1991 …2020

Research output per year

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Research Output

Article

MPTP’s Pathway of Toxicity Indicates Central Role of Transcription Factor SP1

Maertens, A., Luechtefeld, T., Kleensang, A. & Hartung, T., May 1 2015, In : Archives of Toxicology. 89, 5, p. 743-755 13 p.

Research output: Contribution to journalArticle

mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach

Hogberg, H. T., Kinsner-Ovaskainen, A., Coecke, S., Hartung, T. & Bal-Price, A. K., Aug 3 2009, In : Toxicological Sciences. 113, 1, p. 95-115 21 p., kfp175.

Research output: Contribution to journalArticle

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Skardal, A., Murphy, S. V., Devarasetty, M., Mead, I., Kang, H. W., Seol, Y. J., Zhang, Y. S., Shin, S. R., Zhao, L., Aleman, J., Hall, A. R., Shupe, T. D., Kleensang, A., Dokmeci, M. R., Jin Lee, S., Jackson, J. D., Yoo, J. J., Hartung, T., Khademhosseini, A., Soker, S. & 2 others, Bishop, C. E. & Atala, A., Dec 1 2017, In : Scientific reports. 7, 1, 8837.

Research output: Contribution to journalArticle

Nachweis eines breiten Pyrogenspektrums im Monozyten-Aktivierungstest

Translated title of the contribution: In vitro pyrogen test: Proof of a broad pyrogen spectrum in the monocyte-activation testHoltkamp, B., Schmitz, G. & Härtung, T., Nov 1 2010, In : BioSpektrum. 16, 7, p. 779-781 3 p.

Research output: Contribution to journalArticle

New European Union statistics on laboratory animal use - what really counts!

Busquet, F., Kleensang, A., Rovida, C., Herrmann, K., Leist, M. & Hartung, T., Jan 1 2020, In : ALTEX. 37, 2, p. 167-186 20 p.

Research output: Contribution to journalArticle

Open Access

Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across

Russo, D. P., Strickland, J., Karmaus, A. L., Wang, W., Shende, S., Hartung, T., Aleksunes, L. M. & Zhu, H., Apr 1 2019, In : Environmental health perspectives. 127, 4, 1 p.

Research output: Contribution to journalArticle

Open Access

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology

Gordon, S., Daneshian, M., Bouwstra, J., Caloni, F., Constant, S., Davies, D. E., Dandekar, G., Guzman, C. A., Fabian, E., Haltner, E., Hartung, T., Hasiwa, N., Hayden, P., Kandarova, H., Khare, S., Krug, H. F., Kneuer, C., Leist, M., Lian, G., Marx, U. & 9 others, Metzger, M., Ott, K., Prieto, P., Roberts, M. S., Roggen, E. L., Tralau, T., Van Den Braak, C., Walles, H. & Lehr, C. M., 2015, In : ALTEX. 32, 4, p. 327-378 52 p.

Research output: Contribution to journalArticle

Novel advanced in vitro methods for long-term toxicity testing

Pfaller, W., Balls, M., Clothier, R., Coecke, S., Dierickx, P., Ekwall, B., Hanley, B. A., Hartung, T., Prieto, P., Ryan, M. P., Schmuck, G., Šladowski, D., Vericat, J. A., Wendel, A., Wolf, A. & Zimmer, J., Sep 21 2001, In : ATLA Alternatives to Laboratory Animals. 29, 4, p. 393-426 34 p.

Research output: Contribution to journalArticle

Novel pyrogen tests based on the human fever reaction

Hartung, T., Aaberge, I., Berthold, S., Carlin, G., Charton, E., Coecke, S., Fennrich, S., Fischer, M., Gommer, M., Halder, M., Haslov, K., Jahnke, M., Montag-Lessing, T., Poole, S., Schechtman, L., Wendel, A. & Werner-Felmayer, G., Jan 1 2001, In : ATLA Alternatives to Laboratory Animals. 29, 2, p. 99-123 25 p.

Research output: Contribution to journalArticle

Opinion versus evidence for the need to move away from animal testing

Hartung, T., 2017, In : ALTEX. 34, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

Optimisation of pyrogen testing in parenterals according to different pharmacopoeias by probabilistic modelling

Hoffmann, S., Lüderitz-Püchel, U., Montag, T. & Hartung, T., Apr 29 2005, In : Journal of Endotoxin Research. 11, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

Optimisation of the post-validation process: The report and recommendations of ECVAM workshop 67

Bottini, A. A., Alepee, N., Phillips, B., Gribaldo, L., De Silva, O., Hartung, T., Hendriksen, C., Kuil, J., Pazos, P., Rhein, C., Schiffelers, M. J., Stokes, W., Theobald, A., Vidal, J. M., Van De Sandt, H., Breier, S., Sintes, J. R. & Blaauboer, B., Jul 1 2008, In : ATLA Alternatives to Laboratory Animals. 36, 3, p. 353-366 14 p.

Research output: Contribution to journalArticle

Optimizing drug discovery by investigative toxicology: Current and future trends

Beilmann, M., Boonen, H., Czich, A., Dear, G., Hewitt, P., Mow, T., Newham, P., Oinonen, T., Pognan, F., Roth, A., Valentin, J. P., Van Goethem, F., Weaver, R. J., Birk, B., Boyer, S., Caloni, F., Chen, A. E., Corvi, R., Cronin, M. T. D., Daneshian, M. & 14 others, Ewart, L. C., FitzGerald, R. E., Hamilton, G. A., Hartung, T., Kangas, J. D., Kramer, N. I., Leist, M., Marx, U., Polak, S., Rovida, C., Testai, E., Van de Water, B., Vulto, P. & Steger-Hartmann, T., 2019, In : ALTEX. 36, 2, p. 289-313 25 p.

Research output: Contribution to journalArticle

Open Access

Outcome prediction by traditional and new markers of inflammation in patients with sepsis

Oberhoffer, M., Vogelsang, H., Rußwurm, S., Hartung, T. & Reinhart, K., May 17 1999, In : Clinical Chemistry and Laboratory Medicine. 37, 3, p. 363-368 6 p.

Research output: Contribution to journalArticle

Perioperative prophylaxis with granulocyte colony-stimulating factor (G-CSF) in high-risk colorectal cancer patients for an improved recovery: A randomized, controlled trial

Bauhofer, A., Plaul, U., Torossian, A., Koller, M., Stinner, B., Celik, I., Sitter, H., Greger, B., Middeke, M., Schein, M., Wyatt, J., Nyström, P. O., Hartung, T., Rothmund, M. & Lorenz, W., Apr 1 2007, In : Surgery. 141, 4, p. 501-510 10 p.

Research output: Contribution to journalArticle

Perioperative Recombinant Human Granulocyte Colony-Stimulating Factor (Filgrastim) Treatment Prevents Immunoinflammatory Dysfunction Associated with Major Surgery

Schneider, C., Von Aulock, S., Zedler, S., Schinkel, C., Hartung, T. & Faist, E., Jan 1 2004, In : Annals of surgery. 239, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

Judson, R., Kavlock, R., Martin, M., Reif, D., Houck, K., Knudsen, T., Richard, A., Tice, R. R., Whelan, M., Xia, M., Huang, R., Austin, C., Daston, G., Hartung, T., Fowle, J. R., Wooge, W., Tong, W. & Dix, D., 2013, In : ALTEX. 30, 1, p. 51-66 16 p.

Research output: Contribution to journalArticle

Open Access

Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-κB pathway

Kiemer, A. K., Hartung, T., Huber, C. & Vollmar, A. M., Mar 1 2003, In : Journal of Hepatology. 38, 3, p. 289-297 9 p.

Research output: Contribution to journalArticle

Points of reference in the validation process

Hoffmann, S., Edler, L., Gardner, I., Gribaldo, L., Hartung, T., Klein, C., Liebsch, M., Sauerland, S., Schechtman, L., Stammati, A. & Nikolaidis, E., Jul 2008, In : ATLA Alternatives to Laboratory Animals. 36, 3, p. 343-352 10 p.

Research output: Contribution to journalArticle

Polypropylene glycol is a selective binding inhibitor for LTA and other structurally related TLR2 agonists

Draing, C., Traub, S., Deininger, S., Mang, P., Möller, H. M., Manso, M., Rossi, F., Morath, S., Hartung, T. & von Aulock, S., Mar 1 2008, In : European Journal of Immunology. 38, 3, p. 797-808 12 p.

Research output: Contribution to journalArticle

Predicting toxicity of chemicals: software beats animal testing

Hartung, T., Jul 2019, In : EFSA Journal. 17, S1, e170710.

Research output: Contribution to journalArticle

Open Access

Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells

Ramirez, T., Strigun, A., Verlohner, A., Huener, H. A., Peter, E., Herold, M., Bordag, N., Mellert, W., Walk, T., Spitzer, M., Jiang, X., Sperber, S., Hofmann, T., Hartung, T., Kamp, H. & van Ravenzwaay, B., Feb 1 2018, In : Archives of Toxicology. 92, 2, p. 893-906 14 p.

Research output: Contribution to journalArticle

Preface

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, p. 83-86 4 p.

Research output: Contribution to journalArticle

Presentation of lipoteichoic acid potentiates its inflammatory activity

Deininger, S., Traub, S., Aichele, D., Rupp, T., Baris, T., Möller, H. M., Hartung, T. & von Aulock, S., Jul 10 2008, In : Immunobiology. 213, 6, p. 519-529 11 p.

Research output: Contribution to journalArticle

Prevalence of Borrelia burgdorferi sensu lato genospecies in Ixodes ricinus ticks in Europe: A metaanalysis

Rauter, C. & Hartung, T., Nov 1 2005, In : Applied and environmental microbiology. 71, 11, p. 7203-7216 14 p.

Research output: Contribution to journalArticle

Probabilistic hazard assessment for skin sensitiza tion potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships

Luechtefeld, T., Maertens, A., Mckim, J. M., Hartung, T., Kleensang, A. & Sá-Rocha, V., Nov 1 2015, In : Journal of Applied Toxicology. 35, 11, p. 1361-1371 11 p.

Research output: Contribution to journalArticle

Profound differences in leukocyte-endothelial cell responses to lipopolysaccharide versus lipoteichoic acid

Yipp, B. G., Andonegui, G., Howlett, C. J., Robbins, S. M., Hartung, T., Ho, M. & Kubes, P., May 1 2002, In : Journal of Immunology. 168, 9, p. 4650-4658 9 p.

Research output: Contribution to journalArticle

Open Access

Proposal for a Brazilian centre on alternative test methods

Eskes, C., Sá-Rocha, V. D. M., Nunes, J., Presgrave, O., De Carvalho, D., Masson, P., Rivera, E., Coecke, S., Kreysa, J. & Hartung, T., 2009, In : ALTEX. 26, 4, p. 303-306 4 p.

Research output: Contribution to journalArticle

Protection with antibody to tumor necrosis factor differs with similarly lethal Escherichia coli versus Staphylococcus aureus pneumonia in rats

Karzai, W., Cui, X., Mehlhorn, B., Straube, E., Hartung, T., Gerstenberger, E., Banks, S. M., Natanson, C., Reinhart, K. & Eichacker, P. Q., Jul 1 2003, In : Anesthesiology. 99, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Pyrogen testing of lipidic parenterals with a novel in vitro test--application of the IPT based on cryopreserved human whole blood.

Schindler, S., Rosenberg, U., Schlote, D., Panse, K., Kempe, A., Fennrich, S. & Hartung, T., Aug 2006, In : Pharmeuropa scientific notes. 2006, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Quality assurance of metabolomics

Bouhifd, M., Beger, R., Flynn, T., Guo, L., Harris, G., Hogberg, H., Kaddurah-Daouk, R., Kamp, H., Kleensang, A., Maertens, A., Odwin-DaCosta, S., Pamies, D., Robertson, D., Smirnova, L., Sun, J., Zhao, L. & Hartung, T., 2015, In : ALTEX. 32, 4, p. 319-326 8 p.

Research output: Contribution to journalArticle

Read-across approaches - Misconceptions, promises and challenges ahead

Patlewicz, G., Ball, N., Becker, R. A., Booth, E. D., Cronin, M. T. D., Kroese, D., Steup, D., Van Ravenzwaay, B. & Hartung, T., Jan 1 2014, In : Archivos de Medicina Veterinaria. 46, 4, p. 387-396 10 p.

Research output: Contribution to journalArticle

Rebooting the generally recognized as safe (GRAS) approach for food additive safety in the US

Hartung, T., 2018, In : ALTEX. 35, 1, p. 3-25 23 p.

Research output: Contribution to journalArticle

Open Access

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists & criteria for their selection & use

Aschner, M., Ceccatelli, S., Daneshian, M., Fritsche, E., Hasiwa, N., Hartung, T., Hogberg, H. T., Leist, M., Li, A., Mundy, W. R., Padilla, S., Piersma, A. H., Bal-Price, A., Seiler, A., Westerink, R. H., Zimmer, B. & Lein, P. J., 2017, In : ALTEX. 34, 1, p. 49-74 26 p.

Research output: Contribution to journalArticle

Regulatory acceptance of read-across

Chesnut, M., Yamada, T., Adams, T., Knight, D., Kleinstreuer, N., Kass, G., Luechtefeld, T. & Hartung, T., Jan 1 2018, In : ALTEX. 35, 3, p. 413-419 7 p.

Research output: Contribution to journalArticle

Removal of immune-stimulatory components from surfaces by plasma discharges

Hasiwa, M., Kylián, O., Hartung, T. & Rossi, F., Apr 2008, In : Innate Immunity. 14, 2, p. 89-97 9 p.

Research output: Contribution to journalArticle

Role of lipoteichoic acid in the phagocyte response to group B Streptococcus

Henneke, P., Morath, S., Uematsu, S., Weichert, S., Pfitzenmaier, M., Takeuchi, O., Müller, A., Poyart, C., Akira, S., Berner, R., Teti, G., Geyer, A., Hartung, T., Trieu-Cuot, P., Kasper, D. L. & Golenbock, D. T., May 15 2005, In : Journal of Immunology. 174, 10, p. 6449-6455 7 p.

Research output: Contribution to journalArticle

Open Access

Role of TNF-α in high-dose antigen therapy in experimental autoimmune neuritis: Inhibition of TNF-α by neutralizing antibodies reduces T-cell apoptosis and prevents liver necrosis

Weishaupt, A., Gold, R., Hartung, T., Gaupp, S., Wendel, A., Brück, W. & Toyka, K. V., May 2000, In : Journal of neuropathology and experimental neurology. 59, 5, p. 368-376 9 p.

Research output: Contribution to journalArticle

Open Access

Rotenone exerts developmental neurotoxicity in a human brain spheroid model

Pamies, D., Block, K., Lau, P., Gribaldo, L., Pardo, C. A., Barreras, P., Smirnova, L., Wiersma, D., Zhao, L., Harris, G., Hartung, T. & Hogberg, H. T., Sep 1 2018, In : Toxicology and Applied Pharmacology. 354, p. 101-114 14 p.

Research output: Contribution to journalArticle

Safety first

Hartung, T., Sep 1 2015, Innovations in Pharmaceutical Technology, 54, p. 40-43 4 p.

Research output: Contribution to specialist publicationArticle

Schwann cell apoptosis in experimental autoimmune neuritis of the Lewis rat and the functional role of tumor necrosis factor-α

Weishaupt, A., Brück, W., Hartung, T., Toyka, K. V. & Gold, R., Jun 22 2001, In : Neuroscience Letters. 306, 1-2, p. 77-80 4 p.

Research output: Contribution to journalArticle

Skin irritation: Prevalence, variability, and regulatory classification of existing in vivo data from industrial chemicals

Hoffmann, S., Cole, T. & Hartung, T., Apr 2005, In : Regulatory Toxicology and Pharmacology. 41, 3, p. 159-166 8 p.

Research output: Contribution to journalArticle

Skin sensitisation and epidermal disposition: The relevance of epidermal disposition for sensitisation hazard identification and risk assessment: The report and recommendations of ECVAM workshop 59a

Basketter, D., Pease, C., Kasting, G., Kimber, I., Casati, S., Cronin, M., Diembeck, W., Gerberick, F., Hadgraft, J., Hartung, T., Marty, J. P., Nikolaidis, E., Patlewicz, G., Roberts, D., Roggen, E., Rovida, C. & Van De Sandt, J., Mar 2007, In : ATLA Alternatives to Laboratory Animals. 35, 1, p. 137-154 18 p.

Research output: Contribution to journalArticle

Solcoseryl prevents inflammatory and hypoxic but not toxic liver damage in rodents

Hartung, T., Leist, M., Tiegs, G., Baschong, W. & Wendel, A., Mar 1 1991, In : Inflammopharmacology. 1, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity

Delp, J., Gutbier, S., Cerff, M., Zasada, C., Niedenführ, S., Zhao, L., Smirnova, L., Hartung, T., Borlinghaus, H., Schreiber, F., Bergemann, J., Gätgens, J., Beyss, M., Azzouzi, S., Waldmann, T., Kempa, S., Nöh, K. & Leist, M., Jan 1 2018, (Accepted/In press) In : Toxicology and Applied Pharmacology.

Research output: Contribution to journalArticle

Staphylococcus aureus–derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2

Kaesler, S., Skabytska, Y., Chen, K. M., Kempf, W. E., Volz, T., Köberle, M., Wölbing, F., Hein, U., Hartung, T., Kirschning, C., Röcken, M. & Biedermann, T., Sep 1 2016, In : Journal of Allergy and Clinical Immunology. 138, 3, p. 780-790.e6

Research output: Contribution to journalArticle

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Alépée, N., Bahinski, A., Daneshian, M., De Wever, B., Fritsche, E., Goldberg, A., Hansmann, J., Hartung, T., Haycock, J., Hogberg, H. T., Hoelting, L., Kelm, J. M., Kadereit, S., McVey, E., Landsiedel, R., Leist, M., Lübberstedt, M., Noor, F., Pellevoisin, C., Petersohn, D. & 7 others, Pfannenbecker, U., Reisinger, K., Ramirez, T., Rothen-Rutishauser, B., Schäfer-Korting, M., Zeilinger, K. & Zurich, M. G., 2014, In : ALTEX. 31, 4, p. 441-477 37 p.

Research output: Contribution to journalArticle