1991 …2020

Research output per year

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Research Output

2006

In vitro pyrogen test for toxic or immunomodulatory drugs

Daneshian, M., Guenther, A., Wendel, A., Hartung, T. & von Aulock, S., Jun 30 2006, In : Journal of Immunological Methods. 313, 1-2, p. 169-175 7 p.

Research output: Contribution to journalArticle

Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechanism: Autocrine role of tumor necrosis factor-α in mediating LTA-induced interleukin-8 generation

Hattar, K., Grandel, U., Moeller, A., Fink, L., Iglhaut, J., Hartung, T., Morath, S., Seeger, W., Grimminger, F. & Sibelius, U., Mar 1 2006, In : Critical care medicine. 34, 3, p. 835-841 7 p.

Research output: Contribution to journalArticle

Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use

Corvi, R., Ahr, H. J., Albertini, S., Blakey, D. H., Clerici, L., Coecke, S., Douglas, G. R., Gribaldo, L., Groten, J. P., Haase, B., Hamernik, K., Hartung, T., Inoue, T., Indans, I., Maurici, D., Orphanides, G., Rembges, D., Sansone, S. A., Snape, J. R., Toda, E. & 4 others, Tong, W., van Delft, J. H., Weis, B. & Schechtman, L. M., Mar 1 2006, In : Environmental health perspectives. 114, 3, p. 420-429 10 p.

Research output: Contribution to journalArticle

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

Triantafilou, M., Gamper, F. G. J., Haston, R. M., Mouratis, M. A., Morath, S., Hartung, T. & Triantafilou, K., Oct 13 2006, In : Journal of Biological Chemistry. 281, 41, p. 31002-31011 10 p.

Research output: Contribution to journalArticle

Metabolism: A bottleneck in in vitro toxicological test development

Coecke, S., Ahr, H., Blaauboer, B. J., Bremer, S., Casati, S., Castell, J., Combes, R., Corvi, R., Crespi, C. L., Cunningham, M. L., Elaut, G., Eletti, B., Freidig, A., Gennari, A., Ghersi-Egea, J. F., Guillouzo, A., Hartung, T., Hoet, P., Ingelman-Sundberg, M., Munn, S. & 18 others, Janssens, W., Ladstetter, B., Leahy, D., Long, A., Meneguz, A., Monshouwer, M., Morath, S., Nagelkerke, F., Pelkonen, O., Ponti, J., Prieto, P., Richert, L., Sabbioni, E., Schaack, B., Steiling, W., Testai, E., Vericat, J. A. & Worth, A., Feb 2006, In : ATLA Alternatives to Laboratory Animals. 34, 1, p. 49-84 36 p.

Research output: Contribution to journalArticle

Protecting more than animals

Goldberg, A. M. & Hartung, T., Jan 2006, In : Scientific American. 294, 1, p. 84-91 8 p.

Research output: Contribution to journalReview article

Pyrogen testing of lipidic parenterals with a novel in vitro test--application of the IPT based on cryopreserved human whole blood.

Schindler, S., Rosenberg, U., Schlote, D., Panse, K., Kempe, A., Fennrich, S. & Hartung, T., Aug 2006, In : Pharmeuropa scientific notes. 2006, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction

Figueroa-Perez, I., Stadelmaier, A., Deininger, S., Aulock, S. V., Hartung, T. & Schmidt, R. R., Dec 29 2006, In : Carbohydrate Research. 341, 18, p. 2901-2911 11 p.

Research output: Contribution to journalArticle

Testing times

Hartung, T., Jun 1 2006, In : European Pharmaceutical Contractor. SUMMER, p. 10-12 3 p.

Research output: Contribution to journalShort survey

The assessment of repeated dose toxicity in vitro: A proposed approach

Prieto, P., Baird, A. W., Blaauboer, B. J., Ripoll, J. V. C., Corvi, R., Dekant, W., Dietl, P., Gennari, A., Gribaldo, L., Griffin, J. L., Hartung, T., Heindel, J. J., Hoet, P., Jennings, P., Marocchio, L., Noraberg, J., Pazos, P., Westmorland, C., Wolf, A., Wright, J. & 1 others, Pfaller, W., Jun 1 2006, In : ATLA Alternatives to Laboratory Animals. 34, 3, p. 315-341 27 p.

Research output: Contribution to journalArticle

The effects of solvents on embryonic stem cell differentiation

Adler, S., Pellizzer, C., Paparella, M., Hartung, T. & Bremer, S., Apr 1 2006, In : Toxicology in Vitro. 20, 3, p. 265-271 7 p.

Research output: Contribution to journalArticle

The practical application of three validated in vitro embryotoxicity tests

Spielmann, H., Seiler, A., Bremer, S., Hareng, L., Hartung, T., Ahr, H., Faustman, E., Haas, U., Moffat, G. J., Nau, H., Vanparys, P., Piersma, A., Sintes, J. R. & Stuart, J., Oct 1 2006, In : ATLA Alternatives to Laboratory Animals. 34, 5, p. 527-538 12 p.

Research output: Contribution to journalArticle

The principles of weight of evidence validation of test methods and testing strategies: The report and recommendations of ECVAM Workshop 58

Balls, M., Amcoff, P., Bremer, S., Casati, S., Coecke, S., Clothier, R., Combes, R., Corvi, R., Curren, R., Eskes, C., Fentem, J., Gribaldo, L., Halder, M., Hartung, T., Hoffmann, S., Schechtman, L., Scott, L., Spielmann, H., Stokes, W., Tice, R. & 2 others, Wagner, D. & Zuang, V., Dec 1 2006, In : ATLA Alternatives to Laboratory Animals. 34, 6, p. 603-620 18 p.

Research output: Contribution to journalArticle

The value of alternative testing for neurotoxicity in the context of regulatory needs

Coecke, S., Eskes, C., Gartlon, J., Kinsner, A., Price, A., Van Vliet, E., Prieto, P., Boveri, M., Bremer, S., Adler, S., Pellizzer, C., Wendel, A. & Hartung, T., Feb 2006, In : Environmental Toxicology and Pharmacology. 21, 2 SPEC. ISS., p. 153-167 15 p.

Research output: Contribution to journalArticle

Toward an evidence-based toxicology

Hoffmann, S. & Hartung, T., Sep 1 2006, In : Human and Experimental Toxicology. 25, 9, p. 497-513 17 p.

Research output: Contribution to journalReview article

β-lactam antibiotic-induced release of lipoteichoic acid from Staphylococcus aureus leads to activation of neutrophil granulocytes

Lotz, S., Starke, A., Ziemann, C., Morath, S., Hartung, T., Solbach, W. & Laskay, T., Jun 27 2006, In : Annals of Clinical Microbiology and Antimicrobials. 5, 15.

Research output: Contribution to journalArticle

2005

A new method to measure air-borne pyrogens based on human whole blood cytokine response

Kindinger, I., Daneshian, M., Baur, H., Gabrio, T., Hofmann, A., Fennrich, S., Von Aulock, S. & Hartung, T., Mar 2005, In : Journal of Immunological Methods. 298, 1-2, p. 143-153 11 p.

Research output: Contribution to journalArticle

A new strategy for the synthesis of dinucleotides loaded with glycosylated amino acids - Investigations on in vitro non-natural amino acid mutagenesis for glycoprotein synthesis

Röhrig, C. H., Retz, O. A., Hareng, L., Hartung, T. & Schmidt, R. R., Oct 1 2005, In : ChemBioChem. 6, 10, p. 1805-1816 12 p.

Research output: Contribution to journalArticle

Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation

Hattar, K., Van Bürck, S., Bickenbach, A., Grandel, U., Maus, U., Lohmeyer, J., Csernok, E., Hartung, T., Seeger, W., Grimminger, F. & Sibelius, U., Oct 1 2005, In : Journal of Leukocyte Biology. 78, 4, p. 992-1000 9 p.

Research output: Contribution to journalArticle

CD36 is a sensor of diacylglycerides

Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zähringer, U. & Beutler, B., Feb 3 2005, In : Nature. 433, 7025, p. 523-527 5 p.

Research output: Contribution to journalArticle

Critical evaluation of urine-based PCR assay for diagnosis of Lyme borreliosis.

Rauter, C., Mueller, M., Diterich, I., Zeller, S., Hassler, D., Meergans, T. & Hartung, T., Aug 2005, In : Clinical and Diagnostic Laboratory Immunology. 12, 8, p. 910-917 8 p.

Research output: Contribution to journalArticle

Dendritic cells as a tool for the predictive identification of skin sensitisation hazard

Casati, S., Aeby, P., Basketter, D. A., Cavani, A., Gennari, A., Gerberick, G. F., Griem, P., Hartung, T., Kimber, I., Lepoittevin, J. P., Meade, B. J., Pallardy, M., Rougier, N., Rousset, F., Rubinstenn, G., Sallusto, F., Verheyen, G. R. & Zuang, V., Feb 1 2005, In : ATLA Alternatives to Laboratory Animals. 33, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

Developmental toxicity testing from animal towards embryonic stem cells

Pellizzer, C., Bremer, S. & Hartung, T., Jul 25 2005, In : ALTEX. 22, 2, p. 47-57 11 p.

Research output: Contribution to journalReview article

Diagnosis: Toxic! - Trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations

Hoffmann, S. & Hartung, T., May 1 2005, In : Toxicological Sciences. 85, 1, p. 422-428 7 p.

Research output: Contribution to journalReview article

Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance

Dalpke, A. H., Lehner, M. D., Hartung, T. & Heeg, K., Oct 1 2005, In : Immunology. 116, 2, p. 203-212 10 p.

Research output: Contribution to journalArticle

Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids

Grangette, C., Nutten, S., Palumbo, E., Morath, S., Hermann, C., Dewulf, J., Pot, B., Hartung, T., Hols, P. & Mercenier, A., Jul 19 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 29, p. 10321-10326 6 p.

Research output: Contribution to journalArticle

Guidance on good cell culture practice: A Report of the Second ECVAM Task Force on good cell culture practice

Coecke, S., Balls, M., Bowe, G., Davis, J., Gstraunthaler, G., Hartung, T., Hay, R., Merten, O. W., Price, A., Schechtman, L., Stacey, G. & Stokes, W., Jun 2005, In : ATLA Alternatives to Laboratory Animals. 33, 3, p. 261-287 27 p.

Research output: Contribution to journalReview article

Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage lyme disease

Schröder, N. W. J., Diterich, I., Zinke, A., Eckert, J., Draing, C., Baehr, V. V., Hassler, D., Priem, S., Hahn, K., Michelsen, K. S., Hartung, T., Burmester, G. R., Göbel, U. B., Hermann, C. & Schumann, R. R., Aug 15 2005, In : Journal of Immunology. 175, 4, p. 2534-2540 7 p.

Research output: Contribution to journalArticle

Open Access

Induction of blood-brain barrier properties in cultured brain capillary endothelial cells: Comparison between primary glial cells and C6 cell line

Boveri, M., Berezowski, V., Price, A., Slupek, S., Lenfant, A. M., Benaud, C., Hartung, T., Cecchelli, R., Prieto, P. & Dehouck, M. P., Aug 15 2005, In : Glia. 51, 3, p. 187-198 12 p.

Research output: Contribution to journalArticle

Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation

Kinsner, A., Pilotto, V., Deininger, S., Brown, G. C., Coecke, S., Hartung, T. & Bal-Price, A., Nov 1 2005, In : Journal of Neurochemistry. 95, 4, p. 1132-1143 12 p.

Research output: Contribution to journalArticle

Inhibition of microglial inflammation by the MLK inhibitor CEP-1347

Lund, S., Porzgen, P., Mortensen, A. L., Hasseldam, H., Bozyczko-Coyne, D., Morath, S., Hartung, T., Bianchi, M., Ghezzi, P., Bsibsi, M., Dijkstra, S. & Leist, M., Mar 1 2005, In : Journal of Neurochemistry. 92, 6, p. 1439-1451 13 p.

Research output: Contribution to journalArticle

International validation of novel pyrogen tests based on human monocytoid cells

Hoffmann, S., Peterbauer, A., Schindler, S., Fennrich, S., Poole, S., Mistry, Y., Montag-Lessing, T., Spreitzer, I., Löschner, B., Van Aalderen, M., Bos, R., Gommer, M., Nibbeling, R., Werner-Felmayer, G., Loitzl, P., Jungi, T., Brcic, M., Brügger, P., Frey, E., Bowe, G. & 8 others, Casado, J., Coecke, S., De Lange, J., Mogster, B., Næss, L. M., Aaberge, I. S., Wendel, A. & Hartung, T., Mar 2005, In : Journal of Immunological Methods. 298, 1-2, p. 161-173 13 p.

Research output: Contribution to journalArticle

Mechanisms of cardiac depression caused by lipoteichoic acids from Staphylococcus aureus in isolated rat hearts

Grandel, U., Hopf, M., Buerke, M., Hattar, K., Heep, M., Fink, L., Bohle, R. M., Morath, S., Hartung, T., Pullamsetti, S., Schermuly, R. T., Seeger, W., Grimminger, F. & Sibelius, U., Aug 2 2005, In : Circulation. 112, 5, p. 691-698 8 p.

Research output: Contribution to journalArticle

Optimisation of pyrogen testing in parenterals according to different pharmacopoeias by probabilistic modelling

Hoffmann, S., Lüderitz-Püchel, U., Montag, T. & Hartung, T., Apr 29 2005, In : Journal of Endotoxin Research. 11, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

Prevalence of Borrelia burgdorferi sensu lato genospecies in Ixodes ricinus ticks in Europe: A metaanalysis

Rauter, C. & Hartung, T., Nov 1 2005, In : Applied and environmental microbiology. 71, 11, p. 7203-7216 14 p.

Research output: Contribution to journalArticle

Role of lipoteichoic acid in the phagocyte response to group B Streptococcus

Henneke, P., Morath, S., Uematsu, S., Weichert, S., Pfitzenmaier, M., Takeuchi, O., Müller, A., Poyart, C., Akira, S., Berner, R., Teti, G., Geyer, A., Hartung, T., Trieu-Cuot, P., Kasper, D. L. & Golenbock, D. T., May 15 2005, In : Journal of Immunology. 174, 10, p. 6449-6455 7 p.

Research output: Contribution to journalArticle

Open Access

Skin irritation: Prevalence, variability, and regulatory classification of existing in vivo data from industrial chemicals

Hoffmann, S., Cole, T. & Hartung, T., Apr 2005, In : Regulatory Toxicology and Pharmacology. 41, 3, p. 159-166 8 p.

Research output: Contribution to journalArticle

Structure/function relationships of lipoteichoic acids

Morath, S., von Aulock, S. & Hartung, T., Dec 12 2005, In : Journal of Endotoxin Research. 11, 6, p. 348-356 9 p.

Research output: Contribution to journalArticle

Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles

Bogni, A., Monshouwer, M., Moscone, A., Hidestrand, M., Ingelman-Sundberg, M., Hartung, T. & Coecke, S., Aug 1 2005, In : Toxicology in Vitro. 19, 5, p. 621-629 9 p.

Research output: Contribution to journalArticle

Synthesis of structural variants of Staphylococcus aureus lipoteichoic acid (LTA)

Figueroa-Perez, I., Stadelmaier, A., Morath, S., Hartung, T. & Schmidt, R. R., Jan 24 2005, In : Tetrahedron Asymmetry. 16, 2, p. 493-506 14 p.

Research output: Contribution to journalArticle

The detection of differentiation-inducing chemicals by using green fluorescent protein expression in genetically engineered teratocarcinoma cells

Adler, S., Paparella, M., Pellizzer, C., Hartung, T. & Bremer, S., Apr 1 2005, In : ATLA Alternatives to Laboratory Animals. 33, 2, p. 91-103 13 p.

Research output: Contribution to journalArticle

The Integrated Project ReProTect: A novel approach in reproductive toxicity hazard assessment

Hareng, L., Pellizzer, C., Bremer, S., Schwarz, M. & Hartung, T., Sep 1 2005, In : Reproductive Toxicology. 20, 3, p. 441-452 12 p.

Research output: Contribution to journalReview article

The use of in vitro systems for evaluating immunotoxicity: The report and recommendations of an ECVAM workshop

Gennari, A., Ban, M., Braun, A., Casati, S., Corsini, E., Dastych, J., Descotes, J., Hartung, T., Hooghe-Peters, R., House, R., Pallardy, M., Pieters, R., Reid, L., Tryphonas, H., Tschirhart, E., Tuschl, H., Vandebriel, R. & Gribaldo, L., Jan 1 2005, In : Journal of Immunotoxicology. 2, 2, p. 61-83 23 p.

Research output: Contribution to journalArticle

2004

Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumonia

Knapp, S., Hareng, L., Rijneveld, A. W., Bresser, P., Van Der Zee, J. S., Florquin, S., Hartung, T. & Van Der Poll, T., Apr 15 2004, In : Journal of Infectious Diseases. 189, 8, p. 1506-1514 9 p.

Research output: Contribution to journalArticle

Alternatives to animal experimentation in basic research

Gruber, F. P. & Hartung, T., Dec 1 2004, In : ALTEX. 21, SUPPL. 1, p. 3-31 29 p.

Research output: Contribution to journalArticle

A modular approach to the ECVAM principles on test validity

Hartung, T., Bremer, S., Casati, S., Coecke, S., Corvi, R., Fortaner, S., Gribaldo, L., Halder, M., Hoffmann, S., Roi, A. J., Prieto, P., Sabbioni, E., Scott, L., Worth, A. & Zuang, V., Nov 1 2004, In : ATLA Alternatives to Laboratory Animals. 32, 5, p. 467-472 6 p.

Research output: Contribution to journalReview article

Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part I: Technical description

Koppelstaetter, C., Jennings, P., Ryan, M. P., Morin, J. P., Hartung, T. & Pfaller, W., Aug 6 2004, In : ALTEX. 21, 2, p. 51-60 10 p.

Research output: Contribution to journalArticle

Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing part 2: Toxicological evaluation

Jennings, P., Koppelstaetter, C., Pfaller, W., Morin, J. P., Hartung, T. & Ryan, M. P., Aug 6 2004, In : ALTEX. 21, 2, p. 61-66 6 p.

Research output: Contribution to journalArticle

Comparison of the sensitivity of different toxicological endpoints in Caco-2 cells after cadmium chloride treatment

Boveri, M., Pazos, P., Gennari, A., Casado, J., Hartung, T. & Prieto, P., Apr 1 2004, In : Archives of Toxicology. 78, 4, p. 201-206 6 p.

Research output: Contribution to journalArticle