1991 …2020

Research output per year

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Research Output

2016

Pathway-Based Approaches for Environmental Monitoring and Risk Assessment

Ankley, G., Escher, B., Hartung, T. & Shah, I., Nov 21 2016, In : Chemical Research in Toxicology. 29, 11, p. 1789-1790 2 p.

Research output: Contribution to journalEditorial

Staphylococcus aureus–derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2

Kaesler, S., Skabytska, Y., Chen, K. M., Kempf, W. E., Volz, T., Köberle, M., Wölbing, F., Hein, U., Hartung, T., Kirschning, C., Röcken, M. & Biedermann, T., Sep 1 2016, In : Journal of Allergy and Clinical Immunology. 138, 3, p. 780-790.e6

Research output: Contribution to journalArticle

Supporting read-across using biological data

Zhu, H., Bouhifd, M., Donley, E., Egnash, L., Kleinstreuer, N., Kroese, E. D., Liu, Z., Luechtefeld, T., Palmer, J., Pamies, D., Shen, J., Strauss, V., Wu, S. & Hartung, T., Jan 1 2016, In : ALTEX. 33, 2, p. 167-182 16 p.

Research output: Contribution to journalArticle

The emergence of systematic review in toxicology

Stephens, M. L., Betts, K., Beck, N. B., Cogliano, V., Dickersin, K., Fitzpatrick, S., Freeman, J., Gray, G., Hartung, T., McPartland, J., Rooney, A. A., Scherer, R., Verloo, D. & Hoffmann, S., Jul 1 2016, In : Toxicological Sciences. 152, 1, p. 10-16 7 p., kfw059.

Research output: Contribution to journalArticle

The Lesser Evil of E-Cigarettes

Hartung, T., Aug 1 2016, In : Scientific American. 315, 2, p. 9 1 p.

Research output: Contribution to journalArticle

The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency

Bowman, C. E., Rodriguez, S., Selen Alpergin, E. S., Acoba, M. G., Zhao, L., Hartung, T., Claypool, S. M., Watkins, P. A. & Wolfgang, M. J., Nov 10 2016, (Accepted/In press) In : Cell Chemical Biology.

Research output: Contribution to journalArticle

Toward good read-across practice (GRAP) guidance

Ball, N., Cronin, M. T. D., Shen, J., Blackburn, K., Booth, E. D., Bouhifd, M., Donley, E., Egnash, L., Hastings, C., Juberg, D. R., Kleensang, A., Kleinstreuer, N., Kroese, E. D., Lee, A. C., Luechtefeld, T., Maertens, A., Marty, S., Naciff, J. M., Palmer, J., Pamies, D. & 9 others, Penman, M., Richarz, A. N., Russo, D. P., Stuard, S. B., Patlewicz, G., Van Ravenzwaay, B., Wu, S., Zhu, H. & Hartung, T., Jan 1 2016, In : ALTEX. 33, 2, p. 149-166 18 p.

Research output: Contribution to journalArticle

Utility of the adverse outcome pathway concept in drug development

Hartung, T., Oct 23 2016, (Accepted/In press) In : Expert Opinion on Drug Metabolism and Toxicology. p. 1-3 3 p.

Research output: Contribution to journalArticle

2015

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

Head, S. A., Shi, W., Zhao, L., Gorshkov, K., Pasunooti, K., Chen, Y., Deng, Z., Li, R. J., Shim, J. S., Tan, W., Hartung, T., Zhang, J., Zhao, Y., Colombini, M. & Liu, J. O., Dec 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. E7276-E7285

Research output: Contribution to journalArticle

Editorial

ALTEX Editorial Team, Jan 1 2015, In : ALTEX. 32, 4, p. U2

Research output: Contribution to journalEditorial

Food for Thought... Toxicity testing in the 21st century beyond environmental chemicals

Rovida, C., Asakura, S., Daneshian, M., Hofman-Huether, H., Leist, M., Meunier, L., Reif, D., Rossi, A., Schmutz, M., Valentin, J. P., Zurlo, J. & Hartung, T., Jan 1 2015, In : ALTEX. 32, 3, p. 171-181 11 p.

Research output: Contribution to journalArticle

Food for thought⋯: Animal use for science in Europe

Daneshian, M., Busquet, F., Hartung, T. & Leist, M., Jan 1 2015, In : ALTEX. 32, 4, p. 261-274 14 p.

Research output: Contribution to journalArticle

Food for thought⋯cellular resilience

Smirnova, L., Harris, G., Leist, M. & Hartung, T., Jan 1 2015, In : ALTEX. 32, 4, p. 247-260 14 p.

Research output: Contribution to journalArticle

From "weight of evidence" to quantitative data integration using multicriteria decision analysis and bayesian methods

Linkov, I., Massey, O., Keisler, J., Rusyn, I. & Hartung, T., Jan 1 2015, In : ALTEX. 32, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review

Samuel, G. O., Hoffmann, S., Wright, R. A., Lalu, M. M., Patlewicz, G., Becker, R. A., DeGeorge, G. L., Fergusson, D., Hartung, T., Lewis, R. J. & Stephens, M. L., Aug 6 2015, (Accepted/In press) In : Environment International.

Research output: Contribution to journalArticle

Improved detection of pyrogens using the monocyte activation test

Borel, A., Holtkamp, B., Schmitz, G. & Hartung, T., May 2015, In : Pharmaceutical Processing. 30, 4, p. 32-33 2 p.

Research output: Contribution to journalComment/debate

Integrated testing strategies (ITS) for safety assessment

Rovida, C., Alépée, N., Api, A. M., Basketter, D. A., Bois, F. Y., Caloni, F., Corsini, E., Daneshian, M., Eskes, C., Ezendam, J., Fuchs, H., Hayden, P., Hegele-Hartung, C., Hoffmann, S., Hubesch, B., Jacobs, M. N., Jaworska, J., Kleensang, A., Kleinstreuer, N., Lalko, J. & 16 others, Landsiedel, R., Lebreux, F., Luechtefeld, T., Locatelli, M., Mehling, A., Natsch, A., Pitchford, J. W., Prater, D., Prieto, P., Schepky, A., Schüürmann, G., Smirnova, L., Toole, C., Van Vliet, E., Weisensee, D. & Hartung, T., Jan 1 2015, In : ALTEX. 32, 1, p. 25-40 16 p.

Research output: Contribution to journalArticle

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

Bal-Price, A., Crofton, K. M., Leist, M., Allen, S., Arand, M., Buetler, T., Delrue, N., FitzGerald, R. E., Hartung, T., Heinonen, T., Hogberg, H., Bennekou, S. H., Lichtensteiger, W., Oggier, D., Paparella, M., Axelstad, M., Piersma, A., Rached, E., Schilter, B., Schmuck, G. & 7 others, Stoppini, L., Tongiorgi, E., Tiramani, M., Monnet-Tschudi, F., Wilks, M. F., Ylikomi, T. & Fritsche, E., Jan 1 2015, In : Archives of Toxicology. 89, 2, p. 269-287 19 p.

Research output: Contribution to journalReview article

Metabonomics and toxicology

Zhao, L. & Hartung, T., Jan 1 2015, In : Methods in Molecular Biology. 1277, p. 209-231 23 p.

Research output: Contribution to journalArticle

MPTP’s Pathway of Toxicity Indicates Central Role of Transcription Factor SP1

Maertens, A., Luechtefeld, T., Kleensang, A. & Hartung, T., May 1 2015, In : Archives of Toxicology. 89, 5, p. 743-755 13 p.

Research output: Contribution to journalArticle

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology

Gordon, S., Daneshian, M., Bouwstra, J., Caloni, F., Constant, S., Davies, D. E., Dandekar, G., Guzman, C. A., Fabian, E., Haltner, E., Hartung, T., Hasiwa, N., Hayden, P., Kandarova, H., Khare, S., Krug, H. F., Kneuer, C., Leist, M., Lian, G., Marx, U. & 9 others, Metzger, M., Ott, K., Prieto, P., Roberts, M. S., Roggen, E. L., Tralau, T., Van Den Braak, C., Walles, H. & Lehr, C. M., Jan 1 2015, In : ALTEX. 32, 4, p. 327-378 52 p.

Research output: Contribution to journalArticle

Probabilistic hazard assessment for skin sensitiza tion potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships

Luechtefeld, T., Maertens, A., Mckim, J. M., Hartung, T., Kleensang, A. & Sá-Rocha, V., Nov 1 2015, In : Journal of Applied Toxicology. 35, 11, p. 1361-1371 11 p.

Research output: Contribution to journalArticle

Quality assurance of metabolomics

Bouhifd, M., Beger, R., Flynn, T., Guo, L., Harris, G., Hogberg, H., Kaddurah-Daouk, R., Kamp, H., Kleensang, A., Maertens, A., Odwin-DaCosta, S., Pamies, D., Robertson, D., Smirnova, L., Sun, J., Zhao, L. & Hartung, T., Jan 1 2015, In : ALTEX. 32, 4, p. 319-326 8 p.

Research output: Contribution to journalArticle

Safety first

Hartung, T., Sep 1 2015, Innovations in Pharmaceutical Technology, 54, p. 40-43 4 p.

Research output: Contribution to specialist publicationArticle

Systems Toxicology: The Future of Risk Assessment

Sauer, J. M., Hartung, T., Leist, M., Knudsen, T. B., Hoeng, J. & Hayes, A. W., Jul 8 2015, In : International Journal of Toxicology. 34, 4, p. 346-348 3 p.

Research output: Contribution to journalArticle

The human toxome collaboratorium: A shared environment for multi-omic computational collaboration within a consortium

Fasani, R. A., Livi, C. B., Choudhury, D. R., Kleensang, A., Bouhifd, M., Pendse, S. N., McMullen, P. D., Andersen, M. E., Hartung, T. & Rosenberg, M., 2015, In : Frontiers in Pharmacology. 6, 322.

Research output: Contribution to journalArticle

The Human Toxome Project

Bouhifd, M., Andersen, M. E., Baghdikian, C., Boekelheide, K., Crofton, K. M., Fornace, A. J., Kleensang, A., Li, H., Livi, C., Maertens, A., McMullen, P. D., Rosenberg, M., Thomas, R., Vantangoli, M., Yager, J. D., Zhao, L. & Hartung, T., Jan 1 2015, In : ALTEX. 32, 2, p. 112-124 13 p.

Research output: Contribution to journalArticle

The human whole blood pyrogen test - Lessons learned in twenty years

Hartung, T., Jan 1 2015, In : ALTEX. 32, 2, p. 79-100 22 p.

Research output: Contribution to journalReview article

2014

3D - A new dimension of in vitro research

Hartung, T., Jan 1 2014, In : Advanced Drug Delivery Reviews. 69-70, 1 p.

Research output: Contribution to journalEditorial

Addendum to evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

Hasiwa, N., Daneshian, M., Bruegger, P., Fennrich, S., Hochadel, A., Hoffmann, S., Rivera-Mariani, F. E., Rockel, C., Schindler, S., Spreitzer, I., Stoppelkamp, S., Vysyaraju, K. & Hartung, T., 2014, In : ALTEX. 31, 2, 1 p.

Research output: Contribution to journalComment/debate

Addendum to evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test (ALTEX (2013) 30: 2)

Hasiwa, N., Daneshian, M., Bruegger, P., Fennrich, S., Hochadel, A., Hoffmann, S., Rivera-Mariani, F. E., Rockel, C., Schindler, S., Spreitzer, I., Stoppelkamp, S., Vysyaraju, K. & Hartung, T., 2014, In : Altex. 31, 4, p. 499 1 p.

Research output: Contribution to journalComment/debate

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

Tollefsen, K. E., Scholz, S., Cronin, M. T., Edwards, S. W., de Knecht, J., Crofton, K., Garcia-Reyero, N., Hartung, T., Worth, A. & Patlewicz, G., Dec 1 2014, In : Regulatory Toxicology and Pharmacology. 70, 3, p. 629-640 12 p.

Research output: Contribution to journalArticle

Biological and medical applications of a brain-on-a-chip

Pamies, D., Hartung, T. & Hogberg, H. T., Sep 1 2014, In : Experimental Biology and Medicine. 239, 9, p. 1096-1107 12 p.

Research output: Contribution to journalArticle

Building shared experience to advance practical application of pathway-based toxicology: Liver toxicity mode-of-action

Willett, C., Rae, J. C., Goyak, K. O., Minsavage, G., Westmoreland, C., Andersen, M., Avigan, M., Duché, D., Harris, G., Hartung, T., Jaeschke, H., Kleensang, A., Landesmann, B., Martos, S., Matevia, M., Toole, C., Rowan, A., Schultz, T., Seed, J., Senior, J. & 4 others, Shah, I., Subramanian, K., Vinken, M. & Watkins, P., Jan 1 2014, In : ALTEX. 31, 4, p. 500-519 20 p.

Research output: Contribution to journalArticle

Comparison of the interleukin-1β-inducing potency of allergenic spores from higher fungi (basidiomycetes) in a cryopreserved human whole blood system

Rivera-Mariani, F. E., Vysyaraju, K., Negherbon, J., Levetin, E., Horner, W. E., Hartung, T. & Breysse, P. N., Feb 1 2014, In : International archives of allergy and immunology. 163, 2, p. 154-162 9 p.

Research output: Contribution to journalArticle

Consensus report on the future of animal-free systemic toxicity testing

Leist, M., Hasiwa, N., Rovida, C., Daneshian, M., Basketter, D., Kimber, I., Clewell, H., Gocht, T., Goldberg, A., Busquet, F., Rossi, A. M., Schwarz, M., Stephens, M., Taalman, R., Knudsen, T. B., McKim, J., Harris, G., Pamies, D. & Hartung, T., 2014, In : ALTEX. 31, 3, p. 341-356 16 p.

Research output: Contribution to journalArticle

Current approaches and future role of high content imaging in safety sciences and drug discovery

Van Vliet, E., Daneshian, M., Beilmann, M., Davies, A., Fava, E., Fleck, R., Julé, Y., Kansy, M., Kustermann, S., Macko, P., Mundy, W. R., Roth, A., Shah, I., Uteng, M., Van De Water, B., Hartung, T. & Leist, M., Jan 1 2014, In : ALTEX. 31, 4, p. 479-493 15 p.

Research output: Contribution to journalArticle

Developing microphysiological systems for use as regulatory tools - Challenges and opportunities

Andersen, M. E., Betts, K., Dragan, Y., Fitzpatrick, S., Goodman, J. L., Hartung, T., Himmelfarb, J., Ingber, D. E., Jacobs, A., Kavlock, R., Kolaja, K., Stevens, J. L., Tagle, D., Taylor, D. L. & Throckmorton, D., 2014, In : ALTEX. 31, 3, p. 364-367 4 p.

Research output: Contribution to journalArticle

Editorial

Von Aulock, S., Gruber, F. P., Hartung, T., Hoesli, H. P., Hughes, M. M., Krummenacher, G., Mayr, P., Rauter, C., Zurlo, J. & Schindler, S., Jan 1 2014, In : ALTEX. 31, 4, p. U2

Research output: Contribution to journalEditorial

Evidence-Based Toxicology

Hoffmann, S., Stephens, M. & Hartung, T., Jan 1 2014, Encyclopedia of Toxicology: Third Edition. Elsevier, p. 565-567 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Food for thought... Developmental neurotoxicity - Challenges in the 21st century and in vitro opportunities

Smirnova, L., Hogberg, H. T., Leist, M. & Hartung, T., 2014, In : ALTEX. 31, 2, p. 129-156 28 p.

Research output: Contribution to journalReview article

Glossary of reference terms for alternative test methods and their validation

Ferrario, D., Brustio, R. & Hartung, T., 2014, In : ALTEX. 31, 3, p. 319-335 17 p.

Research output: Contribution to journalArticle

Green toxicology

Maertens, A., Anastas, N., Spencer, P. J., Stephens, M., Goldberg, A. & Hartung, T., 2014, In : ALTEX. 31, 3, p. 243-249 7 p.

Research output: Contribution to journalArticle

Mapping the human toxome by systems toxicology

Bouhifd, M., Hogberg, H. T., Kleensang, A., Maertens, A., Zhao, L. & Hartung, T., Jul 2014, In : Basic and Clinical Pharmacology and Toxicology. 115, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

Read-across approaches - Misconceptions, promises and challenges ahead

Patlewicz, G., Ball, N., Becker, R. A., Booth, E. D., Cronin, M. T. D., Kroese, D., Steup, D., Van Ravenzwaay, B. & Hartung, T., Jan 1 2014, In : Archivos de Medicina Veterinaria. 46, 4, p. 387-396 10 p.

Research output: Contribution to journalArticle

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Alépée, N., Bahinski, A., Daneshian, M., De Wever, B., Fritsche, E., Goldberg, A., Hansmann, J., Hartung, T., Haycock, J., Hogberg, H. T., Hoelting, L., Kelm, J. M., Kadereit, S., McVey, E., Landsiedel, R., Leist, M., Lübberstedt, M., Noor, F., Pellevoisin, C., Petersohn, D. & 7 others, Pfannenbecker, U., Reisinger, K., Ramirez, T., Rothen-Rutishauser, B., Schäfer-Korting, M., Zeilinger, K. & Zurich, M. G., Jan 1 2014, In : ALTEX. 31, 4, p. 441-477 37 p.

Research output: Contribution to journalArticle

Symposium report: Correlating in vitro data to in vivo findings for risk assessment

Bale, A. S., Kenyon, E., Flynn, T. J., Lipscomb, J. C., Mendrick, D. L., Hartung, T. & Patton, G. W., Feb 3 2014, In : ALTEX. 31, 1, p. 79-90 12 p.

Research output: Contribution to journalArticle

t 4 workshop report

Kleensang, A., Maertens, A., Rosenberg, M., Fitzpatrick, S., Lamb, J., Auerbach, S., Brennan, R., Crofton, K. M., Gordon, B., Fornace, A. J., Gaido, K., Gerhold, D., Haw, R., Henney, A., Ma'Ayan, A., McBride, M., Monti, S., Ochs, M. F., Pandey, A., Sharan, R. & 17 others, Stierum, R., Tugendreich, S., Willett, C., Wittwehr, C., Xia, J., Patton, G. W., Arvidson, K., Bouhifd, M., Hogberg, H. T., Luechtefeld, T., Smirnova, L., Zhao, L., Adeleye, Y., Kanehisa, M., Carmichael, P., Andersen, M. E. & Hartung, T., 2014, In : ALTEX. 31, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

t 4 workshop report: Lessons learned, challenges, and opportunities: The U.S. endocrine disruptor screening program

Juberg, D. R., Borghoff, S. J., Becker, R. A., Casey, W., Hartung, T., Holsapple, M. P., Marty, M. S., Mihaich, E. M., Van Der Kraak, G., Wade, M. G., Willett, C. E., Andersen, M. E., Borgert, C. J., Coady, K. K., Dourson, M. L., Fowle, J. R., Gray, L. E., Lamb, J. C., Ortego, L. S., Schug, T. T. & 6 others, Toole, C. M., Zorrilla, L. M., Kroner, O. L., Patterson, J., Rinckel, L. A. & Jones, B. R., 2014, In : ALTEX. 31, 1, p. 63-78 16 p.

Research output: Contribution to journalArticle