1991 …2020

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2020

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

Zhong, X., Harris, G., Smirnova, L., Zufferey, V., Sá, R. D. C. D. S. E., Baldino Russo, F., Baleeiro Beltrao Braga, P. C., Chesnut, M., Zurich, M. G., Hogberg, H. T., Hartung, T. & Pamies, D., Feb 21 2020, In : Frontiers in Cellular Neuroscience. 14, 25.

Research output: Contribution to journalArticle

Open Access

Functionally Enigmatic Genes in Cancer: Using TCGA Data to Map the Limitations of Annotations

Maertens, A., Tran, V. H., Maertens, M., Kleensang, A., Luechtefeld, T. H., Hartung, T. & Paller, C. J., Dec 1 2020, In : Scientific reports. 10, 1, 4106.

Research output: Contribution to journalArticle

Open Access

New European Union statistics on laboratory animal use - what really counts!

Busquet, F., Kleensang, A., Rovida, C., Herrmann, K., Leist, M. & Hartung, T., Jan 1 2020, In : ALTEX. 37, 2, p. 167-186 20 p.

Research output: Contribution to journalArticle

Open Access
2019

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine

Plummer, S., Wallace, S., Ball, G., Lloyd, R., Schiapparelli, P., Quiñones-Hinojosa, A., Hartung, T. & Pamies, D., Dec 1 2019, In : Scientific reports. 9, 1, 1407.

Research output: Contribution to journalArticle

Long-term effects of chromium on morphological and immunological parameters of Wistar rats

Karaulov, A. V., Renieri, E. A., Smolyagin, A. I., Mikhaylova, I. V., Stadnikov, A. A., Begun, D. N., Tsarouhas, K., Buha Djordjevic, A., Hartung, T. & Tsatsakis, A., Nov 1 2019, In : Food and Chemical Toxicology. 133, 110748.

Research output: Contribution to journalArticle

Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across

Russo, D. P., Strickland, J., Karmaus, A. L., Wang, W., Shende, S., Hartung, T., Aleksunes, L. M. & Zhu, H., Apr 1 2019, In : Environmental health perspectives. 127, 4, 1 p.

Research output: Contribution to journalArticle

Open Access

Optimizing drug discovery by investigative toxicology: Current and future trends

Beilmann, M., Boonen, H., Czich, A., Dear, G., Hewitt, P., Mow, T., Newham, P., Oinonen, T., Pognan, F., Roth, A., Valentin, J. P., Van Goethem, F., Weaver, R. J., Birk, B., Boyer, S., Caloni, F., Chen, A. E., Corvi, R., Cronin, M. T. D., Daneshian, M. & 14 others, Ewart, L. C., FitzGerald, R. E., Hamilton, G. A., Hartung, T., Kangas, J. D., Kramer, N. I., Leist, M., Marx, U., Polak, S., Rovida, C., Testai, E., Van de Water, B., Vulto, P. & Steger-Hartmann, T., Jan 1 2019, In : ALTEX. 36, 2, p. 289-313 25 p.

Research output: Contribution to journalArticle

Open Access

Predicting toxicity of chemicals: software beats animal testing

Hartung, T., Jul 2019, In : EFSA Journal. 17, S1, e170710.

Research output: Contribution to journalArticle

Open Access

Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

Leite, P. E. C., Pereira, M. R., Harris, G., Pamies, D., Dos Santos, L. M. G., Granjeiro, J. M., Hogberg, H., Hartung, T. & Smirnova, L., Jun 3 2019, In : Particle and Fibre Toxicology. 16, 1, 22.

Research output: Contribution to journalArticle

Open Access

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

Krebs, A., Waldmann, T., Wilks, M. F., Van Vugt-Lussenburg, B. M. A., Van der Burg, B., Terron, A., Steger-Hartmann, T., Ruegg, J., Rovida, C., Pedersen, E., Pallocca, G., Luijten, M., Leite, S. B., Kustermann, S., Kamp, H., Hoeng, J., Hewitt, P., Herzler, M., Hengstler, J. G., Heinonen, T. & 16 others, Hartung, T., Hardy, B., Gantner, F., Fritsche, E., Fant, K., Ezendam, J., Exner, T., Dunkern, T., Dietrich, D. R., Coecke, S., Busquet, F., Braeuning, A., Bondarenko, O., Bennekou, S. H., Beilmann, M. & Leist, M., Jan 1 2019, In : ALTEX. 36, 4, p. 682-699 18 p.

Research output: Contribution to journalArticle

Open Access

The effect of chronic vitamin deficiency and long term very low dose exposure to 6 pesticides mixture on neurological outcomes – A real-life risk simulation approach

Tsatsakis, A., Tyshko, N. V., Docea, A. O., Shestakova, S. I., Sidorova, Y. S., Petrov, N. A., Zlatian, O., Mach, M., Hartung, T. & Tutelyan, V. A., Oct 15 2019, In : Toxicology Letters. 315, p. 96-106 11 p.

Research output: Contribution to journalArticle

Toward Good In Vitro Reporting Standards

Hartung, T., De Vries, R., Hoffmann, S., Hogberg, H., Smirnova, L., Tsaioun, K., Whaley, P. & Leist, M., Jan 1 2019, In : Altex. 36, 1, p. 3-17 15 p.

Research output: Contribution to journalArticle

Towards quality assurance and quality control in untargeted metabolomics studies

Beger, R. D., Dunn, W. B., Bandukwala, A., Bethan, B., Broadhurst, D., Clish, C. B., Dasari, S., Derr, L., Evans, A., Fischer, S., Flynn, T., Hartung, T., Herrington, D., Higashi, R., Hsu, P. C., Jones, C., Kachman, M., Karuso, H., Kruppa, G., Lippa, K. & 18 others, Maruvada, P., Mosley, J., Ntai, I., O’Donovan, C., Playdon, M., Raftery, D., Shaughnessy, D., Souza, A., Spaeder, T., Spalholz, B., Tayyari, F., Ubhi, B., Verma, M., Walk, T., Wilson, I., Witkin, K., Bearden, D. W. & Zanetti, K. A., Jan 1 2019, In : Metabolomics. 15, 1, 4.

Research output: Contribution to journalArticle

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Nguyen, T., Kirsch, B. J., Asaka, R., Nabi, K., Quinones, A., Tan, J., Antonio, M. J., Camelo, F., Li, T., Nguyen, S., Hoang, G., Nguyen, K., Udupa, S., Sazeides, C., Shen, Y. A., Elgogary, A., Reyes, J., Zhao, L., Kleensang, A., Chaichana, K. L. & 7 others, Hartung, T., Betenbaugh, M. J., Marie, S. K., Jung, J. G., Wang, T-L., Gabrielson, E. & Le Thi, Q. H., Apr 9 2019, In : Cell Reports. 27, 2, p. 491-501.e6

Research output: Contribution to journalArticle

Open Access
2018

3S - Systematic, systemic, and systems biology and toxicology

Smirnova, L., Kleinstreuer, N., Corvi, R., Levchenko, A., Fitzpatrick, S. C. & Hartung, T., Jan 1 2018, In : Altex. 35, 2, p. 139-162 24 p.

Research output: Contribution to journalArticle

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

Pamies, D., Bal-Price, A., Chesné, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J. C., Stacey, G. N., Ellinger-Ziegelbauer, H. & Daneshian, M., Jan 1 2018, In : ALTEX. 35, 3, p. 353-378 26 p.

Research output: Contribution to journalArticle

Animal testing and its alternatives - the most important omics is economics

Meigs, L., Smirnova, L., Rovida, C., Leist, M. & Hartung, T., Jan 1 2018, In : ALTEX. 35, 3, p. 275-305 31 p.

Research output: Contribution to journalArticle

Big-data and machine learning to revamp computational toxicology and its use in risk assessment

Luechtefeld, T., Rowlands, C. & Hartung, T., Jan 1 2018, In : Toxicology Research. 7, 5, p. 732-744 13 p.

Research output: Contribution to journalArticle

Induction of IL-10-balanced immune profiles following exposure to LTA from Staphylococcus epidermidis

Volz, T., Kaesler, S., Draing, C., Hartung, T., Röcken, M., Skabytska, Y. & Biedermann, T., Apr 1 2018, In : Experimental Dermatology. 27, 4, p. 318-326 9 p.

Research output: Contribution to journalArticle

Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility

Luechtefeld, T., Marsh, D., Rowlands, C. & Hartung, T., Jan 1 2018, In : Toxicological Sciences. 165, 1, p. 198-212 15 p.

Research output: Contribution to journalArticle

Rebooting the generally recognized as safe (GRAS) approach for food additive safety in the US

Hartung, T., Jan 1 2018, In : Altex. 35, 1, p. 3-25 23 p.

Research output: Contribution to journalArticle

Regulatory acceptance of read-across

Chesnut, M., Yamada, T., Adams, T., Knight, D., Kleinstreuer, N., Kass, G., Luechtefeld, T. & Hartung, T., Jan 1 2018, In : ALTEX. 35, 3, p. 413-419 7 p.

Research output: Contribution to journalArticle

Rotenone exerts developmental neurotoxicity in a human brain spheroid model

Pamies, D., Block, K., Lau, P., Gribaldo, L., Pardo, C. A., Barreras, P., Smirnova, L., Wiersma, D., Zhao, L., Harris, G., Hartung, T. & Hogberg, H. T., Sep 1 2018, In : Toxicology and Applied Pharmacology. 354, p. 101-114 14 p.

Research output: Contribution to journalArticle

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity

Delp, J., Gutbier, S., Cerff, M., Zasada, C., Niedenführ, S., Zhao, L., Smirnova, L., Hartung, T., Borlinghaus, H., Schreiber, F., Bergemann, J., Gätgens, J., Beyss, M., Azzouzi, S., Waldmann, T., Kempa, S., Nöh, K. & Leist, M., Jan 1 2018, (Accepted/In press) In : Toxicology and Applied Pharmacology.

Research output: Contribution to journalArticle

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

Harris, G., Eschment, M., Orozco, S. P., McCaffery, J. M., Maclennan, R., Severin, D., Leist, M., Kleensang, A., Pamies, D., Maertens, A., Hogberg, H. T., Freeman, D., Kirkwood, A., Hartung, T. & Smirnova, L., Aug 1 2018, In : Archives of Toxicology. 92, 8, p. 2587-2606 20 p.

Research output: Contribution to journalArticle

2017

21st Century Cell Culture for 21st Century Toxicology

Pamies, D. & Hartung, T., Jan 17 2017, In : Chemical Research in Toxicology. 30, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

Adverse outcome pathways: opportunities, limitations and open questions

Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S. H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., Danen, E., van Ravenzwaay, B., Kamp, H., Gardner, I., Godoy, P., Bois, F. Y., Braeuning, A., Reif, R., Oesch, F., Drasdo, D. & 33 others, Höhme, S., Schwarz, M., Hartung, T., Braunbeck, T., Beltman, J., Vrieling, H., Sanz, F., Forsby, A., Gadaleta, D., Fisher, C., Kelm, J., Fluri, D., Ecker, G., Zdrazil, B., Terron, A., Jennings, P., van der Burg, B., Dooley, S., Meijer, A. H., Willighagen, E., Martens, M., Evelo, C., Mombelli, E., Taboureau, O., Mantovani, A., Hardy, B., Koch, B., Escher, S., van Thriel, C., Cadenas, C., Kroese, D., van de Water, B. & Hengstler, J. G., Nov 1 2017, In : Archives of Toxicology. 91, 11, p. 3477-3505 29 p.

Research output: Contribution to journalArticle

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

Pamies, D., Barreras, P., Block, K., Makri, G., Kumar, A., Wiersma, D., Smirnova, L., Zhang, C., Bressler, J., Christian, K. M., Harris, G., Ming, G. L., Berlinicke, C. J., Kyro, K., Song, H., Pardo, C. A., Hartung, T. & Hogberg, H. T., Jan 1 2017, In : ALTEX. 34, 3, p. 362-376 15 p.

Research output: Contribution to journalArticle

A primer on systematic reviews in toxicology

Hoffmann, S., de Vries, R. B. M., Stephens, M. L., Beck, N. B., Dirven, H. A. A. M., Fowle, J. R., Goodman, J. E., Hartung, T., Kimber, I., Lalu, M. M., Thayer, K., Whaley, P., Wikoff, D. & Tsaioun, K., May 13 2017, (Accepted/In press) In : Archives of Toxicology. p. 1-25 25 p.

Research output: Contribution to journalArticle

CIIPro: a new read-across portal to fill data gaps using public large-scale chemical and biological data

Russo, D. P., Kim, M. T., Wang, W., Pinolini, D., Shende, S., Strickland, J., Hartung, T. & Zhu, H., Feb 1 2017, In : Bioinformatics (Oxford, England). 33, 3, p. 464-466 3 p.

Research output: Contribution to journalArticle

Computational approaches to chemical hazard assessment

Luechtefeld, T. & Hartung, T., Jan 1 2017, In : ALTEX. 34, 4, p. 459-478 20 p.

Research output: Contribution to journalArticle

Evolution of toxicological science: The need for change

Hartung, T., 2017, In : International Journal of Risk Assessment and Management. 20, 1, p. 21-45 25 p.

Research output: Contribution to journalArticle

Food for thought: The need for strategic development of safety sciences

Busquet, F. & Hartung, T., 2017, In : Altex. 34, 1, p. 3-21 19 p.

Research output: Contribution to journalArticle

From in vivo to in vitro: The medical device testing paradigm shift

Myers, D. K., Goldberg, A., Poth, A., Wolf, M. F., Carraway, J., McKim, J., Coleman, K. P., Hutchinson, R., Brown, R., Krug, H. F., Bahinski, A. & Hartung, T., Jan 1 2017, In : Altex. 34, 4, p. 479-500 22 p.

Research output: Contribution to journalArticle

Future Tox III: Bridges for translation

Juberg, D. R., Knudsen, T. B., Sander, M., Beck, N. B., Faustman, E. M., Mendrick, D. L., Fowle, J. R., Hartung, T., Tice, R. R., Lemazurier, E., Becker, R. A., Fitzpatrick, S. C., Daston, G. P., Harrill, A., Hines, R. N., Keller, D. A., Lipscomb, J. C., Watson, D., Bahadori, T. & Crofton, K. M., 2017, In : Toxicological Sciences. 155, 1, p. 22-31 10 p.

Research output: Contribution to journalArticle

Good cell culture practice for stem cells & stem-cell-derived models

Pamies, D., Bal-Price, A., Simeonov, A., Tagle, D., Allen, D., Gerhold, D., Yin, D., Pistollato, F., Inutsuka, T., Sullivan, K., Stacey, G., Salem, H., Leist, M., Daneshian, M., Vemuri, M. C., Mcfarland, R., Coecke, S., Fitzpatrick, S. C., Lakshmipathy, U., Mack, A. & 6 others, Wang, W. B., Yamazaki, D., Sekino, Y., Kanda, Y., Smirnova, L. & Hartung, T., Jan 1 2017, In : ALTEX. 34, 1, p. 95-132 38 p.

Research output: Contribution to journalArticle

Good cell culture practices &in vitro toxicology

Eskes, C., Boström, A. C., Bowe, G., Coecke, S., Hartung, T., Hendriks, G., Pamies, D., Piton, A. & Rovida, C., Mar 7 2017, (Accepted/In press) In : Toxicology in Vitro.

Research output: Contribution to journalArticle

Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity

Pendse, S. N., Maertens, A., Rosenberg, M., Roy, D., Fasani, R. A., Vantangoli, M. M., Madnick, S. J., Boekelheide, K., Fornace, A. J., Odwin, S. A., Yager, J. D., Hartung, T., Andersen, M. E. & McMullen, P. D., Apr 1 2017, In : Archives of Toxicology. 91, 4, p. 1749-1762 14 p.

Research output: Contribution to journalArticle

Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance

Lee, J., Choi, J., Selen Alpergin, E. S., Zhao, L., Hartung, T., Scafidi, S., Riddle, R. & Wolfgang, M. J., Jul 18 2017, In : Cell Reports. 20, 3, p. 655-667 13 p.

Research output: Contribution to journalArticle

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Skardal, A., Murphy, S. V., Devarasetty, M., Mead, I., Kang, H. W., Seol, Y. J., Zhang, Y. S., Shin, S. R., Zhao, L., Aleman, J., Hall, A. R., Shupe, T. D., Kleensang, A., Dokmeci, M. R., Jin Lee, S., Jackson, J. D., Yoo, J. J., Hartung, T., Khademhosseini, A., Soker, S. & 2 others, Bishop, C. E. & Atala, A., Dec 1 2017, In : Scientific reports. 7, 1, 8837.

Research output: Contribution to journalArticle

Opinion versus evidence for the need to move away from animal testing

Hartung, T., 2017, In : Altex. 34, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells

Ramirez, T., Strigun, A., Verlohner, A., Huener, H. A., Peter, E., Herold, M., Bordag, N., Mellert, W., Walk, T., Spitzer, M., Jiang, X., Sperber, S., Hofmann, T., Hartung, T., Kamp, H. & van Ravenzwaay, B., Sep 30 2017, (Accepted/In press) In : Archives of Toxicology. p. 1-14 14 p.

Research output: Contribution to journalArticle

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists & criteria for their selection & use

Aschner, M., Ceccatelli, S., Daneshian, M., Fritsche, E., Hasiwa, N., Hartung, T., Hogberg, H. T., Leist, M., Li, A., Mundy, W. R., Padilla, S., Piersma, A. H., Bal-Price, A., Seiler, A., Westerink, R. H., Zimmer, B. & Lein, P. J., Jan 1 2017, In : ALTEX. 34, 1, p. 49-74 26 p.

Research output: Contribution to journalArticle

The Threshold of Toxicological Concern for prenatal developmental toxicity in rats and rabbits

van Ravenzwaay, B., Jiang, X., Luechtefeld, T. & Hartung, T., Aug 1 2017, In : Regulatory Toxicology and Pharmacology. 88, p. 157-172 16 p.

Research output: Contribution to journalArticle

Thresholds of toxicological concern - Setting a threshold for testing below which there is little concern

Hartung, T., Jan 1 2017, In : ALTEX. 34, 3, p. 331-351 21 p.

Research output: Contribution to journalArticle

Whole blood cytokine response to local traffic-related particulate matter in peruvian children with and without asthma

Negherbon, J. P., Romero, K., Williams, DA. L., Guerrero-Preston, R. E., Hartung, T., Scott, A. L., Breysse, P. N., Checkley, W. & Hansel, N., Mar 30 2017, In : Frontiers in Pharmacology. 8, MAR, 157.

Research output: Contribution to journalArticle

2016

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis

Smirnova, L., Harris, G., Delp, J., Valadares, M., Pamies, D., Hogberg, H. T., Waldmann, T., Leist, M. & Hartung, T., Nov 1 2016, In : Archives of Toxicology. 90, 11, p. 2725-2743 19 p.

Research output: Contribution to journalArticle