1991 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: Selective potentiation of nitric oxide production by muramyl dipeptide

Kinsner, A., Boveri, M., Hareng, L., Brown, G. C., Coecke, S., Hartung, T. & Bal-Price, A., Oct 1 2006, In : Journal of Neurochemistry. 99, 2, p. 596-607 12 p.

Research output: Contribution to journalArticle

High sensitivity pyrogen testing in water and dialysis solutions

Daneshian, M., Wendel, A., Hartung, T. & von Aulock, S., Jul 20 2008, In : Journal of Immunological Methods. 336, 1, p. 64-70 7 p.

Research output: Contribution to journalArticle

How to leverage an endogenous immune defense mechanism: The example of granulocyte colony-stimulating factor

Hartung, T., Von Aulock, S., Schneider, C. & Faist, E., Jan 1 2003, In : Critical care medicine. 31, 1 SUPPL., p. S65-S75

Research output: Contribution to journalReview article

Human 3D in vitro models for developmental neurotoxicity

Smirnova, L. & Hartung, T., Jan 1 2018, Handbook of Developmental Neurotoxicology. Elsevier, p. 163-172 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Human monocytes express functional receptors for granulocyte colony- stimulating factor that mediate suppression of monokines and interferon-γ

Boneberg, E. M., Hareng, L., Gantner, F., Wendel, A. & Hartung, T., Jan 1 2000, In : Blood. 95, 1, p. 270-276 7 p.

Research output: Contribution to journalArticle

Identification of Borrelia burgdorferi ribosomal protein L25 by the phage surface display method and evaluation of the protein's value for serodiagnosis

Mueller, M., Bunk, S., Diterich, I., Weichel, M., Rauter, C., Hassler, D., Hermann, C., Crameri, R. & Hartung, T., Oct 1 2006, In : Journal of clinical microbiology. 44, 10, p. 3778-3780 3 p.

Research output: Contribution to journalArticle

Immune protection against septic peritonitis in endotoxin-primed mice is related to reduced neutrophil apoptosis

Feterowski, C., Weighardt, H., Emmanuilidis, K., Hartung, T. & Holzmann, B., May 3 2001, In : European Journal of Immunology. 31, 4, p. 1268-1277 10 p.

Research output: Contribution to journalArticle

Immunomodulation by colony-stimulating factors.

Hartung, T., 1999, In : Reviews of Physiology, Biochemistry and Pharmacology. 136, p. 1-164 164 p.

Research output: Contribution to journalReview article

Immunomodulatory action of G-CSF in a rat model of endotoxin-induced liver injury: An intravital microscopic analysis of Kupffer cell and leukocyte response

Vollmar, B., Messner, S., Wanner, G. A., Hartung, T. & Menger, M. D., Dec 1997, In : Journal of Leukocyte Biology. 62, 6, p. 710-718 9 p.

Research output: Contribution to journalArticle

Improved detection of pyrogens using the monocyte activation test

Borel, A., Holtkamp, B., Schmitz, G. & Hartung, T., May 2015, In : Pharmaceutical Processing. 30, 4, p. 32-33 2 p.

Research output: Contribution to journalComment/debate

Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response

Lehner, M. D., Ittner, J., Bundschuh, D. S., Van Rooijen, N., Wendel, A. & Hartung, T., 2001, In : Infection and immunity. 69, 1, p. 463-471 9 p.

Research output: Contribution to journalArticle

Increased D-alanylation of lipoteichoic and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis

Kramer, N. E., Hasper, H. E., van den Bogaard, P. T. C., Morath, S., de Kruijff, B., Hartung, T., Smid, E. J., Breukink, E., Kok, J. & Kuipers, O. P., 2008, In : Microbiology. 154, 6, p. 1755-1762 8 p.

Research output: Contribution to journalArticle

Induction and regulation of endogenous granulocyte colony-stimulating factor formation

Hareng, L. & Hartung, T., Oct 1 2002, In : Biological Chemistry. 383, 10, p. 1501-1517 17 p.

Research output: Contribution to journalReview article

Induction of blood-brain barrier properties in cultured brain capillary endothelial cells: Comparison between primary glial cells and C6 cell line

Boveri, M., Berezowski, V., Price, A., Slupek, S., Lenfant, A. M., Benaud, C., Hartung, T., Cecchelli, R., Prieto, P. & Dehouck, M. P., Aug 15 2005, In : Glia. 51, 3, p. 187-198 12 p.

Research output: Contribution to journalArticle

Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different toll-like receptors independent of paracrine mediators

Lehner, M. D., Morath, S., Michelsen, K. S., Schumann, R. R. & Hartung, T., Apr 15 2001, In : Journal of Immunology. 166, 8, p. 5161-5167 7 p.

Research output: Contribution to journalArticle

Open Access

Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.

Ellingsen, E., Morath, S., Flo, T., Schromm, A., Hartung, T., Thiemermann, C., Espevik, T., Golenbock, D., Foster, D., Solberg, R., Aasen, A. & Wang, J., May 2002, In : Medical science monitor : international medical journal of experimental and clinical research. 8, 5, p. BR149-156

Research output: Contribution to journalArticle

Induction of IL-10-balanced immune profiles following exposure to LTA from Staphylococcus epidermidis

Volz, T., Kaesler, S., Draing, C., Hartung, T., Röcken, M., Skabytska, Y. & Biedermann, T., Apr 1 2018, In : Experimental Dermatology. 27, 4, p. 318-326 9 p.

Research output: Contribution to journalArticle

Induction of the chemokines IL-8 and MCP-1 in human whole blood by a cell-lysate of human fibroblast cells

Schneider, M. & Hartung, T., Jan 1 2001, In : Immunology Letters. 75, 2, p. 163-165 3 p.

Research output: Contribution to journalArticle

Inflammatory and immunological parameters in children with haemolytic uremic syndrome (HUS) and gastroenteritis - Pathophysiological and diagnostic clues

Westerholt, S., Hartung, T., Tollens, M., Güstrau, A., Oberhoffer, M., Karch, H., Klare, B., Pfeffer, K., Emmrich, P. & Oberhoffer, R., Jun 2000, In : Cytokine. 12, 6, p. 822-827 6 p.

Research output: Contribution to journalArticle

Inflammatory findings on species extrapolations: Humans are definitely no 70-kg mice

Leist, M. & Hartung, T., Apr 1 2013, In : Archives of Toxicology. 87, 4, p. 563-567 5 p.

Research output: Contribution to journalReview article

Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation

Kinsner, A., Pilotto, V., Deininger, S., Brown, G. C., Coecke, S., Hartung, T. & Bal-Price, A., Nov 1 2005, In : Journal of Neurochemistry. 95, 4, p. 1132-1143 12 p.

Research output: Contribution to journalArticle

Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity

Pendse, S. N., Maertens, A., Rosenberg, M., Roy, D., Fasani, R. A., Vantangoli, M. M., Madnick, S. J., Boekelheide, K., Fornace, A. J., Odwin, S. A., Yager, J. D., Hartung, T., Andersen, M. E. & McMullen, P. D., Apr 1 2017, In : Archives of Toxicology. 91, 4, p. 1749-1762 14 p.

Research output: Contribution to journalArticle

Inhibition of cyclooxygenase-2 by natriuretic peptides

Kiemer, A. K., Lehner, M. D., Hartung, T. & Vollmar, A. M., 2002, In : Endocrinology. 143, 3, p. 846-852 7 p.

Research output: Contribution to journalArticle

Open Access

Inhibition of microglial inflammation by the MLK inhibitor CEP-1347

Lund, S., Porzgen, P., Mortensen, A. L., Hasseldam, H., Bozyczko-Coyne, D., Morath, S., Hartung, T., Bianchi, M., Ghezzi, P., Bsibsi, M., Dijkstra, S. & Leist, M., Mar 1 2005, In : Journal of Neurochemistry. 92, 6, p. 1439-1451 13 p.

Research output: Contribution to journalArticle

Innate immunity in Arabidopsis thaliana: Lipopolysaccharides activate nitric oxide synthase (NOS) and induce defense genes

Zeidler, D., Zähringer, U., Gerber, I., Dubery, I., Hartung, T., Bors, W., Hutzler, P. & Durner, J., Nov 2 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 44, p. 15811-15816 6 p.

Research output: Contribution to journalArticle

Integrated testing strategies (ITS) for safety assessment

Rovida, C., Alépée, N., Api, A. M., Basketter, D. A., Bois, F. Y., Caloni, F., Corsini, E., Daneshian, M., Eskes, C., Ezendam, J., Fuchs, H., Hayden, P., Hegele-Hartung, C., Hoffmann, S., Hubesch, B., Jacobs, M. N., Jaworska, J., Kleensang, A., Kleinstreuer, N., Lalko, J. & 16 others, Landsiedel, R., Lebreux, F., Luechtefeld, T., Locatelli, M., Mehling, A., Natsch, A., Pitchford, J. W., Prater, D., Prieto, P., Schepky, A., Schüürmann, G., Smirnova, L., Toole, C., Van Vliet, E., Weisensee, D. & Hartung, T., 2015, In : ALTEX. 32, 1, p. 25-40 16 p.

Research output: Contribution to journalArticle

Interaction of lipoteichoic acid and CpG-DNA during activation of innate immune cells

Dalpke, A. H., Frey, M., Morath, S., Hartung, T. & Heeg, K., Oct 2002, In : Immunobiology. 206, 4, p. 392-407 16 p.

Research output: Contribution to journalArticle

Interleukin-10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis

Keel, M., Ungethüm, U., Steckholzer, U., Niederer, E., Hartung, T., Trentz, O. & Ertel, W., Nov 15 1997, In : Blood. 90, 9, p. 3356-3363 8 p.

Research output: Contribution to journalArticle

Intermittent G-CSF (filgrastim) treatment cannot induce lymphocytosis in volunteers

Von Aulock, S., Boneberg, E. M. & Hartung, T., Aug 19 2000, In : Clinical pharmacology and therapeutics. 68, 1, 1 p.

Research output: Contribution to journalLetter

Internalization and coreceptor expression are critical for TLR2-mediated recognition of lipoteichoic acid in human peripheral blood

Bunk, S., Sigel, S., Metzdorf, D., Sharif, O., Triantafilou, K., Triantafilou, M., Hartung, T., Knapp, S. & Von Aulock, S., Sep 15 2010, In : Journal of Immunology. 185, 6, p. 3708-3717 10 p.

Research output: Contribution to journalArticle

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

Bal-Price, A., Crofton, K. M., Leist, M., Allen, S., Arand, M., Buetler, T., Delrue, N., FitzGerald, R. E., Hartung, T., Heinonen, T., Hogberg, H., Bennekou, S. H., Lichtensteiger, W., Oggier, D., Paparella, M., Axelstad, M., Piersma, A., Rached, E., Schilter, B., Schmuck, G. & 7 others, Stoppini, L., Tongiorgi, E., Tiramani, M., Monnet-Tschudi, F., Wilks, M. F., Ylikomi, T. & Fritsche, E., 2015, In : Archives of Toxicology. 89, 2, p. 269-287 19 p.

Research output: Contribution to journalReview article

International validation of novel pyrogen tests based on human monocytoid cells

Hoffmann, S., Peterbauer, A., Schindler, S., Fennrich, S., Poole, S., Mistry, Y., Montag-Lessing, T., Spreitzer, I., Löschner, B., Van Aalderen, M., Bos, R., Gommer, M., Nibbeling, R., Werner-Felmayer, G., Loitzl, P., Jungi, T., Brcic, M., Brügger, P., Frey, E., Bowe, G. & 8 others, Casado, J., Coecke, S., De Lange, J., Mogster, B., Næss, L. M., Aaberge, I. S., Wendel, A. & Hartung, T., Mar 2005, In : Journal of Immunological Methods. 298, 1-2, p. 161-173 13 p.

Research output: Contribution to journalArticle

International validation of pyrogen tests based on cryopreserved human primary blood cells

Schindler, S., Spreitzer, I., Löschner, B., Hoffmann, S., Hennes, K., Halder, M., Brügger, P., Frey, E., Hartung, T. & Montag, T., Oct 30 2006, In : Journal of Immunological Methods. 316, 1-2, p. 42-51 10 p.

Research output: Contribution to journalArticle

Invited review: MDP and other muropeptides - Direct and synergistic effects on the immune system

Traub, S., von Aulock, S., Hartung, T. & Hermann, C., Apr 1 2006, In : Journal of Endotoxin Research. 12, 2, p. 69-85 17 p.

Research output: Contribution to journalReview article

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

Schmidt, B. Z., Lehmann, M., Gutbier, S., Nembo, E., Noel, S., Smirnova, L., Forsby, A., Hescheler, J., Avci, H. X., Hartung, T., Leist, M., Kobolák, J. & Dinnyés, A., Aug 4 2016, (Accepted/In press) In : Archives of Toxicology. p. 1-33 33 p.

Research output: Contribution to journalArticle

In vitro developmental neurotoxicity (DNT) testing: Relevant models and endpoints

Bal-Price, A. K., Hogberg, H. T., Buzanska, L., Lenas, P., van Vliet, E. & Hartung, T., Sep 1 2010, In : NeuroToxicology. 31, 5, p. 545-554 10 p.

Research output: Contribution to journalArticle

In Vitro Prevention and Reversal of Lipopolysaccharide Desensitization by IFN-γ, IL-12, and Granulocyte-Macrophage Colony-Stimulating Factor

Randow, F., Döcke, W. D., Bundschuh, D. S., Hartung, T., Wendel, A. & Volk, H. D., Mar 15 1997, In : Journal of Immunology. 158, 6, p. 2911-2918 8 p.

Research output: Contribution to journalArticle

In vitro pyrogen test - A new test method for solid medical devices

Mazzotti, F., Beuttler, J., Zeller, R., Fink, U., Schindler, S., Wendel, A., Harlung, T. & Von Aulock, S., Feb 1 2007, In : Journal of Biomedical Materials Research - Part A. 80, 2, p. 276-282 7 p.

Research output: Contribution to journalArticle

In vitro pyrogen test for toxic or immunomodulatory drugs

Daneshian, M., Guenther, A., Wendel, A., Hartung, T. & von Aulock, S., Jun 30 2006, In : Journal of Immunological Methods. 313, 1-2, p. 169-175 7 p.

Research output: Contribution to journalArticle

In vitro testicular toxicity models: Opportunities for advancement via biomedical engineering techniques

Saldutti, L. P., Beyer, B. K., Breslin, W., Brown, T. R., Chapin, R. E., Campion, S., Enright, B., Faustman, E., Foster, P. M. D., Hartung, T., Kelce, W., Kim, J. H., Loboa, E. G., Piersma, A. H., Seyler, D., Turner, K. J., Yu, H., Yu, X. & Sasaki, J. C., Sep 18 2013, In : ALTEX. 30, 3, p. 353-377 25 p.

Research output: Contribution to journalArticle

In vitro tests to evaluate immunotoxicity: A preliminary study

Carfi', M., Gennari, A., Malerba, I., Corsini, E., Pallardy, M., Pieters, R., Van Loveren, H., Vohr, H. W., Hartung, T. & Gribaldo, L., Jan 5 2007, In : Toxicology. 229, 1-2, p. 11-22 12 p.

Research output: Contribution to journalArticle

In Vivo, In Vitro, and stem cell technologies to predict human pharmacology and toxicology

Salem, H., Dorsey, R., Carmany, D. & Hartung, T., Nov 30 2016, Regenerative Medicine Technology: On-a-Chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine. CRC Press, p. 363-376 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

iPS, organoids and 3D models as advanced tools for in vitro toxicology

Steimberg, N., Bertero, A., Chiono, V., Dell'Era, P., Di Angelantonio, S., Hartung, T., Perego, S., Raimondi, M., Xinaris, C., Caloni, F., De Angelis, I., Alloisio, S. & Baderna, D., 2020, In : ALTEX. 37, 1, p. 136-140 5 p.

Research output: Contribution to journalEditorial

Open Access

Keratinocyte growth factor protects murine hepatocytes from tumor necrosis factor-induced apoptosis in vivo and in vitro

Senaldi, G., Shaklee, C. L., Simon, B., Rowan, C. G., Lacey, D. L. & Hartung, T., Jun 20 1998, In : Hepatology. 27, 6, p. 1584-1591 8 p.

Research output: Contribution to journalArticle

Key read across framework components and biology based improvements

Ball, N., Madden, J., Paini, A., Mathea, M., Palmer, A. D., Sperber, S., Hartung, T. & van Ravenzwaay, B., May 2020, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 853, 503172.

Research output: Contribution to journalReview article

Lateral diffusion of Toll-like receptors reveals that they are transiently confined within lipid rafts on the plasma membrane

Triantafilou, M., Morath, S., Mackie, A., Hartung, T. & Triantafilou, K., Aug 1 2004, In : Journal of cell science. 117, 17, p. 4007-4014 8 p.

Research output: Contribution to journalArticle

L-Ficolin Specifically Binds to Lipoteichoic Acid, a Cell Wall Constituent of Gram-Positive Bacteria, and Activates the Lectin Pathway of Complement

Lynch, N. J., Roscher, S., Hartung, T., Morath, S., Matsushita, M., Maennel, D. N., Kuraya, M., Fujita, T. & Schwaeble, W. J., Jan 15 2004, In : Journal of Immunology. 172, 2, p. 1198-1202 5 p.

Research output: Contribution to journalArticle

Open Access

Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons

Vreugdenhil, A. C. E., Rousseau, C. H., Hartung, T., Greve, J. W. M., Van 't Veer, C. & Buurman, W. A., Feb 1 2003, In : Journal of Immunology. 170, 3, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

Open Access