1991 …2020

Research output per year

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Research Output

Article

A toxicology for the 21st century - Mapping the road ahead

Hartung, T., May 13 2009, In : Toxicological Sciences. 109, 1, p. 18-23 6 p.

Research output: Contribution to journalArticle

Autophagy as an ultrastructural marker of heavy metal toxicity in human cord blood hematopoietic stem cells

Di Gioacchino, M., Petrarca, C., Perrone, A., Farina, M., Sabbioni, E., Hartung, T., Martino, S., Esposito, D. L., Lotti, L. V. & Mariani-Costantini, R., Mar 15 2008, In : Science of the Total Environment. 392, 1, p. 50-58 9 p.

Research output: Contribution to journalArticle

Barriers to validation

Ahr, H. J., Alepée, N., Breier, S., Brekelmans, C., Cotgreave, I., Gribaldo, L., Dal Negro, G., De Silva, O., Hartung, T., Lacerda, A., Leblanc, B., Lecerf, C., Linge, J. P., Louhimies, S., Manou, I., Maxwell, G., Müller, K. K., Pape, W., Redhead, K., Schröder, K. R. & 3 others, Sladowski, D., Van Der Jagt, K. & Vanparys, P., Sep 1 2008, In : ATLA Alternatives to Laboratory Animals. 36, 4, p. 459-464 6 p.

Research output: Contribution to journalArticle

Beispiel eines neuen Einsatzbereichs des humanen Vollbluttests: Entwicklung eines Messverfahrens zur Abschätzung der gesundheitlichen Gefährdung durch luftgetragene mikrobielle Verunreinigungen.

Translated title of the contribution: A new application for the human whole blood test: development of an assay to assess the health risk of air-borne microbial contaminationsFennrich, S., Zucker, B. & Hartung, T., 2001, In : ALTEX : Alternativen zu Tierexperimenten. 18, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

Big-data and machine learning to revamp computational toxicology and its use in risk assessment

Luechtefeld, T., Rowlands, C. & Hartung, T., Jan 1 2018, In : Toxicology Research. 7, 5, p. 732-744 13 p.

Research output: Contribution to journalArticle

Binding of surfactant protein D to lipoteichoic acid

Van De Watering, J. K., Van Eijk, M., Spreitzer, I., Härtung, T., Van Golde, L. M. G. & Batenburg, J. J., Dec 1 2000, In : Applied Cardiopulmonary Pathophysiology. 9, 3, 1 p.

Research output: Contribution to journalArticle

Biological and medical applications of a brain-on-a-chip

Pamies, D., Hartung, T. & Hogberg, H. T., Sep 1 2014, In : Experimental Biology and Medicine. 239, 9, p. 1096-1107 12 p.

Research output: Contribution to journalArticle

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Marx, U., Andersson, T. B., Bahinski, A., Beilmann, M., Beken, S., Cassee, F. R., Cirit, M., Daneshian, M., Fitzpatrick, S., Frey, O., Gaertner, C., Giese, C., Griffith, L., Hartung, T., Heringa, M. B., Hoeng, J., De Jong, W. H., Kojima, H., Kuehnl, J., Leist, M. & 16 others, Luch, A., Maschmeyer, I., Sakharov, D., Sips, A. J. A. M., Steger-Hartmann, T., Tagle, D. A., Tonevitsky, A., Tralau, T., Tsyb, S., Van De Stolpe, A., Vandebriel, R., Vulto, P., Wang, J., Wiest, J., Rodenburg, M. & Roth, A., 2016, In : Altex. 33, 3, p. 272-321 50 p.

Research output: Contribution to journalArticle

Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients

Hartung, T., Von Aulock, S., Freitag, M., Höxtermann, S., Stücker, M., Hoffmann, K., Altmeyer, P., Kottke, A. & Wendel, A., Jan 1 2000, In : Cytokine. 12, 10, p. 1570-1574 5 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi-induced tolerance as a model of persistence via immunosuppression

Diterich, I., Rauter, C., Kirschning, C. J. & Hartung, T., Jul 1 2003, In : Infection and immunity. 71, 7, p. 3979-3987 9 p.

Research output: Contribution to journalArticle

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis

Kilic, O., Pamies, D., Lavell, E., Schiapparelli, P., Feng, Y., Hartung, T., Bal-Price, A., Hogberg, H. T., Quinones-Hinojosa, A., Guerrero-Cazares, H. & Levchenko, A., 2016, In : Lab on a Chip. 16, 21, p. 4152-4162 11 p.

Research output: Contribution to journalArticle

Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages

Liljeroos, M., Vuolteenaho, R., Morath, S., Hartung, T., Hallman, M. & Ojaniemi, M., Mar 1 2007, In : Cellular Signalling. 19, 3, p. 625-633 9 p.

Research output: Contribution to journalArticle

Building shared experience to advance practical application of pathway-based toxicology: Liver toxicity mode-of-action

Willett, C., Rae, J. C., Goyak, K. O., Minsavage, G., Westmoreland, C., Andersen, M., Avigan, M., Duché, D., Harris, G., Hartung, T., Jaeschke, H., Kleensang, A., Landesmann, B., Martos, S., Matevia, M., Toole, C., Rowan, A., Schultz, T., Seed, J., Senior, J. & 4 others, Shah, I., Subramanian, K., Vinken, M. & Watkins, P., 2014, In : ALTEX. 31, 4, p. 500-519 20 p.

Research output: Contribution to journalArticle

Cancer-related thromboembolic disease in patients with solid tumours: A retrospective analysis

Harrington, K. J., Bateman, A. R., Syrigos, K. N., Rintoul, R., Bhidayasiri, R., McCormack, M. & Thomas, H., Jul 1 1997, In : Annals of Oncology. 8, 7, p. 669-673 5 p.

Research output: Contribution to journalArticle

Can TTIP improve laboratory animal welfare in safety testing and 3Rs?

Busquet, F., Zurlo, J. & Hartung, T., Jan 1 2016, In : ILAR journal. 57, 3, p. 358-367 10 p.

Research output: Contribution to journalArticle

CD36 is a sensor of diacylglycerides

Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zähringer, U. & Beutler, B., Feb 3 2005, In : Nature. 433, 7025, p. 523-527 5 p.

Research output: Contribution to journalArticle

Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages

Scheel, O., Papavlassopoulos, M., Blunck, R., Gebert, A., Hartung, T., Zähringer, U., Seydel, U. & Schromm, A. B., Jul 1 2006, In : Infection and immunity. 74, 7, p. 4354-4356 3 p.

Research output: Contribution to journalArticle

Cell activation of human macrophages by lipoteichoic acid is strongly attenuated by lipopolysaccharide-binding protein

Mueller, M., Stamme, C., Draing, C., Hartung, T., Seydel, U. & Schromm, A. B., Oct 20 2006, In : Journal of Biological Chemistry. 281, 42, p. 31448-31456 9 p.

Research output: Contribution to journalArticle

cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4

Spiller, S., Dreher, S., Meng, G., Grabiec, A., Thomas, W., Hartung, T., Pfeffer, K., Hochrein, H., Brade, H., Bessler, W., Wagner, H. & Kirschning, C. J., May 4 2007, In : Journal of Biological Chemistry. 282, 18, p. 13190-13198 9 p.

Research output: Contribution to journalArticle

Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36

Nilsen, N. J., Deininger, S., Nonstad, U., Skjeldal, F., Husebye, H., Rodionov, D., Von Aulock, S., Hartung, T., Lien, E., Bakke, O. & Espevik, T., Jul 1 2008, In : Journal of Leukocyte Biology. 84, 1, p. 280-291 12 p.

Research output: Contribution to journalArticle

cGMP-mediated inhibition of TNF-α production by the atrial natriuretic peptide in murine macrophages

Kiemer, A. K., Hartung, T. & Vollmar, A. M., Jul 1 2000, In : Journal of Immunology. 165, 1, p. 175-181 7 p.

Research output: Contribution to journalArticle

Open Access

Characterisation of cadmium chloride induced molecular and functional alterations in airway epithelial cells

Forti, E., Bulgheroni, A., Cetin, Y., Hartung, T., Jennings, P., Pfaller, W. & Prieto, P., 2010, In : Cellular Physiology and Biochemistry. 25, 1, p. 159-168 10 p.

Research output: Contribution to journalArticle

Characteristics of surfactant protein A and D binding to lipoteichoic acid and peptidoglycan, 2 major cell wall components of gram-positive bacteria

Van de Wetering, J. K., Van Eijk, M., Van Golde, L. M. G., Hartung, T., Van Strijp, J. A. G. & Batenburg, J. J., Nov 1 2001, In : Journal of Infectious Diseases. 184, 9, p. 1143-1151 9 p.

Research output: Contribution to journalArticle

Characterization of the Cytokine Immune Response in Children Who Have Experienced an Episode of Typical Hemolytic-Uremic Syndrome

Westerholt, S., Pieper, A. K., Griebel, M., Volk, H. D., Hartung, T. & Oberhoffer, R., Nov 1 2003, In : Clinical and Diagnostic Laboratory Immunology. 10, 6, p. 1090-1095 6 p.

Research output: Contribution to journalArticle

Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening

Tong, Z. B., Hogberg, H., Kuo, D., Sakamuru, S., Xia, M., Smirnova, L., Hartung, T. & Gerhold, D., 2016, (Accepted/In press) In : Journal of Applied Toxicology.

Research output: Contribution to journalArticle

Chemical respiratory allergy: Opportunities for hazard identification and characterisation

Kimber, I., Agius, R., Basketter, D. A., Corsini, E., Cullinan, P., Dearman, R. J., Gimenez-Arnau, E., Greenwell, L., Hartung, T., Kuper, F., Maestrelli, P., Roggen, E., Rovida, C. & Casati, S., May 2007, In : ATLA Alternatives to Laboratory Animals. 35, 2, p. 243-265 23 p.

Research output: Contribution to journalArticle

Chip, Chip, Hurra! Die Amerikaner feiern den Gen-Chip--feiern wir mit?

Translated title of the contribution: Hip, hip, hurrah! Americans celebrate Gen-Chip--are we celebrating too?Hartung, T., 2000, In : ALTEX : Alternativen zu Tierexperimenten. 17, 2, p. 101-102 2 p.

Research output: Contribution to journalArticle

CIIPro: a new read-across portal to fill data gaps using public large-scale chemical and biological data

Russo, D. P., Kim, M. T., Wang, W., Pinolini, D., Shende, S., Strickland, J., Hartung, T. & Zhu, H., Feb 1 2017, In : Bioinformatics (Oxford, England). 33, 3, p. 464-466 3 p.

Research output: Contribution to journalArticle

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., Neisser, M., Nguyen, C., Lee, R., Park, J. K., Reyes, J., Hartung, T., Rojas, C., Rais, R., Tsukamoto, T., Semenza, G. L. & 3 others, Hanes, J., Slusher, B. S. & Le, A., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. E5328-E5336

Research output: Contribution to journalArticle

Comparison and validation of novel pyrogen tests based on the human fever reaction

Hartung, T., Poole, S., Montag-Lessing, T., Nibbeling, R., Werner-Felmayer, G., Jungi, T., Brügger, P., Coecke, S., Aaberge, I. & Berthold, S., Dec 2002, In : ATLA Alternatives to Laboratory Animals. 30, SUPPL. 2, p. 49-51 3 p.

Research output: Contribution to journalArticle

Comparison and validation of novel pyrogen tests based on the human fever reaction.

Schindler, S. & Hartung, T., 2002, In : Developments in biologicals. 111, p. 181-186 6 p.

Research output: Contribution to journalArticle

Comparison of eleven commercial tests for Chlamydia pneumoniae-specific immunoglobulin G in asymptomatic healthy individuals

Hermann, C., Graf, K., Groh, A., Straube, E. & Hartung, T., 2002, In : Journal of clinical microbiology. 40, 5, p. 1603-1609 7 p.

Research output: Contribution to journalArticle

Comparison of lipoteichoic acid from different serotypes of Streptococcus pneumoniae

Draing, C., Pfitzenmaier, M., Zummo, S., Mancuso, G., Geyer, A., Hartung, T. & Von Aulock, S., Nov 10 2006, In : Journal of Biological Chemistry. 281, 45, p. 33849-33859 11 p.

Research output: Contribution to journalArticle

Comparison of the interleukin-1β-inducing potency of allergenic spores from higher fungi (basidiomycetes) in a cryopreserved human whole blood system

Rivera-Mariani, F. E., Vysyaraju, K., Negherbon, J., Levetin, E., Horner, W. E., Hartung, T. & Breysse, P. N., Feb 1 2014, In : International archives of allergy and immunology. 163, 2, p. 154-162 9 p.

Research output: Contribution to journalArticle

Comparison of the reactivity of human and rabbit blood towards pyrogenic stimuli.

Schindler, S., Bristow, A., Cartmell, T., Hartung, T. & Fennrich, S., 2003, In : ALTEX : Alternativen zu Tierexperimenten. 20, 2, p. 59-63 5 p.

Research output: Contribution to journalArticle

Comparison of the sensitivity of different toxicological endpoints in Caco-2 cells after cadmium chloride treatment

Boveri, M., Pazos, P., Gennari, A., Casado, J., Hartung, T. & Prieto, P., Apr 1 2004, In : Archives of Toxicology. 78, 4, p. 201-206 6 p.

Research output: Contribution to journalArticle

Computational approaches to chemical hazard assessment

Luechtefeld, T. & Hartung, T., Jan 1 2017, In : ALTEX. 34, 4, p. 459-478 20 p.

Research output: Contribution to journalArticle

Consensus report on the future of animal-free systemic toxicity testing

Leist, M., Hasiwa, N., Rovida, C., Daneshian, M., Basketter, D., Kimber, I., Clewell, H., Gocht, T., Goldberg, A., Busquet, F., Rossi, A. M., Schwarz, M., Stephens, M., Taalman, R., Knudsen, T. B., McKim, J., Harris, G., Pamies, D. & Hartung, T., 2014, In : ALTEX. 31, 3, p. 341-356 16 p.

Research output: Contribution to journalArticle

Control of fecal peritoneal infection in mice by colony-stimulating factors

Barsig, J., Bundschuh, D. S., Hartung, T., Bauhofer, A., Sauer, A. & Wendel, A., Jan 1 1996, In : Journal of Infectious Diseases. 174, 4, p. 790-799 10 p.

Research output: Contribution to journalArticle

Open Access

Critical evaluation of the use of dogs in biomedical research and testing in Europe

Hasiwa, N., Bailey, J., Clausing, P., Daneshian, M., Eileraas, M., Farkas, S., Gyertyań, I., Hubrecht, R., Kobel, W., Krummenacher, G., Leist, M., Lohi, H., Miklośi, A., Ohl, F., Olejniczak, K., Schmitt, G., Sinnett-Smith, P., Smith, D., Wagner, K., Yager, J. D. & 2 others, Zurlo, J. & Hartung, T., Dec 30 2011, In : ALTEX. 28, 4, p. 326-340 15 p.

Research output: Contribution to journalArticle

Critical evaluation of urine-based PCR assay for diagnosis of Lyme borreliosis.

Rauter, C., Mueller, M., Diterich, I., Zeller, S., Hassler, D., Meergans, T. & Hartung, T., Aug 2005, In : Clinical and Diagnostic Laboratory Immunology. 12, 8, p. 910-917 8 p.

Research output: Contribution to journalArticle

Cryopreservation of human whole blood for pyrogenicity testing

Schindler, S., Asmus, S., Von Aulock, S., Wendel, A., Hartung, T. & Fennrich, S., Nov 1 2004, In : Journal of Immunological Methods. 294, 1-2, p. 89-100 12 p.

Research output: Contribution to journalArticle

Current approaches and future role of high content imaging in safety sciences and drug discovery

Van Vliet, E., Daneshian, M., Beilmann, M., Davies, A., Fava, E., Fleck, R., Julé, Y., Kansy, M., Kustermann, S., Macko, P., Mundy, W. R., Roth, A., Shah, I., Uteng, M., Van De Water, B., Hartung, T. & Leist, M., Jan 1 2014, In : ALTEX. 31, 4, p. 479-493 15 p.

Research output: Contribution to journalArticle

Cytokine induction by Gram-positive bacteria

Draing, C., Sigel, S., Deininger, S., Traub, S., Munke, R., Mayer, C., Hareng, L., Hartung, T., von Aulock, S. & Hermann, C., May 14 2008, In : Immunobiology. 213, 3-4, p. 285-296 12 p.

Research output: Contribution to journalArticle

Cytokine induction by purified lipoteichoic acids from various bacterial species - Role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-γ release

Hermann, C., Spreitzer, I., Schröder, N. W. J., Morath, S., Lehner, M. D., Fischer, W., Schütt, C., Schumann, R. R. & Hartung, T., 2002, In : European Journal of Immunology. 32, 2, p. 541-551 11 p.

Research output: Contribution to journalArticle

D-alanyl ester depletion of teichoic acids in Lactobacillus plantarum results in a major modification of lipoteichoic acid composition and cell wall perforations at the septum mediated by the Acm2 autolysin

Palumbo, E., Deghorain, M., Cocconcelli, P. S., Kleerebezem, M., Geyer, A., Hartung, T., Morath, S. & Hols, P., May 1 2006, In : Journal of bacteriology. 188, 10, p. 3709-3715 7 p.

Research output: Contribution to journalArticle

Definition of structural prerequisites for lipoteichoic acid-inducible cytokine induction by synthetic derivatives

Deininger, S., Stadelmaier, A., Von Aulock, S., Morath, S., Schmidt, R. R. & Hartung, T., Apr 15 2003, In : Journal of Immunology. 170, 8, p. 4134-4138 5 p.

Research output: Contribution to journalArticle

Open Access

Dendritic cells as a tool for the predictive identification of skin sensitisation hazard

Casati, S., Aeby, P., Basketter, D. A., Cavani, A., Gennari, A., Gerberick, G. F., Griem, P., Hartung, T., Kimber, I., Lepoittevin, J. P., Meade, B. J., Pallardy, M., Rougier, N., Rousset, F., Rubinstenn, G., Sallusto, F., Verheyen, G. R. & Zuang, V., Feb 1 2005, In : ATLA Alternatives to Laboratory Animals. 33, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle