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2016

Alzheimer disease research in the 21st century: Past and current failures, new perspectives and funding priorities

Pistollato, F., Ohayon, E. L., Lam, A., Langley, G. R., Novak, T. J., Pamies, D., Perry, G., Trushina, E., Williams, R. S. B., Roher, A. E., Hartung, T., Harnad, S., Barnard, N., Morris, M. C., Lai, M. C., Merkley, R. & Charukeshi Chandrasekera, P., 2016, In : Oncotarget. 7, 26, p. 38999-39016 18 p.

Research output: Contribution to journalArticle

Open Access

Analysis of draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., Jan 1 2016, In : ALTEX. 33, 2, p. 123-134 12 p.

Research output: Contribution to journalArticle

Analysis of publically available skin sensitization data from REACH registrations 2008-2014

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., 2016, In : ALTEX. 33, 2, p. 135-148 14 p.

Research output: Contribution to journalArticle

Analysis of public oral toxicity data from REACH registrations 2008-2014

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., 2016, In : ALTEX. 33, 2, p. 111-122 12 p.

Research output: Contribution to journalArticle

Applicability of the Monocyte Activation Test (MAT) for hyperimmune sera in the routine of the quality control laboratory: Comparison with the Rabbit Pyrogen Test (RPT)

da Silva, C. C., Presgrave, O. A. F., Hartung, T., de Moraes, A. M. L. & Delgado, I. F., Apr 1 2016, In : Toxicology in Vitro. 32, p. 70-75 6 p.

Research output: Contribution to journalArticle

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Marx, U., Andersson, T. B., Bahinski, A., Beilmann, M., Beken, S., Cassee, F. R., Cirit, M., Daneshian, M., Fitzpatrick, S., Frey, O., Gaertner, C., Giese, C., Griffith, L., Hartung, T., Heringa, M. B., Hoeng, J., De Jong, W. H., Kojima, H., Kuehnl, J., Leist, M. & 16 others, Luch, A., Maschmeyer, I., Sakharov, D., Sips, A. J. A. M., Steger-Hartmann, T., Tagle, D. A., Tonevitsky, A., Tralau, T., Tsyb, S., Van De Stolpe, A., Vandebriel, R., Vulto, P., Wang, J., Wiest, J., Rodenburg, M. & Roth, A., 2016, In : Altex. 33, 3, p. 272-321 50 p.

Research output: Contribution to journalArticle

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis

Kilic, O., Pamies, D., Lavell, E., Schiapparelli, P., Feng, Y., Hartung, T., Bal-Price, A., Hogberg, H. T., Quinones-Hinojosa, A., Guerrero-Cazares, H. & Levchenko, A., 2016, In : Lab on a Chip. 16, 21, p. 4152-4162 11 p.

Research output: Contribution to journalArticle

Can TTIP improve laboratory animal welfare in safety testing and 3Rs?

Busquet, F., Zurlo, J. & Hartung, T., Jan 1 2016, In : ILAR journal. 57, 3, p. 358-367 10 p.

Research output: Contribution to journalArticle

Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening

Tong, Z. B., Hogberg, H., Kuo, D., Sakamuru, S., Xia, M., Smirnova, L., Hartung, T. & Gerhold, D., 2016, (Accepted/In press) In : Journal of Applied Toxicology.

Research output: Contribution to journalArticle

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., Neisser, M., Nguyen, C., Lee, R., Park, J. K., Reyes, J., Hartung, T., Rojas, C., Rais, R., Tsukamoto, T., Semenza, G. L. & 3 others, Hanes, J., Slusher, B. S. & Le, A., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. E5328-E5336

Research output: Contribution to journalArticle

Detecting the broad spectrum of pyrogens with the human whole-blood monocyte activation test

Hartung, T., Borel, A. & Schmitz, G., Mar 1 2016, In : BioProcess International. 14, 3

Research output: Contribution to journalArticle

Evidence-based absorption, distribution, metabolism, excretion (ADME) and its interplay with alternative toxicity methods

Tsaioun, K., Blaauboer, B. J. & Hartung, T., 2016, In : ALTEX. 33, 4, p. 343-358 16 p.

Research output: Contribution to journalArticle

Food for thought... E-cigarettes and the need and opportunities for alternatives to animal testing

Hartung, T., 2016, In : ALTEX. 33, 3, p. 211-224 14 p.

Research output: Contribution to journalArticle

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

Kleensang, A., Vantangoli, M. M., Odwin-Dacosta, S., Andersen, M. E., Boekelheide, K., Bouhifd, M., Fornace, A. J., Li, H. H., Livi, C. B., Madnick, S., Maertens, A., Rosenberg, M., Yager, J. D., Zhaog, L. & Hartung, T., Jul 26 2016, In : Scientific reports. 6, 28994.

Research output: Contribution to journalArticle

Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., 2016, In : ALTEX. 33, 2, p. 95-109 15 p.

Research output: Contribution to journalArticle

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

Schmidt, B. Z., Lehmann, M., Gutbier, S., Nembo, E., Noel, S., Smirnova, L., Forsby, A., Hescheler, J., Avci, H. X., Hartung, T., Leist, M., Kobolák, J. & Dinnyés, A., Aug 4 2016, (Accepted/In press) In : Archives of Toxicology. p. 1-33 33 p.

Research output: Contribution to journalArticle

Making big sense from big data in toxicology by read-across

Hartung, T., 2016, In : Altex. 33, 2, p. 83-93 11 p.

Research output: Contribution to journalArticle

Staphylococcus aureus–derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2

Kaesler, S., Skabytska, Y., Chen, K. M., Kempf, W. E., Volz, T., Köberle, M., Wölbing, F., Hein, U., Hartung, T., Kirschning, C., Röcken, M. & Biedermann, T., Sep 1 2016, In : Journal of Allergy and Clinical Immunology. 138, 3, p. 780-790.e6

Research output: Contribution to journalArticle

Supporting read-across using biological data

Zhu, H., Bouhifd, M., Donley, E., Egnash, L., Kleinstreuer, N., Kroese, E. D., Liu, Z., Luechtefeld, T., Palmer, J., Pamies, D., Shen, J., Strauss, V., Wu, S. & Hartung, T., 2016, In : ALTEX. 33, 2, p. 167-182 16 p.

Research output: Contribution to journalArticle

The emergence of systematic review in toxicology

Stephens, M. L., Betts, K., Beck, N. B., Cogliano, V., Dickersin, K., Fitzpatrick, S., Freeman, J., Gray, G., Hartung, T., McPartland, J., Rooney, A. A., Scherer, R., Verloo, D. & Hoffmann, S., Jul 1 2016, In : Toxicological Sciences. 152, 1, p. 10-16 7 p., kfw059.

Research output: Contribution to journalArticle

The Lesser Evil of E-Cigarettes

Hartung, T., Aug 1 2016, In : Scientific American. 315, 2, p. 9 1 p.

Research output: Contribution to journalArticle

The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency

Bowman, C. E., Rodriguez, S., Selen Alpergin, E. S., Acoba, M. G., Zhao, L., Hartung, T., Claypool, S. M., Watkins, P. A. & Wolfgang, M. J., Nov 10 2016, (Accepted/In press) In : Cell Chemical Biology.

Research output: Contribution to journalArticle

Toward good read-across practice (GRAP) guidance

Ball, N., Cronin, M. T. D., Shen, J., Blackburn, K., Booth, E. D., Bouhifd, M., Donley, E., Egnash, L., Hastings, C., Juberg, D. R., Kleensang, A., Kleinstreuer, N., Kroese, E. D., Lee, A. C., Luechtefeld, T., Maertens, A., Marty, S., Naciff, J. M., Palmer, J., Pamies, D. & 9 others, Penman, M., Richarz, A. N., Russo, D. P., Stuard, S. B., Patlewicz, G., Van Ravenzwaay, B., Wu, S., Zhu, H. & Hartung, T., 2016, In : ALTEX. 33, 2, p. 149-166 18 p.

Research output: Contribution to journalArticle

Utility of the adverse outcome pathway concept in drug development

Hartung, T., Oct 23 2016, (Accepted/In press) In : Expert Opinion on Drug Metabolism and Toxicology. p. 1-3 3 p.

Research output: Contribution to journalArticle

2015

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

Head, S. A., Shi, W., Zhao, L., Gorshkov, K., Pasunooti, K., Chen, Y., Deng, Z., Li, R. J., Shim, J. S., Tan, W., Hartung, T., Zhang, J., Zhao, Y., Colombini, M. & Liu, J. O., Dec 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. E7276-E7285

Research output: Contribution to journalArticle

Food for Thought... Toxicity testing in the 21st century beyond environmental chemicals

Rovida, C., Asakura, S., Daneshian, M., Hofman-Huether, H., Leist, M., Meunier, L., Reif, D., Rossi, A., Schmutz, M., Valentin, J. P., Zurlo, J. & Hartung, T., Jan 1 2015, In : ALTEX. 32, 3, p. 171-181 11 p.

Research output: Contribution to journalArticle

Food for thought⋯: Animal use for science in Europe

Daneshian, M., Busquet, F., Hartung, T. & Leist, M., Jan 1 2015, In : ALTEX. 32, 4, p. 261-274 14 p.

Research output: Contribution to journalArticle

Food for thought⋯cellular resilience

Smirnova, L., Harris, G., Leist, M. & Hartung, T., Jan 1 2015, In : ALTEX. 32, 4, p. 247-260 14 p.

Research output: Contribution to journalArticle

From "weight of evidence" to quantitative data integration using multicriteria decision analysis and bayesian methods

Linkov, I., Massey, O., Keisler, J., Rusyn, I. & Hartung, T., 2015, In : ALTEX. 32, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review

Samuel, G. O., Hoffmann, S., Wright, R. A., Lalu, M. M., Patlewicz, G., Becker, R. A., DeGeorge, G. L., Fergusson, D., Hartung, T., Lewis, R. J. & Stephens, M. L., Aug 6 2015, (Accepted/In press) In : Environment International.

Research output: Contribution to journalArticle

Integrated testing strategies (ITS) for safety assessment

Rovida, C., Alépée, N., Api, A. M., Basketter, D. A., Bois, F. Y., Caloni, F., Corsini, E., Daneshian, M., Eskes, C., Ezendam, J., Fuchs, H., Hayden, P., Hegele-Hartung, C., Hoffmann, S., Hubesch, B., Jacobs, M. N., Jaworska, J., Kleensang, A., Kleinstreuer, N., Lalko, J. & 16 others, Landsiedel, R., Lebreux, F., Luechtefeld, T., Locatelli, M., Mehling, A., Natsch, A., Pitchford, J. W., Prater, D., Prieto, P., Schepky, A., Schüürmann, G., Smirnova, L., Toole, C., Van Vliet, E., Weisensee, D. & Hartung, T., 2015, In : ALTEX. 32, 1, p. 25-40 16 p.

Research output: Contribution to journalArticle

Metabonomics and toxicology

Zhao, L. & Hartung, T., Jan 1 2015, In : Methods in Molecular Biology. 1277, p. 209-231 23 p.

Research output: Contribution to journalArticle

MPTP’s Pathway of Toxicity Indicates Central Role of Transcription Factor SP1

Maertens, A., Luechtefeld, T., Kleensang, A. & Hartung, T., May 1 2015, In : Archives of Toxicology. 89, 5, p. 743-755 13 p.

Research output: Contribution to journalArticle

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology

Gordon, S., Daneshian, M., Bouwstra, J., Caloni, F., Constant, S., Davies, D. E., Dandekar, G., Guzman, C. A., Fabian, E., Haltner, E., Hartung, T., Hasiwa, N., Hayden, P., Kandarova, H., Khare, S., Krug, H. F., Kneuer, C., Leist, M., Lian, G., Marx, U. & 9 others, Metzger, M., Ott, K., Prieto, P., Roberts, M. S., Roggen, E. L., Tralau, T., Van Den Braak, C., Walles, H. & Lehr, C. M., 2015, In : ALTEX. 32, 4, p. 327-378 52 p.

Research output: Contribution to journalArticle

Probabilistic hazard assessment for skin sensitiza tion potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships

Luechtefeld, T., Maertens, A., Mckim, J. M., Hartung, T., Kleensang, A. & Sá-Rocha, V., Nov 1 2015, In : Journal of Applied Toxicology. 35, 11, p. 1361-1371 11 p.

Research output: Contribution to journalArticle

Quality assurance of metabolomics

Bouhifd, M., Beger, R., Flynn, T., Guo, L., Harris, G., Hogberg, H., Kaddurah-Daouk, R., Kamp, H., Kleensang, A., Maertens, A., Odwin-DaCosta, S., Pamies, D., Robertson, D., Smirnova, L., Sun, J., Zhao, L. & Hartung, T., 2015, In : ALTEX. 32, 4, p. 319-326 8 p.

Research output: Contribution to journalArticle

Safety first

Hartung, T., Sep 1 2015, Innovations in Pharmaceutical Technology, 54, p. 40-43 4 p.

Research output: Contribution to specialist publicationArticle

Systems Toxicology: The Future of Risk Assessment

Sauer, J. M., Hartung, T., Leist, M., Knudsen, T. B., Hoeng, J. & Hayes, A. W., Jul 8 2015, In : International Journal of Toxicology. 34, 4, p. 346-348 3 p.

Research output: Contribution to journalArticle

The human toxome collaboratorium: A shared environment for multi-omic computational collaboration within a consortium

Fasani, R. A., Livi, C. B., Choudhury, D. R., Kleensang, A., Bouhifd, M., Pendse, S. N., McMullen, P. D., Andersen, M. E., Hartung, T. & Rosenberg, M., 2015, In : Frontiers in Pharmacology. 6, 322.

Research output: Contribution to journalArticle

The Human Toxome Project

Bouhifd, M., Andersen, M. E., Baghdikian, C., Boekelheide, K., Crofton, K. M., Fornace, A. J., Kleensang, A., Li, H., Livi, C., Maertens, A., McMullen, P. D., Rosenberg, M., Thomas, R., Vantangoli, M., Yager, J. D., Zhao, L. & Hartung, T., 2015, In : ALTEX. 32, 2, p. 112-124 13 p.

Research output: Contribution to journalArticle

2014

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

Tollefsen, K. E., Scholz, S., Cronin, M. T., Edwards, S. W., de Knecht, J., Crofton, K., Garcia-Reyero, N., Hartung, T., Worth, A. & Patlewicz, G., Dec 1 2014, In : Regulatory Toxicology and Pharmacology. 70, 3, p. 629-640 12 p.

Research output: Contribution to journalArticle

Biological and medical applications of a brain-on-a-chip

Pamies, D., Hartung, T. & Hogberg, H. T., Sep 1 2014, In : Experimental Biology and Medicine. 239, 9, p. 1096-1107 12 p.

Research output: Contribution to journalArticle

Building shared experience to advance practical application of pathway-based toxicology: Liver toxicity mode-of-action

Willett, C., Rae, J. C., Goyak, K. O., Minsavage, G., Westmoreland, C., Andersen, M., Avigan, M., Duché, D., Harris, G., Hartung, T., Jaeschke, H., Kleensang, A., Landesmann, B., Martos, S., Matevia, M., Toole, C., Rowan, A., Schultz, T., Seed, J., Senior, J. & 4 others, Shah, I., Subramanian, K., Vinken, M. & Watkins, P., 2014, In : ALTEX. 31, 4, p. 500-519 20 p.

Research output: Contribution to journalArticle

Comparison of the interleukin-1β-inducing potency of allergenic spores from higher fungi (basidiomycetes) in a cryopreserved human whole blood system

Rivera-Mariani, F. E., Vysyaraju, K., Negherbon, J., Levetin, E., Horner, W. E., Hartung, T. & Breysse, P. N., Feb 1 2014, In : International archives of allergy and immunology. 163, 2, p. 154-162 9 p.

Research output: Contribution to journalArticle

Consensus report on the future of animal-free systemic toxicity testing

Leist, M., Hasiwa, N., Rovida, C., Daneshian, M., Basketter, D., Kimber, I., Clewell, H., Gocht, T., Goldberg, A., Busquet, F., Rossi, A. M., Schwarz, M., Stephens, M., Taalman, R., Knudsen, T. B., McKim, J., Harris, G., Pamies, D. & Hartung, T., 2014, In : ALTEX. 31, 3, p. 341-356 16 p.

Research output: Contribution to journalArticle

Current approaches and future role of high content imaging in safety sciences and drug discovery

Van Vliet, E., Daneshian, M., Beilmann, M., Davies, A., Fava, E., Fleck, R., Julé, Y., Kansy, M., Kustermann, S., Macko, P., Mundy, W. R., Roth, A., Shah, I., Uteng, M., Van De Water, B., Hartung, T. & Leist, M., Jan 1 2014, In : ALTEX. 31, 4, p. 479-493 15 p.

Research output: Contribution to journalArticle

Developing microphysiological systems for use as regulatory tools - Challenges and opportunities

Andersen, M. E., Betts, K., Dragan, Y., Fitzpatrick, S., Goodman, J. L., Hartung, T., Himmelfarb, J., Ingber, D. E., Jacobs, A., Kavlock, R., Kolaja, K., Stevens, J. L., Tagle, D., Taylor, D. L. & Throckmorton, D., 2014, In : ALTEX. 31, 3, p. 364-367 4 p.

Research output: Contribution to journalArticle

Glossary of reference terms for alternative test methods and their validation

Ferrario, D., Brustio, R. & Hartung, T., 2014, In : ALTEX. 31, 3, p. 319-335 17 p.

Research output: Contribution to journalArticle