1991 …2020

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2002

Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.

Ellingsen, E., Morath, S., Flo, T., Schromm, A., Hartung, T., Thiemermann, C., Espevik, T., Golenbock, D., Foster, D., Solberg, R., Aasen, A. & Wang, J., May 2002, In : Medical science monitor : international medical journal of experimental and clinical research. 8, 5, p. BR149-156

Research output: Contribution to journalArticle

Inhibition of cyclooxygenase-2 by natriuretic peptides

Kiemer, A. K., Lehner, M. D., Hartung, T. & Vollmar, A. M., 2002, In : Endocrinology. 143, 3, p. 846-852 7 p.

Research output: Contribution to journalArticle

Open Access

Interaction of lipoteichoic acid and CpG-DNA during activation of innate immune cells

Dalpke, A. H., Frey, M., Morath, S., Hartung, T. & Heeg, K., Oct 2002, In : Immunobiology. 206, 4, p. 392-407 16 p.

Research output: Contribution to journalArticle

Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: Distinct alterations in IL-1 receptor-associated kinase

Jacinto, R., Hartung, T., McCall, C. & Li, L., Jun 15 2002, In : Journal of Immunology. 168, 12, p. 6136-6141 6 p.

Research output: Contribution to journalArticle

Open Access

Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection

Lehner, M. D., Schwoebel, F., Kotlyarov, A., Leist, M., Gaestel, M. & Hartung, T., May 1 2002, In : Journal of Immunology. 168, 9, p. 4667-4673 7 p.

Research output: Contribution to journalArticle

Open Access

Profound differences in leukocyte-endothelial cell responses to lipopolysaccharide versus lipoteichoic acid

Yipp, B. G., Andonegui, G., Howlett, C. J., Robbins, S. M., Hartung, T., Ho, M. & Kubes, P., May 1 2002, In : Journal of Immunology. 168, 9, p. 4650-4658 9 p.

Research output: Contribution to journalArticle

Open Access

Structural decomposition and heterogeneity of commercial lipoteichoic acid preparations

Morath, S., Geyer, A., Spreitzer, I., Hermann, C. & Hartung, T., Jan 31 2002, In : Infection and immunity. 70, 2, p. 938-944 7 p.

Research output: Contribution to journalArticle

Synthetic lipoteichoic acid from Staphylococcus aureus is a potent stimulus of cytokine release

Morath, S., Stadelmaier, A., Geyer, A., Schmidt, R. R. & Hartung, T., Jun 17 2002, In : Journal of Experimental Medicine. 195, 12, p. 1635-1640 6 p.

Research output: Contribution to journalArticle

Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide

Lorenz, E., Patel, D. D., Hartung, T. & Schwartz, D. A., Sep 2002, In : Infection and immunity. 70, 9, p. 4892-4896 5 p.

Research output: Contribution to journalArticle

2001

Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

Sommer, C., Lindenlaub, T., Teuteberg, P., Schäfers, M., Hartung, T. & Toyka, K. V., Sep 14 2001, In : Brain research. 913, 1, p. 86-89 4 p.

Research output: Contribution to journalArticle

Beispiel eines neuen Einsatzbereichs des humanen Vollbluttests: Entwicklung eines Messverfahrens zur Abschätzung der gesundheitlichen Gefährdung durch luftgetragene mikrobielle Verunreinigungen.

Translated title of the contribution: A new application for the human whole blood test: development of an assay to assess the health risk of air-borne microbial contaminationsFennrich, S., Zucker, B. & Hartung, T., 2001, In : ALTEX : Alternativen zu Tierexperimenten. 18, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

Characteristics of surfactant protein A and D binding to lipoteichoic acid and peptidoglycan, 2 major cell wall components of gram-positive bacteria

Van de Wetering, J. K., Van Eijk, M., Van Golde, L. M. G., Hartung, T., Van Strijp, J. A. G. & Batenburg, J. J., Nov 1 2001, In : Journal of Infectious Diseases. 184, 9, p. 1143-1151 9 p.

Research output: Contribution to journalArticle

Dissociation of LPS-induced monocytic ex vivo production of granulocyte colony-stimulating factor (G-CSF) and TNF-α in patients with septic shock

Weiss, M., Fischer, G., Barth, E., Boneberg, E., Schneider, E. M., Georgieff, M. & Hartung, T., Jan 7 2001, In : Cytokine. 13, 1, p. 51-54 4 p.

Research output: Contribution to journalArticle

Einfluss des Konservierungsmittels Thiomersal auf die Interleukin-1 Beta Ausschüttung humaner peripherer Blutzellen.

Translated title of the contribution: Effect of the preservative thiomersal on the release of interleukin-1 beta from human peripheral blood cellsFischer, M., Keller-Stanislawski, B., Schober-Bendixen, S., Schosser, R., Hacke, K., Hartung, T. & Montag, T., 2001, In : ALTEX : Alternativen zu Tierexperimenten. 18, 1, p. 47-49 3 p.

Research output: Contribution to journalArticle

Good Cell Culture Practice (GCCP)--eine Initiative zur Standardisierung und Qualitätssicherung von in vitro Arbeiten. Die Etablierung einer ECVAM Task Force on GCCP.

Translated title of the contribution: Good cell culture practice (GCCP)--an initiative for standardization and quality control of in vitro studies. The establishment of an ECVAM Task Force on GCCPHartung, T., Gstraunthaler, G., Coecke, S., Lewis, D., Blanck, O. & Balls, M., 2001, In : ALTEX : Alternativen zu Tierexperimenten. 18, 1, p. 75-78 4 p.

Research output: Contribution to journalArticle

Immune protection against septic peritonitis in endotoxin-primed mice is related to reduced neutrophil apoptosis

Feterowski, C., Weighardt, H., Emmanuilidis, K., Hartung, T. & Holzmann, B., May 3 2001, In : European Journal of Immunology. 31, 4, p. 1268-1277 10 p.

Research output: Contribution to journalArticle

Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response

Lehner, M. D., Ittner, J., Bundschuh, D. S., Van Rooijen, N., Wendel, A. & Hartung, T., 2001, In : Infection and immunity. 69, 1, p. 463-471 9 p.

Research output: Contribution to journalArticle

Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different toll-like receptors independent of paracrine mediators

Lehner, M. D., Morath, S., Michelsen, K. S., Schumann, R. R. & Hartung, T., Apr 15 2001, In : Journal of Immunology. 166, 8, p. 5161-5167 7 p.

Research output: Contribution to journalArticle

Open Access

Induction of the chemokines IL-8 and MCP-1 in human whole blood by a cell-lysate of human fibroblast cells

Schneider, M. & Hartung, T., Jan 1 2001, In : Immunology Letters. 75, 2, p. 163-165 3 p.

Research output: Contribution to journalArticle

Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts

Pfeiffer, A., Bttcher, A., Ors, E., Kapinsky, M., Nagy, P., Bodnr, A., Spreitzer, I., Liebisch, G., Drobnik, W., Gempel, K., Horn, M., Holmer, S., Hartung, T., Multhoff, G., Schtz, G., Schindler, H., Ulmer, A. J., Heine, H., Stelter, F., Schtt, C. & 4 others, Rothe, G., Szlli, J., Damjanovich, S. & Schmitz, G., 2001, In : European Journal of Immunology. 31, 11, p. 3153-3164 12 p.

Research output: Contribution to journalArticle

Modulation of cytokine release in ex vivo-stimulated blood from borreliosis patients

Diterich, I., Härter, L., Hassler, D., Wendel, A. & Hartung, T., 2001, In : Infection and immunity. 69, 2, p. 687-694 8 p.

Research output: Contribution to journalArticle

Novel advanced in vitro methods for long-term toxicity testing

Pfaller, W., Balls, M., Clothier, R., Coecke, S., Dierickx, P., Ekwall, B., Hanley, B. A., Hartung, T., Prieto, P., Ryan, M. P., Schmuck, G., Šladowski, D., Vericat, J. A., Wendel, A., Wolf, A. & Zimmer, J., Sep 21 2001, In : ATLA Alternatives to Laboratory Animals. 29, 4, p. 393-426 34 p.

Research output: Contribution to journalArticle

Novel pyrogen tests based on the human fever reaction

Hartung, T., Aaberge, I., Berthold, S., Carlin, G., Charton, E., Coecke, S., Fennrich, S., Fischer, M., Gommer, M., Halder, M., Haslov, K., Jahnke, M., Montag-Lessing, T., Poole, S., Schechtman, L., Wendel, A. & Werner-Felmayer, G., Jan 1 2001, In : ATLA Alternatives to Laboratory Animals. 29, 2, p. 99-123 25 p.

Research output: Contribution to journalArticle

Schwann cell apoptosis in experimental autoimmune neuritis of the Lewis rat and the functional role of tumor necrosis factor-α

Weishaupt, A., Brück, W., Hartung, T., Toyka, K. V. & Gold, R., Jun 22 2001, In : Neuroscience Letters. 306, 1-2, p. 77-80 4 p.

Research output: Contribution to journalArticle

Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus

Morath, S., Geyer, A. & Hartung, T., Feb 5 2001, In : Journal of Experimental Medicine. 193, 3, p. 393-397 5 p.

Research output: Contribution to journalArticle

The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCs): Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2

Michelsen, K. S., Aicher, A., Mohaupt, M., Hartung, T., Dimmeler, S., Kirschning, C. J. & Schumann, R. R., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 25680-25686 7 p.

Research output: Contribution to journalArticle

The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects

Coecke, S., Bogni, A., Langezaal, I., Worth, A., Hartung, T. & Monshouwer, M., Oct 4 2001, In : Toxicology in Vitro. 15, 4-5, p. 553-556 4 p.

Research output: Contribution to journalArticle

Three Rs potential in the development and quality control of pharmaceuticals.

Hartung, T., 2001, In : ALTEX : Alternativen zu Tierexperimenten. 18 Suppl 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Toll-like Receptor-2 Mediates Treponema Glycolipid and Lipoteichoic Acid-induced NF-κB Translocation

Opitz, B., Schröder, N. W. J., Spreitzer, I., Michelsen, K. S., Kirschning, C. J., Hallatschek, W., Zähringer, U., Hartung, T., Göbel, U. B. & Schumann, R. R., Jun 22 2001, In : Journal of Biological Chemistry. 276, 25, p. 22041-22047 7 p.

Research output: Contribution to journalArticle

Whole blood cytokine response as a measure of immunotoxicity

Langezaal, I., Coecke, S. & Hartung, T., Oct 3 2001, In : Toxicology in Vitro. 15, 4-5, p. 313-318 6 p.

Research output: Contribution to journalArticle

2000

A new mechanism for IL-5-dependent helminth control: Neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5

Al-Qaoud, K. M., Pearlman, E., Hartung, T., Klukowski, J., Fleischer, B. & Hoerauf, A., Jan 1 2000, In : International Immunology. 12, 6, p. 899-908 10 p.

Research output: Contribution to journalArticle

Open Access

Binding of surfactant protein D to lipoteichoic acid

Van De Watering, J. K., Van Eijk, M., Spreitzer, I., Härtung, T., Van Golde, L. M. G. & Batenburg, J. J., Dec 1 2000, In : Applied Cardiopulmonary Pathophysiology. 9, 3, 1 p.

Research output: Contribution to journalArticle

Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients

Hartung, T., Von Aulock, S., Freitag, M., Höxtermann, S., Stücker, M., Hoffmann, K., Altmeyer, P., Kottke, A. & Wendel, A., Jan 1 2000, In : Cytokine. 12, 10, p. 1570-1574 5 p.

Research output: Contribution to journalArticle

cGMP-mediated inhibition of TNF-α production by the atrial natriuretic peptide in murine macrophages

Kiemer, A. K., Hartung, T. & Vollmar, A. M., Jul 1 2000, In : Journal of Immunology. 165, 1, p. 175-181 7 p.

Research output: Contribution to journalArticle

Open Access

Chip, Chip, Hurra! Die Amerikaner feiern den Gen-Chip--feiern wir mit?

Translated title of the contribution: Hip, hip, hurrah! Americans celebrate Gen-Chip--are we celebrating too?Hartung, T., 2000, In : ALTEX : Alternativen zu Tierexperimenten. 17, 2, p. 101-102 2 p.

Research output: Contribution to journalArticle

Effects of neutralizing antibodies to TNF-alpha on pain-related behavior and nerve regeneration in mice with chronic constriction injury

Lindenlaub, T., Teuteberg, P., Hartung, T. & Sommer, C., Jun 2 2000, In : Brain research. 866, 1-2, p. 15-22 8 p.

Research output: Contribution to journalArticle

Human monocytes express functional receptors for granulocyte colony- stimulating factor that mediate suppression of monokines and interferon-γ

Boneberg, E. M., Hareng, L., Gantner, F., Wendel, A. & Hartung, T., Jan 1 2000, In : Blood. 95, 1, p. 270-276 7 p.

Research output: Contribution to journalArticle

Inflammatory and immunological parameters in children with haemolytic uremic syndrome (HUS) and gastroenteritis - Pathophysiological and diagnostic clues

Westerholt, S., Hartung, T., Tollens, M., Güstrau, A., Oberhoffer, M., Karch, H., Klare, B., Pfeffer, K., Emmrich, P. & Oberhoffer, R., Jun 2000, In : Cytokine. 12, 6, p. 822-827 6 p.

Research output: Contribution to journalArticle

Role of TNF-α in high-dose antigen therapy in experimental autoimmune neuritis: Inhibition of TNF-α by neutralizing antibodies reduces T-cell apoptosis and prevents liver necrosis

Weishaupt, A., Gold, R., Hartung, T., Gaupp, S., Wendel, A., Brück, W. & Toyka, K. V., May 2000, In : Journal of neuropathology and experimental neurology. 59, 5, p. 368-376 9 p.

Research output: Contribution to journalArticle

Open Access
1999

Detection of endotoxins and other pyrogens using human whole blood.

Fennrich, S., Fischer, M., Hartung, T., Lexa, P., Montag-Lessing, T., Sonntag, H. G., Weigandt, M. & Wendel, A., 1999, In : Developments in biological standardization. 101, p. 131-139 9 p.

Research output: Contribution to journalArticle

Effect of filgrastim treatment on inflammatory cytokines and lymphocyte functions

Hartung, T., Doecke, W. D., Bundschuh, D., Foote, M. A., Gantner, F., Hermann, C., Lenz, A., Milwee, S., Rich, B., Simon, B., Volk, H. D., Von Aulock, S. & Wendel, A., Nov 1 1999, In : Clinical pharmacology and therapeutics. 66, 4, p. 415-424 10 p.

Research output: Contribution to journalArticle

Granulocyte colony-stimulating factor: Its potential role in infectious disease

Hartung, T., Dec 21 1999, In : AIDS, Supplement. 13, 2, p. S3-S9

Research output: Contribution to journalArticle

Granulocyte colony-stimulating factor inhibits neutrophil apoptois at the local site after severe head and thoracic injury

Ertel, W., Keel, M., Buergi, U., Hartung, T., Imhof, H. G. & Trentz, O., May 1 1999, In : Journal of Trauma - Injury, Infection and Critical Care. 46, 5, p. 784-793 10 p.

Research output: Contribution to journalArticle

Outcome prediction by traditional and new markers of inflammation in patients with sepsis

Oberhoffer, M., Vogelsang, H., Rußwurm, S., Hartung, T. & Reinhart, K., May 17 1999, In : Clinical Chemistry and Laboratory Medicine. 37, 3, p. 363-368 6 p.

Research output: Contribution to journalArticle

Structures in Bacillus subtilis are recognized by CD14 in a lipopolysaccharide binding protein-dependent reaction

Fan, X., Stelter, F., Menzel, R., Jack, R., Spreitzer, I., Hartung, T. & Schütt, C., Jun 1 1999, In : Infection and immunity. 67, 6, p. 2964-2968 5 p.

Research output: Contribution to journalArticle

Temporal sequence of pulmonary and systemic inflammatory responses to graded polymicrobial peritonitis in mice

Stamme, C., Bundschuh, D. S., Hartung, T., Gebert, U., Wollin, L., Nüsing, R., Wendel, A. & Uhlig, S., Nov 1999, In : Infection and immunity. 67, 11, p. 5642-5650 9 p.

Research output: Contribution to journalArticle

Open Access
1998

Different efficacy of soluble CD14 treatment in high- and low-dose LPS models

Stelter, F., Witt, S., Fürll, B., Jack, R. S., Hartung, T. & Schütt, C., Apr 27 1998, In : European Journal of Clinical Investigation. 28, 3, p. 205-213 9 p.

Research output: Contribution to journalArticle

Filgrastim restores interleukin-2 production in blood from patients with advanced human immunodeficiency virus infection

Hartung, T., Pitrak, D. L., Foote, M., Shatzen, E. M., Verral, S. C. & Wendel, A., Jan 1 1998, In : Journal of Infectious Diseases. 178, 3, p. 686-692 7 p.

Research output: Contribution to journalArticle

Open Access

G-CSF and GM-CSF in the treatment of sepsis and inflammation

Wendel, A., Hartung, T. & Bundschuh, D. S., Jan 1 1998, In : Clinical Chemistry and Laboratory Medicine. 36, 4, p. A32

Research output: Contribution to journalArticle