1991 …2020

Research output per year

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Research Output

2008

Toxicity testing in the 21st century: Better results, less use of animals

Cohen, B. C., Crofton, K. M., Hartung, T., Krewski, D., Locke, P. A. & Stephens, M. L., Mar 1 2008, Environmental Forum, 25, 2, p. 46-51 6 p.

Research output: Contribution to specialist publicationArticle

Vor- und nachdenkliches... zur evolution der toxikologie und dem ausstieg aus tierversuchen

Translated title of the contribution: Food for Thought... on the evolution of toxicology and the phasing out of animal testingHartung, T. & Leist, M., Dec 1 2008, In : ALTEX. 25, 2, p. 91-102 12 p.

Research output: Contribution to journalReview article

Vor- und nachdenkliches... zur sicherheitsprüfung von nahrungsmitteln

Translated title of the contribution: Food for thought... on food safety testingHartung, T. & Koëter, H., Dec 1 2008, In : ALTEX. 25, 4, p. 259-265 7 p.

Research output: Contribution to journalReview article

Vor- und nachdenkliches... zu tierversuchen

Translated title of the contribution: Food for thought... on animal testsHartung, T., Dec 1 2008, In : ALTEX. 25, 1, p. 3-16 14 p.

Research output: Contribution to journalReview article

2009

1 Fundamentals of a an evidence-based toxicology: 1.1 Opening statement

Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, p. 93-94 2 p.

Research output: Contribution to journalArticle

4.8 Current schemes for decision-making in toxicology

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

4.9 Current information sources for hazard identification

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.2 Evidence-based tools in toxicological hazard identification

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.3 Evidence-based tools in toxicological decision-making

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.4 Possible improvement of information sources on hazard and risk

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.6 An online portal to evidence-based toxicology

Kinsner, A., Griesinger, C., Hoffmann, S., Coecke, S., Bowe, G., Campana, C. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5 Steps toward an evidence-based toxicology: 5.1 Evidence-based tools in toxicological basic research

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

A modular approach to the extended one-generation reproduction toxicity study

Moore, N., Bremer, S., Carmichael, N., Daston, G., Dent, M., Gaoua-Chapelle, W., Hallmark, N., Hartung, T., Holzum, B., Hübel, U., Meisters, M. L., Schneider, S., Van Ravenzwaay, B. & Hennes, C., Apr 1 2009, In : ATLA Alternatives to Laboratory Animals. 37, 2, p. 219-225 7 p.

Research output: Contribution to journalArticle

Are in vitro tests suitable for regulatory use?

Hartung, T. & Daston, G., Sep 25 2009, In : Toxicological Sciences. 111, 2, p. 233-237 5 p.

Research output: Contribution to journalArticle

Arsenic induces telomerase expression and maintains telomere length in human cord blood cells

Ferrario, D., Collotta, A., Carfi, M., Bowe, G., Vahter, M., Hartung, T. & Gribaldo, L., Jun 16 2009, In : Toxicology. 260, 1-3, p. 132-141 10 p.

Research output: Contribution to journalArticle

Assessment of pyrogenic contaminations with validated human whole-blood assay

Daneshian, M., Von Aulock, S. & Hartung, T., Nov 1 2009, In : Nature protocols. 4, 12, p. 1709-1721 13 p.

Research output: Contribution to journalArticle

A toxicology for the 21st century - Mapping the road ahead

Hartung, T., May 13 2009, In : Toxicological Sciences. 109, 1, p. 18-23 6 p.

Research output: Contribution to journalArticle

Chemical regulators have overreached

Hartung, T. & Rovida, C., Aug 27 2009, In : Nature. 460, 7259, p. 1080-1081 2 p.

Research output: Contribution to journalComment/debate

Development validation and applications of the monocyte activation test for pyrogens based on human whole blood

Schindler, S., Von Aulock, S., Daneshian, M. & Hartung, T., Dec 1 2009, In : ALTEX. 26, 4, p. 265-277 13 p.

Research output: Contribution to journalReview article

ECVAM's ongoing activities in the area of acute oral toxicity

Kinsner-Ovaskainen, A., Bulgheroni, A., Hartung, T. & Prieto, P., Dec 1 2009, In : Toxicology in Vitro. 23, 8, p. 1535-1540 6 p.

Research output: Contribution to journalArticle

Estimation of acute oral toxicity using the No Observed Adverse Effect Level (NOAEL) from the 28 day repeated dose toxicity studies in rats

Bulgheroni, A., Kinsner-Ovaskainen, A., Hoffmann, S., Hartung, T. & Prieto, P., Feb 1 2009, In : Regulatory Toxicology and Pharmacology. 53, 1, p. 16-19 4 p.

Research output: Contribution to journalArticle

Food for thought... on education in alternative methods in toxicology

Hartung, T., Blaauboer, B. & Leist, M., Dec 1 2009, In : ALTEX. 26, 4, p. 255-263 9 p.

Research output: Contribution to journalReview article

Food for thought... on evidence-based toxicology

Hartung, T., 2009, In : ALTEX. 26, 2, p. 75-82 8 p.

Research output: Contribution to journalReview article

Open Access

Food for thought... on in silico methods in toxicology

Hartung, T. & Hoffmann, S., 2009, In : ALTEX. 26, 3, p. 155-166 12 p.

Research output: Contribution to journalReview article

Open Access

Food for thought... on the economics of animal testing

Bottini, A. A. & Hartung, T., Dec 1 2009, In : ALTEX. 26, 1, p. 3-16 14 p.

Research output: Contribution to journalReview article

Macroamphiphilic components of thermophilic actinomycetes: Identification of lipoteichoic acid in Thermobifida fusca

Rahman, O., Pfitzenmaier, M., Pester, O., Morath, S., Cummings, S. P., Hartung, T. & Sutcliffe, I. C., Jan 1 2009, In : Journal of bacteriology. 91, 1, p. 152-160 9 p.

Research output: Contribution to journalArticle

mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach

Hogberg, H. T., Kinsner-Ovaskainen, A., Coecke, S., Hartung, T. & Bal-Price, A. K., Aug 3 2009, In : Toxicological Sciences. 113, 1, p. 95-115 21 p., kfp175.

Research output: Contribution to journalArticle

Per aspirin ad astra...

Hartung, T., Dec 1 2009, In : ATLA Alternatives to Laboratory Animals. 37, SUPPL. 2, p. 45-47 3 p.

Research output: Contribution to journalReview article

Preface

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, p. 83-86 4 p.

Research output: Contribution to journalArticle

Proposal for a Brazilian centre on alternative test methods

Eskes, C., Sá-Rocha, V. D. M., Nunes, J., Presgrave, O., De Carvalho, D., Masson, P., Rivera, E., Coecke, S., Kreysa, J. & Hartung, T., 2009, In : ALTEX. 26, 4, p. 303-306 4 p.

Research output: Contribution to journalArticle

Open Access

That which must not, can not be... a reply to the EChA and EDF responses to the REACH analysis of animal use and costs

Hartung, T. & Rovida, C., Dec 1 2009, In : ALTEX. 26, 4, p. 307-311 5 p.

Research output: Contribution to journalComment/debate

Toxicology for the twenty-first century

Hartung, T., Jul 9 2009, In : Nature. 460, 7252, p. 208-212 5 p.

Research output: Contribution to journalReview article

"ToxRTool", a new tool to assess the reliability of toxicological data

Schneider, K., Schwarz, M., Burkholder, I., Kopp-Schneider, A., Edler, L., Kinsner-Ovaskainen, A., Hartung, T. & Hoffmann, S., Sep 10 2009, In : Toxicology Letters. 189, 2, p. 138-144 7 p.

Research output: Contribution to journalArticle

2010

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches

Scott, L., Eskes, C., Hoffmann, S., Adriaens, E., Alepée, N., Bufo, M., Clothier, R., Facchini, D., Faller, C., Guest, R., Harbell, J., Hartung, T., Kamp, H., Varlet, B. L., Meloni, M., McNamee, P., Osborne, R., Pape, W., Pfannenbecker, U., Prinsen, M. & 9 others, Seaman, C., Spielmann, H., Stokes, W., Trouba, K., Berghe, C. V. D., Goethem, F. V., Vassallo, M., Vinardell, P. & Zuang, V., Feb 1 2010, In : Toxicology in Vitro. 24, 1, p. 1-9 9 p.

Research output: Contribution to journalReview article

A structured approach to identifying European critical infrastructures

Di Mauro, C., Bouchon, S., Logtmeijer, C., Pride, R. D., Hartung, T. & Nordvik, J. P., Jun 2010, In : International Journal of Critical Infrastructures. 6, 3, p. 277-292 16 p.

Research output: Contribution to journalArticle

Characterisation of cadmium chloride induced molecular and functional alterations in airway epithelial cells

Forti, E., Bulgheroni, A., Cetin, Y., Hartung, T., Jennings, P., Pfaller, W. & Prieto, P., 2010, In : Cellular Physiology and Biochemistry. 25, 1, p. 159-168 10 p.

Research output: Contribution to journalArticle

Open Access

Evidence-Based Toxicology - The Toolbox of Validation for the 21 st Century?

Hartung, T., Dec 1 2010, In : ALTEX. 27, 4, p. 253-263 11 p.

Research output: Contribution to journalReview article

First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye test for the identification of non-irritant substances for a defined applicability domain.

Hartung, T., Bruner, L., Curren, R., Eskes, C., Goldberg, A., McNamee, P., Scott, L. & Zuang, V., 2010, In : ALTEX. 27, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

Open Access

Food for thought...on alternative methods for chemical safety testing.

Hartung, T., 2010, In : ALTEX. 27, 1, p. 3-14 12 p.

Research output: Contribution to journalArticle

Food for thought ... on alternative methods for nanoparticle safety testing.

Hartung, T., 2010, In : ALTEX. 27, 2, p. 87-95 9 p.

Research output: Contribution to journalArticle

Open Access

Internalization and coreceptor expression are critical for TLR2-mediated recognition of lipoteichoic acid in human peripheral blood

Bunk, S., Sigel, S., Metzdorf, D., Sharif, O., Triantafilou, K., Triantafilou, M., Hartung, T., Knapp, S. & Von Aulock, S., Sep 15 2010, In : Journal of Immunology. 185, 6, p. 3708-3717 10 p.

Research output: Contribution to journalArticle

In vitro developmental neurotoxicity (DNT) testing: Relevant models and endpoints

Bal-Price, A. K., Hogberg, H. T., Buzanska, L., Lenas, P., van Vliet, E. & Hartung, T., Sep 1 2010, In : NeuroToxicology. 31, 5, p. 545-554 10 p.

Research output: Contribution to journalArticle

Nachweis eines breiten Pyrogenspektrums im Monozyten-Aktivierungstest

Translated title of the contribution: In vitro pyrogen test: Proof of a broad pyrogen spectrum in the monocyte-activation testHoltkamp, B., Schmitz, G. & Härtung, T., Nov 1 2010, In : BioSpektrum. 16, 7, p. 779-781 3 p.

Research output: Contribution to journalArticle

The Center for Alternatives to Animal Testing - Europe (CAAT-EU): a transatlantic bridge for the paradigm shift in toxicology.

Daneshian, M., Leist, M. & Hartung, T., 2010, In : ALTEX. 27, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

Open Access

The evolution of validation: A commentary

Basketter, D. A., Kimber, I. & Hartung, T., Mar 1 2010, In : Cutaneous and Ocular Toxicology. 29, 1, p. 1-3 3 p.

Research output: Contribution to journalReview article

2011

A framework program for the teaching of alternative methods (replacement, reduction, refinement) to animal experimentation

Daneshian, M., Akbarsha, M. A., Blaauboer, B., Caloni, F., Cosson, P., Curren, R., Goldberg, A., Gruber, F., Ohl, F., Pfaller, W., Van Der Valk, J., Vinardell, P., Zurlo, J., Hartung, T. & Leist, M., 2011, In : ALTEX. 28, 4, p. 341-352 12 p.

Research output: Contribution to journalArticle

Open Access