1991 …2020

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2014

Green toxicology

Maertens, A., Anastas, N., Spencer, P. J., Stephens, M., Goldberg, A. & Hartung, T., 2014, In : ALTEX. 31, 3, p. 243-249 7 p.

Research output: Contribution to journalArticle

Mapping the human toxome by systems toxicology

Bouhifd, M., Hogberg, H. T., Kleensang, A., Maertens, A., Zhao, L. & Hartung, T., Jul 2014, In : Basic and Clinical Pharmacology and Toxicology. 115, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

Read-across approaches - Misconceptions, promises and challenges ahead

Patlewicz, G., Ball, N., Becker, R. A., Booth, E. D., Cronin, M. T. D., Kroese, D., Steup, D., Van Ravenzwaay, B. & Hartung, T., Jan 1 2014, In : Archivos de Medicina Veterinaria. 46, 4, p. 387-396 10 p.

Research output: Contribution to journalArticle

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Alépée, N., Bahinski, A., Daneshian, M., De Wever, B., Fritsche, E., Goldberg, A., Hansmann, J., Hartung, T., Haycock, J., Hogberg, H. T., Hoelting, L., Kelm, J. M., Kadereit, S., McVey, E., Landsiedel, R., Leist, M., Lübberstedt, M., Noor, F., Pellevoisin, C., Petersohn, D. & 7 others, Pfannenbecker, U., Reisinger, K., Ramirez, T., Rothen-Rutishauser, B., Schäfer-Korting, M., Zeilinger, K. & Zurich, M. G., 2014, In : ALTEX. 31, 4, p. 441-477 37 p.

Research output: Contribution to journalArticle

Symposium report: Correlating in vitro data to in vivo findings for risk assessment

Bale, A. S., Kenyon, E., Flynn, T. J., Lipscomb, J. C., Mendrick, D. L., Hartung, T. & Patton, G. W., 2014, In : ALTEX. 31, 1, p. 79-90 12 p.

Research output: Contribution to journalArticle

t 4 workshop report: Lessons learned, challenges, and opportunities: The U.S. endocrine disruptor screening program

Juberg, D. R., Borghoff, S. J., Becker, R. A., Casey, W., Hartung, T., Holsapple, M. P., Marty, M. S., Mihaich, E. M., Van Der Kraak, G., Wade, M. G., Willett, C. E., Andersen, M. E., Borgert, C. J., Coady, K. K., Dourson, M. L., Fowle, J. R., Gray, L. E., Lamb, J. C., Ortego, L. S., Schug, T. T. & 6 others, Toole, C. M., Zorrilla, L. M., Kroner, O. L., Patterson, J., Rinckel, L. A. & Jones, B. R., 2014, In : ALTEX. 31, 1, p. 63-78 16 p.

Research output: Contribution to journalArticle

t 4 workshop report

Kleensang, A., Maertens, A., Rosenberg, M., Fitzpatrick, S., Lamb, J., Auerbach, S., Brennan, R., Crofton, K. M., Gordon, B., Fornace, A. J., Gaido, K., Gerhold, D., Haw, R., Henney, A., Ma'Ayan, A., McBride, M., Monti, S., Ochs, M. F., Pandey, A., Sharan, R. & 17 others, Stierum, R., Tugendreich, S., Willett, C., Wittwehr, C., Xia, J., Patton, G. W., Arvidson, K., Bouhifd, M., Hogberg, H. T., Luechtefeld, T., Smirnova, L., Zhao, L., Adeleye, Y., Kanehisa, M., Carmichael, P., Andersen, M. E. & Hartung, T., 2014, In : ALTEX. 31, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP +

Krug, A. K., Gutbier, S., Zhao, L., Pöltl, D., Kullmann, C., Ivanova, V., Förster, S., Jagtap, S., Meiser, J., Leparc, G., Schildknecht, S., Adam, M., Hiller, K., Farhan, H., Brunner, T., Hartung, T., Sachinidis, A. & Leist, M., May 2014, In : Cell Death and Disease. 5, 5, e1222.

Research output: Contribution to journalArticle

2013

A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment

Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M. T. D., Eggen, R. I. L., Embry, M., Ekman, D., Gourmelon, A. & 23 others, Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M. A., Lee, L., Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A. J., Navas, J. M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K. E., Walter-Rohde, S., Whale, G., Wheeler, J. R. & Winter, M. J., Dec 1 2013, In : Regulatory Toxicology and Pharmacology. 67, 3, p. 506-530 25 p.

Research output: Contribution to journalArticle

Eine wirklich humane Bestimmung von Endotoxinen und Nicht-Endotoxin- Pyrogenen

Translated title of the contribution: A truely human(e) determination of endotoxins and non-endotoxin pyrogensHartung, T., Hasiwa, N., Daneshian, M., Holtkamp, B., Schmitz, G. & Hossfeld, A., Jul 19 2013, In : Pharmazeutische Industrie. 75, 5, p. 825-834 10 p.

Research output: Contribution to journalArticle

Evidence-based toxicology for the 21st century: Opportunities and challenges

Stephens, M. L., Andersen, M., Becker, R. A., Betts, K., Boekelheide, K., Carney, E., Chapin, R., Devlin, D., Fitzpatrick, S., Fowle, J. R., Harlow, P., Hartung, T., Hoffmann, S., Holsapple, M., Jacobs, A., Judson, R., Naidenko, O., Pastoor, T., Patlewicz, G., Rowan, A. & 5 others, Scherer, R., Shaikh, R., Simon, T., Wolf, D. & Zurlo, J., May 13 2013, In : ALTEX. 30, 1, p. 74-103 30 p.

Research output: Contribution to journalArticle

Food for thought: Immunotoxicology: Challenges in the 21st century and in vitro opportunities

Hartung, T. & Corsini, E., Dec 1 2013, In : ALTEX. 30, 4, p. 411-426 16 p.

Research output: Contribution to journalArticle

Food for thought: Integrated testing strategies for safety assessments

Hartung, T., Luechtefeld, T., Maertens, A. & Kleensang, A., 2013, In : ALTEX. 30, 1, p. 3-18 16 p.

Research output: Contribution to journalArticle

Open Access

Food for thought; Look back in anger - What clinical studies tell us about preclinical work

Hartung, T., 2013, In : ALTEX. 30, 3, p. 275-291 17 p.

Research output: Contribution to journalArticle

Open Access

Food for thought Mechanistic validation

Hartung, T., Hoffmann, S. & Stephens, M., 2013, In : ALTEX. 30, 2, p. 119-130 12 p.

Research output: Contribution to journalArticle

Open Access

In vitro testicular toxicity models: Opportunities for advancement via biomedical engineering techniques

Saldutti, L. P., Beyer, B. K., Breslin, W., Brown, T. R., Chapin, R. E., Campion, S., Enright, B., Faustman, E., Foster, P. M. D., Hartung, T., Kelce, W., Kim, J. H., Loboa, E. G., Piersma, A. H., Seyler, D., Turner, K. J., Yu, H., Yu, X. & Sasaki, J. C., Sep 18 2013, In : ALTEX. 30, 3, p. 353-377 25 p.

Research output: Contribution to journalArticle

Metabolomics Reveals Metabolic Alterations by Intrauterine Growth Restriction in the Fetal Rabbit Brain

van Vliet, E., Eixarch, E., Illa, M., Arbat-Plana, A., González-Tendero, A., Hogberg, H. T., Zhao, L., Hartung, T. & Gratacos, E., May 27 2013, In : PloS one. 8, 5, e64545.

Research output: Contribution to journalArticle

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

Judson, R., Kavlock, R., Martin, M., Reif, D., Houck, K., Knudsen, T., Richard, A., Tice, R. R., Whelan, M., Xia, M., Huang, R., Austin, C., Daston, G., Hartung, T., Fowle, J. R., Wooge, W., Tong, W. & Dix, D., 2013, In : ALTEX. 30, 1, p. 51-66 16 p.

Research output: Contribution to journalArticle

Open Access

T4 Report* Metabolomics in toxicology and preclinical research

Ramirez, T., Daneshian, M., Kamp, H., Bois, F. Y., Clench, M. R., Coen, M., Donley, B., Fischer, S. M., Ekman, D. R., Fabian, E., Guillou, C., Heuer, J., Hogberg, H. T., Jungnickel, H., Keun, H. C., Krennrich, G., Krupp, E., Luch, A., Noor, F., Peter, E. & 9 others, Riefke, B., Seymour, M., Skinner, N., Smirnova, L., Verheij, E., Wagner, S., Hartung, T., Van Ravenzwaay, B. & Leist, M., 2013, In : ALTEX. 30, 2, p. 209-225 17 p.

Research output: Contribution to journalArticle

Open Access

T4 Report evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

Hasiwa, N., Daneshian, M., Bruegger, P., Fennrich, S., Hochadel, A., Hoffmann, S., Rivera-Mariani, F. E., Rockel, C., Schindler, S., Spreitzer, I., Stoppelkamp, S., Vysyaraju, K. & Hartung, T., 2013, In : ALTEX. 30, 2, p. 169-208 40 p.

Research output: Contribution to journalArticle

Open Access

The new revolution in toxicology: The good, the bad, and the ugly

Davis, M., Boekelheide, K., Boverhof, D. R., Eichenbaum, G., Hartung, T., Holsapple, M. P., Jones, T. W., Richard, A. M. & Watkins, P. B., Mar 2013, In : Annals of the New York Academy of Sciences. 1278, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

2012

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

Basketter, D. A., Clewell, H., Kimber, I., Rossi, A., Blaauboer, B., Burrier, R., Daneshian, M., Eskes, C., Goldberg, A., Hasiwa, N., Hoffmann, S., Jaworska, J., Knudsen, T. B., Landsiedel, R., Leist, M., Locke, P., Maxwell, G., McKim, J., McVey, E. A., Ouédraogo, G. & 15 others, Patlewicz, G., Pelkonen, O., Roggen, E., Rovida, C., Ruhdel, I., Schwarz, M., Schepky, A., Schoeters, G., Skinner, N., Trentz, K., Turner, M., Vanparys, P., Yager, J., Zurlo, J. & Hartung, T., 2012, In : ALTEX. 29, 1, p. 3-91 89 p.

Research output: Contribution to journalArticle

Open Access

Food for thought... towards tailored assays for cell-based approaches to toxicity testing

Rossini, G. P. & Hartung, T., 2012, In : ALTEX. 29, 4, p. 359-372 14 p.

Research output: Contribution to journalArticle

Open Access
2011

A framework program for the teaching of alternative methods (replacement, reduction, refinement) to animal experimentation

Daneshian, M., Akbarsha, M. A., Blaauboer, B., Caloni, F., Cosson, P., Curren, R., Goldberg, A., Gruber, F., Ohl, F., Pfaller, W., Van Der Valk, J., Vinardell, P., Zurlo, J., Hartung, T. & Leist, M., 2011, In : ALTEX. 28, 4, p. 341-352 12 p.

Research output: Contribution to journalArticle

Open Access

Alternative in vitro assays in nanomaterial toxicology

Hartung, T. & Sabbioni, E., Nov 1 2011, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 3, 6, p. 545-573 29 p.

Research output: Contribution to journalArticle

Critical evaluation of the use of dogs in biomedical research and testing in Europe

Hasiwa, N., Bailey, J., Clausing, P., Daneshian, M., Eileraas, M., Farkas, S., Gyertyań, I., Hubrecht, R., Kobel, W., Krummenacher, G., Leist, M., Lohi, H., Miklośi, A., Ohl, F., Olejniczak, K., Schmitt, G., Sinnett-Smith, P., Smith, D., Wagner, K., Yager, J. D. & 2 others, Zurlo, J. & Hartung, T., Dec 30 2011, In : ALTEX. 28, 4, p. 326-340 15 p.

Research output: Contribution to journalArticle

Different Staphylococcus aureus whole bacteria mutated in putative pro-inflammatory membrane components have similar cytokine inducing activity

Rockel, C., Hartung, T. & Hermann, C., Mar 1 2011, In : Immunobiology. 216, 3, p. 316-321 6 p.

Research output: Contribution to journalArticle

Growth temperature-dependent expression of structural variants of Listeria monocytogenes lipoteichoic acid

Dehus, O., Pfitzenmaier, M., Stuebs, G., Fischer, N., Schwaeble, W., Morath, S., Hartung, T., Geyer, A. & Hermann, C., Jan 1 2011, In : Immunobiology. 216, 1-2, p. 24-31 8 p.

Research output: Contribution to journalArticle

T 4 workshop report nanotoxicology: "The end of the beginning" - Signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials

Silbergeld, E. K., Contreras, E. Q., Hartung, T., Hirsch, C., Hogberg, H., Jachak, A. C., Jordan, W., Landsiedel, R., Morris, J., Patri, A., Pounds, J. G., De Vizcaya Ruiz, A., Shvedova, A., Tanguay, R., Tatarazako, N., Van Vliet, E., Walker, N. J., Wiesner, M., Wilcox, N. & Zurlo, J., Oct 11 2011, In : ALTEX. 28, 3, p. 236-241 6 p.

Research output: Contribution to journalArticle

2010

A structured approach to identifying European critical infrastructures

Di Mauro, C., Bouchon, S., Logtmeijer, C., Pride, R. D., Hartung, T. & Nordvik, J. P., Jun 2010, In : International Journal of Critical Infrastructures. 6, 3, p. 277-292 16 p.

Research output: Contribution to journalArticle

Characterisation of cadmium chloride induced molecular and functional alterations in airway epithelial cells

Forti, E., Bulgheroni, A., Cetin, Y., Hartung, T., Jennings, P., Pfaller, W. & Prieto, P., 2010, In : Cellular Physiology and Biochemistry. 25, 1, p. 159-168 10 p.

Research output: Contribution to journalArticle

First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye test for the identification of non-irritant substances for a defined applicability domain.

Hartung, T., Bruner, L., Curren, R., Eskes, C., Goldberg, A., McNamee, P., Scott, L. & Zuang, V., 2010, In : ALTEX. 27, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

Open Access

Food for thought...on alternative methods for chemical safety testing.

Hartung, T., 2010, In : ALTEX. 27, 1, p. 3-14 12 p.

Research output: Contribution to journalArticle

Food for thought ... on alternative methods for nanoparticle safety testing.

Hartung, T., 2010, In : ALTEX. 27, 2, p. 87-95 9 p.

Research output: Contribution to journalArticle

Open Access

Internalization and coreceptor expression are critical for TLR2-mediated recognition of lipoteichoic acid in human peripheral blood

Bunk, S., Sigel, S., Metzdorf, D., Sharif, O., Triantafilou, K., Triantafilou, M., Hartung, T., Knapp, S. & Von Aulock, S., Sep 15 2010, In : Journal of Immunology. 185, 6, p. 3708-3717 10 p.

Research output: Contribution to journalArticle

In vitro developmental neurotoxicity (DNT) testing: Relevant models and endpoints

Bal-Price, A. K., Hogberg, H. T., Buzanska, L., Lenas, P., van Vliet, E. & Hartung, T., Sep 1 2010, In : NeuroToxicology. 31, 5, p. 545-554 10 p.

Research output: Contribution to journalArticle

Nachweis eines breiten Pyrogenspektrums im Monozyten-Aktivierungstest

Translated title of the contribution: In vitro pyrogen test: Proof of a broad pyrogen spectrum in the monocyte-activation testHoltkamp, B., Schmitz, G. & Härtung, T., Nov 1 2010, In : BioSpektrum. 16, 7, p. 779-781 3 p.

Research output: Contribution to journalArticle

The Center for Alternatives to Animal Testing - Europe (CAAT-EU): a transatlantic bridge for the paradigm shift in toxicology.

Daneshian, M., Leist, M. & Hartung, T., 2010, In : ALTEX. 27, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

Open Access
2009

1 Fundamentals of a an evidence-based toxicology: 1.1 Opening statement

Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, p. 93-94 2 p.

Research output: Contribution to journalArticle

4.8 Current schemes for decision-making in toxicology

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

4.9 Current information sources for hazard identification

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.2 Evidence-based tools in toxicological hazard identification

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.3 Evidence-based tools in toxicological decision-making

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.4 Possible improvement of information sources on hazard and risk

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.6 An online portal to evidence-based toxicology

Kinsner, A., Griesinger, C., Hoffmann, S., Coecke, S., Bowe, G., Campana, C. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5 Steps toward an evidence-based toxicology: 5.1 Evidence-based tools in toxicological basic research

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

A modular approach to the extended one-generation reproduction toxicity study

Moore, N., Bremer, S., Carmichael, N., Daston, G., Dent, M., Gaoua-Chapelle, W., Hallmark, N., Hartung, T., Holzum, B., Hübel, U., Meisters, M. L., Schneider, S., Van Ravenzwaay, B. & Hennes, C., Apr 1 2009, In : ATLA Alternatives to Laboratory Animals. 37, 2, p. 219-225 7 p.

Research output: Contribution to journalArticle

Are in vitro tests suitable for regulatory use?

Hartung, T. & Daston, G., Sep 25 2009, In : Toxicological Sciences. 111, 2, p. 233-237 5 p.

Research output: Contribution to journalArticle

Arsenic induces telomerase expression and maintains telomere length in human cord blood cells

Ferrario, D., Collotta, A., Carfi, M., Bowe, G., Vahter, M., Hartung, T. & Gribaldo, L., Jun 16 2009, In : Toxicology. 260, 1-3, p. 132-141 10 p.

Research output: Contribution to journalArticle