1991 …2020

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2009

Assessment of pyrogenic contaminations with validated human whole-blood assay

Daneshian, M., Von Aulock, S. & Hartung, T., Nov 1 2009, In : Nature protocols. 4, 12, p. 1709-1721 13 p.

Research output: Contribution to journalArticle

A toxicology for the 21st century - Mapping the road ahead

Hartung, T., May 13 2009, In : Toxicological Sciences. 109, 1, p. 18-23 6 p.

Research output: Contribution to journalArticle

ECVAM's ongoing activities in the area of acute oral toxicity

Kinsner-Ovaskainen, A., Bulgheroni, A., Hartung, T. & Prieto, P., Dec 1 2009, In : Toxicology in Vitro. 23, 8, p. 1535-1540 6 p.

Research output: Contribution to journalArticle

Estimation of acute oral toxicity using the No Observed Adverse Effect Level (NOAEL) from the 28 day repeated dose toxicity studies in rats

Bulgheroni, A., Kinsner-Ovaskainen, A., Hoffmann, S., Hartung, T. & Prieto, P., Feb 1 2009, In : Regulatory Toxicology and Pharmacology. 53, 1, p. 16-19 4 p.

Research output: Contribution to journalArticle

Macroamphiphilic components of thermophilic actinomycetes: Identification of lipoteichoic acid in Thermobifida fusca

Rahman, O., Pfitzenmaier, M., Pester, O., Morath, S., Cummings, S. P., Hartung, T. & Sutcliffe, I. C., Jan 1 2009, In : Journal of bacteriology. 91, 1, p. 152-160 9 p.

Research output: Contribution to journalArticle

mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach

Hogberg, H. T., Kinsner-Ovaskainen, A., Coecke, S., Hartung, T. & Bal-Price, A. K., Aug 3 2009, In : Toxicological Sciences. 113, 1, p. 95-115 21 p., kfp175.

Research output: Contribution to journalArticle

Preface

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, p. 83-86 4 p.

Research output: Contribution to journalArticle

Proposal for a Brazilian centre on alternative test methods

Eskes, C., Sá-Rocha, V. D. M., Nunes, J., Presgrave, O., De Carvalho, D., Masson, P., Rivera, E., Coecke, S., Kreysa, J. & Hartung, T., 2009, In : ALTEX. 26, 4, p. 303-306 4 p.

Research output: Contribution to journalArticle

Open Access

"ToxRTool", a new tool to assess the reliability of toxicological data

Schneider, K., Schwarz, M., Burkholder, I., Kopp-Schneider, A., Edler, L., Kinsner-Ovaskainen, A., Hartung, T. & Hoffmann, S., Sep 10 2009, In : Toxicology Letters. 189, 2, p. 138-144 7 p.

Research output: Contribution to journalArticle

2008

A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine

van Vliet, E., Morath, S., Eskes, C., Linge, J., Rappsilber, J., Honegger, P., Hartung, T. & Coecke, S., Jan 1 2008, In : NeuroToxicology. 29, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Autophagy as an ultrastructural marker of heavy metal toxicity in human cord blood hematopoietic stem cells

Di Gioacchino, M., Petrarca, C., Perrone, A., Farina, M., Sabbioni, E., Hartung, T., Martino, S., Esposito, D. L., Lotti, L. V. & Mariani-Costantini, R., Mar 15 2008, In : Science of the Total Environment. 392, 1, p. 50-58 9 p.

Research output: Contribution to journalArticle

Barriers to validation

Ahr, H. J., Alepée, N., Breier, S., Brekelmans, C., Cotgreave, I., Gribaldo, L., Dal Negro, G., De Silva, O., Hartung, T., Lacerda, A., Leblanc, B., Lecerf, C., Linge, J. P., Louhimies, S., Manou, I., Maxwell, G., Müller, K. K., Pape, W., Redhead, K., Schröder, K. R. & 3 others, Sladowski, D., Van Der Jagt, K. & Vanparys, P., Sep 1 2008, In : ATLA Alternatives to Laboratory Animals. 36, 4, p. 459-464 6 p.

Research output: Contribution to journalArticle

Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36

Nilsen, N. J., Deininger, S., Nonstad, U., Skjeldal, F., Husebye, H., Rodionov, D., Von Aulock, S., Hartung, T., Lien, E., Bakke, O. & Espevik, T., Jul 1 2008, In : Journal of Leukocyte Biology. 84, 1, p. 280-291 12 p.

Research output: Contribution to journalArticle

Cytokine induction by Gram-positive bacteria

Draing, C., Sigel, S., Deininger, S., Traub, S., Munke, R., Mayer, C., Hareng, L., Hartung, T., von Aulock, S. & Hermann, C., May 14 2008, In : Immunobiology. 213, 3-4, p. 285-296 12 p.

Research output: Contribution to journalArticle

ECVAM retrospective validation of in vitro micronucleus test (MNT)

Corvi, R., Albertini, S., Hartung, T., Hoffmann, S., Maurici, D., Pfuhler, S., Van Benthem, J. & Vanparys, P., Jul 2008, In : Mutagenesis. 23, 4, p. 271-283 13 p.

Research output: Contribution to journalArticle

Emerging new toxicology: An opportunity for contract research

Goldberg, A. M. & Hartung, T., Dec 2008, In : European Pharmaceutical Contractor. 49, p. 42-46 5 p.

Research output: Contribution to journalArticle

Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components

Bucki, R., Byfield, F. J., Kulakowska, A., McCormick, M. E., Drozdowski, W., Namiot, Z., Hartung, T. & Janmey, P. A., Oct 1 2008, In : Journal of Immunology. 181, 7, p. 4936-4944 9 p.

Research output: Contribution to journalArticle

Open Access

First steps in establishing a developmental toxicity test method based on human embryonic stem cells

Adler, S., Pellizzer, C., Hareng, L., Hartung, T. & Bremer, S., Feb 1 2008, In : Toxicology in Vitro. 22, 1, p. 200-211 12 p.

Research output: Contribution to journalArticle

High sensitivity pyrogen testing in water and dialysis solutions

Daneshian, M., Wendel, A., Hartung, T. & von Aulock, S., Jul 20 2008, In : Journal of Immunological Methods. 336, 1, p. 64-70 7 p.

Research output: Contribution to journalArticle

Increased D-alanylation of lipoteichoic and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis

Kramer, N. E., Hasper, H. E., van den Bogaard, P. T. C., Morath, S., de Kruijff, B., Hartung, T., Smid, E. J., Breukink, E., Kok, J. & Kuipers, O. P., 2008, In : Microbiology. 154, 6, p. 1755-1762 8 p.

Research output: Contribution to journalArticle

Optimisation of the post-validation process: The report and recommendations of ECVAM workshop 67

Bottini, A. A., Alepee, N., Phillips, B., Gribaldo, L., De Silva, O., Hartung, T., Hendriksen, C., Kuil, J., Pazos, P., Rhein, C., Schiffelers, M. J., Stokes, W., Theobald, A., Vidal, J. M., Van De Sandt, H., Breier, S., Sintes, J. R. & Blaauboer, B., Jul 1 2008, In : ATLA Alternatives to Laboratory Animals. 36, 3, p. 353-366 14 p.

Research output: Contribution to journalArticle

Points of reference in the validation process

Hoffmann, S., Edler, L., Gardner, I., Gribaldo, L., Hartung, T., Klein, C., Liebsch, M., Sauerland, S., Schechtman, L., Stammati, A. & Nikolaidis, E., Jul 2008, In : ATLA Alternatives to Laboratory Animals. 36, 3, p. 343-352 10 p.

Research output: Contribution to journalArticle

Polypropylene glycol is a selective binding inhibitor for LTA and other structurally related TLR2 agonists

Draing, C., Traub, S., Deininger, S., Mang, P., Möller, H. M., Manso, M., Rossi, F., Morath, S., Hartung, T. & von Aulock, S., Mar 1 2008, In : European Journal of Immunology. 38, 3, p. 797-808 12 p.

Research output: Contribution to journalArticle

Presentation of lipoteichoic acid potentiates its inflammatory activity

Deininger, S., Traub, S., Aichele, D., Rupp, T., Baris, T., Möller, H. M., Hartung, T. & von Aulock, S., Jul 10 2008, In : Immunobiology. 213, 6, p. 519-529 11 p.

Research output: Contribution to journalArticle

Removal of immune-stimulatory components from surfaces by plasma discharges

Hasiwa, M., Kylián, O., Hartung, T. & Rossi, F., Apr 2008, In : Innate Immunity. 14, 2, p. 89-97 9 p.

Research output: Contribution to journalArticle

Thoughts on limitations of animal models

Hartung, T., Jul 1 2008, In : Parkinsonism and Related Disorders. 14, SUPPL.2, p. S81-S83

Research output: Contribution to journalArticle

Toward a new toxicology - evolution or revolution?

Hartung, T., Dec 1 2008, In : ATLA Alternatives to Laboratory Animals. 36, 6, p. 635-639 5 p.

Research output: Contribution to journalArticle

Toxicity testing in the 21st century: Better results, less use of animals

Cohen, B. C., Crofton, K. M., Hartung, T., Krewski, D., Locke, P. A. & Stephens, M. L., Mar 1 2008, Environmental Forum, 25, 2, p. 46-51 6 p.

Research output: Contribution to specialist publicationArticle

2007

An in vitro pyrogen safety test for immune-stimulating components on surfaces

Hasiwa, M., Kullmann, K., von Aulock, S., Klein, C. & Hartung, T., Mar 1 2007, In : Biomaterials. 28, 7, p. 1367-1375 9 p.

Research output: Contribution to journalArticle

Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages

Liljeroos, M., Vuolteenaho, R., Morath, S., Hartung, T., Hallman, M. & Ojaniemi, M., Mar 1 2007, In : Cellular Signalling. 19, 3, p. 625-633 9 p.

Research output: Contribution to journalArticle

cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4

Spiller, S., Dreher, S., Meng, G., Grabiec, A., Thomas, W., Hartung, T., Pfeffer, K., Hochrein, H., Brade, H., Bessler, W., Wagner, H. & Kirschning, C. J., May 4 2007, In : Journal of Biological Chemistry. 282, 18, p. 13190-13198 9 p.

Research output: Contribution to journalArticle

Chemical respiratory allergy: Opportunities for hazard identification and characterisation

Kimber, I., Agius, R., Basketter, D. A., Corsini, E., Cullinan, P., Dearman, R. J., Gimenez-Arnau, E., Greenwell, L., Hartung, T., Kuper, F., Maestrelli, P., Roggen, E., Rovida, C. & Casati, S., May 2007, In : ATLA Alternatives to Laboratory Animals. 35, 2, p. 243-265 23 p.

Research output: Contribution to journalArticle

Development of a mechanistically-based genetically engineered PC12 cell system to detect p53-mediated cytotoxicity

van Vliet, E., Eskes, C., Stingele, S., Gartlon, J., Price, A., Farina, M., Ponti, J., Hartung, T., Sabbioni, E. & Coecke, S., Jun 1 2007, In : Toxicology in Vitro. 21, 4, p. 698-705 8 p.

Research output: Contribution to journalArticle

Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects

van Vliet, E., Stoppini, L., Balestrino, M., Eskes, C., Griesinger, C., Sobanski, T., Whelan, M., Hartung, T. & Coecke, S., Nov 1 2007, In : NeuroToxicology. 28, 6, p. 1136-1146 11 p.

Research output: Contribution to journalArticle

Fever in the test tube--towards a human(e) pyrogen test.

Schindler, S., Fennrich, S., Crameri, R., Jungi, T. W., Montag, T. & Hartung, T., 2007, In : ALTEX : Alternativen zu Tierexperimenten. 24 Spec No, p. 60-62 3 p.

Research output: Contribution to journalArticle

First international forum toward evidence-based toxicology

Hoffmann, S., Griesinger, C., Coecke, S., Kinsner, A. & Hartung, T., Dec 1 2007, In : ALTEX. 24, 4, p. 354-355 2 p.

Research output: Contribution to journalArticle

In vitro pyrogen test - A new test method for solid medical devices

Mazzotti, F., Beuttler, J., Zeller, R., Fink, U., Schindler, S., Wendel, A., Harlung, T. & Von Aulock, S., Feb 1 2007, In : Journal of Biomedical Materials Research - Part A. 80, 2, p. 276-282 7 p.

Research output: Contribution to journalArticle

In vitro tests to evaluate immunotoxicity: A preliminary study

Carfi', M., Gennari, A., Malerba, I., Corsini, E., Pallardy, M., Pieters, R., Van Loveren, H., Vohr, H. W., Hartung, T. & Gribaldo, L., Jan 5 2007, In : Toxicology. 229, 1-2, p. 11-22 12 p.

Research output: Contribution to journalArticle

Lipoteichoic acid from Lactobacillus plantarum elicits both the production of interleukin-23p19 and suppression of pathogen-mediated interleukin-10 in THP-1 cells

Kim, H. G., Gim, M. G., Kim, J. Y., Jin Hwang, H., Ham, M. S., Lee, J. M., Hartung, T., Park, J. W., Han, S. H. & Chung, D. K., Mar 1 2007, In : FEMS Immunology and Medical Microbiology. 49, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

Molecular interaction between lipoteichoic acids and Lactobacillus delbrueckii phages depends on D-alanyl and α-glucose substitution of poly(glycerophosphate) backbones

Räisänen, L., Draing, C., Pfitzenmaier, M., Schubert, K., Jaakonsaari, T., Von Aulock, S., Hartung, T. & Alatossava, T., Jun 1 2007, In : Journal of bacteriology. 189, 11, p. 4135-4140 6 p.

Research output: Contribution to journalArticle

Perioperative prophylaxis with granulocyte colony-stimulating factor (G-CSF) in high-risk colorectal cancer patients for an improved recovery: A randomized, controlled trial

Bauhofer, A., Plaul, U., Torossian, A., Koller, M., Stinner, B., Celik, I., Sitter, H., Greger, B., Middeke, M., Schein, M., Wyatt, J., Nyström, P. O., Hartung, T., Rothmund, M. & Lorenz, W., Apr 1 2007, In : Surgery. 141, 4, p. 501-510 10 p.

Research output: Contribution to journalArticle

Skin sensitisation and epidermal disposition: The relevance of epidermal disposition for sensitisation hazard identification and risk assessment: The report and recommendations of ECVAM workshop 59a

Basketter, D., Pease, C., Kasting, G., Kimber, I., Casati, S., Cronin, M., Diembeck, W., Gerberick, F., Hadgraft, J., Hartung, T., Marty, J. P., Nikolaidis, E., Patlewicz, G., Roberts, D., Roggen, E., Rovida, C. & Van De Sandt, J., Mar 2007, In : ATLA Alternatives to Laboratory Animals. 35, 1, p. 137-154 18 p.

Research output: Contribution to journalArticle

The inhibition of TNF-α anti-tumoral properties by blocking antibodies promotes tumor growth in a rat model

Larmonier, N., Cathelin, D., Larmonier, C., Nicolas, A., Merino, D., Janikashvili, N., Audia, S., Bateman, A., Thompson, J., Kottke, T., Hartung, T., Katsanis, E., Vile, R. & Bonnotte, B., Jul 1 2007, In : Experimental cell research. 313, 11, p. 2345-2355 11 p.

Research output: Contribution to journalArticle

The usefulness of toxicogenomics for predicting acute skin irritation on in vitro reconstructed human epidermis

Borlon, C., Godard, P., Eskes, C., Hartung, T., Zuang, V. & Toussaint, O., Nov 30 2007, In : Toxicology. 241, 3, p. 157-166 10 p.

Research output: Contribution to journalArticle

Use of synthetic derivatives to determine the minimal active structure of cytokine-inducing lipoteichoic acid

Deininger, S., Figueroa-Perez, I., Sigel, S., Stadelmaier, A., Schmidt, R. R., Hartung, T. & Von Aulock, S., Dec 1 2007, In : Clinical and Vaccine Immunology. 14, 12, p. 1629-1633 5 p.

Research output: Contribution to journalArticle

Workgroup report: Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity into International Hazard and Risk Assessment Strategies

Coecke, S., Goldberg, A. M., Allen, S., Buzanska, L., Calamandrei, G., Crofton, K., Hareng, L., Hartung, T., Knaut, H., Honegger, P., Jacobs, M., Lein, P., Li, A., Mundy, W., Owen, D., Schneider, S., Silbergeld, E., Reum, T., Trnovec, T., Monnet-Tschudi, F. & 1 others, Bal-Price, A., Jun 2007, In : Environmental health perspectives. 115, 6, p. 924-931 8 p.

Research output: Contribution to journalArticle

2006

A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues

Stadelmaier, A., Figueroa-Perez, I., Deininger, S., von Aulock, S., Hartung, T. & Schmidt, R. R., Sep 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 18, p. 6239-6254 16 p.

Research output: Contribution to journalArticle