1991 …2020

Research output per year

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Research Output

2008

The dawning of a new age of toxicology

Leist, M., Hartung, T. & Nicotera, P., Dec 1 2008, In : ALTEX. 25, 2, p. 103-114 12 p.

Research output: Contribution to journalReview article

Thoughts on limitations of animal models

Hartung, T., Jul 1 2008, In : Parkinsonism and Related Disorders. 14, SUPPL.2, p. S81-S83

Research output: Contribution to journalArticle

Toward a new toxicology - evolution or revolution?

Hartung, T., Dec 1 2008, In : ATLA Alternatives to Laboratory Animals. 36, 6, p. 635-639 5 p.

Research output: Contribution to journalArticle

Toxicity testing in the 21st century: Better results, less use of animals

Cohen, B. C., Crofton, K. M., Hartung, T., Krewski, D., Locke, P. A. & Stephens, M. L., Mar 1 2008, Environmental Forum, 25, 2, p. 46-51 6 p.

Research output: Contribution to specialist publicationArticle

Vor- und nachdenkliches... zur evolution der toxikologie und dem ausstieg aus tierversuchen

Translated title of the contribution: Food for Thought... on the evolution of toxicology and the phasing out of animal testingHartung, T. & Leist, M., Dec 1 2008, In : ALTEX. 25, 2, p. 91-102 12 p.

Research output: Contribution to journalReview article

Vor- und nachdenkliches... zur sicherheitsprüfung von nahrungsmitteln

Translated title of the contribution: Food for thought... on food safety testingHartung, T. & Koëter, H., Dec 1 2008, In : ALTEX. 25, 4, p. 259-265 7 p.

Research output: Contribution to journalReview article

Vor- und nachdenkliches... zu tierversuchen

Translated title of the contribution: Food for thought... on animal testsHartung, T., Dec 1 2008, In : ALTEX. 25, 1, p. 3-16 14 p.

Research output: Contribution to journalReview article

2007

An in vitro pyrogen safety test for immune-stimulating components on surfaces

Hasiwa, M., Kullmann, K., von Aulock, S., Klein, C. & Hartung, T., Mar 1 2007, In : Biomaterials. 28, 7, p. 1367-1375 9 p.

Research output: Contribution to journalArticle

Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages

Liljeroos, M., Vuolteenaho, R., Morath, S., Hartung, T., Hallman, M. & Ojaniemi, M., Mar 1 2007, In : Cellular Signalling. 19, 3, p. 625-633 9 p.

Research output: Contribution to journalArticle

cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4

Spiller, S., Dreher, S., Meng, G., Grabiec, A., Thomas, W., Hartung, T., Pfeffer, K., Hochrein, H., Brade, H., Bessler, W., Wagner, H. & Kirschning, C. J., May 4 2007, In : Journal of Biological Chemistry. 282, 18, p. 13190-13198 9 p.

Research output: Contribution to journalArticle

Chemical respiratory allergy: Opportunities for hazard identification and characterisation

Kimber, I., Agius, R., Basketter, D. A., Corsini, E., Cullinan, P., Dearman, R. J., Gimenez-Arnau, E., Greenwell, L., Hartung, T., Kuper, F., Maestrelli, P., Roggen, E., Rovida, C. & Casati, S., May 1 2007, In : ATLA Alternatives to Laboratory Animals. 35, 2, p. 243-265 23 p.

Research output: Contribution to journalArticle

Development of a mechanistically-based genetically engineered PC12 cell system to detect p53-mediated cytotoxicity

van Vliet, E., Eskes, C., Stingele, S., Gartlon, J., Price, A., Farina, M., Ponti, J., Hartung, T., Sabbioni, E. & Coecke, S., Jun 1 2007, In : Toxicology in Vitro. 21, 4, p. 698-705 8 p.

Research output: Contribution to journalArticle

ECVAM news & views

Hartung, T., Jun 1 2007, In : ATLA Alternatives to Laboratory Animals. 35, 3, p. 303-312 10 p.

Research output: Contribution to journalShort survey

ECVAM's approach to intellectual property rights in the validation of alternative methods

Linge, J. P. & Hartung, T., Aug 1 2007, In : ATLA Alternatives to Laboratory Animals. 35, 4, p. 441-446 6 p.

Research output: Contribution to journalReview article

Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects

van Vliet, E., Stoppini, L., Balestrino, M., Eskes, C., Griesinger, C., Sobanski, T., Whelan, M., Hartung, T. & Coecke, S., Nov 1 2007, In : NeuroToxicology. 28, 6, p. 1136-1146 11 p.

Research output: Contribution to journalArticle

Fever in the test tube--towards a human(e) pyrogen test.

Schindler, S., Fennrich, S., Crameri, R., Jungi, T. W., Montag, T. & Hartung, T., 2007, In : ALTEX : Alternativen zu Tierexperimenten. 24 Spec No, p. 60-62 3 p.

Research output: Contribution to journalArticle

First international forum toward evidence-based toxicology

Hoffmann, S., Griesinger, C., Coecke, S., Kinsner, A. & Hartung, T., Dec 1 2007, In : ALTEX. 24, 4, p. 354-355 2 p.

Research output: Contribution to journalArticle

In vitro pyrogen test - A new test method for solid medical devices

Mazzotti, F., Beuttler, J., Zeller, R., Fink, U., Schindler, S., Wendel, A., Harlung, T. & Von Aulock, S., Feb 1 2007, In : Journal of Biomedical Materials Research - Part A. 80, 2, p. 276-282 7 p.

Research output: Contribution to journalArticle

In vitro tests to evaluate immunotoxicity: A preliminary study

Carfi', M., Gennari, A., Malerba, I., Corsini, E., Pallardy, M., Pieters, R., Van Loveren, H., Vohr, H. W., Hartung, T. & Gribaldo, L., Jan 5 2007, In : Toxicology. 229, 1-2, p. 11-22 12 p.

Research output: Contribution to journalArticle

Lipoteichoic acid from Lactobacillus plantarum elicits both the production of interleukin-23p19 and suppression of pathogen-mediated interleukin-10 in THP-1 cells

Kim, H. G., Gim, M. G., Kim, J. Y., Jin Hwang, H., Ham, M. S., Lee, J. M., Hartung, T., Park, J. W., Han, S. H. & Chung, D. K., Mar 1 2007, In : FEMS Immunology and Medical Microbiology. 49, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

Molecular interaction between lipoteichoic acids and Lactobacillus delbrueckii phages depends on D-alanyl and α-glucose substitution of poly(glycerophosphate) backbones

Räisänen, L., Draing, C., Pfitzenmaier, M., Schubert, K., Jaakonsaari, T., Von Aulock, S., Hartung, T. & Alatossava, T., Jun 1 2007, In : Journal of bacteriology. 189, 11, p. 4135-4140 6 p.

Research output: Contribution to journalArticle

Perioperative prophylaxis with granulocyte colony-stimulating factor (G-CSF) in high-risk colorectal cancer patients for an improved recovery: A randomized, controlled trial

Bauhofer, A., Plaul, U., Torossian, A., Koller, M., Stinner, B., Celik, I., Sitter, H., Greger, B., Middeke, M., Schein, M., Wyatt, J., Nyström, P. O., Hartung, T., Rothmund, M. & Lorenz, W., Apr 1 2007, In : Surgery. 141, 4, p. 501-510 10 p.

Research output: Contribution to journalArticle

Physiologically-based kinetic modelling (PBK modelling): Meeting the 3Rs agenda. The report and recommendations of ECVAM workshop 63

Bouvier D'Yvoire, M., Prieto, P., Blaauboer, B. J., Bois, F. Y., Boobis, A., Brochot, C., Coecke, S., Freidig, A., Gundert-Remy, U., Hartung, T., Jacobs, M. N., Lavé, T., Leahy, D. E., Lennernäs, H., Loizou, G. D., Meek, B., Pease, C., Rowland, M., Spendiff, M., Yang, J. & 1 others, Zeilmaker, M., Dec 2007, In : ATLA Alternatives to Laboratory Animals. 35, 6, p. 661-671 11 p.

Research output: Contribution to journalReview article

Skin sensitisation and epidermal disposition: The relevance of epidermal disposition for sensitisation hazard identification and risk assessment: The report and recommendations of ECVAM workshop 59a

Basketter, D., Pease, C., Kasting, G., Kimber, I., Casati, S., Cronin, M., Diembeck, W., Gerberick, F., Hadgraft, J., Hartung, T., Marty, J. P., Nikolaidis, E., Patlewicz, G., Roberts, D., Roggen, E., Rovida, C. & Van De Sandt, J., Mar 1 2007, In : ATLA Alternatives to Laboratory Animals. 35, 1, p. 137-154 18 p.

Research output: Contribution to journalArticle

The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes

Bremer, S., Pellizzer, C., Hoffmann, S., Seidle, T. & Hartung, T., Oct 1 2007, In : Current pharmaceutical design. 13, 29, p. 3047-3058 12 p.

Research output: Contribution to journalReview article

The inhibition of TNF-α anti-tumoral properties by blocking antibodies promotes tumor growth in a rat model

Larmonier, N., Cathelin, D., Larmonier, C., Nicolas, A., Merino, D., Janikashvili, N., Audia, S., Bateman, A., Thompson, J., Kottke, T., Hartung, T., Katsanis, E., Vile, R. & Bonnotte, B., Jul 1 2007, In : Experimental cell research. 313, 11, p. 2345-2355 11 p.

Research output: Contribution to journalArticle

The usefulness of toxicogenomics for predicting acute skin irritation on in vitro reconstructed human epidermis

Borlon, C., Godard, P., Eskes, C., Hartung, T., Zuang, V. & Toussaint, O., Nov 30 2007, In : Toxicology. 241, 3, p. 157-166 10 p.

Research output: Contribution to journalArticle

Use of synthetic derivatives to determine the minimal active structure of cytokine-inducing lipoteichoic acid

Deininger, S., Figueroa-Perez, I., Sigel, S., Stadelmaier, A., Schmidt, R. R., Hartung, T. & Von Aulock, S., Dec 1 2007, In : Clinical and Vaccine Immunology. 14, 12, p. 1629-1633 5 p.

Research output: Contribution to journalArticle

Vor- und nachdenkliches... zur globalisierung von alternativmethoden

Translated title of the contribution: Food for thought... on globalisation of alternative methodsBottini, A. A., Amcoff, P. & Hartung, T., Dec 1 2007, In : ALTEX. 24, 4, p. 255-269 15 p.

Research output: Contribution to journalReview article

Vor- und Nachdenkliches... zur Validierung

Translated title of the contribution: Food for thought... on validationHartung, T., Jun 11 2007, In : ALTEX. 24, 2, p. 67-80 14 p.

Research output: Contribution to journalEditorial

Vor- und nachdenkliches... zur zellkultur

Translated title of the contribution: Food for thought... on cell cultureHartung, T., Dec 1 2007, In : ALTEX. 24, 3, p. 143-152 10 p.

Research output: Contribution to journalReview article

Workgroup report: Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity into International Hazard and Risk Assessment Strategies

Coecke, S., Goldberg, A. M., Allen, S., Buzanska, L., Calamandrei, G., Crofton, K., Hareng, L., Hartung, T., Knaut, H., Honegger, P., Jacobs, M., Lein, P., Li, A., Mundy, W., Owen, D., Schneider, S., Silbergeld, E., Reum, T., Trnovec, T., Monnet-Tschudi, F. & 1 others, Bal-Price, A., Jun 1 2007, In : Environmental health perspectives. 115, 6, p. 924-931 8 p.

Research output: Contribution to journalArticle

2006

A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues

Stadelmaier, A., Figueroa-Perez, I., Deininger, S., von Aulock, S., Hartung, T. & Schmidt, R. R., Sep 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 18, p. 6239-6254 16 p.

Research output: Contribution to journalArticle

Availability, Standardization and Safety of Human Cells and Tissues for Drug Screening and Testing

Stacey, G. N. & Hartung, T., Nov 8 2006, Drug Testing in vitro: Breakthroughs and Trends in Cell Culture Technology. Wiley-VCH Verlag GmbH & Co. KGaA, p. 229-250 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages

Scheel, O., Papavlassopoulos, M., Blunck, R., Gebert, A., Hartung, T., Zähringer, U., Seydel, U. & Schromm, A. B., Jul 1 2006, In : Infection and immunity. 74, 7, p. 4354-4356 3 p.

Research output: Contribution to journalArticle

Cell activation of human macrophages by lipoteichoic acid is strongly attenuated by lipopolysaccharide-binding protein

Mueller, M., Stamme, C., Draing, C., Hartung, T., Seydel, U. & Schromm, A. B., Oct 20 2006, In : Journal of Biological Chemistry. 281, 42, p. 31448-31456 9 p.

Research output: Contribution to journalArticle

Comparison of lipoteichoic acid from different serotypes of Streptococcus pneumoniae

Draing, C., Pfitzenmaier, M., Zummo, S., Mancuso, G., Geyer, A., Hartung, T. & Von Aulock, S., Nov 10 2006, In : Journal of Biological Chemistry. 281, 45, p. 33849-33859 11 p.

Research output: Contribution to journalArticle

D-alanyl ester depletion of teichoic acids in Lactobacillus plantarum results in a major modification of lipoteichoic acid composition and cell wall perforations at the septum mediated by the Acm2 autolysin

Palumbo, E., Deghorain, M., Cocconcelli, P. S., Kleerebezem, M., Geyer, A., Hartung, T., Morath, S. & Hols, P., May 1 2006, In : Journal of bacteriology. 188, 10, p. 3709-3715 7 p.

Research output: Contribution to journalArticle

Endogenous cortisol determines the circadian rhythm of lipopolysaccharide- but not lipoteichoic acid-inducible cytokine release

Hermann, C., von Aulock, S., Dehus, O., Keller, M., Okigami, H., Gantner, F., Wendel, A. & Hartung, T., Feb 1 2006, In : European Journal of Immunology. 36, 2, p. 371-379 9 p.

Research output: Contribution to journalArticle

Endotoxin evaluation of eleven lipopolysaccharides by whole blood assay does not always correlate with Limulus amebocyte lysate assay

Dehus, O., Hartung, T. & Hermann, C., Jun 1 2006, In : Journal of Endotoxin Research. 12, 3, p. 171-180 10 p.

Research output: Contribution to journalArticle

Erratum: Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease (Journal of Immunology (2005) 175 (2534-2540))

Schröder, N. W. J., Diterich, I., Zinke, A., Eckert, J., Draing, C., Baehr, V. V., Hassler, D., Priem, S., Hahn, K., Michelsen, K. S., Hartung, T., Burmester, G. R., Göbel, U. B., Hermann, C. & Schumann, R. R., May 1 2006, In : Journal of Immunology. 176, 9, 1 p.

Research output: Contribution to journalComment/debate

Highly purified lipoteichoic acid from gram-positive bacteria induces in vitro blood-brain barrier disruption through glia activation: Role of pro-inflammatory cytokines and nitric oxide

Boveri, M., Kinsner, A., Berezowski, V., Lenfant, A. M., Draing, C., Cecchelli, R., Dehouck, M. P., Hartung, T., Prieto, P. & Bal-Price, A., Jan 30 2006, In : Neuroscience. 137, 4, p. 1193-1209 17 p.

Research output: Contribution to journalArticle

Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: Selective potentiation of nitric oxide production by muramyl dipeptide

Kinsner, A., Boveri, M., Hareng, L., Brown, G. C., Coecke, S., Hartung, T. & Bal-Price, A., Oct 1 2006, In : Journal of Neurochemistry. 99, 2, p. 596-607 12 p.

Research output: Contribution to journalArticle

Identification of Borrelia burgdorferi ribosomal protein L25 by the phage surface display method and evaluation of the protein's value for serodiagnosis

Mueller, M., Bunk, S., Diterich, I., Weichel, M., Rauter, C., Hassler, D., Hermann, C., Crameri, R. & Hartung, T., Oct 1 2006, In : Journal of clinical microbiology. 44, 10, p. 3778-3780 3 p.

Research output: Contribution to journalArticle

International validation of pyrogen tests based on cryopreserved human primary blood cells

Schindler, S., Spreitzer, I., Löschner, B., Hoffmann, S., Hennes, K., Halder, M., Brügger, P., Frey, E., Hartung, T. & Montag, T., Oct 30 2006, In : Journal of Immunological Methods. 316, 1-2, p. 42-51 10 p.

Research output: Contribution to journalArticle

Invited review: MDP and other muropeptides - Direct and synergistic effects on the immune system

Traub, S., von Aulock, S., Hartung, T. & Hermann, C., Apr 1 2006, In : Journal of Endotoxin Research. 12, 2, p. 69-85 17 p.

Research output: Contribution to journalReview article

In vitro pyrogen test for toxic or immunomodulatory drugs

Daneshian, M., Guenther, A., Wendel, A., Hartung, T. & von Aulock, S., Jun 30 2006, In : Journal of Immunological Methods. 313, 1-2, p. 169-175 7 p.

Research output: Contribution to journalArticle