccharomyces pombe

Clyne, R. K. & Kelly, T. J., Dec 1 1995, In : EMBO Journal. 14, 24, p. 6348-6357 10 p.

Research output: Contribution to journalArticle

Identification of Eukaryotic DNA Replication Proteins Using Simian Virus 40 in Vitro Replication System

Brush, G. S., Kelly, T. J. & Stillman, B., Jan 1 1995, In : Methods in Enzymology. 262, C, p. 522-548 27 p.

Research output: Contribution to journalArticle

1994

High-Resolution Genomic Mapping of the Three Human Replication Protein A Genes (RPA1, RPA2, and RPA3)

Umbricht, C. B., Griffin, C. A., Hawkins, A. L., Grzeschik, K. H., O'Connell, P., Leach, R., Green, E. D. & Kelly, T. J., Mar 15 1994, In : Genomics. 20, 2, p. 249-257 9 p.

Research output: Contribution to journalArticle

Replication and Transcription: Silence of the ORCs

Kelly, T. J., Jallepalli, P. V. & Clyne, R. K., Mar 1 1994, In : Current Biology. 4, 3, p. 238-241 4 p.

Research output: Contribution to journalArticle

1993

Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A

Umbricht, C. B., Erdile, L. F., Jabs, E. W. & Kelly, T. J., Jan 1 1993, In : Journal of Biological Chemistry. 268, 9, p. 6131-6138 8 p.

Research output: Contribution to journalArticle

Coupling DNA replication to the cell cycle

Kelly, T. J., Nurse, P. & Forsburg, S. L., Jan 1 1993, In : Cold Spring Harbor symposia on quantitative biology. 58, p. 637-644 8 p.

Research output: Contribution to journalArticle

Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding

Moarefi, I. F., Small, D., Gilbert, I., Hopfner, M., Randall, S. K., Schneider, C., Russo, A. A. R., Ramsperger, U., Arthur, A. K., Stahl, H., Kelly, T. J. & Fanning, E., Jan 1 1993, In : Journal of virology. 67, 8, p. 4992-5002 11 p.

Research output: Contribution to journalArticle

The fission yeast cdc18+ gene product couples S phase to START and mitosis

Kelly, T. J., Martin, G. S., Forsburg, S. L., Stephen, R. J., Russo, A. & Nurse, P., Jul 30 1993, In : Cell. 74, 2, p. 371-382 12 p.

Research output: Contribution to journalArticle

The role of the 70 kDa subunit of human DNA polymerase α in DNA replication

Collins, K. L., Russo, A. A. R., Tseng, O. Y. & Kelly, T. J., Jan 1 1993, In : EMBO Journal. 12, 12, p. 4555-4566 12 p.

Research output: Contribution to journalArticle

1992

Interaction of DNA polymerase α-primase with cellular replication protein A and SV40 T antigen

Dornreiter, I., Erdile, L. F., Gilbert, L. U., Von Winkler, D., Kelly, T. J. & Fanning, E., Jan 1 1992, In : EMBO Journal. 11, 2, p. 769-776 8 p.

Research output: Contribution to journalArticle