1991 …2020

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2004

Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing part 2: Toxicological evaluation

Jennings, P., Koppelstaetter, C., Pfaller, W., Morin, J. P., Hartung, T. & Ryan, M. P., Aug 6 2004, In : ALTEX. 21, 2, p. 61-66 6 p.

Research output: Contribution to journalArticle

Comparison of the sensitivity of different toxicological endpoints in Caco-2 cells after cadmium chloride treatment

Boveri, M., Pazos, P., Gennari, A., Casado, J., Hartung, T. & Prieto, P., Apr 1 2004, In : Archives of Toxicology. 78, 4, p. 201-206 6 p.

Research output: Contribution to journalArticle

Cryopreservation of human whole blood for pyrogenicity testing

Schindler, S., Asmus, S., Von Aulock, S., Wendel, A., Hartung, T. & Fennrich, S., Nov 1 2004, In : Journal of Immunological Methods. 294, 1-2, p. 89-100 12 p.

Research output: Contribution to journalArticle

Detection of tissue-specific effects by methotrexate on differentiating mouse embryonic stem cells

Pellizzer, C., Bello, E., Adler, S., Hartung, T. & Bremer, S., Oct 1 2004, In : Birth Defects Research Part B - Developmental and Reproductive Toxicology. 71, 5, p. 331-341 11 p.

Research output: Contribution to journalArticle

G-CSF: Boosting endogenous production - A new strategy?

von Aulock, S., Diterich, I., Hareng, L. & Hartung, T., Nov 1 2004, In : Current Opinion in Investigational Drugs. 5, 11, p. 1148-1152 5 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor (Filgrastim) Treatment Primes for Increased ex Vivo Inducible Prostanoid Release

Von Aulock, S., Boneberg, E. M., Diterich, I. & Hartung, T., Feb 2004, In : Journal of Pharmacology and Experimental Therapeutics. 308, 2, p. 754-759 6 p.

Research output: Contribution to journalArticle

Heterozygous Toll-Like Receptor 2 Polymorphism Does Not Affect Lipoteichoic Acid-Induced Chemokine and Inflammatory Responses

Von Aulock, S., Schröder, N. W. J., Traub, S., Gueinzius, K., Lorenz, E., Hartung, T., Schumann, R. R. & Hermann, C., Mar 2004, In : Infection and immunity. 72, 3, p. 1828-1831 4 p.

Research output: Contribution to journalArticle

Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2

Lotz, S., Aga, E., Wilde, I., Van Zandbergen, G., Hartung, T., Solbach, W. & Laskay, T., Mar 1 2004, In : Journal of Leukocyte Biology. 75, 3, p. 467-477 11 p.

Research output: Contribution to journalArticle

Innate immunity in Arabidopsis thaliana: Lipopolysaccharides activate nitric oxide synthase (NOS) and induce defense genes

Zeidler, D., Zähringer, U., Gerber, I., Dubery, I., Hartung, T., Bors, W., Hutzler, P. & Durner, J., Nov 2 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 44, p. 15811-15816 6 p.

Research output: Contribution to journalArticle

Lateral diffusion of Toll-like receptors reveals that they are transiently confined within lipid rafts on the plasma membrane

Triantafilou, M., Morath, S., Mackie, A., Hartung, T. & Triantafilou, K., Aug 1 2004, In : Journal of cell science. 117, 17, p. 4007-4014 8 p.

Research output: Contribution to journalArticle

L-Ficolin Specifically Binds to Lipoteichoic Acid, a Cell Wall Constituent of Gram-Positive Bacteria, and Activates the Lectin Pathway of Complement

Lynch, N. J., Roscher, S., Hartung, T., Morath, S., Matsushita, M., Maennel, D. N., Kuraya, M., Fujita, T. & Schwaeble, W. J., Jan 15 2004, In : Journal of Immunology. 172, 2, p. 1198-1202 5 p.

Research output: Contribution to journalArticle

Open Access

Lipoteichoic acid and Toll-like receptor 2 internalization and targeting to the Golgi are lipid raft-dependent

Trianiafilou, M., Manukyan, M., Mackie, A., Morath, S., Hartung, T., Heine, H. & Triantafilou, K., Sep 24 2004, In : Journal of Biological Chemistry. 279, 39, p. 40882-40889 8 p.

Research output: Contribution to journalArticle

Monitoring of teratogenic effects in vitro by analysing a selected gene expression pattern

Pellizzer, C., Adler, S., Corvi, R., Hartung, T. & Bremer, S., Jun 1 2004, In : Toxicology in Vitro. 18, 3, p. 325-335 11 p.

Research output: Contribution to journalArticle

Perioperative Recombinant Human Granulocyte Colony-Stimulating Factor (Filgrastim) Treatment Prevents Immunoinflammatory Dysfunction Associated with Major Surgery

Schneider, C., Von Aulock, S., Zedler, S., Schinkel, C., Hartung, T. & Faist, E., Jan 1 2004, In : Annals of surgery. 239, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

Strategies to replace in vivo acute systemic toxicity testing: The report and recommendations of ECVAM workshop 50

Gennari, A., Van Den Berghe, C., Casati, S., Castell, J., Clemedson, C., Coecke, S., Colombo, A., Curren, R., Dal Negro, G., Goldberg, A., Gosmore, C., Hartung, T., Langezaal, I., Lessigiarska, I., Maas, W., Mangelsdorf, I., Parchment, R., Prieto, P., Sintes, J. R., Ryan, M. & 5 others, Schmuck, G., Stitzel, K., Stokes, W., Vericat, J. A. & Gribaldo, L., Oct 1 2004, In : ATLA Alternatives to Laboratory Animals. 32, 4, p. 437-459 23 p.

Research output: Contribution to journalArticle

Structural Requirements of Synthetic Muropeptides to Synergime with Lipopolysaceharide in Cytokine Induction

Traub, S., Kubasch, N., Morath, S., Kresse, M., Hartung, T., Schmidt, R. R. & Hermann, C., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 8694-8700 7 p.

Research output: Contribution to journalArticle

The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10

Dahle, M. K., Øverland, G., Myhre, A. E., Stuestøl, J. F., Hartung, T., Krohn, C. D., Mathiesen, Ø., Wang, J. E. & Aasen, A. O., Oct 1 2004, In : Infection and immunity. 72, 10, p. 5704-5711 8 p.

Research output: Contribution to journalArticle

The role of the european centre for the validation of alternative methods (ECVAM) in the validation of (Q)SARs

Worth, A. P., Hartung, T. & Van Leeuwen, C. J., Oct 1 2004, In : SAR and QSAR in Environmental Research. 15, 5-6, p. 345-358 14 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells

Netea, M. G., Sutmuller, R., Hermann, C., Van Der Graaf, C. A. A., Van Der Meer, J. W. M., Van Krieken, J. H., Hartung, T., Adema, G. & Kullberg, B. J., Mar 15 2004, In : Journal of Immunology. 172, 6, p. 3712-3718 7 p.

Research output: Contribution to journalArticle

Open Access
2003

A model of human whole blood lymphokine release for in vitro and ex vivo use

Hermann, C., Von Aulock, S., Graf, K. & Hartung, T., Apr 1 2003, In : Journal of Immunological Methods. 275, 1-2, p. 69-79 11 p.

Research output: Contribution to journalArticle

ANP inhibits TNF-α-induced endothelial MCP-1 expression involvement of p38 MAPK and MKP-1

Weber, N. C., Blumenthal, S. B., Hartung, T., Vollmar, A. M. & Kiemer, A. K., Nov 1 2003, In : Journal of Leukocyte Biology. 74, 5, p. 932-941 10 p.

Research output: Contribution to journalArticle

Anti-tumor necrosis factor antibody impairs the therapeutic effect of ceftriaxone in murine pneumococcal pneumonia

Rijneveld, A. W., Florquin, S., Hartung, T., Speelman, P. & Van Der Poll, T., Jul 15 2003, In : Journal of Infectious Diseases. 188, 2, p. 282-285 4 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi-induced tolerance as a model of persistence via immunosuppression

Diterich, I., Rauter, C., Kirschning, C. J. & Hartung, T., Jul 1 2003, In : Infection and immunity. 71, 7, p. 3979-3987 9 p.

Research output: Contribution to journalArticle

Characterization of the Cytokine Immune Response in Children Who Have Experienced an Episode of Typical Hemolytic-Uremic Syndrome

Westerholt, S., Pieper, A. K., Griebel, M., Volk, H. D., Hartung, T. & Oberhoffer, R., Nov 1 2003, In : Clinical and Diagnostic Laboratory Immunology. 10, 6, p. 1090-1095 6 p.

Research output: Contribution to journalArticle

Comparison of the reactivity of human and rabbit blood towards pyrogenic stimuli.

Schindler, S., Bristow, A., Cartmell, T., Hartung, T. & Fennrich, S., 2003, In : ALTEX : Alternativen zu Tierexperimenten. 20, 2, p. 59-63 5 p.

Research output: Contribution to journalArticle

Definition of structural prerequisites for lipoteichoic acid-inducible cytokine induction by synthetic derivatives

Deininger, S., Stadelmaier, A., Von Aulock, S., Morath, S., Schmidt, R. R. & Hartung, T., Apr 15 2003, In : Journal of Immunology. 170, 8, p. 4134-4138 5 p.

Research output: Contribution to journalArticle

Open Access

Determination of the eicosanoid response to inflammatory stimuli in whole blood and its pharmacological modulation ex vivo

Von Aulock, S., Hermann, C. & Hartung, T., Jun 1 2003, In : Journal of Immunological Methods. 277, 1-2, p. 53-63 11 p.

Research output: Contribution to journalArticle

EU: Dritter Report der EU zu Versuchstierzahlen liegt vor.

Translated title of the contribution: EU: third report of the EU research animal numbers presentedCasati, S. & Hartung, T., 2003, In : ALTEX : Alternativen zu Tierexperimenten. 20, 2, 1 p.

Research output: Contribution to journalArticle

Open Access

Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-κB activity

Keiss, H. P., Dirsch, V. M., Hartung, T., Haffner, T., Trueman, L., Auger, J., Kahane, R. & Vollmar, A. M., Jul 1 2003, In : Journal of Nutrition. 133, 7, p. 2171-2175 5 p.

Research output: Contribution to journalArticle

Open Access

Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood

Von Aulock, S., Schröder, N. W. J., Gueinzius, K., Traub, S., Hoffmann, S., Graf, K., Dimmeler, S., Hartung, T., Schumann, R. R. & Hermann, C., Sep 15 2003, In : Journal of Infectious Diseases. 188, 6, p. 938-943 6 p.

Research output: Contribution to journalArticle

High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR

Schröder, N. W. J., Hermann, C., Hamann, L., Göbel, U. B., Hartung, T. & Schumann, R. R., Jun 1 2003, In : Journal of Molecular Medicine. 81, 6, p. 368-372 5 p.

Research output: Contribution to journalArticle

Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons

Vreugdenhil, A. C. E., Rousseau, C. H., Hartung, T., Greve, J. W. M., Van 't Veer, C. & Buurman, W. A., Feb 1 2003, In : Journal of Immunology. 170, 3, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

Open Access

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

Schröder, N. W. J., Morath, S., Alexander, C., Hamann, L., Hartung, T., Zähringer, U., Göbel, U. B., Weber, J. R. & Schumann, R. R., May 2 2003, In : Journal of Biological Chemistry. 278, 18, p. 15587-15594 8 p.

Research output: Contribution to journalArticle

Lipoteichoic acid from Staphylococcus aureus is a potent stimulus for neutrophil recruitment

von Aulock, S., Morath, S., Hareng, L., Knapp, S., van Kessel, K. P. M., van Strijp, J. A. G. & Hartung, T., 2003, In : Immunobiology. 208, 4, p. 413-422 10 p.

Research output: Contribution to journalArticle

Lipoteichoic acid is a potent inducer of cytokine production in rat and human Kupffer cells in vitro

Øverland, G., Morath, S., Yndestad, A., Hartung, T., Thiemermann, C., Foster, S. J., Smedsrød, B., Mathisen, Ø., Aukrust, P., Aasen, A. O. & Wang, J. E., Jan 1 2003, In : Surgical infections. 4, 2, p. 181-191 11 p.

Research output: Contribution to journalArticle

Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-κB pathway

Kiemer, A. K., Hartung, T., Huber, C. & Vollmar, A. M., Mar 1 2003, In : Journal of Hepatology. 38, 3, p. 289-297 9 p.

Research output: Contribution to journalArticle

Protection with antibody to tumor necrosis factor differs with similarly lethal Escherichia coli versus Staphylococcus aureus pneumonia in rats

Karzai, W., Cui, X., Mehlhorn, B., Straube, E., Hartung, T., Gerstenberger, E., Banks, S. M., Natanson, C., Reinhart, K. & Eichacker, P. Q., Jul 1 2003, In : Anesthesiology. 99, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Synthesis of the first fully active lipoteichoic acid

Stadelmaier, A., Morath, S., Hartung, T. & Schmidt, R. R., Feb 24 2003, In : Angewandte Chemie - International Edition. 42, 8, p. 916-920 5 p.

Research output: Contribution to journalArticle

2002

Comparison and validation of novel pyrogen tests based on the human fever reaction

Hartung, T., Poole, S., Montag-Lessing, T., Nibbeling, R., Werner-Felmayer, G., Jungi, T., Brügger, P., Coecke, S., Aaberge, I. & Berthold, S., Dec 2002, In : ATLA Alternatives to Laboratory Animals. 30, SUPPL. 2, p. 49-51 3 p.

Research output: Contribution to journalArticle

Comparison and validation of novel pyrogen tests based on the human fever reaction.

Schindler, S. & Hartung, T., 2002, In : Developments in biologicals. 111, p. 181-186 6 p.

Research output: Contribution to journalArticle

Comparison of eleven commercial tests for Chlamydia pneumoniae-specific immunoglobulin G in asymptomatic healthy individuals

Hermann, C., Graf, K., Groh, A., Straube, E. & Hartung, T., 2002, In : Journal of clinical microbiology. 40, 5, p. 1603-1609 7 p.

Research output: Contribution to journalArticle

Cytokine induction by purified lipoteichoic acids from various bacterial species - Role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-γ release

Hermann, C., Spreitzer, I., Schröder, N. W. J., Morath, S., Lehner, M. D., Fischer, W., Schütt, C., Schumann, R. R. & Hartung, T., 2002, In : European Journal of Immunology. 32, 2, p. 541-551 11 p.

Research output: Contribution to journalArticle

Distribution of clinically relevant Borrelia genospecies in ticks assessed by a novel, single-run, real-time PCR

Rauter, C., Oehme, R., Diterich, I., Engele, M. & Hartung, T., Jan 12 2002, In : Journal of clinical microbiology. 40, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

Evaluation and prevalidation of an immunotoxicity test based on human whole-blood cytokine release

Langezaal, I., Hoffmann, S., Hartung, T. & Coecke, S., Jan 1 2002, In : ATLA Alternatives to Laboratory Animals. 30, 6, p. 581-595 15 p.

Research output: Contribution to journalArticle

Good cell culture practice: ECVAM good cell culture practice task force report 1

Hartung, T., Balls, M., Bardouille, C., Blanck, O., Coecke, S., Gstraunthaler, G. & Lewis, D., 2002, In : ATLA Alternatives to Laboratory Animals. 30, 4, p. 407-414 8 p.

Research output: Contribution to journalArticle