1991 …2020

Research output per year

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Research Output

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Review article
2020

Key read across framework components and biology based improvements

Ball, N., Madden, J., Paini, A., Mathea, M., Palmer, A. D., Sperber, S., Hartung, T. & van Ravenzwaay, B., May 2020, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 853, 503172.

Research output: Contribution to journalReview article

Toxicity testing in the 21st century: progress in the past decade and future perspectives

Krewski, D., Andersen, M. E., Tyshenko, M. G., Krishnan, K., Hartung, T., Boekelheide, K., Wambaugh, J. F., Jones, D., Whelan, M., Thomas, R., Yauk, C., Barton-Maclaren, T. & Cote, I., Jan 1 2020, In : Archives of Toxicology. 94, 1

Research output: Contribution to journalReview article

Open Access
2019

Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned with the Zebrafish Embryotoxicity Test

Stephens, M. L., Akgün-Ölmez, S. G., Hoffmann, S., De Vries, R., Flick, B., Hartung, T., Lalu, M., Maertens, A., Witters, H., Wright, R. & Tsaioun, K., Sep 1 2019, In : Toxicological Sciences. 171, 1, p. 56-68 13 p.

Research output: Contribution to journalReview article

Open Access
2018

A Perspective and a New Integrated Computational Strategy for Skin Sensitization Assessment

Alves, V. M., Capuzzi, S. J., Braga, R. C., Borba, J. V. B., Silva, A. C., Luechtefeld, T., Hartung, T., Andrade, C. H., Muratov, E. N. & Tropsha, A., Mar 5 2018, In : ACS Sustainable Chemistry and Engineering. 6, 3, p. 2845-2859 15 p.

Research output: Contribution to journalReview article

Perspectives on in vitro to in vivo extrapolations

Hartung, T., Dec 1 2018, In : Applied In Vitro Toxicology. 4, 4, p. 305-316 12 p.

Research output: Contribution to journalReview article

2017

From the exposome to mechanistic understanding of chemical-induced adverse effects

Escher, B. I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S. K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J. J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J. & 16 others, Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G. W., Müller, A., Phillips, D. H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y. M., Trump, S., Walter-Rohde, S. & Wambaugh, J. F., Feb 1 2017, In : Environment International. 99, p. 97-106 10 p.

Research output: Contribution to journalReview article

Systems Toxicology: Real World Applications and Opportunities

Hartung, T., FitzGerald, R. E., Jennings, P., Mirams, G. R., Peitsch, M. C., Rostami-Hodjegan, A., Shah, I., Wilks, M. F. & Sturla, S. J., Apr 17 2017, In : Chemical research in toxicology. 30, 4, p. 870-882 13 p.

Research output: Contribution to journalReview article

2016

Arsenic Exposure and Immunotoxicity: a Review Including the Possible Influence of Age and Sex

Ferrario, D., Gribaldo, L. & Hartung, T., Mar 1 2016, In : Current environmental health reports. 3, 1, p. 1-12 12 p.

Research output: Contribution to journalReview article

2015

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

Bal-Price, A., Crofton, K. M., Leist, M., Allen, S., Arand, M., Buetler, T., Delrue, N., FitzGerald, R. E., Hartung, T., Heinonen, T., Hogberg, H., Bennekou, S. H., Lichtensteiger, W., Oggier, D., Paparella, M., Axelstad, M., Piersma, A., Rached, E., Schilter, B., Schmuck, G. & 7 others, Stoppini, L., Tongiorgi, E., Tiramani, M., Monnet-Tschudi, F., Wilks, M. F., Ylikomi, T. & Fritsche, E., Jan 1 2015, In : Archives of Toxicology. 89, 2, p. 269-287 19 p.

Research output: Contribution to journalReview article

The human whole blood pyrogen test - Lessons learned in twenty years

Hartung, T., Jan 1 2015, In : ALTEX. 32, 2, p. 79-100 22 p.

Research output: Contribution to journalReview article

2014

Food for thought... Developmental neurotoxicity - Challenges in the 21st century and in vitro opportunities

Smirnova, L., Hogberg, H. T., Leist, M. & Hartung, T., 2014, In : ALTEX. 31, 2, p. 129-156 28 p.

Research output: Contribution to journalReview article

Workshop report: Developing microphysiological systems for use as regulatory tools

Andersen, M. E., Betts, K., Dragan, Y., Fitzpatrick, S., Goodman, J. L., Hartung, T., Himmelfarb, J., Ingber, D. E., Jacobs, A., Kavlock, R., Kolaja, K., Stevens, J. L., Tagle, D., Taylor, D. L. & Throckmorton, D., Jan 1 2014, In : ALTEX. 31

Research output: Contribution to journalReview article

2013

Inflammatory findings on species extrapolations: Humans are definitely no 70-kg mice

Leist, M. & Hartung, T., Apr 1 2013, In : Archives of Toxicology. 87, 4, p. 563-567 5 p.

Research output: Contribution to journalReview article

Reprint: Inflammatory findings on species extrapolations: Humans are definitely no 70-kg mice1

Leist, M. & Hartung, T., 2013, In : ALTEX. 30, 2, p. 227-230 4 p.

Research output: Contribution to journalReview article

Open Access

Review: Toxicometabolomics

Bouhifd, M., Hartung, T., Hogberg, H. T., Kleensang, A. & Zhao, L., Dec 1 2013, In : Journal of Applied Toxicology. 33, 12, p. 1365-1383 19 p.

Research output: Contribution to journalReview article

T4 Report: A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems

Daneshian, M., Botana, L. M., Bottein, M. Y. D., Buckland, G., Campàs, M., Dennison, N., Dickey, R. W., Diogène, J., Fessard, V., Hartung, T., Humpage, A., Leist, M., Molgó, J., Quilliam, M. A., Rovida, C., Suarez-Isla, B. A., Tubaro, A., Wagner, K., Zoller, O. & Dietrich, D., Dec 1 2013, In : ALTEX. 30, 4, p. 487-545 59 p.

Research output: Contribution to journalReview article

Toward a 3D model of human brain development for studying gene/environment interactions

Hogberg, H. T., Bressler, J., Christian, K. M., Harris, G., Makri, G., O'Driscoll, C., Pamies, D., Smirnova, L., Wen, Z. & Hartung, T., Dec 20 2013, In : Stem Cell Research and Therapy. 4, SUPPL.1, S4.

Research output: Contribution to journalReview article

2012

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing

Basketter, D. A., Clewell, H., Kimber, I., Rossi, A., Blaauboer, B., Burrier, R., Daneshian, M., Eskes, C., Goldberg, A., Hasiwa, N., Hoffmann, S., Jaworska, J., Knudsen, T. B., Landsiedel, R., Leist, M., Locke, P., Maxwell, G., McKim, J., McVey, E. A., Ouédraogo, G. & 15 others, Patlewicz, G., Pelkonen, O., Roggen, E., Rovida, C., Ruhdel, I., Schwarz, M., Schepky, A., Schoeters, G., Skinner, N., Trentz, K., Turner, M., Vanparys, P., Yager, J., Zurlo, J. & Hartung, T., May 15 2012, In : ALTEX. 29, 1, p. 5-91 87 p.

Research output: Contribution to journalReview article

Food for thought... Alternative approaches for medical countermeasures to biological and chemical terrorism and warfare

Hartung, T. & Zurlo, J., 2012, In : ALTEX. 29, 3, p. 251-260 10 p.

Research output: Contribution to journalReview article

Open Access

Systems toxicology

Hartung, T., Van Vliet, E., Jaworska, J., Bonilla, L., Skinner, N. & Thomas, R., May 15 2012, In : ALTEX. 29, 2, p. 119-128 10 p.

Research output: Contribution to journalReview article

Validation and quality control of replacement alternatives - Current status and future challenges

Leist, M., Hasiwa, N., Daneshian, M. & Hartung, T., Jan 1 2012, In : Toxicology Research. 1, 1, p. 8-22 15 p.

Research output: Contribution to journalReview article

2011

Food for thought... on mapping the human toxome

Hartung, T. & McBride, M., Oct 11 2011, In : ALTEX. 28, 2, p. 83-93 11 p.

Research output: Contribution to journalReview article

From alternative methods to a new toxicology

Hartung, T., Apr 1 2011, In : European Journal of Pharmaceutics and Biopharmaceutics. 77, 3, p. 338-349 12 p.

Research output: Contribution to journalReview article

T4 report. An expert consortium review of the EC-commissioned report "Alternative (non-animal) methods for cosmetics testing: Current status and future prospects - 2010"

Hartung, T., Blaauboer, B. J., Bosgra, S., Carney, E., Coenen, J., Conolly, R. B., Corsini, E., Green, S., Faustman, E. M., Gaspari, A., Hayashi, M., Hayes, A. W., Hengstler, J. G., Knudsen, L. E., Knudsen, T. B., McKim, J. M., Pfaller, W. & Roggen, E. L., Oct 11 2011, In : ALTEX. 28, 3, p. 183-209 27 p.

Research output: Contribution to journalReview article

2010

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches

Scott, L., Eskes, C., Hoffmann, S., Adriaens, E., Alepée, N., Bufo, M., Clothier, R., Facchini, D., Faller, C., Guest, R., Harbell, J., Hartung, T., Kamp, H., Varlet, B. L., Meloni, M., McNamee, P., Osborne, R., Pape, W., Pfannenbecker, U., Prinsen, M. & 9 others, Seaman, C., Spielmann, H., Stokes, W., Trouba, K., Berghe, C. V. D., Goethem, F. V., Vassallo, M., Vinardell, P. & Zuang, V., Feb 1 2010, In : Toxicology in Vitro. 24, 1, p. 1-9 9 p.

Research output: Contribution to journalReview article

Evidence-Based Toxicology - The Toolbox of Validation for the 21 st Century?

Hartung, T., Dec 1 2010, In : ALTEX. 27, 4, p. 253-263 11 p.

Research output: Contribution to journalReview article

The evolution of validation: A commentary

Basketter, D. A., Kimber, I. & Hartung, T., Mar 1 2010, In : Cutaneous and Ocular Toxicology. 29, 1, p. 1-3 3 p.

Research output: Contribution to journalReview article

2009

Development validation and applications of the monocyte activation test for pyrogens based on human whole blood

Schindler, S., Von Aulock, S., Daneshian, M. & Hartung, T., Dec 1 2009, In : ALTEX. 26, 4, p. 265-277 13 p.

Research output: Contribution to journalReview article

Food for thought... on education in alternative methods in toxicology

Hartung, T., Blaauboer, B. & Leist, M., Dec 1 2009, In : ALTEX. 26, 4, p. 255-263 9 p.

Research output: Contribution to journalReview article

Food for thought... on evidence-based toxicology

Hartung, T., Dec 1 2009, In : ALTEX. 26, 2, p. 75-82 8 p.

Research output: Contribution to journalReview article

Food for thought... on in silico methods in toxicology

Hartung, T. & Hoffmann, S., 2009, In : ALTEX. 26, 3, p. 155-166 12 p.

Research output: Contribution to journalReview article

Open Access

Food for thought... on the economics of animal testing

Bottini, A. A. & Hartung, T., Dec 1 2009, In : ALTEX. 26, 1, p. 3-16 14 p.

Research output: Contribution to journalReview article

Per aspirin ad astra...

Hartung, T., Dec 1 2009, In : ATLA Alternatives to Laboratory Animals. 37, SUPPL. 2, p. 45-47 3 p.

Research output: Contribution to journalReview article

Toxicology for the twenty-first century

Hartung, T., Jul 9 2009, In : Nature. 460, 7252, p. 208-212 5 p.

Research output: Contribution to journalReview article

2008

Food for thought... on alternative methods for cosmetics safety testing

Hartung, T., Dec 1 2008, In : ALTEX. 25, 3, p. 147-162 16 p.

Research output: Contribution to journalReview article

The dawning of a new age of toxicology

Leist, M., Hartung, T. & Nicotera, P., Dec 1 2008, In : ALTEX. 25, 2, p. 103-114 12 p.

Research output: Contribution to journalReview article

Vor- und nachdenkliches... zur evolution der toxikologie und dem ausstieg aus tierversuchen

Translated title of the contribution: Food for Thought... on the evolution of toxicology and the phasing out of animal testingHartung, T. & Leist, M., Dec 1 2008, In : ALTEX. 25, 2, p. 91-102 12 p.

Research output: Contribution to journalReview article

Vor- und nachdenkliches... zur sicherheitsprüfung von nahrungsmitteln

Translated title of the contribution: Food for thought... on food safety testingHartung, T. & Koëter, H., Dec 1 2008, In : ALTEX. 25, 4, p. 259-265 7 p.

Research output: Contribution to journalReview article

Vor- und nachdenkliches... zu tierversuchen

Translated title of the contribution: Food for thought... on animal testsHartung, T., Dec 1 2008, In : ALTEX. 25, 1, p. 3-16 14 p.

Research output: Contribution to journalReview article

2007

ECVAM's approach to intellectual property rights in the validation of alternative methods

Linge, J. P. & Hartung, T., Aug 1 2007, In : ATLA Alternatives to Laboratory Animals. 35, 4, p. 441-446 6 p.

Research output: Contribution to journalReview article

Physiologically-based kinetic modelling (PBK modelling): Meeting the 3Rs agenda. The report and recommendations of ECVAM workshop 63

Bouvier D'Yvoire, M., Prieto, P., Blaauboer, B. J., Bois, F. Y., Boobis, A., Brochot, C., Coecke, S., Freidig, A., Gundert-Remy, U., Hartung, T., Jacobs, M. N., Lavé, T., Leahy, D. E., Lennernäs, H., Loizou, G. D., Meek, B., Pease, C., Rowland, M., Spendiff, M., Yang, J. & 1 others, Zeilmaker, M., Dec 1 2007, In : ATLA Alternatives to Laboratory Animals. 35, 6, p. 661-671 11 p.

Research output: Contribution to journalReview article

The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes

Bremer, S., Pellizzer, C., Hoffmann, S., Seidle, T. & Hartung, T., Oct 1 2007, In : Current pharmaceutical design. 13, 29, p. 3047-3058 12 p.

Research output: Contribution to journalReview article

Vor- und nachdenkliches... zur globalisierung von alternativmethoden

Translated title of the contribution: Food for thought... on globalisation of alternative methodsBottini, A. A., Amcoff, P. & Hartung, T., Dec 1 2007, In : ALTEX. 24, 4, p. 255-269 15 p.

Research output: Contribution to journalReview article

Vor- und nachdenkliches... zur zellkultur

Translated title of the contribution: Food for thought... on cell cultureHartung, T., Dec 1 2007, In : ALTEX. 24, 3, p. 143-152 10 p.

Research output: Contribution to journalReview article

2006

Invited review: MDP and other muropeptides - Direct and synergistic effects on the immune system

Traub, S., von Aulock, S., Hartung, T. & Hermann, C., Apr 1 2006, In : Journal of Endotoxin Research. 12, 2, p. 69-85 17 p.

Research output: Contribution to journalReview article

Protecting more than animals

Goldberg, A. M. & Hartung, T., Jan 2006, In : Scientific American. 294, 1, p. 84-91 8 p.

Research output: Contribution to journalReview article

Toward an evidence-based toxicology

Hoffmann, S. & Hartung, T., Sep 1 2006, In : Human and Experimental Toxicology. 25, 9, p. 497-513 17 p.

Research output: Contribution to journalReview article

2005

Developmental toxicity testing from animal towards embryonic stem cells

Pellizzer, C., Bremer, S. & Hartung, T., Jul 25 2005, In : ALTEX. 22, 2, p. 47-57 11 p.

Research output: Contribution to journalReview article